著者 | 後藤田 達洋| 川野 誠司| 河野 吉泰| 三浦 公| 神崎 洋光| 岩室 雅也| 河原 祥朗| 田中 健大| 吉野 正| 白川 靖博| 田端 雅弘| 谷本 光音| 岡田 裕之| |
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発行日 | 2016-12-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 128巻 |
号 | 3号 |
資料タイプ | 学術雑誌論文 |
タイトル(別表記) | Magnified observation of spontaneous morphological changes of duodenal follicular lymphoma |
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フルテキストURL | 128_111.pdf |
著者 | 岩室 雅也| 高田 尚良| 川野 誠司| 河原 祥朗| 吉野 正| 岡田 裕之| |
抄録 | A 63-year-old Japanese woman was diagnosed with duodenal follicular lymphoma. The initial esophagogastroduodenoscopic examination with magnifying observation revealed opaque white spots and enlarged whitish villi. Nine months later, esophagogastroduodenoscopy showed that the size of the lymphoma lesion decreased, and only opaque white spots were visible. The histological analysis of biopsy samples obtained during the initial endoscopy examination showed both neoplastic follicles and an inter-follicular infiltration of lymphoma cells, whereas the biopsy samples obtained at the endoscopy performed 9 months later showed only neoplastic follicle formation. These results suggest that the magnifying endoscopic features may reflect the underlying pathological mechanisms : enlarged whitish villi are probably due to lymphoma cell infiltration in the inter-follicular area, and opaque white spots are probably caused by neoplastic follicle formation. |
キーワード | 消化管原発濾胞性リンパ腫(primary gastrointestinal follicular lymphoma) 悪性リンパ腫(malignant lymphoma) 拡大内視鏡検査(magnifying endoscopy) |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2016-08-01 |
巻 | 128巻 |
号 | 2号 |
開始ページ | 111 |
終了ページ | 116 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.128.111 |
言語 | 日本語 |
著作権者 | Copyright (c) 2016 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.128.111 |
NAID | 130005262531 |
タイトル(別表記) | A primary diffuse large B-cell lymphoma of the liver treated with R-CHOP regimen |
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フルテキストURL | 127_209.pdf |
著者 | 岡田 博| 藤井 総一郎| 渡邉 謙太郎| 重松 照伸| 宮下 雄博| 岡崎 守宏| 小橋 春彦| 横山 元浩| 吉野 正| |
抄録 | A 78-year-old Japanese man was referred to our hospital after experiencing black feces. No abnormal finding was detected in the endoscopic examination of his stomach and large intestines. Computed tomography (CT) of the abdomen revealed a tumor lesion in the right lobe of the liver. A needle biopsy of the tumor under ultrasound guidance was performed. A pathological examination of the biopsy specimen showed a diffuse proliferation of lymphoma cells, which was compatible with diffuse large B-cell lymphoma (DLBCL). F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT demonstrated increased FDG uptake only in the liver tumor. We made the diagnosis of primary DLBCL of the liver. After six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), the patient achieved complete remission and has maintained remission for 2 years since the diagnosis. The R-CHOP regimen might be effective therapy for primary DLBCL of the liver. |
キーワード | びまん性大細胞型B細胞リンパ腫(diffuse large B-cell lymphoma) 肝臓(liver) R-CHOP療法(R-CHOP regimen) |
出版物タイトル | 岡山医学会雑誌 |
発行日 | 2015-12-01 |
巻 | 127巻 |
号 | 3号 |
開始ページ | 209 |
終了ページ | 212 |
ISSN | 0030-1558 |
関連URL | isVersionOf https://doi.org/10.4044/joma.127.209 |
言語 | 日本語 |
著作権者 | Copyright (c) 2015 岡山医学会 |
論文のバージョン | publisher |
DOI | 10.4044/joma.127.209 |
NAID | 130005116809 |
JaLCDOI | 10.18926/AMO/53676 |
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フルテキストURL | 69_5_301.pdf |
著者 | Seki, Anna| Iwamuro, Masaya| Yoshioka, Masao| Fujii, Nobuharu| Okada, Hiroyuki| Nose, Soichiro| Takata, Katsuyoshi| Yoshino, Tadashi| Yamamoto, Kazuhide| |
抄録 | A 41-year-old woman was diagnosed with duodenal follicular lymphoma. She had no other lesions and was assigned to a "watch and wait" policy. Swelling of the inguinal lymph nodes appeared 45 months later, and rituximab monotherapy resulted in complete remission. However, follicular lymphoma recurred in the stomach, rectum and mesenteric and external iliac lymph nodes 81 months after the therapy. The patient received rituximab monotherapy again and has remained in complete remission in the fifteenth year after the initial diagnosis. This case suggests the usefulness of rituximab monotherapy in the long-term management of intestinal follicular lymphoma. |
キーワード | follicular lymphoma duodenum rituximab |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 301 |
終了ページ | 306 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490027 |
Web of Science KeyUT | 000365519600006 |
著者 | Kyotaro, Ohno| Yasuharu, Sato| Koh-ichi, Ohshima| Katsuyoshi, Takata| Tomoko, Miyata-Takata| Mai, Takeuchi| Yuka, Gion| Tomoyasu, Tachibana| Yorihisa, Orita| Toshihiro, Ito| Steven, H. Swerdlow| Tadashi, Yoshino| |
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発行日 | 2015 |
出版物タイトル | Scientific Reports |
巻 | 5巻 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/53120 |
---|---|
フルテキストURL | 69_1_37.pdf |
著者 | Iwamuro, Masaya| Okada, Hiroyuki| Takata, Katsuyoshi| Kawai, Yoshinari| Kawano, Seiji| Nasu, Junichiro| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Yamamoto, Kazuhide| |
抄録 | The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. We retrospectively reviewed the cases of patients with follicular lymphoma (n=9), lymphangiectasia (n=7), adenoma (n=10), duodenitis (n=4), erosion (n=1), lymphangioma (n=1), and hyperplastic polyp (n=1). The magnified features of the nine follicular lymphomas included enlarged villi (n=8), dilated microvessels (n=5), and opaque white spots of various sizes (n=9). The lymphangiectasias showed enlarged villi, dilated microvessels, and white spots, but the sizes of the white spots were relatively homogeneous and their margin was clear. Observation of the adenoma and duodenitis revealed only whitish villi. Although the lymphangioma was indistinguishable from the follicular lymphomas by magnified features, it was easily diagnosed based on the macroscopic morphology. In conclusion, magnified endoscopic features, in combination with macroscopic features, are useful for differentiating follicular lymphomas from other duodenal diseases presenting whitish lesions. |
キーワード | duodenal neoplasm follicular lymphoma gastrointestinal lymphoma magnifying endoscopy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-02 |
巻 | 69巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 37 |
終了ページ | 44 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25703169 |
Web of Science KeyUT | 000349740300004 |
著者 | Iwatani, Kayoko| Takata, Katsuyoshi| Sato, Yasuharu| Miyata-Takata, Tomoko| Iwaki, Noriko| Cui, Wei| Sawada-Kitamura, Seiko| Sonobe, Hiroshi| Tamura, Maiko| Saito, Katsuhiko| Miyatani, Katsuya| Yamasaki, Rie| Yamadori, Ichiro| Fujii, Nobuharu| Terasaki, Yasushi| Maeda, Yoshinobu| Tanimoto, Mitsune| Nakamura, Naoya| Yoshino, Tadashi| |
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発行日 | 2014-07 |
出版物タイトル | Human Pathology |
巻 | 45巻 |
号 | 7号 |
資料タイプ | 学術雑誌論文 |
著者 | Sonoi, Norihiro| Soga, Yoshihiko| Maeda, Hiroshi| Ichimura, Koichi| Yoshino, Tadashi| Aoyama, Kazutoshi| Fujii, Nobuharu| Maeda, Yoshinobu| Tanimoto, Mitsune| Logan, Richard| Raber-Durlacher, Judith| Takashiba, Shogo| |
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発行日 | 2012-07 |
出版物タイトル | Odontology |
巻 | 100巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Ando, Midori| Sato, Yasuharu| Takata, Katsuyoshi| Nomoto, Junko| Nakamura, Shigeo| Ohshima, Koichi| Takeuchi, Tamotsu| Orita, Yorihisa| Kobayashi, Yukio| Yoshino, Tadashi| |
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発行日 | 2013-02-13 |
出版物タイトル | PLoS ONE |
巻 | 8巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Abd Al Kader, Lamia| Oka, Takashi| Takata, Katsuyoshi| Sun, Xu| Sato, Hiaki| Murakami, Ichiro| Toji, Tomohiro| Manabe, Akihiro| Kimura, Hiroshi| Yoshino, Tadashi| |
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発行日 | 2013-11 |
出版物タイトル | Virchows Archiv |
巻 | 463巻 |
号 | 5号 |
資料タイプ | 学術雑誌論文 |
著者 | Hayashi, Eiko| Takata, Katsuyoshi| Sato, Yasuharu| Tashiro, Yukie| Tachiyama, Yoshiro| Sawada-Kitamura, Seiko| Hiramatsu, Yasushi| Sugiguchi, Shun| Nose, Soichiro| Hirokawa, Mitsuyoshi| Ando, Midori| Abd Mader, Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Yoshino, Tadashi| |
---|---|
発行日 | 2013-09 |
出版物タイトル | Human Pathology |
巻 | 44巻 |
号 | 9号 |
資料タイプ | 学術雑誌論文 |
著者 | Toda, Hiroko| Sato, Yasuharu| Takata, Katsuyoshi| Orita, Yorihisa| Asano, Naoko| Yoshino, Tadashi| |
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発行日 | 2013-02-28 |
出版物タイトル | PLoS ONE |
巻 | 8巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/51072 |
---|---|
フルテキストURL | 67_4_265.pdf |
著者 | Hanakawa, Hiroyuki| Orita, Yorihisa| Sato, Yasuharu| Uno, Kinya| Nishizaki, Kazunori| Yoshino, Tadashi| |
抄録 | We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis. |
キーワード | ulceration methotrexate oropharynx lymphoproliferative disorders |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2013-08 |
巻 | 67巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 265 |
終了ページ | 269 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 23970326 |
Web of Science KeyUT | 000323470100009 |
著者 | Miki, Yukari| Gion, Yuka| Mukae, Yuriko| Hayashi, Atsushi| Sato, Hiaki| Yoshino, Tadashi| Takahashi, Kiyoshi| |
---|---|
発行日 | 2013-02 |
出版物タイトル | European Journal of Haematology |
巻 | 90巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | 高田 尚良| 佐藤 康晴| 中村 直哉| 徳中 摩美| 三木 由香里| 菊池 イアーラ幸江| 五十嵐 和彦| 伊藤 悦郎| 張替 秀雄| 加藤 省一| 林 詠子| 岡 剛史| 星井 嘉信| 田利 晶| 岡田 裕之| Mohamado, ABD Alkader Lamia| 前田 嘉信| 谷本 光音| 木下 朝博| 吉野 正| |
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発行日 | 2013-08-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 125巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | 大熊 佑| 劉 克約| 和気 秀徳| 春間 純| 吉野 正| 大塚 愛二| 高橋 英夫| 森 秀治| 西堀 正洋| 伊達 勲| |
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発行日 | 2013-08-01 |
出版物タイトル | 岡山医学会雑誌 |
巻 | 125巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/32636 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Kondo, Eisaku| Yoshino, Tadashi| Akagi, Tadaatsu| Hayashi, Kazuhiko| Takahashi, Kiyoshi| |
抄録 | Southern blot hybridization was used to detect the rearrangement and amplification of five proto-oncogenes (bcl-2, bcl-1, c-myc, c-myb and c-Ha-ras) and one tumor suppressor gene (RB-1) in 55 Japanese patients with non-Hodgkin's lymphoma; 16 with T-cell lymphomas and 39 with B-cell lymphomas (7 follicular and 32 diffuse lymphomas). Genetic abnormalities of the proto-oncogenes were detected in 7 of the 55 (13%). Genetic abnormalities of bcl-2 plus other genes were detected in 5 of 7 cases of follicular lymphoma (71%), rearrangements of bcl-2 and c-myc, rearrangement of bcl-2 and amplification of c-myb. Genetic abnormalities were observed in only three cases of diffuse lymphoma. In each of 3 cases of B-cell lymphoma, one of the genes, blc-2 mbr, bcl-2 mcr and c-myc, was rearranged respectively. The incidence of genetic abnormalities in diffuse lymphomas (6.3%) was lower than that in follicular lymphomas. None of diffuse lymphomas had double oncogene abnormality. No abnormalities were found in RB-1, bcl-1, and Ha-ras. These findings suggest that follicular lymphomas are associated with some abnormalities of oncogenes not restricted to bcl-2 that facilitate growth which may be associated with their clinical features. |
キーワード | malignant lymphoma cellular oncogenes |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1992-12 |
巻 | 46巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 407 |
終了ページ | 415 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1485535 |
Web of Science KeyUT | A1992KE49600002 |
JaLCDOI | 10.18926/AMO/32620 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Takata, Hiroshi| Yoshino, Tadashi| Hoshida, Yoshihiko| Takata, Ikuko| Akagi, Tadaatsu| |
抄録 | A cell line of human lung large cell carcinoma (LCC) was established directly from the metastatic skin tumor tissue. The clinical course of the patient who carried this carcinoma was peculiar; generalized lymphadenopathy, histologically resembling Hodgkin's disease, was found as the first clinical symptom. The lung tumor was not discovered until the time of autopsy. This cell line (KaMi) grew adherent to culture vessels with the population doubling time of 20.6h, formed colonies in soft agars with efficiency of 22.6%, and formed tumors in athymic nude mice. The authenticity of KaMi was confirmed by chromosomal analysis and isoenzyme patterns. KaMi cells bore a strong resemblance to the original tumor cells which were composed of small spindle cells, large polygonal cells, and multinucleated giant cells. Immunohistochemically, KaMi cells showed a weak tendency to differentiate to squamous cells, and these immunohistochemical reactivities were almost compatible to those of the original tumor cells, but ultrastructurally, KaMi cells were more immature than the original ones. Treatment with several reagents could not augment a differentiation of KaMi cells. Cytokeratin profiles showed a tendency of squamous cell differentiation. KaMi cells may aid in elucidating the pathogenesis and biology of LCC and its relationship to other lung tumors. |
キーワード | Large cell lung carcinoma cell line cytokeratin |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1992-08 |
巻 | 46巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 257 |
終了ページ | 264 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1279943 |
Web of Science KeyUT | A1992JL44200005 |
JaLCDOI | 10.18926/AMO/32293 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Jin, Zaishun| Teramoto, Norihiro| Yoshino, Tadashi| Takada, Kenzo| Oka, Takashi| Hayashi, Kazuhiko| Akagi, Tadaatsu| |
抄録 | It has been reported that Epstein-Barr virus (EBV) resides in resting B cells in vivo. However, an ideal in vitro system for studying EBV latent infection in vivo has not yet been established. In this study, a mantle cell lymphoma line, SP53, was successfully infected with a recombinant EBV containing a neomycin-resistant gene. The EBV-carrying SP53 cells were obtained by selection using G418. They expressed EBER-1, EBNAs, and LMP1; this expression pattern of the EBV genes was similar to that in a lymphoblastoid cell line (LCL). However, proliferation assay showed that the EBV-carrying SP53 cells have a doubling time of 73 h, compared with 57 h of SP53 cells. Transplantation of 10(8) SP53 cells to nude mice formed tumors in 4 of 10 mice inoculated, but the EBV-carrying SP53 cells did not. Unexpectedly, EBV infection reduced the proliferation and tumorigenicity of SP53 cells. However, the EBV-carrying SP53 cells showed higher resistance to apoptosis induced by serum starvation than did the SP53 cells. The inhibition of proliferation and the resistance to apoptosis induced in SP53 cells by EBV infection indicate that this cell line might to some extent provide a model of in vivo EBV reservoir cells. |
キーワード | Epstein-Barr virus mantle cell lymphoma latent infection in vivo reservoir SP53 line |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2000-10 |
巻 | 54巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 193 |
終了ページ | 200 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 11061568 |
Web of Science KeyUT | 000090098600002 |
JaLCDOI | 10.18926/AMO/32209 |
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フルテキストURL | fulltext.pdf |
著者 | Mukuzono, Hiroshi| Yoshino, Tadashi| Akagi, Tadaatsu| |
抄録 | A monoclonal antibody (MAb), OPT1, reactive with T cells in formalin-fixed, paraffin-embedded tissue sections, has been identified through immunization with activated T cells from peripheral blood lymphocytes (PBL). The antibody is an IgG1 antibody as demonstrated by the Ouchterlony technique. By cytofluorometric analysis, almost all CD3+ lymphocytes and only a few CD20+ lymphocytes of peripheral blood expressed the OPT1 antigen. Nonhematolymphoid cell lines were negative for OPT1 by the immunoperoxidase staining using acetone-fixed cell lines. On the contrary, peripheral T cells, cells of two T cell lines out of four and a part of the cells of one B cell line out of two were positive for OPT1. The immunoperoxidase staining of paraffin-embedded tissue sections revealed that most of lymphocytes in T cell areas of lymph nodes expressed OPT1 antigen. Some lymphocytes in both cortex and medulla of the thymus and erythroid precursors of the bone marrow were OPT1+. In the malignant lymphoma series, approximately 90% of T cell lymphomas and 6% of B cell lymphomas reacted with OPT1. None of the Reed-Sternberg cells nor Hodgkin cells in Hodgkin's disease were positive. Consequently, OPT1 may be useful for the diagnosis and study of malignant lymphomas and other related lesions.</P> |
キーワード | monoclonal antibody OPTI T cells lymphocytes lymphoma |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1991-06 |
巻 | 45巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 147 |
終了ページ | 154 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1891974 |
Web of Science KeyUT | A1991FV15000004 |