result 1495 件
| Title Alternative | Adenoviral p53 gene therapy for lung cancer |
|---|---|
| FullText URL | 119_229.pdf |
| Author | Fujiwara, Toshiyoshi| Tanaka, Noriaki| |
| Abstract | To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit. |
| Keywords | p53 遺伝子 アデノウイルスベクター (adenovirus vector) 肺癌 (lung cancer) 臨床試験 (clinical trial) |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-01-04 |
| Volume | volume119 |
| Issue | issue3 |
| Start Page | 229 |
| End Page | 234 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.119.229 |
| NAID | 10020282723 |
| Author | Sato, Tomoaki| Ueshima, Satoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Matsuoka, Junji| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Fujiwara, Satoko| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nishimoto, Hitomi| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Doihara, Hiroyoshi| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nakagawa, Kazuhiko| Noguchi, Yuji| Okumura, Hideo| Sato, Shuichiro| Tanaka, Motoyuki| Shimono, Michihide| Ali Eldib, Ali Mohamed| Aoe, Motoi| Ono, Toshiro| Uenaka, Akiko| Ohara, Nobuya| Yoshino, Tadashi| Yamashita, Kazuki| Tsunoda, Tsukasa| Shimizu, Nobuyoshi| Nakayama, Eiichi| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Yamasaki, Osamu| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Sagara, Hidenori| Kitamura, Yoshihisa| Sendo, Toshiaki| Gomita, Yutaka| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Okada, Hiroki| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Tabata, Masahiro| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nishie, Hiroyuki| Mizobuchi, Satoshi| Matsusaki, Takashi| Miyake, Asako| Kaku, Ryuji| Ishikawa, Shinichi| Sato, Kenji| Matsumi, Masaki| Kiyoshi, Morita| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 成島 道樹| Kobayashi, Naoya| 興津 輝| 田中 斎仁| 李 順愛| 陳 勇| 三木 厚| 田中 公章| 中路 修平| 竹居 孝二| Alejandro, Soto Gutierrez| Jorge, David Rivas-Carrillo| Nalu, Navarro-Alvarez| Hee-Sook, Jun| Karen, A Westerman| 野口 洋文| Jonathan, R T Lakey| Philippe, Leboulch| 田中 紀章| Ji-Won, Yoon| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 松尾 嘉禮| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Article |
| Author | Shinomiya, Kazuaki| Kitamura, Yoshihisa| Ueshima, Satoshi| Satoh, Tomoaki| Sendo, Toshiaki| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yagi, Takahito| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院| |
|---|---|
| Published Date | 1991-08 |
| Publication Title | 環境病態研報告 |
| Volume | volume62 |
| Content Type | Others |
| JaLCDOI | 10.18926/11936 |
|---|---|
| Title Alternative | The contrast media containing soft drinks for X-ray examination of the stomach |
| FullText URL | 005_111_114.pdf |
| Author | Shibuya, Koichi| Nakagiri, Yoshitada| Azuma, Yoshiharu| Goto, Sachiko| Sugita, Katsuhiko| Okura, Yasuhiko| Tandani, Nobuyoshi| Nobuhara, Eitaro| Mikami, Yasutaka| |
| Abstract | 胃検診の受診者を増やし、検査を円滑に行う上で、造影剤である硫酸バリウム懸濁液の飲みにくさが障害の一つとなっている。これを改善する試みとして、懸濁液に市販の粉末清涼飲料を混入し検討したところ72.1％の人から通常のものよりも飲みやすいという回答を得た。今後、臨床的な検討を加えながら、さらに創意工夫していく必要がある。 |
| Keywords | 造影剤 (contrast media) 硫酸バリウム製剤 (barium sulfate suspension) 粘度 (viscosity) 飲みやすさ (easiness to drink) |
| Publication Title | 岡山大学医療技術短期大学部紀要 |
| Published Date | 1995-01-31 |
| Volume | volume5 |
| Start Page | 111 |
| End Page | 114 |
| ISSN | 0917-4494 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002313324 |
| JaLCDOI | 10.18926/11934 |
|---|---|
| Title Alternative | Granularity of Asymmetric Screen-Film System |
| FullText URL | 005_105_110.pdf |
| Author | Honda, Mitsugi| Yoshida, Akira| Nakamura, Nobue| Mimura, Seiichi| Kadohisa, Sigefumi| Mikami, Yasutaka| Azuma, Yoshiharu| Takeuchi, Tomoyuki| Sugita, Katsuhiko| Hiraki, Yoshio| |
| Abstract | 非対称増感紙フィルム系について、両面乳剤フィルムのウィナースペクトル測定に及ぼす影響を検討した。濃度0.5～2.5のノイズ試料のフロント乳剤、バック乳剤、支持体層それぞれで測定したスペクトルの和と、両面同時に測定した全スペクトルとを比較した。その結果、全ウィナースペクトルの値は、フロント乳剤、バック乳剤の和より高くなった。また、試料濃度が高いほど、その差は大きくなった。これらは、マイクロデンシトメータの光学系の配置と両面乳剤フィルムの構造に起因している。したがって、非対称システムのようにフィルムの前面と後面で特性を分けて考える場合、注意を要する。 |
| Keywords | 非対称増感紙フィルム系 (asymmetric screen-film system) 両面乳剤フィルム (double-emulsion film) ウィナースペクトル (Wiener spectrum) 粒状性 (granularity) マイクロデンシトメータ (microdensitometer) |
| Publication Title | 岡山大学医療技術短期大学部紀要 |
| Published Date | 1995-01-31 |
| Volume | volume5 |
| Start Page | 105 |
| End Page | 110 |
| ISSN | 0917-4494 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002313805 |
| JaLCDOI | 10.18926/11931 |
|---|---|
| Title Alternative | Statistics and analysis on the troubles of linear accelarator. |
| FullText URL | 005_099_103.pdf |
| Author | Nakagiri, Yoshitada| Mikami, Yasutaka| Azuma, Yoshiharu| Sibuya, Koichi| Goto, Sachiko| Inamura, Keiji| Tahara, Seiji| Uno, Hirofumi| Sugita, Katsuhiko| Hiraki, Yoshio| |
| Abstract | 放射線治療の成否は厳密に設定されたTarget Volumeに如何に正確な線量を照射するかによって決まる。治療術式の過程において、最も大きな誤差を生む要因は照射機器である。誤差の少ない治療を目指す第一歩は機器を正確に作動させることであり、日常からの保守点検および整備が必要である。今回、岡山大学附属病院で1976年から1991年までに使用されたリニアックについて、その故障状況を集計し、部位別故障件数、管球の寿命、稼動率などを分析検討した。その結果、故障件数では設置され稼動を始めた1976年、装置の老朽化が進んだ1990、1991年に多かった。部位別集計では加速部に圧倒的に多く、次いで照射口、高圧部の順であった。稼動率は設置年および1987年を除いてはいずれも96％以上とよい結果であった。この結果は全国に稼動している同型の装置の保守点検に役立つものと考える。 |
| Keywords | 放射線治療 (radiotherapy) 直線加速器 (linear accelarator) 故障 (troubles of radiation system) |
| Publication Title | 岡山大学医療技術短期大学部紀要 |
| Published Date | 1995-01-31 |
| Volume | volume5 |
| Start Page | 99 |
| End Page | 103 |
| ISSN | 0917-4494 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002313722 |
