ID | 46944 |
FullText URL | |
Author |
Ishimoto, Hidekazu
Shibata, Mari
Myojin, Yuki
Tai, Akihiro
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Abstract | Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.
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Keywords | Ellagitannin
Urolithin A
Antioxidant activity
Anti-inflammatory activity
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Published Date | 2011-10-01
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Publication Title |
Bioorganic & Medicinal Chemistry Letters
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Volume | volume21
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Issue | issue19
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Publisher | Pergamon-Elsevier Science Ltd.
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Start Page | 5901
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End Page | 5904
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ISSN | 0960-894X
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NCID | AA1079577X
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Content Type |
Journal Article
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language |
English
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Copyright Holders | © 2011 Elsevier Ltd. All rights reserved.
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File Version | author
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Refereed |
True
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DOI | |
PubMed ID | |
Web of Science KeyUT |