| JaLCDOI | 10.18926/AMO/54978 |
|---|---|
| FullText URL | 71_2_105.pdf |
| Author | Shinya, Takayoshi| Tanaka, Takashi| Soh, Junichi| Matsushita, Toshi| Sato, Shuhei| Toyooka, Shinichi| Yoshino, Tadashi| Miyoshi, Shinichiro| Kanazawa, Susumu| |
| Abstract | We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy. |
| Keywords | thymic epithelial neoplasm thymic carcinoma thymoma dual-time-point PET/CT chest CT |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 105 |
| End Page | 112 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420891 |
| JaLCDOI | 10.18926/AMO/54815 |
|---|---|
| FullText URL | 70_6_503.pdf |
| Author | Kanazawa, Yui| Yamashita, Yuka| Fujiwara, Mitsuhiro| Muraoka, Michiko| Washio, Kana| Kanamitsu, Kiichiro| Ishida, Hisashi| Nakano, Takae| Yamada, Miho| Horibe, Keizo| Tanaka, Takehiro| Yoshino, Tadashi| Shimada, Akira| |
| Abstract | Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10–30 of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60–75 disease-free survival; however, a relatively high relapse rate was observed (25–30 ). We report 2 patients with Stage III ALCL who relapsed 6–18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample. |
| Keywords | ALCL NPM-ALK fusion lymphoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-12 |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 503 |
| End Page | 506 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003677 |
| Author | Gotoda, Tatsuhiro| Kawano, Seiji| Kono, Yoshiyasu| Miura, Kou| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Shirakawad, Yasuhiro| Tabata, Masahiro| Tanimoto, Mitsune| Okada, Hiroyuki| |
|---|---|
| Published Date | 2016-12-01 |
| Publication Title | Journal of Okayama Medical Association |
| Volume | volume128 |
| Issue | issue3 |
| Content Type | Journal Article |
| Title Alternative | Magnified observation of spontaneous morphological changes of duodenal follicular lymphoma |
|---|---|
| FullText URL | 128_111.pdf |
| Author | Iwamuro, Masaya| Takata, Katsuyoshi| Kawano, Seiji| Kawahara, Yoshiro| Yoshino, Tadashi| Okada, Hiroyuki| |
| Abstract | A 63-year-old Japanese woman was diagnosed with duodenal follicular lymphoma. The initial esophagogastroduodenoscopic examination with magnifying observation revealed opaque white spots and enlarged whitish villi. Nine months later, esophagogastroduodenoscopy showed that the size of the lymphoma lesion decreased, and only opaque white spots were visible. The histological analysis of biopsy samples obtained during the initial endoscopy examination showed both neoplastic follicles and an inter-follicular infiltration of lymphoma cells, whereas the biopsy samples obtained at the endoscopy performed 9 months later showed only neoplastic follicle formation. These results suggest that the magnifying endoscopic features may reflect the underlying pathological mechanisms : enlarged whitish villi are probably due to lymphoma cell infiltration in the inter-follicular area, and opaque white spots are probably caused by neoplastic follicle formation. |
| Keywords | 消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma） 悪性リンパ腫（malignant lymphoma） 拡大内視鏡検査（magnifying endoscopy） |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 111 |
| End Page | 116 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.111 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.111 |
| NAID | 130005262531 |
| Title Alternative | A primary diffuse large B-cell lymphoma of the liver treated with R-CHOP regimen |
|---|---|
| FullText URL | 127_209.pdf |
| Author | Okada, Hiroshi| Fujii, Soichiro| Watanabe, Kentaro| Shigematu, Terunobu| Miyashita, Katsuhiro| Okazaki, Morihiro| Kobashi, Haruhiko| Yokoyama, Motohiro| Yoshino, Tadashi| |
| Abstract | A 78-year-old Japanese man was referred to our hospital after experiencing black feces. No abnormal finding was detected in the endoscopic examination of his stomach and large intestines. Computed tomography (CT) of the abdomen revealed a tumor lesion in the right lobe of the liver. A needle biopsy of the tumor under ultrasound guidance was performed. A pathological examination of the biopsy specimen showed a diffuse proliferation of lymphoma cells, which was compatible with diffuse large B-cell lymphoma (DLBCL). F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT demonstrated increased FDG uptake only in the liver tumor. We made the diagnosis of primary DLBCL of the liver. After six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), the patient achieved complete remission and has maintained remission for 2 years since the diagnosis. The R-CHOP regimen might be effective therapy for primary DLBCL of the liver. |
| Keywords | びまん性大細胞型Ｂ細胞リンパ腫（diffuse large B-cell lymphoma） 肝臓（liver） R-CHOP療法（R-CHOP regimen） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-12-01 |
| Volume | volume127 |
| Issue | issue3 |
| Start Page | 209 |
| End Page | 212 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.127.209 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.209 |
| NAID | 130005116809 |
| JaLCDOI | 10.18926/AMO/53676 |
|---|---|
| FullText URL | 69_5_301.pdf |
| Author | Seki, Anna| Iwamuro, Masaya| Yoshioka, Masao| Fujii, Nobuharu| Okada, Hiroyuki| Nose, Soichiro| Takata, Katsuyoshi| Yoshino, Tadashi| Yamamoto, Kazuhide| |
| Abstract | A 41-year-old woman was diagnosed with duodenal follicular lymphoma. She had no other lesions and was assigned to a "watch and wait" policy. Swelling of the inguinal lymph nodes appeared 45 months later, and rituximab monotherapy resulted in complete remission. However, follicular lymphoma recurred in the stomach, rectum and mesenteric and external iliac lymph nodes 81 months after the therapy. The patient received rituximab monotherapy again and has remained in complete remission in the fifteenth year after the initial diagnosis. This case suggests the usefulness of rituximab monotherapy in the long-term management of intestinal follicular lymphoma. |
| Keywords | follicular lymphoma duodenum rituximab |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-10 |
| Volume | volume69 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26490027 |
| Web of Science KeyUT | 000365519600006 |
| Author | Kyotaro, Ohno| Yasuharu, Sato| Koh-ichi, Ohshima| Katsuyoshi, Takata| Tomoko, Miyata-Takata| Mai, Takeuchi| Yuka, Gion| Tomoyasu, Tachibana| Yorihisa, Orita| Toshihiro, Ito| Steven, H. Swerdlow| Tadashi, Yoshino| |
|---|---|
| Published Date | 2015 |
| Publication Title | Scientific Reports |
| Volume | volume5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/53120 |
|---|---|
| FullText URL | 69_1_37.pdf |
| Author | Iwamuro, Masaya| Okada, Hiroyuki| Takata, Katsuyoshi| Kawai, Yoshinari| Kawano, Seiji| Nasu, Junichiro| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Yamamoto, Kazuhide| |
| Abstract | The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. We retrospectively reviewed the cases of patients with follicular lymphoma (n＝9), lymphangiectasia (n＝7), adenoma (n＝10), duodenitis (n＝4), erosion (n＝1), lymphangioma (n＝1), and hyperplastic polyp (n＝1). The magnified features of the nine follicular lymphomas included enlarged villi (n＝8), dilated microvessels (n＝5), and opaque white spots of various sizes (n＝9). The lymphangiectasias showed enlarged villi, dilated microvessels, and white spots, but the sizes of the white spots were relatively homogeneous and their margin was clear. Observation of the adenoma and duodenitis revealed only whitish villi. Although the lymphangioma was indistinguishable from the follicular lymphomas by magnified features, it was easily diagnosed based on the macroscopic morphology. In conclusion, magnified endoscopic features, in combination with macroscopic features, are useful for differentiating follicular lymphomas from other duodenal diseases presenting whitish lesions. |
| Keywords | duodenal neoplasm follicular lymphoma gastrointestinal lymphoma magnifying endoscopy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703169 |
| Web of Science KeyUT | 000349740300004 |
| Author | Iwatani, Kayoko| Takata, Katsuyoshi| Sato, Yasuharu| Miyata-Takata, Tomoko| Iwaki, Noriko| Cui, Wei| Sawada-Kitamura, Seiko| Sonobe, Hiroshi| Tamura, Maiko| Saito, Katsuhiko| Miyatani, Katsuya| Yamasaki, Rie| Yamadori, Ichiro| Fujii, Nobuharu| Terasaki, Yasushi| Maeda, Yoshinobu| Tanimoto, Mitsune| Nakamura, Naoya| Yoshino, Tadashi| |
|---|---|
| Published Date | 2014-07 |
| Publication Title | Human Pathology |
| Volume | volume45 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Sonoi, Norihiro| Soga, Yoshihiko| Maeda, Hiroshi| Ichimura, Koichi| Yoshino, Tadashi| Aoyama, Kazutoshi| Fujii, Nobuharu| Maeda, Yoshinobu| Tanimoto, Mitsune| Logan, Richard| Raber-Durlacher, Judith| Takashiba, Shogo| |
|---|---|
| Published Date | 2012-07 |
| Publication Title | Odontology |
| Volume | volume100 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ando, Midori| Sato, Yasuharu| Takata, Katsuyoshi| Nomoto, Junko| Nakamura, Shigeo| Ohshima, Koichi| Takeuchi, Tamotsu| Orita, Yorihisa| Kobayashi, Yukio| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-02-13 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Abd Al Kader, Lamia| Oka, Takashi| Takata, Katsuyoshi| Sun, Xu| Sato, Hiaki| Murakami, Ichiro| Toji, Tomohiro| Manabe, Akihiro| Kimura, Hiroshi| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-11 |
| Publication Title | Virchows Archiv |
| Volume | volume463 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Hayashi, Eiko| Takata, Katsuyoshi| Sato, Yasuharu| Tashiro, Yukie| Tachiyama, Yoshiro| Sawada-Kitamura, Seiko| Hiramatsu, Yasushi| Sugiguchi, Shun| Nose, Soichiro| Hirokawa, Mitsuyoshi| Ando, Midori| Abd Mader, Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-09 |
| Publication Title | Human Pathology |
| Volume | volume44 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Toda, Hiroko| Sato, Yasuharu| Takata, Katsuyoshi| Orita, Yorihisa| Asano, Naoko| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-02-28 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/51072 |
|---|---|
| FullText URL | 67_4_265.pdf |
| Author | Hanakawa, Hiroyuki| Orita, Yorihisa| Sato, Yasuharu| Uno, Kinya| Nishizaki, Kazunori| Yoshino, Tadashi| |
| Abstract | We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis. |
| Keywords | ulceration methotrexate oropharynx lymphoproliferative disorders |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 265 |
| End Page | 269 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970326 |
| Web of Science KeyUT | 000323470100009 |
| Author | Miki, Yukari| Gion, Yuka| Mukae, Yuriko| Hayashi, Atsushi| Sato, Hiaki| Yoshino, Tadashi| Takahashi, Kiyoshi| |
|---|---|
| Published Date | 2013-02 |
| Publication Title | European Journal of Haematology |
| Volume | volume90 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Takata, Katsuyoshi| Sato, Yasuharu| Nakamura, Naoya| Tokunaka, Mami| Miki, Yukari| Kikuti, Yara Yukie| Igarashi, Kazuhiko| Ito, Etsuro| Harigae, Hideo| Kato, Seiichi| Hayashi, Eiko| Oka, Takashi| Hoshii, Yoshinobu| Tari, Akira| Okada, Hiroyuki| Mohamado, ABD Alkader Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Kinoshita, Tomohiro| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Okuma, Yu| Liu, Keyue| Wake, Hidenori| Haruma, Jun| Yoshino, Tadashi| Ohtsuka, Aiji| Takahashi, Hideo| Mori, Shuji| Nishibori, Masahiro| Date, Isao| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/32636 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Kondo, Eisaku| Yoshino, Tadashi| Akagi, Tadaatsu| Hayashi, Kazuhiko| Takahashi, Kiyoshi| |
| Abstract | Southern blot hybridization was used to detect the rearrangement and amplification of five proto-oncogenes (bcl-2, bcl-1, c-myc, c-myb and c-Ha-ras) and one tumor suppressor gene (RB-1) in 55 Japanese patients with non-Hodgkin's lymphoma; 16 with T-cell lymphomas and 39 with B-cell lymphomas (7 follicular and 32 diffuse lymphomas). Genetic abnormalities of the proto-oncogenes were detected in 7 of the 55 (13%). Genetic abnormalities of bcl-2 plus other genes were detected in 5 of 7 cases of follicular lymphoma (71%), rearrangements of bcl-2 and c-myc, rearrangement of bcl-2 and amplification of c-myb. Genetic abnormalities were observed in only three cases of diffuse lymphoma. In each of 3 cases of B-cell lymphoma, one of the genes, blc-2 mbr, bcl-2 mcr and c-myc, was rearranged respectively. The incidence of genetic abnormalities in diffuse lymphomas (6.3%) was lower than that in follicular lymphomas. None of diffuse lymphomas had double oncogene abnormality. No abnormalities were found in RB-1, bcl-1, and Ha-ras. These findings suggest that follicular lymphomas are associated with some abnormalities of oncogenes not restricted to bcl-2 that facilitate growth which may be associated with their clinical features. |
| Keywords | malignant lymphoma cellular oncogenes |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1992-12 |
| Volume | volume46 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 415 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1485535 |
| Web of Science KeyUT | A1992KE49600002 |
| JaLCDOI | 10.18926/AMO/32620 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Takata, Hiroshi| Yoshino, Tadashi| Hoshida, Yoshihiko| Takata, Ikuko| Akagi, Tadaatsu| |
| Abstract | A cell line of human lung large cell carcinoma (LCC) was established directly from the metastatic skin tumor tissue. The clinical course of the patient who carried this carcinoma was peculiar; generalized lymphadenopathy, histologically resembling Hodgkin's disease, was found as the first clinical symptom. The lung tumor was not discovered until the time of autopsy. This cell line (KaMi) grew adherent to culture vessels with the population doubling time of 20.6h, formed colonies in soft agars with efficiency of 22.6%, and formed tumors in athymic nude mice. The authenticity of KaMi was confirmed by chromosomal analysis and isoenzyme patterns. KaMi cells bore a strong resemblance to the original tumor cells which were composed of small spindle cells, large polygonal cells, and multinucleated giant cells. Immunohistochemically, KaMi cells showed a weak tendency to differentiate to squamous cells, and these immunohistochemical reactivities were almost compatible to those of the original tumor cells, but ultrastructurally, KaMi cells were more immature than the original ones. Treatment with several reagents could not augment a differentiation of KaMi cells. Cytokeratin profiles showed a tendency of squamous cell differentiation. KaMi cells may aid in elucidating the pathogenesis and biology of LCC and its relationship to other lung tumors. |
| Keywords | Large cell lung carcinoma cell line cytokeratin |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1992-08 |
| Volume | volume46 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 257 |
| End Page | 264 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1279943 |
| Web of Science KeyUT | A1992JL44200005 |
