検索結果 631 件
フルテキストURL | K0006986_abstract_review.pdf K0006986_fulltext.pdf K0006986_summary.pdf |
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著者 | 森本 光作| |
発行日 | 2024-03-25 |
資料タイプ | 学位論文 |
学位授与番号 | 甲第6986号 |
学位授与年月日 | 2024-03-25 |
学位・専攻分野 | 博士(医学) |
授与大学 | 岡山大学 |
言語 | 英語 |
著作権者 | © The Author(s), 2023. |
フルテキストURL | fulltext.pdf |
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著者 | Takahashi, Yosuke| Noma, Kazuhiro| Hashimoto, Masashi| Maeda, Naoaki| Tanabe, Shunsuke| Fujiwara, Toshiyoshi| |
キーワード | Parahiatal hernia Esophageal hiatal hernia Laparoscopic repair Three-dimensional laparoscopy |
発行日 | 2024-04 |
出版物タイトル | International Journal of Surgery Case Reports |
巻 | 117巻 |
出版者 | Elsevier |
開始ページ | 109565 |
ISSN | 2210-2612 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 The Author(s). |
論文のバージョン | publisher |
PubMed ID | 38547697 |
DOI | 10.1016/j.ijscr.2024.109565 |
Web of Science KeyUT | 001224601000001 |
関連URL | isVersionOf https://doi.org/10.1016/j.ijscr.2024.109565 |
フルテキストURL | fulltext.pdf |
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著者 | Tsutsumi, Koichiro| Otsuka, Motoyuki| |
キーワード | biomarker early diagnosis high-grade PanIN IPMN liquid biopsy pancreatic ductal carcinoma pancreatic juice small extracellular vesicle treatment |
発行日 | 2023-03-28 |
出版物タイトル | Clinical and Translational Discovery |
巻 | 3巻 |
号 | 2号 |
出版者 | Wiley |
開始ページ | e177 |
ISSN | 2768-0622 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2023 The Authors. |
論文のバージョン | publisher |
DOI | 10.1002/ctd2.177 |
Web of Science KeyUT | 001224381800004 |
関連URL | isVersionOf https://doi.org/10.1002/ctd2.177 |
フルテキストURL | fulltext.pdf |
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著者 | Iwamuro, Masaya| Kawano, Seiji| Otsuka, Motoyuki| |
キーワード | Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Esophageal lesions Gastric lesions Duodenal lesions |
発行日 | 2024-04-28 |
出版物タイトル | World Journal of Gastroenterology |
巻 | 30巻 |
号 | 16号 |
出版者 | Baishideng Publishing Group |
開始ページ | 2220 |
終了ページ | 2232 |
ISSN | 1007-9327 |
NCID | AA11690631 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2024. |
論文のバージョン | publisher |
PubMed ID | 38690017 |
DOI | 10.3748/wjg.v30.i16.2220 |
Web of Science KeyUT | 001214282500009 |
関連URL | isVersionOf https://doi.org/10.3748/wjg.v30.i16.2220 |
フルテキストURL | fulltext.pdf |
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著者 | Oyama, Atsushi| Takaki, Akinobu| Adachi, Takuya| Wada, Nozomu| Takeuchi, Yasuto| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| Otsuka, Motoyuki| |
キーワード | Primary sclerosing cholangitis Oxidative stress marker Prognosis Serum reactive oxygen metabolite Total serum antioxidant capacity Revised Mayo risk score Child–Pugh score MELD score FIB-4 index Serum dROM Serum OXY-adsorbent test Immunoglobulin A |
備考 | The version of record of this article, first published in Hepatology International, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12072-023-10557-2| |
発行日 | 2023-07-26 |
出版物タイトル | Hepatology International |
巻 | 17巻 |
号 | 5号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 1215 |
終了ページ | 1224 |
ISSN | 1936-0533 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37493884 |
DOI | 10.1007/s12072-023-10557-2 |
Web of Science KeyUT | 001034200900001 |
関連URL | isVersionOf https://doi.org/10.1007/s12072-023-10557-2 |
フルテキストURL | fulltext.pdf |
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著者 | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
キーワード | Hepaticojejunostomy Robotic surgery Pancreatoduodenectomy Biliary complications |
備考 | The version of record of this article, first published in Langenbeck's Archives of Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00423-023-03020-1| |
発行日 | 2023-07-20 |
出版物タイトル | Langenbeck's Archives of Surgery |
巻 | 408巻 |
号 | 1号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 284 |
ISSN | 1435-2451 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37468703 |
DOI | 10.1007/s00423-023-03020-1 |
Web of Science KeyUT | 001032102900001 |
関連URL | isVersionOf https://doi.org/10.1007/s00423-023-03020-1 |
フルテキストURL | fulltext.pdf |
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著者 | Takagi, Kosei| Hata, Nanako| Kimura, Jiro| Kikuchi, Satoru| Noma, Kazuhiro| Yasui, Kazuya| Fuji, Tomokazu| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| |
キーワード | Virtual reality Robotic simulations Educational video Robotic surgery Learning curve Cumulative sum analysis |
備考 | The version of record of this article, first published in Journal of Robotic Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11701-023-01556-4| |
発行日 | 2023-03-11 |
出版物タイトル | Journal of Robotic Surgery |
巻 | 17巻 |
号 | 4号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 1547 |
終了ページ | 1553 |
ISSN | 1863-2491 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 36905486 |
DOI | 10.1007/s11701-023-01556-4 |
Web of Science KeyUT | 000946947400001 |
関連URL | isVersionOf https://doi.org/10.1007/s11701-023-01556-4 |
フルテキストURL | fulltext.pdf |
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著者 | Kawasaki, Kento| Noma, Kazuhiro| Kato, Takuya| Ohara, Toshiaki| Tanabe, Shunsuke| Takeda, Yasushige| Matsumoto, Hijiri| Nishimura, Seitaro| Kunitomo, Tomoyoshi| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Kashima, Hajime| Maeda, Naoaki| Kikuchi, Satoru| Tazawa, Hiroshi| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| |
キーワード | Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors |
備考 | The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2| |
発行日 | 2023-09-05 |
出版物タイトル | Cancer Immunology, Immunotherapy |
巻 | 72巻 |
号 | 11号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 3787 |
終了ページ | 3802 |
ISSN | 0340-7004 |
NCID | AA00598499 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37668710 |
DOI | 10.1007/s00262-023-03531-2 |
Web of Science KeyUT | 001062743200002 |
関連URL | isVersionOf https://doi.org/10.1007/s00262-023-03531-2 |
フルテキストURL | fulltext.pdf |
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著者 | Iwamuro, Masaya| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Tanaka, Takehiro| Inokuchi, Toshihiro| Hiraoka, Sakiko| Otsuka, Motoyuki| |
キーワード | Colonoscopy Esophagogastroduodenoscopy Graft-versus-host disease Hematopoietic stem cell transplantation Intestinal transplant-associated microangiopathy iTAM |
備考 | The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-024-03221-y| |
発行日 | 2024-04-22 |
出版物タイトル | BMC Gastroenterology |
巻 | 24巻 |
号 | 1号 |
出版者 | BMC |
開始ページ | 140 |
ISSN | 1471-230X |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2024. |
論文のバージョン | publisher |
PubMed ID | 38649868 |
DOI | 10.1186/s12876-024-03221-y |
Web of Science KeyUT | 001206319800003 |
関連URL | isVersionOf https://doi.org/10.1186/s12876-024-03221-y |
フルテキストURL | fulltext.pdf |
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著者 | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
発行日 | 2024-02-20 |
出版物タイトル | PLoS ONE |
巻 | 19巻 |
号 | 2号 |
出版者 | Public Library of Science |
開始ページ | e0298292 |
ISSN | 1932-6203 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 Uotani et al. |
論文のバージョン | publisher |
PubMed ID | 38377118 |
DOI | 10.1371/journal.pone.0298292 |
Web of Science KeyUT | 001176939600021 |
関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
フルテキストURL | fulltext.pdf |
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著者 | Kobashi, Mayu| Ishikawa, Shigenao| Inaba, Tomoki| Iwamuro, Masaya| Aoyama, Yuki| Kagawa, Tomo| Takeuchi, Yasuto| Ando, Midori| Nakamura, Satoko| Okada, Hiroyuki| |
キーワード | Frozen section Pathological diagnosis Diagnostic accuracy Early gastric cancer Endoscopic submucosal dissection Lateral margin |
備考 | The version of record of this article, first published in Surgical Endoscopy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00464-023-10100-2| |
発行日 | 2023-05-22 |
出版物タイトル | Surgical Endoscopy |
巻 | 37巻 |
号 | 9号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 6736 |
終了ページ | 6748 |
ISSN | 0930-2794 |
NCID | AA10750363 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37217685 |
DOI | 10.1007/s00464-023-10100-2 |
Web of Science KeyUT | 000993678400007 |
関連URL | isVersionOf https://doi.org/10.1007/s00464-023-10100-2 |
フルテキストURL | fulltext.pdf |
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著者 | Ihara, Hiroki| Yoshio, Kotaro| Tanabe, Shunsuke| Sugiyama, Soichi| Hashimoto, Masashi| Maeda, Naoaki| Akagi, Shinsuke| Takao, Soshi| Noma, Kazuhiro| Hiraki, Takao| |
キーワード | Radiation therapy Esophageal squamous cell carcinoma Recurrence 18F-fluorodeoxyglucose positron emission tomography Survival |
備考 | The version of record of this article, first published in Esophagus, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10388-023-01000-4| |
発行日 | 2023-04-07 |
出版物タイトル | Esophagus |
巻 | 20巻 |
号 | 3号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 548 |
終了ページ | 556 |
ISSN | 1612-9059 |
NCID | AA11885266 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023 |
論文のバージョン | publisher |
PubMed ID | 37027045 |
DOI | 10.1007/s10388-023-01000-4 |
Web of Science KeyUT | 000964113700001 |
関連URL | isVersionOf https://doi.org/10.1007/s10388-023-01000-4 |
JaLCDOI | 10.18926/AMO/66931 |
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フルテキストURL | 78_2_201.pdf |
著者 | Masunaga, Akari| Tabuchi, Motoyasu| Sakamoto, Shinya| Yoshimatsu, Rika| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
抄録 | Trousseau syndrome is characterized by cancer-associated systemic thrombosis. We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical resection of the gallbladder tumor was performed. The resected gallbladder was filled with mucus and was pathologically diagnosed as an adenocarcinoma. Her postoperative course was uneventful, and she received a one-year course of adjuvant therapy with oral S-1. No cancer recurrence or thrombosis was noted 26 months postoperatively. Despite concurrent Trousseau syndrome, a radical cure of the primary tumor and thrombosis could be achieved with the appropriate treatment. |
キーワード | gallbladder cancer Trousseau syndrome radical surgery |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-04 |
巻 | 78巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 201 |
終了ページ | 204 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38688839 |
Web of Science KeyUT | 001227932200001 |
JaLCDOI | 10.18926/AMO/66930 |
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フルテキストURL | 78_2_197.pdf |
著者 | Teraishi, Fuminori| Matsumi, Yuki| Tachibana, Kota| Watanabe, Toshiyuki| Fujiwara, Toshiyoshi| |
抄録 | A 90-year-old Japanese woman who had been aware of a subcutaneous mass on the right perineal region for 5 years was referred to our hospital for further examination and treatment because of the rapid growth of the mass and bleeding that began 3 months earlier. A biopsy of the mass revealed a diagnosis of well-differentiated squamous cell carcinoma. On preoperative examination, the tumor was 90×40 mm in size and was suspected to have partially invaded the levator ani muscle and external sphincter. Since a preoperative cardiac evaluation indicated severe aortic stenosis, we performed transcatheter aortic valve implantation. A radical resection was then performed with general anesthesia. The skin and subcutaneous tissue defects were reconstructed with a posterior gluteal-thigh propeller flap, and a sigmoid colostomy was created. The patient had a good postoperative course and was transferred to a rehabilitation facility 28 days after the surgery. Epidermal cysts are a common benign tumor, and clinicians should keep in mind that these cysts can become malignant. |
キーワード | squamous cell carcinoma epidermoid cyst gluteal thigh flap |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-04 |
巻 | 78巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 197 |
終了ページ | 200 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38688838 |
Web of Science KeyUT | 001227932200004 |
フルテキストURL | fulltext20240423-01.pdf fig20240423-01.pdf table20240423-01.pdf suppl20240423-01.pdf |
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著者 | Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi| |
備考 | This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.| |
発行日 | 2024-04-15 |
出版物タイトル | Nutrition and Cancer |
巻 | 76巻 |
号 | 6号 |
出版者 | Informa UK Limited |
開始ページ | 476 |
終了ページ | 485 |
ISSN | 0163-5581 |
NCID | AA00325612 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | author |
PubMed ID | 38619145 |
DOI | 10.1080/01635581.2024.2340782 |
Web of Science KeyUT | 001202947500001 |
関連URL | isVersionOf https://doi.org/10.1080/01635581.2024.2340782 |
JaLCDOI | 10.18926/AMO/66928 |
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フルテキストURL | 78_2_193.pdf |
著者 | Kashima, Hajime| Teraishi, Fuminori| Matsumi, Yuki| Shimamura, Hiroshi| Fujiwara, Toshiyoshi| |
抄録 | Tailgut cyst is a rare cystic disease of the anterior sacral surface and the remains of an embryonic tail gut. Tailgut cysts have a potential for malignancy, and complete resection with an adequate surgical margin is necessary. Even if incomplete resection does not result in recurrence of malignant disease, there is a risk of local infection leading to refractory fistulas. The optimal treatment for such refractory recurrent lesions has not been reported. We describe a case in which the combination of laparoscopic and transsacral approaches was effective for resecting a recurrent refractory fistula after incomplete resection of a tail gut cyst. |
キーワード | tailgut cyst laparoscopic resection fistula formation |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-04 |
巻 | 78巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 193 |
終了ページ | 196 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38688837 |
Web of Science KeyUT | 001227932200003 |
JaLCDOI | 10.18926/AMO/66924 |
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フルテキストURL | 78_2_151.pdf |
著者 | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
抄録 | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
キーワード | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-04 |
巻 | 78巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 151 |
終了ページ | 161 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38688833 |
Web of Science KeyUT | 001229151800007 |
フルテキストURL | fulltext.pdf |
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著者 | Kawai, Daisuke| Iwamuro, Masaya| Takenaka, Ryuta| Obata, Taisuke| Yamamoto, Takashi| Hirata, Shoichiro| Miura, Ko| Takemoto, Koji| Tsugeno, Hirofumi| Fujiki, Shigeatsu| |
キーワード | endoscopic submucosal dissection antithrombotic agents thienopyridine gastric tumor postoperative bleeding delayed bleeding |
発行日 | 2024-03-25 |
出版物タイトル | Journal of Clinical Medicine |
巻 | 13巻 |
号 | 7号 |
出版者 | MDPI |
開始ページ | 1886 |
ISSN | 2077-0383 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 by the authors. |
論文のバージョン | publisher |
PubMed ID | 38610651 |
DOI | 10.3390/jcm13071886 |
Web of Science KeyUT | 001200991800001 |
関連URL | isVersionOf https://doi.org/10.3390/jcm13071886 |
JaLCDOI | 10.18926/AMO/66913 |
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フルテキストURL | 78_2_107.pdf |
著者 | Han, Dongxiang| Du, Jianxiu| Wang, Wei| Wang, Cui| |
抄録 | Vertical transmission of hepatitis B virus (HBV), especially in Asia, is a key target in the global elimination of HBV. This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. There were no significant differences in liver function markers, including alanine aminotransferase, total bilirubin, blood creatinine, and blood urea nitrogen levels before and after TDF treatment. The serum HBV DNA viral load of the TDF-treated group became significantly lower than those of the control group and their own pre-medication levels. Infants showed no significant difference in body growth, including weight, height, head size, and five-min Apgar score. At 7 months after birth, 94.29% of infants in the TDF group and 86.54% of control-group infants had protective HBsAb levels ≥ 10 mIU/ml (p>0.05). The HBV infection rate of infants in the TDF-treated group was lower than that in the non-treated group. In high-HBV-DNA-load pregnant women, TDF administered from 28 weeks gestational age to delivery was associated with a lower risk of mother-to-infant transmission of HBV. |
キーワード | mother-to-infant transmission tenofovir disoproxil fumarate hepatitis B virus |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-04 |
巻 | 78巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 107 |
終了ページ | 113 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 38688828 |
Web of Science KeyUT | 001229151800002 |
フルテキストURL | fulltext.pdf |
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著者 | Iwamuro, Masaya| Takenaka, Ryuta| Miyahara, Koji| Okanoue, Shotaro| Yoshioka, Masao| Sakaguchi, Chihiro| Yamamoto, Kumiko| Kawai, Yoshinari| Toyokawa, Tatsuya| Tanaka, Takehiro| Otsuka, Motoyuki| |
キーワード | Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue Gastric neoplasms Esophagogastroduodenoscopy t(11;18) translocation, Trisomy 18 |
備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55663-9| |
発行日 | 2024-02-29 |
出版物タイトル | Scientific Reports |
巻 | 14巻 |
号 | 1号 |
出版者 | Nature Portfolio |
開始ページ | 4953 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2024 |
論文のバージョン | publisher |
PubMed ID | 38418651 |
DOI | 10.1038/s41598-024-55663-9 |
Web of Science KeyUT | 001178149200009 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-024-55663-9 |