start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=18 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inhibitory effects of caffeine on allergic rhinitis symptoms in mice kn-title=カフェインによるアレルギー性鼻炎の抑制効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms. en-copyright= kn-copyright= en-aut-name=TsujimotoMadoka en-aut-sei=Tsujimoto en-aut-mei=Madoka kn-aut-name=辻本まどか kn-aut-sei=辻本 kn-aut-mei=まどか aut-affil-num=1 ORCID= en-aut-name=Saiki Akiko en-aut-sei=Saiki en-aut-mei= Akiko kn-aut-name=佐伯綾希子 kn-aut-sei=佐伯 kn-aut-mei=綾希子 aut-affil-num=2 ORCID= en-aut-name=SuzukiManami en-aut-sei=Suzuki en-aut-mei=Manami kn-aut-name=鈴木真奈美 kn-aut-sei=鈴木 kn-aut-mei=真奈美 aut-affil-num=3 ORCID= en-aut-name=ShiragaToshiyuki en-aut-sei=Shiraga en-aut-mei=Toshiyuki kn-aut-name=白神俊幸 kn-aut-sei=白神 kn-aut-mei=俊幸 aut-affil-num=4 ORCID= en-aut-name=SugimotoYukio en-aut-sei=Sugimoto en-aut-mei=Yukio kn-aut-name=杉本幸雄 kn-aut-sei=杉本 kn-aut-mei=幸雄 aut-affil-num=5 ORCID= en-aut-name=HayashiYasushi en-aut-sei=Hayashi en-aut-mei=Yasushi kn-aut-name=林泰資 kn-aut-sei=林 kn-aut-mei=泰資 aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=2 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=3 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=4 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=5 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=6 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=19 article-no= start-page=5901 end-page=5904 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A en-subtitle= kn-subtitle= en-abstract= kn-abstract=Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases. en-copyright= kn-copyright= en-aut-name=IshimotoHidekazu en-aut-sei=Ishimoto en-aut-mei=Hidekazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShibataMari en-aut-sei=Shibata en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MyojinYuki en-aut-sei=Myojin en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ItoHideyuki en-aut-sei=Ito en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugimotoYukio en-aut-sei=Sugimoto en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TaiAkihiro en-aut-sei=Tai en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HatanoTsutomu en-aut-sei=Hatano en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Pharmacology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima affil-num=7 en-affil= kn-affil=Department of Pharmacognosy, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=Ellagitannin kn-keyword=Ellagitannin en-keyword=Urolithin A kn-keyword=Urolithin A en-keyword=Antioxidant activity kn-keyword=Antioxidant activity en-keyword=Anti-inflammatory activity kn-keyword=Anti-inflammatory activity END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=6 article-no= start-page=271 end-page=274 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of levocabastine on lipid mediator release from guinea pig lung fragments. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.

en-copyright= kn-copyright= en-aut-name=SugimotoYukio en-aut-sei=Sugimoto en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IbaYoshionori en-aut-sei=Iba en-aut-mei=Yoshionori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshizawaKeisuke en-aut-sei=Ishizawa en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiGenzo en-aut-sei=Suzuki en-aut-mei=Genzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KameiChiaki en-aut-sei=Kamei en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=levocabastine kn-keyword=levocabastine en-keyword=guinea pig kn-keyword=guinea pig en-keyword=lung fragment kn-keyword=lung fragment en-keyword=lipid mediator kn-keyword=lipid mediator END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue= article-no= start-page=45 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200309 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Animal Models of Allergic Diseases kn-title=アレルギー性疾患の動物モデル en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SugimotoYukio en-aut-sei=Sugimoto en-aut-mei=Yukio kn-aut-name=杉本幸雄 kn-aut-sei=杉本 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学薬学部薬物作用解析学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=新規アレルギー性疾患モデルの作製とその応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=杉本幸雄 kn-aut-sei=杉本 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END