検索結果 120 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Mizuki, Yutaka| Sakamoto, Shinji| Okahisa, Yuko| Yada, Yuji| Hashimoto, Nozomu| Takaki, Manabu| Yamada, Norihito| |
| キーワード | DISC1 kalirin ARHGEF11 Akt/GSK3 beta Wnt beta-catenin |
| 発行日 | 2020-12-14 |
| 出版物タイトル | International Journal of Neuropsychopharmacology |
| 巻 | 24巻 |
| 号 | 5号 |
| 出版者 | Oxford Univ Press |
| 開始ページ | 367 |
| 終了ページ | 382 |
| ISSN | 1461-1457 |
| NCID | AA11545519 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2020. |
| 論文のバージョン | publisher |
| PubMed ID | 33315097 |
| NAID | 120007045004 |
| DOI | 10.1093/ijnp/pyaa097 |
| Web of Science KeyUT | 000656192700001 |
| 関連URL | isVersionOf https://doi.org/10.1093/ijnp/pyaa097 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Liang, Yin| Wang, Mengxue| Wang, Chen| Liu, Yun| Naruse, Keiji| Takahashi, Ken| |
| キーワード | prediabetes atherosclerosis metabolic syndrome obesity endothelial dysfunction exosome microRNA |
| 発行日 | 2021-04-15 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 22巻 |
| 号 | 8号 |
| 出版者 | MDPI |
| 開始ページ | 4108 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 33921168 |
| NAID | 120007034439 |
| DOI | 10.3390/ijms22084108 |
| Web of Science KeyUT | 000644360200001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms22084108 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nakatsuka, Atsuko| Yamaguchi, Satoshi| Eguchi, Jun| Kakuta, Shigeru| Iwakura, Yoichiro| Sugiyama, Hitoshi| Wada, Jun| |
| 発行日 | 2021-03-19 |
| 出版物タイトル | Communications Biology |
| 巻 | 4巻 |
| 号 | 1号 |
| 出版者 | Nature |
| 開始ページ | 373 |
| ISSN | 2399-3642 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2021 |
| 論文のバージョン | publisher |
| PubMed ID | 33742129 |
| NAID | 120007004153 |
| DOI | 10.1038/s42003-021-01902-y |
| Web of Science KeyUT | 000631555700003 |
| 関連URL | isVersionOf https://doi.org/10.1038/s42003-021-01902-y |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsumoto, Namiko| Ohta, Yasuyuki| Deguchi, Kentaro| Kishida, Masayuki| Sato, Kota| Shang, Jingwei| Takemoto, Mami| Hishikawa, Nozomi| Yamashita, Toru| Watanabe, Aki| Yokote, Koutaro| Takemoto, Minoru| Oshima, Junko| Abe, Koji| |
| キーワード | werner syndrome compound heterozygous Japanese |
| 発行日 | 2019-04-01 |
| 出版物タイトル | Internal Medicine |
| 巻 | 58巻 |
| 号 | 7号 |
| 出版者 | Japanese Society of Internal Medicine |
| 開始ページ | 1033 |
| 終了ページ | 1036 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 by The Japanese Society of Internal Medicine |
| 論文のバージョン | publisher |
| PubMed ID | 30568144 |
| DOI | 10.2169/internalmedicine.1816-18 |
| Web of Science KeyUT | 000463190700024 |
| 関連URL | isVersionOf https://doi.org/10.2169/internalmedicine.1816-18 |
| JaLCDOI | 10.18926/AMO/61424 |
|---|---|
| フルテキストURL | 75_1_1.pdf |
| 著者 | Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| 抄録 | To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males. |
| キーワード | androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-02 |
| 巻 | 75巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33649607 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kajiwara, Koichiro| Sawa, Yoshihiko| Fujita, Takahiro| Tamaoki, Sachio| |
| キーワード | P. gingivalis LPS Diabetic nephropathy VCAM-1 E-selectin ACE2 FGF23 |
| 発行日 | 2021-01-06 |
| 出版物タイトル | BMC Nephrology |
| 巻 | 22巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 3 |
| ISSN | 1471-2369 |
| NCID | AA12035314 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s). 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 33407253 |
| DOI | 10.1186/s12882-020-02203-y |
| Web of Science KeyUT | 000608270800002 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12882-020-02203-y |
| フルテキストURL | K0006293_abstract_review.pdf K0006293_summary.pdf K0006293_fulltext.pdf |
|---|---|
| 著者 | 野島 一郎| |
| 発行日 | 2020-12-27 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6293号 |
| 学位授与年月日 | 2020-12-27 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Iwamuro, Masaya| Tanaka, Takehiro| Yamauchi, Nao| Nakashima, Yuri| Wada, Takahira| Hiraoka, Sakiko| Kawahara, Yoshiro| Okada, Hiroyuki| |
| キーワード | cytomegalovirus colitis pseudolipomatosis gastric emphysema post-resuscitation diabetes mellitus |
| 発行日 | 2020-02-15 |
| 出版物タイトル | Internal Medicine |
| 巻 | 59巻 |
| 号 | 4号 |
| 出版者 | The Japanese Society of Internal Medicine |
| 開始ページ | 519 |
| 終了ページ | 525 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by The Japanese Society of Internal Medicine |
| 論文のバージョン | publisher |
| PubMed ID | 31645533 |
| NAID | 130007798412 |
| DOI | 10.2169/internalmedicine.3633-19 |
| Web of Science KeyUT | 000516549400009 |
| 関連URL | isVersionOf https://doi.org/10.2169/internalmedicine.3633-19 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishizawa, Hitomi| Sato, Yoshihiko| Ishikawa, Masumi| Arakawa, Yuko| Iijima, Mari| Akiyama, Tomoyuki| Takano, Kyoko| Watanabe, Atsushi| Kosho, Tomoki| |
| キーワード | Hypophosphatasia Alkaline phosphatase Genetic disease Asfotase alfa Recombinant gene therapy Motor function |
| 発行日 | 2020-12 |
| 出版物タイトル | Molecular Genetics and Metabolism Reports |
| 巻 | 25巻 |
| 出版者 | Elsevier |
| 開始ページ | 100643 |
| ISSN | 2214-4269 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 32983894 |
| DOI | 10.1016/j.ymgmr.2020.100643 |
| Web of Science KeyUT | 000600655200010 |
| 関連URL | isVersionof https://doi.org/10.1016/j.ymgmr.2020.100643 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sada, Ken-Ei| Ohashi, Keiji| Asano, Yosuke| Hayashi, Keigo| Morishita, Michiko| Watanabe, Haruki| Matsumoto, Yoshinori| Fujimoto, Shouichi| Takasaki, Yoshinari| Yamagata, Kunihiro| Banno, Shogo| Dobashi, Hiroaki| Amano, Koichi| Harigai, Masayoshi| Arimura, Yoshihiro| Makino, Hirofumi| the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan| |
| キーワード | ANCA-associated vasculitis Chronic damage Elderly patients Glucocorticoids |
| 発行日 | 2020-10-12 |
| 出版物タイトル | Arthritis Research & Therapy |
| 巻 | 22巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 236 |
| ISSN | 1478-6354 |
| NCID | AA11830978 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s). 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 33046139 |
| DOI | 10.1186/s13075-020-02341-6 |
| Web of Science KeyUT | 000582369300003 |
| 関連URL | isVersionOf https://doi.org/10.1186/s13075-020-02341-6 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun| |
| キーワード | Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology |
| 発行日 | 2020-09-10 |
| 出版物タイトル | Scientific Reports |
| 巻 | 10巻 |
| 号 | 1号 |
| 出版者 | Nature Research |
| 開始ページ | 14928 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 32913271 |
| DOI | 10.1038/s41598-020-71946-3 |
| Web of Science KeyUT | 000571915100049 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-020-71946-3 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group| |
| キーワード | Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan |
| 発行日 | 2020-08-08 |
| 出版物タイトル | Journal of Diabetes Investigation |
| 巻 | 12巻 |
| 号 | 2号 |
| 出版者 | Wiley |
| 開始ページ | 207 |
| 終了ページ | 216 |
| ISSN | 2040-1116 |
| NCID | AA12488319 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 The Authors |
| 論文のバージョン | publisher |
| PubMed ID | 32597548 |
| NAID | 120006880216 |
| DOI | 10.1111/jdi.13339 |
| Web of Science KeyUT | 000557091100001 |
| 関連URL | isVersionOf https://doi.org/10.1111/jdi.13339 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kitamura, Shinji| Takahashi, Kensaku| Sang, Yizhen| Fukushima, Kazuhiko| Tsuji, Kenji| Wada, Jun| |
| キーワード | immunofluorescent image renal pathology artificial intelligence deep learning diabetic nephropathy |
| 発行日 | 2020-07-09 |
| 出版物タイトル | Diagnostics |
| 巻 | 10巻 |
| 号 | 7号 |
| 出版者 | MDPI |
| 開始ページ | 466 |
| ISSN | 2075-4418 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 32660112 |
| DOI | 10.3390/diagnostics10070466 |
| Web of Science KeyUT | 000557155500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/diagnostics10070466 |
| JaLCDOI | 10.18926/AMO/59950 |
|---|---|
| フルテキストURL | 74_3_199.pdf |
| 著者 | Fujita, Hirofumi| Bando, Tetsuya| Oyadomari, Seiichi| Ochiai, Kazuhiko| Watanabe, Masami| Kumon, Hiromi| Ohuchi, Hideyo| |
| 抄録 | Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland. |
| キーワード | Dkk3 knockout mouse adrenal gland glucose-regulated protein 78 proteome endoplasmic reticulum stress |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 199 |
| 終了ページ | 208 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577017 |
| Web of Science KeyUT | 000543363400003 |
| NAID | 120006862792 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Katayama, Akihiro| Tone, Atsuhito| Watanabe, Mayu| Teshigawara, Sanae| Miyamoto, Satoshi| Eguchi, Jun| Nakatsuka, Atsuko| Shikata, Kenichi| Wada, Jun| |
| キーワード | Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP) |
| 備考 | This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.| |
| 発行日 | 2019-09-16 |
| 出版物タイトル | Diabetology International |
| 巻 | 11巻 |
| 号 | 2号 |
| 出版者 | Springer |
| 開始ページ | 97 |
| 終了ページ | 104 |
| ISSN | 2190-1678 |
| NCID | AA12503387 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 32206479 |
| NAID | 40022198977 |
| DOI | 10.1007/s13340-019-00408-7 |
| Web of Science KeyUT | 000520711100004 |
| 関連URL | isVersionOf https://doi.org/10.1007/s13340-019-00408-7 |
| JaLCDOI | 10.18926/AMO/57955 |
|---|---|
| フルテキストURL | 74_1_65.pdf |
| 著者 | Akiyama, Tomoyuki| Saigusa, Daisuke| Hyodo, Yuki| Umeda, Keiko| Saijo, Reina| Koshiba, Seizo| Kobayashi, Katsuhiro| |
| 抄録 | To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine. |
| キーワード | antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-02 |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 65 |
| 終了ページ | 72 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099251 |
| Web of Science KeyUT | 000516606200010 |
| NAID | 120006795622 |
| JaLCDOI | 10.18926/AMO/57950 |
|---|---|
| フルテキストURL | 74_1_33.pdf |
| 著者 | Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio| |
| 抄録 | A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful |
| キーワード | blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-02 |
| 巻 | 74巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 33 |
| 終了ページ | 40 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32099246 |
| Web of Science KeyUT | 000516606200005 |
| NAID | 120006795617 |
| JaLCDOI | 10.18926/AMO/57710 |
|---|---|
| フルテキストURL | 73_6_475.pdf |
| 著者 | Umebayashi, Ryoko| Uchida, Haruhito A.| Wada, Junzo| |
| 抄録 | Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair and endovascular repair. This review describes potential medical treatments to slow aneurysm growth or prevent AAA rupture. |
| キーワード | abdominal aortic aneurysms medical treatment anti-platelet drugs |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-12 |
| 巻 | 73巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 475 |
| 終了ページ | 477 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31871328 |
| Web of Science KeyUT | 000503431400001 |
| フルテキストURL | FI_10_17.pdf |
|---|---|
| 著者 | Ohkura, Takahiro| Yoshimura, Teizo| Fujisawa, Masayoshi| Ohara, Toshiaki| Marutani, Rie| Usami, Kaya| Matsukawa, Akihiro| |
| キーワード | Ras/Raf/ERK/MAPK Spred2 adipocyte inflammation macrophage obesity |
| 発行日 | 2019-01-22 |
| 出版物タイトル | Frontiers in Immunology |
| 巻 | 10巻 |
| 出版者 | Frontiers Media S.A |
| 開始ページ | 17 |
| ISSN | 1664-3224 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | Copyright © 2019 Authors |
| 論文のバージョン | publisher |
| PubMed ID | 30723473 |
| DOI | 10.3389/fimmu.2019.00017 |
| Web of Science KeyUT | 000456196900002 |
| 関連URL | isVersionOf https://doi.org/10.3389/fimmu.2019.00017 |
| フルテキストURL | EBioMedicine_2017_154.pdf |
|---|---|
| 著者 | Kunisada, Yuki| Eikawa, Shingo| Tomonobu, Nahoko| Domae, Shohei| Uehara, Takenori| Hori, Shohei| Furusawa, Yukihiro| Hase, Koji| Sasaki, Akira| Udono, Heiichiro| |
| キーワード | Glycolysis Regulatory T cell (Treg) Tumor immunity Tumor microenvironment mTOR |
| 発行日 | 2017-10-16 |
| 出版物タイトル | EBioMedicine |
| 巻 | 25巻 |
| 出版者 | Elsevier Science |
| 開始ページ | 154 |
| 終了ページ | 164 |
| ISSN | 23523964 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2017 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 29066174 |
| DOI | 10.1016/j.ebiom.2017.10.009 |
| Web of Science KeyUT | 000417440500026 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.ebiom.2017.10.009 |