| Title Alternative | Inhibitory effects of caffeine on allergic rhinitis symptoms in mice |
|---|---|
| FullText URL | poalas_033_018_021.pdf |
| Author | Tsujimoto, Madoka| Saiki, Akiko| Suzuki, Manami| Shiraga, Toshiyuki| Sugimoto, Yukio| Hayashi, Yasushi| |
| Abstract | We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms. |
| Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
| Published Date | 2017-04 |
| Volume | volume33 |
| Start Page | 18 |
| End Page | 21 |
| language | Japanese |
| File Version | publisher |
| Author | Ishimoto, Hidekazu| Shibata, Mari| Myojin, Yuki| Ito, Hideyuki| Sugimoto, Yukio| Tai, Akihiro| Hatano, Tsutomu| |
|---|---|
| Published Date | 2011-10-01 |
| Publication Title | Bioorganic & Medicinal Chemistry Letters |
| Volume | volume21 |
| Issue | issue19 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/31623 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Sugimoto, Yukio| Iba, Yoshionori| Ishizawa, Keisuke| Suzuki, Genzo| Kamei, Chiaki| |
| Abstract | The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release. |
| Keywords | levocabastine guinea pig lung fragment lipid mediator |
| Amo Type | Brief Note |
| Publication Title | Acta Medica Okayama |
| Published Date | 1999-12 |
| Volume | volume53 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 271 |
| End Page | 274 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 10631382 |
| Web of Science KeyUT | 000084414300005 |
| Author | Sugimoto, Yukio| |
|---|---|
| Published Date | 2003-09 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume20 |
| Content Type | Journal Article |
| Author | 杉本 幸雄| |
|---|---|
| Published Date | 1998-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
