result 23732 件
| JaLCDOI | 10.18926/AMO/52007 |
|---|---|
| FullText URL | 67_6_343.pdf |
| Author | Yamane, Kentaro| Takigawa, Tomoyuki| Tanaka, Masato| Osaki, Syuhei| Sugimoto, Yoshihisa| Ozaki, Toshifumi| |
| Abstract | Cervical spinal schwannoma is benign, and outcomes after surgical resection are generally excellent. A surgical dilemma sometimes arises as to whether to perform total tumor removal, which carries a risk of sacrificing the nerve root, or subtotal removal, where the risk can be tumor recurrence. The purpose of this study was to identify factors with the potential to predict clinical impairment after surgery for cervical spinal schwannomas. Thirty cases of cervical schwannomas treated surgically in our institute were retrospectively reviewed;initial symptoms, tumor location, Eden classification, surgical method, functional outcome, and tumor recurrence were investigated. All permanent motor deficits were the result of resecting functionally relevant nerve roots (i.e., C5-8). The rate of permanent sensory deficit was 11% after C1-4 nerve root resection, and 67% after C5-8 nerve root resection. Permanent neurological deficits occurred in 14% of patients younger than 40 years and 38% of those older than 40. Dumbbell tumors were associated with the need for total or ventral nerve root transection, as well as with a high incidence of tumor recurrence. The incidence of permanent neurological deficit was significantly higher in patients undergoing C5-8 nerve root resection, and tended to be higher in those over 40. |
| Keywords | cervical spinal schwannoma neurological deficit nerve root resection tumor resection tumor recurrence |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 343 |
| End Page | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356718 |
| Web of Science KeyUT | 000328915700002 |
| JaLCDOI | 10.18926/AMO/52006 |
|---|---|
| FullText URL | 67_6_333.pdf |
| Author | Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses. |
| Keywords | oncolytic adenovirus autophagy E2F1 microRNA |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356717 |
| Web of Science KeyUT | 000328915700001 |
| FullText URL | O0004408_abstract_review.pdf O0004408_fulltext.pdf |
|---|---|
| Author | Osawa, Fuminori| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4408号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Pharmaceutical Sciences |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0004870_abstract_review.pdf K0004870_fulltext.pdf |
|---|---|
| Author | Toyota, Teruaki| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4870号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Health Sciences |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Harimoto, Takashi| |
|---|---|
| Published Date | 2013-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Eguchi, Hitomi| |
|---|---|
| Published Date | 2013-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004867_abstract_review.pdf K0004867_fulltext.pdf |
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| Author | Hartwig, Claudia| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4867号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004866_abstract_review.pdf K0004866_fulltext.pdf |
|---|---|
| Author | Siti Norbaizura Binti MD. Rejab| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4866号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004865_abstract_review.pdf K0004865_fulltext.pdf |
|---|---|
| Author | Sergelenkhuu, Jambal| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4865号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004864_abstract_review.pdf K0004864_fulltext.pdf |
|---|---|
| Author | Kang, Sukkyeong| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4864号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0004853_abstract_review.pdf K0004853_fulltext.pdf |
|---|---|
| Author | Chang, Ning-hui| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4853号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004852_abstract_review.pdf K0004852_fulltext.pdf |
|---|---|
| Author | 焦 佼| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4852号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004851_abstract_review.pdf K0004851_fulltext.pdf |
|---|---|
| Author | He, Xuexia| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4851号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004848_abstract_review.pdf K0004848_fulltext.pdf |
|---|---|
| Author | Wang, Riping| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4848号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004847_abstract_review.pdf K0004847_fulltext.pdf |
|---|---|
| Author | Sanagawa, Toru| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4847号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0004846_abstract_review.pdf K0004846_fulltext.pdf |
|---|---|
| Author | Shinkawa, Shigehiko| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4846号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0004845_abstract_review.pdf K0004845_fulltext.pdf |
|---|---|
| Author | Tai, Naoko| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4845号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| Author | Minami, Daisuke| |
|---|---|
| Published Date | 2013-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004840_abstract_review.pdf K0004840_fulltext.pdf |
|---|---|
| Author | Maki, Yuho| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4840号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004843_abstract_review.pdf K0004843_fulltext.pdf |
|---|---|
| Author | Ando, Midori| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4843号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
