| JaLCDOI | 10.18926/AMO/66159 |
|---|---|
| FullText URL | 77_6_655.pdf |
| Author | Endo, Hirosuke| Yamada, Kazuki| Tetsunaga, Tomonori| Namba, Yoshifumi| Sugimoto, Yoshihisa| Mitani, Shigeru| Nakata, Eiji| Ozaki, Toshifumi| |
| Abstract | Most patients with developmental dysplasia of the hip (DDH) now receive closed-reduction treatment within 6 months after birth. The long-term outcomes of patients with late-detection DDH have remained unclear. We reviewed the clinical records of 18 patients who underwent Colonna capsular arthroplasty (n=8) or closed reduction (n=10) for developmental dysplasia of the hip as infants or young children and underwent total hip arthroplasty approximately in midlife. Both the Colonna capsular arthroplasty and closed reduction groups achieved good clinical results after total hip arthroplasty. However, the operating time was longer and the improvements of hip range of motion and clinical score were significantly worse in the Colonna capsular arthroplasty group than in the closed reduction group. |
| Keywords | developmental hip dysplasia long-term follow-up closed reduction Colonna capsular arthroplasty total hip arthroplasty |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 655 |
| End Page | 663 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145941 |
| Web of Science KeyUT | 001164631200012 |
| JaLCDOI | 10.18926/AMO/66160 |
|---|---|
| FullText URL | 77_6_665.pdf |
| Author | Sakurai, Atsunobu| Uka, Mayu| Iguchi, Toshihiro| Tomita, Koji| Matsui, Yusuke| Kakiuchi, Yoshihiko| Kuroda, Shinji| Fujiwara, Toshiyoshi| Hiraki, Takao| |
| Abstract | We report the case details of a 65-year-old Japanese man with an omental abscess that was discovered 43 days after he underwent a laparoscopic proximal gastrectomy for gastric cancer. His chief complaint was mild abdominal pain that had persisted for several days. The abscess was diagnosed as a rare postoperative complication. We hesitated to perform a reoperation given the invasiveness of general anesthesia and surgery, plus the possibility of postoperative adhesions and because the patient’s general condition was stable and he had only mild abdominal pain. Percutaneous drainage using a 10.2-F catheter was performed with the patient under conscious sedation and computed tomography–fluoroscopy guidance, with no complications. After the procedure, the size of the abscess cavity was remarkably reduced, and 23 days later the catheter was withdrawn. |
| Keywords | drainage omental abscess omental infarction proximal gastrectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 665 |
| End Page | 669 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145942 |
| Web of Science KeyUT | 001164631200013 |
| JaLCDOI | 10.18926/AMO/66161 |
|---|---|
| FullText URL | 77_6_671.pdf |
| Author | Minami, Daisuke| Hosoya, Takeshi| Hosoya, Masaharu| Nagano, Akichika| Nakajima, Yasuhiro| Miyahara, Nobuaki| Kanehiro, Arihiko| |
| Abstract | A 74-year-old Japanese woman presented with a 45-year history of refractory asthma. She had been treated with inhaled corticosteroids, a long-acting β2-agonist, and a long-acting muscarinic antagonist for 6 months. She also had a repeated viral infection. Her condition had been characterized as a refractory asthma associated with type 2 and non-type 2 traits. We began treatment with tezepelumab. The control of the patient’s asthma symptoms and quality of life improved greatly within 1 month (changes in eosinophil count from 748 to 96 /μL, in FeNO from 32 to 17 ppb, in the Asthma Quality of Life Questionnaire score from 3.59 to 6.68, and in the Asthma Control Test score from 13 to 23). Tezepelumab was effective as an initial biologic agent for a patient with refractory asthma associated with type 2 and non-type 2 traits. |
| Keywords | tezepelumab biologic agent eosinophilic non-type 2 severe asthma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 671 |
| End Page | 674 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145943 |
| Web of Science KeyUT | 001164631200014 |
| JaLCDOI | 10.18926/AMO/66664 |
|---|---|
| FullText URL | 78_1_001.pdf |
| Author | Sun, Cuiming| Matsukawa, Akihiro| |
| Abstract | Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis. |
| Keywords | ERK-MAPK SPRED2 fibrosis macrophages |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419308 |
| Web of Science KeyUT | 001203658200006 |
| JaLCDOI | 10.18926/AMO/66665 |
|---|---|
| FullText URL | 78_1_009.pdf |
| Author | Akagi, Naoki| Kanematsu, Akihiro| Shigesaka, Koji| Shimatani, Kimihiro| Yamamoto, Shingo| |
| Abstract | Bacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion coefficient lesions on MRI. The control group was comprised of 28 age- and PSA-matched patients. The relationships among the cancer detection rate and the patients’ PSA levels and MRI findings were analyzed. Prostate cancer was detected by biopsy in only 13.9% (3/22) of the patients in the BCG group but in 78.5% (22/28) of the control patients (p=0.0001). The three patients in the BCG group in whom prostate cancer was detected had all undergone the biopsy > 1 year after their BCG treatment. The remaining biopsies were performed within 1 year after BCG treatment and resulted in no diagnoses of prostate cancer. We suggest that performing a prostate biopsy early after BCG treatment is not informative or useful. |
| Keywords | bacillus Calmette-Guérin prostate granuloma prostate cancer bladder cancer prostate biopsy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 13 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419309 |
| Web of Science KeyUT | 001203658200010 |
| JaLCDOI | 10.18926/AMO/66666 |
|---|---|
| FullText URL | 78_1_015.pdf |
| Author | Maeda, Reina| Shien, Tadahiko| Takahashi, Mina| Kawada, Kengo| Kajiwara, Yukiko| Kubo, Shinichiro| Takabatake, Daisuke| Ohtani, Shoichiro| Matsuoka, Kinya| Hikino, Hajime| Ogasawara, Yutaka| Taira, Naruto| Osumi, Shozo| Ikeda, Masahiko| Doihara, Hiroyoshi| |
| Abstract | While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients. |
| Keywords | oligometastasis breast cancer lung metastasectomy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 15 |
| End Page | 20 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419310 |
| Web of Science KeyUT | 001203658200008 |
| JaLCDOI | 10.18926/AMO/66667 |
|---|---|
| FullText URL | 78_1_021.pdf |
| Author | Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Kintaka, Keisuke| Higashihara, Naohiro| Kawada, Koki| Ozaki, Toshifumi| |
| Abstract | The use of various strategies for arthroscopic meniscal repairs to save the meniscus and prevent the progression of knee osteoarthritis has gradually increased. We investigated the frequency of various arthroscopic treatments and the short-term clinical outcomes of symptomatic isolated medial meniscus (MM) injuries. This retrospective observational study included 193 patients (197 knees) who underwent arthroscopic meniscal treatment for isolated MM injuries between January 2016 and April 2019. Arthroscopic meniscal repairs were divided into two groups: transtibial pullout repairs of MM posterior root tears (MMPRTs) and arthroscopic meniscal repairs for other types of MM injuries. MMPRT pullout repair, other meniscal repairs, and partial meniscectomy were performed in 71.0%, 16.8%, and 12.2% of the knees, respectively. The ratio of women to men and the patient age were higher in the pullout-repair group than the meniscal-repair group. The Preoperative Knee Injury and Osteoarthritis Outcome Score subscale (as an index of daily living activities) was significantly lower in the pullout-repair group than the meniscus-repair group. However, no significant differences were observed in these scores among the two groups postoperatively. Our results suggest that familiarity with the diagnosis and treatment of MMPRTs is necessary for orthopedic surgeons to manage isolated MM injuries. |
| Keywords | knee medial meniscus posterior root tear arthroscopy pullout repair |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 21 |
| End Page | 27 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419311 |
| Web of Science KeyUT | 001203658200002 |
| JaLCDOI | 10.18926/AMO/66668 |
|---|---|
| FullText URL | 78_1_029.pdf |
| Author | Kitayama, Takahiro| Tanaka, Takashi| Kanie, Yuichiro| Marukawa, Yohei| Kojima, Katsuhide| Tanaka, Takehiro| Takao, Soshi| Hiraki, Takao| |
| Abstract | This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD. |
| Keywords | methotrexate lymphoproliferative disorder computed tomography necrosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 36 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419312 |
| Web of Science KeyUT | 001203658200001 |
| JaLCDOI | 10.18926/AMO/66669 |
|---|---|
| FullText URL | 78_1_037.pdf |
| Author | Tanaka, Masato| Meena, Umesh| Taoka, Takuya| Fujiwara, Yoshihiro| Yokomizo, Daiichiro| Bashyal, Santosh Kumar| Sake, Naveen| Arataki, Shinya| |
| Abstract | In adult spinal deformity (ASD) surgery, one of the key factors working to prevent proximal junctional kyphosis is the proximal anchor. The aim of this study was to compare clinical and radiographic outcomes of triangular fixation with conventional fixation as proximal anchoring techniques in ASD surgery. We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD. Fourteen patients underwent proximal triangular fixation (Group T; average 74.6 years), and 40 patients underwent the conventional method (Group C; average 70.5 years). Clinical and radiographic outcomes were assessed using visual analogue scale (VAS) values for back pain and the Oswestry disability index (ODI). Radiographic evaluation was also collected preoperatively and postoperatively. Surgical times and intraoperative blood loss of the two groups were not significantly different (493 vs 490 min, 1,260 vs 1,173 mL). Clinical outcomes such as VAS and ODI were comparable in the two groups. Proximal junctional kyphosis in group T was slightly lower than that of group C (28.5% vs 47.5%, p=0.491). However, based on radiology, proximal screw pullout occurred significantly less frequently in the triangular fixation group than the conventional group (0.0% vs 22.5%, p=0.049). Clinical outcomes in the two groups were not significantly different. |
| Keywords | adult spinal deformity proximal junctional kyphosis triangular fixation minimally invasive surgery C arm free |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 46 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419313 |
| Web of Science KeyUT | 001203658200003 |
| JaLCDOI | 10.18926/AMO/66670 |
|---|---|
| FullText URL | 78_1_047.pdf |
| Author | Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)| |
| Abstract | Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen. |
| Keywords | metastatic colorectal cancer chemotherapy S-1 prospective phase II study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 47 |
| End Page | 52 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419314 |
| Web of Science KeyUT | 001203658200005 |
| JaLCDOI | 10.18926/AMO/66671 |
|---|---|
| FullText URL | 78_1_053.pdf |
| Author | Ichikawa, Yukiko| Ogino, Tetsuya| |
| Abstract | Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy. |
| Keywords | cold compress fever hyperthermia thermal conductivity thermoregulation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 61 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419315 |
| Web of Science KeyUT | 001203658200009 |
| JaLCDOI | 10.18926/AMO/66672 |
|---|---|
| FullText URL | 78_1_063.pdf |
| Author | Murakami, Daizo| Nishimoto, Kohei| Takao, Soshi| Miyamaru, Satoru| Kadowaki, Tomoka| Saito, Haruki| Takeda, Hiroki| Ise, Momoko| Suyama, Koichi| Orita, Yorihisa| |
| Abstract | The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma. |
| Keywords | thyroid carcinoma lenvatinib adverse effect survival |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419316 |
| Web of Science KeyUT | 001203658200007 |
| JaLCDOI | 10.18926/AMO/66673 |
|---|---|
| FullText URL | 78_1_071.pdf |
| Author | Kaneda, Daisuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Harada, Ryozo| Hotta, Yoshifumi| Naniwa, Shuichi| Ozaki, Toshifumi| |
| Abstract | We retrospectively investigated the mid-term outcomes of arthroplasty using the AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients with rheumatoid arthritis (RA). This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoperative flexion range of the implant-fracture group were significantly greater than those in the no-implant-fracture group (p=0.039, 0.034, respectively). These results suggest the importance of patient education and careful rehabilitation to prevent excessive flexion. Overall, the AVANTA silicone implant showed a relatively high rate of implant fracture at our institute. |
| Keywords | AVANTA silicone implant boutonniere deformity implant fracture thumb metacarpophalangeal joint arthroplasty rheumatoid arthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419317 |
| Web of Science KeyUT | 001203658200011 |
| JaLCDOI | 10.18926/AMO/66674 |
|---|---|
| FullText URL | 78_1_079.pdf |
| Author | Takahara, Masahiro| Hiraoka, Sakiko| Ohmori, Masayasu| Takeuchi, Keiko| Takei, Kensuke| Aoyama, Yuki| Yasutomi, Eriko| Igawa, Shoko| Inokuchi, Toshihiro| Toyosawa, Junki| Yamasaki, Yasushi| Kinugasa, Hideaki| Harada, Keita| Onishi, Hideki| Okada, Hiroyuki| |
| Abstract | This study examined the utility of the combined use of transabdominal ultrasonography (TUS) and fecal immunochemical testing (FIT) to detect mucosal inflammation, vis-a-vis the Mayo endoscopic subscore (MES), in ulcerative colitis (UC). Sixty-three UC patients who underwent TUS and FIT were retrospectively enrolled. For TUS, the colon was divided into five segments, and the bowel wall thickness was measured and evaluated. The accuracy of FIT (> 100 ng/ml) in detecting mucosal inflammation (MES>0) was 0.93, whereas that of TUS (BWT>2 mm) in each segment was 0.84-0.97. The combined use of TUS and FIT may be helpful in noninvasive treatment strategies. |
| Keywords | transabdominal ultrasonography fecal immunochemical test ulcerative colitis Mayo endoscopic subscore |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 83 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419318 |
| Web of Science KeyUT | 001203658200004 |
| JaLCDOI | 10.18926/AMO/66675 |
|---|---|
| FullText URL | 78_1_085.pdf |
| Author | Miyake, Keisuke| Tanikawa, Tomohiro| Haruma, Ken| Kawada, Mayuko| Ishii, Katsunori| Urata, Noriyo| Nishino, Ken| Suehiro, Mitsuhiko| Kawanaka, Miwa| Manabe, Noriaki| Kawamoto, Hirofumi| |
| Abstract | A 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential efficacy of TM in treating IPUD and the importance of considering hypercontractility as the underlying cause in cases of IPUD. |
| Keywords | gastric ulcer idiopathic peptic ulcerative disease trimebutine maleate |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 85 |
| End Page | 88 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419319 |
| Web of Science KeyUT | 001204421300002 |
| JaLCDOI | 10.18926/AMO/66676 |
|---|---|
| FullText URL | 78_1_089.pdf |
| Author | Toshima, Kei| Shien, Tadahiko| Nishimura, Midori Filiz| Suzuki, Yoko| Nakamoto, Shogo| Uno, Maya| Yoshioka, Ryo| Tsukioki, Takahiro| Takahashi, Yuko| Iwamoto, Takayuki| Iwatani, Tsuguo| Yanai, Hiroyuki| |
| Abstract | We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis. |
| Keywords | breast cancer ectopic breast cancer axillary lymph node |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 89 |
| End Page | 93 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419320 |
| Web of Science KeyUT | 001204421300001 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| FullText URL | 78_2_095.pdf |
| Author | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| Abstract | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| Keywords | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688827 |
| JaLCDOI | 10.18926/AMO/66913 |
|---|---|
| FullText URL | 78_2_107.pdf |
| Author | Han, Dongxiang| Du, Jianxiu| Wang, Wei| Wang, Cui| |
| Abstract | Vertical transmission of hepatitis B virus (HBV), especially in Asia, is a key target in the global elimination of HBV. This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. There were no significant differences in liver function markers, including alanine aminotransferase, total bilirubin, blood creatinine, and blood urea nitrogen levels before and after TDF treatment. The serum HBV DNA viral load of the TDF-treated group became significantly lower than those of the control group and their own pre-medication levels. Infants showed no significant difference in body growth, including weight, height, head size, and five-min Apgar score. At 7 months after birth, 94.29% of infants in the TDF group and 86.54% of control-group infants had protective HBsAb levels ≥ 10 mIU/ml (p>0.05). The HBV infection rate of infants in the TDF-treated group was lower than that in the non-treated group. In high-HBV-DNA-load pregnant women, TDF administered from 28 weeks gestational age to delivery was associated with a lower risk of mother-to-infant transmission of HBV. |
| Keywords | mother-to-infant transmission tenofovir disoproxil fumarate hepatitis B virus |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 107 |
| End Page | 113 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688828 |
| JaLCDOI | 10.18926/AMO/66914 |
|---|---|
| FullText URL | 78_2_115.pdf |
| Author | Nakamura-Maruyama, Emi| Irie, Keiichiro| Narita, Kazuhiko| Himi, Naoyuki| Miyamoto, Osamu| Nakamura, Takehiro| |
| Abstract | Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model’s usefulness for research regarding new treatments for brain edema. C57BL/6J mice received an intraperitoneal administration of 10% body weight distilled water, and we calculated the brain water content by measuring the brain-tissue weight immediately after dissection and after drying. We analyzed 8-OHdG and caspase-3 values to investigate the brain damage. We also applied this model in aquaporin 4 knockout (AQP4−) mice and compared these mice with wild-type mice. The changes in water content differed by age and gender, and the 8-OHdG and caspase-3 values differed by age. Suppression of brain edema by AQP4− was also confirmed. These results clarified the differences in the onset of brain edema by age and gender, highlighting the importance of considering the age and gender of model animals. Similar studies using genetically modified mice are also possible. Our findings indicate that this water intoxication model is effective for explorations of new brain edema treatments. |
| Keywords | brain edema water intoxication model age gender AQP4 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 115 |
| End Page | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688829 |
| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| FullText URL | 78_2_123.pdf |
| Author | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| Keywords | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688830 |
