Author | 和田 淳| |
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Published Date | 1992-03-31 |
Publication Title | |
Content Type | Thesis or Dissertation |
JaLCDOI | 10.18926/AMO/32029 |
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FullText URL | fulltext.pdf |
Author | Wada, Jun| Makino, Hirofumi| |
Abstract | Galectins are beta-galactoside binding mammalian lectins and they share homologous carbohydrate recognition domains. To date, 11 members of galectin family have been cloned and identified. They have been shown to play roles in diverse biological events, such as embryogenesis, oncogenesis, adhesion and proliferation of the cells, receptor for advanced glycation end products, mRNA splicing, bacterial colonization, apoptosis, and in the modulation of the immune response. The mechanisms by which galectins exert these diverse effects remain largely unknown. However, the elucidation of multi-functional proteins belong to galectin family are going to open new fields in clinical science including diagnosis and therapy of autoimmune disorders, cancers, and vascular complications in diabetes and hypertension.</P> |
Keywords | galectins -galactoside binding lectins cell adhesion and proliferation oncogenesis autoimmune diseases diabetic vascular complications |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2001-02 |
Volume | volume55 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 11 |
End Page | 17 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 11246972 |
Web of Science KeyUT | 000167249900002 |
Author | 肥田 和之| 和田 淳| 江口 潤| Zhang Hong| 馬場 雅子| 清田 綾| 橋本 泉| 岡田 達夫| 安原 章浩| 中司 敦子| 赤木 滋| 四方 賢一| 宝来 真志| 二見 淳一郎| 渡辺 英二郎| 松木 泰| 平松 隆司| 槇野 博史| Yashpal S. Kanwar| |
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Published Date | 2007-01-04 |
Publication Title | 岡山医学会雑誌 |
Volume | volume118 |
Issue | issue3 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/32883 |
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FullText URL | fulltext.pdf |
Author | Miyatake, Nobuyuki| Wada, Jun| Saito, Takeshi| Nishikawa, Hidetaka| Matsumoto, Sumiko| Miyachi, Motohiro| Makino, Hirofumi| Numata, Takeyuki| |
Abstract | We compared muscle strength between Japanese men with and without metabolic syndrome. We used data for 323 Japanese men with metabolic syndrome and 893 Japanese men without the syndrome. Metabolic syndrome was defined by a new criterion in Japan, and the parameters for muscle strength, i.e. grip strength, leg strength were measured. Leg strength was found to be significantly higher in subjects with metabolic syndrome than in those without, while muscle strength per body weight was significantly lower in subjects with the syndrome. Lower muscle strength per body weight may be one of the characteristic features in subjects with metabolic syndrome. |
Keywords | metabolic syndrome grip strength leg strength |
Amo Type | Short Communication |
Publication Title | Acta Medica Okayama |
Published Date | 2007-04 |
Volume | volume61 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 89 |
End Page | 102 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 17471310 |
Web of Science KeyUT | 000245875600007 |
JaLCDOI | 10.18926/AMO/32900 |
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FullText URL | fulltext.pdf |
Author | Miyatake, Nobuyuki| Wada, Jun| Matsumoto, Sumiko| Nishikawa, Hidetaka| Makino, Hirofumi| Numata, Takeyuki| |
Abstract | We re-evaluated the criteria for waist circumference to predict the accumulation of the components of metabolic syndrome. We used data for 3,185 Japanese, aged 20-79 years. Metabolic syndrome has recently been redefined by a new criterion in Japan, in which waist circumference cutoff points, i.e. 85 cm for men and 90 cm for women, are employed. Among the 3,185 Japanese considered in the present study, 335 men (26.8%) and 69 women (3.6%) were diagnosed as having metabolic syndrome. A cutoff point as a predictor for 2 or more components of metabolic syndrome was evaluated by sensitivity/specificity and a receiver operating characteristic (ROC) curve. The optimal point was estimated as being approximately 85 cm of waist circumference in men and 75 cm in women. We therefore recommend a cutoff value, 75 cm of waist circumference, for the criterion of metabolic syndrome in women. |
Keywords | metabolic syndrome waist circumference sensitivity specifi city receiver operating characteristic (ROC) curve |
Amo Type | Short Communication |
Publication Title | Acta Medica Okayama |
Published Date | 2007-06 |
Volume | volume61 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 167 |
End Page | 169 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 17593953 |
Web of Science KeyUT | 000247574700006 |
JaLCDOI | 10.18926/AMO/32895 |
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FullText URL | fulltext.pdf |
Author | Miyatake, Nobuyuki| Saito, Takeshi| Wada, Jun| Nishikawa, Hidetaka| Matsumoto, Sumiko| Miyachi, Motohiko| Fujii, Masafumi| Makino, Hirofumi| Numata, Takeyuki| |
Abstract | We evaluated the linkage between oxygen uptake at the ventilatory threshold (VT) and muscle strength in subjects with and without metabolic syndrome. We used data of 226 Japanese men with metabolic syndrome and 265 Japanese men without the syndrome. Metabolic syndrome has recently been defined by a new criterion in Japan. Oxygen uptake at VT and muscle strength, i.e. grip strength and leg strength were measured. Oxygen uptake at VT and muscle strength/body weight were found to be significantly lower in subjects with metabolic syndrome than in those without the syndrome. However, the differences did not reach significant levels after adjusting for leg strength/body weight or oxygen uptake at VT. A combination of aerobic exercise and resistance training might be considered for preventing and improving metabolic syndrome. |
Keywords | metabolic syndrome oxygen uptake ventilatory threshold muscle strength |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2007-10 |
Volume | volume61 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 255 |
End Page | 259 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 17971842 |
Web of Science KeyUT | 000250431700003 |
Author | Yasuhara, Akihiro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Murakami, Kazutoshi| Kanzaki, Motoko| Teshigawara, Sanae| Makino, Hirofumi| |
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Published Date | 2010-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume122 |
Issue | issue1 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/45266 |
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FullText URL | 65_2_81.pdf |
Author | Sasaki, Motofumi| Shikata, Kenichi| Okada, Shinichi| Miyamoto, Satoshi| Nishishita, Shingo| Usui Kataoka, Hitomi| Sato, Chikage| Wada, Jun| Ogawa, Daisuke| Makino, Hirofumi| |
Abstract | Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease. |
Keywords | kidney inflammation chemokine |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2011-04 |
Volume | volume65 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 81 |
End Page | 89 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21519365 |
Web of Science KeyUT | 000289818800003 |
JaLCDOI | 10.18926/AMO/45272 |
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FullText URL | 65_2_129.pdf |
Author | Toyota, Noriko| Ogawa, Daisuke| Ishii, Keita| Hirata, Kyoji| Wada, Jun| Shikata, Kenichi| Makino, Hirofumi| |
Abstract | A 62-year-old woman with a history of poorly controlled type 2 diabetes mellitus was admitted to our hospital with a 3-week history of mild fever, vomiting, and anorexia. Abdominal computed tomography (CT) showed bilateral hydronephrosis and gas accumulation in the urinary bladder wall and left ureter. Laboratory tests showed leukocytosis and elevated C-reactive protein level. Urine culture showed heavy growth of Escherichia coli. The final diagnosis was emphysematous cystitis. The patient was treated with systemic antibiotics and drainage using a urethral catheter. The clinical and radiographic findings resolved rapidly, and she was discharged from the hospital on day 28. Emphysematous cystitis is a relatively rare urinary tract infection associated with gas formation, and has the potential for a serious outcome if untreated. Early detection by imaging studies such as CT is important in providing prompt treatment and favorable clinical outcome. |
Keywords | computed tomography diabetes mellitus emphysematous cystitis |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2011-04 |
Volume | volume65 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 129 |
End Page | 133 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21519371 |
Web of Science KeyUT | 000289818800009 |
JaLCDOI | 10.18926/AMO/46850 |
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FullText URL | 65_4_247.pdf |
Author | Watanabe, Naomi| Shikata, Kenichi| Shikata, Yasushi| Sarai, Kei| Omori, Kazuyoshi| Kodera, Ryo| Sato, Chikage| Wada, Jun| Makino, Hirofumi| |
Abstract | Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in glomerular endothelial cells under diabetic conditions. We examined the expression of ICAM-1 in the kidneys of experimental diabetic rats. Human glomerular endothelial cells (GE cells) were exposed to normal glucose concentration, high glucose concentration (HG), or high mannitol concentration (HM), and then the expression of the ICAM-1 protein and the phosphorylation of the 3 subfamilies of mitogen-activated protein kinase (MAPK) were determined using Western blot analysis. Next, to evaluate the involvement of MAPKs in HG- or HM-induced ICAM-1 expression, we preincubated GE cells with the inhibitors for ERK, p38 or JNK 1h prior to the application of glucose or mannitol. Expression of ICAM-1 was increased in the glomeruli of diabetic rats. Both HG and HM induced ICAM-1 expression and phosphorylation of ERK1/2, p38 and JNK in GE cells. Expression of ICAM-1 was significantly attenuated by inhibitors of ERK, p38 and JNK. We conclude that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions. |
Keywords | diabetic nephropathy ICAM-1 ERK p38 MAPK JNK |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2011-08 |
Volume | volume65 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 247 |
End Page | 257 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21860531 |
Web of Science KeyUT | 000294236700005 |
Author | Teshigawara, Sanae| Wada, Jun| Hida, Kazuyuki| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Iseda, Izumi| Matsushita, Yuichi| Miyatake, Nobuyuki| McDonald, John F.| Hotta, Kikuko| Makino, Hirofumi| |
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Published Date | 2012-07 |
Publication Title | Journal of Clinical Endocrinology & Metabolism |
Volume | volume97 |
Issue | issue7 |
Content Type | Journal Article |
Author | Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi| |
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Published Date | 2012-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue2 |
Content Type | Journal Article |
Author | Nakatsuka, Atsuko| Wada, Jun| Iseda, Izumi| Teshigawara, Sanae| Higashio, Kanji| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Hida, Kazuyuki| Eguchi, Jun| Horiguchi, Chikage Sato| Ogawa, Daisuke| Matsuki, Yasushi| Hiramatsu, Ryuji| Yagita, Hideo| Kakuta, Shigeru| Iwakura, Yoichiro| Makino, Hirofumi| |
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Published Date | 2012-11 |
Publication Title | Diabetes |
Volume | volume61 |
Issue | issue11 |
Content Type | Journal Article |
Author | Inoue, Junko| Wada, Jun| Teshigawara, Sanae| Hida, Kazuyuki| Nakatsuka, Atsuko| Takatori, Yuji| Kojo, Shoichirou| Akagi, Shigeru| Nakao, Kazushi| Miyatake, Nobuyuki| McDonald, John F.| Makino, Hirofumi| |
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Published Date | 2012-12-03 |
Publication Title | BMC Nephrology |
Volume | volume13 |
Content Type | Journal Article |
Author | Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi| |
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Published Date | 2013-01-22 |
Publication Title | BMC Nephrology |
Volume | volume14 |
Content Type | Journal Article |
Author | Sugiyama, Koichi| Sada, Ken-ei| Kurosawa, Michiko| Wada, Jun| Makino, Hirofumi| |
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Published Date | 2013-02 |
Publication Title | Clinical and Experimental Nephrology |
Volume | volume17 |
Issue | issue1 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/50405 |
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FullText URL | 67_3_129.pdf |
Author | Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi| |
Abstract | In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future. |
Keywords | nuclear receptor cell cycle metabolic syndrome diabetic nephropathy |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2013-06 |
Volume | volume67 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 129 |
End Page | 134 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23804135 |
Web of Science KeyUT | 000320747900001 |
Author | Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi| |
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Published Date | 2013-10-15 |
Publication Title | PLoS ONE |
Volume | volume8 |
Issue | issue10 |
Content Type | Journal Article |
Author | Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi| |
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Published Date | 2013-10-22 |
Publication Title | International Journal of Nephrology and Renovascular Disease |
Volume | volume6 |
Content Type | Journal Article |
Author | Nakayama, Kazunori| Nakao, Kazushi| Takatori, Yuji| Inoue, Junko| Kojo, Shoichirou| Akagi, Shigeru| Fukushima, Masaki| Wada, Jun| Makino, Hirofumi| |
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Published Date | 2013-12-18 |
Publication Title | International Journal of Nephrology and Renovascular Disease |
Volume | volume7 |
Content Type | Journal Article |