FullText URL | fulltext.pdf |
---|---|
Author | Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group| |
Keywords | Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan |
Published Date | 2020-08-08 |
Publication Title | Journal of Diabetes Investigation |
Volume | volume12 |
Issue | issue2 |
Publisher | Wiley |
Start Page | 207 |
End Page | 216 |
ISSN | 2040-1116 |
NCID | AA12488319 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors |
File Version | publisher |
PubMed ID | 32597548 |
NAID | 120006880216 |
DOI | 10.1111/jdi.13339 |
Web of Science KeyUT | 000557091100001 |
Related Url | isVersionOf https://doi.org/10.1111/jdi.13339 |
FullText URL | fulltext.pdf |
---|---|
Author | Shikata, Kenichi| Kodera, Ryo| Utsunomiya, Kazunori| Koya, Daisuke| Nishimura, Rimei| Miyamoto, Satoshi| Tajima, Naoko| the JDCP study group| |
Keywords | Diabetic nephropathy Diabetic kidney disease Japan Diabetes Complication and its Prevention study |
Published Date | 2020-05-17 |
Publication Title | Journal of Diabetes Investigation |
Volume | volume11 |
Issue | issue2 |
Publisher | Wiley |
Start Page | 325 |
End Page | 332 |
ISSN | 2040-1116 |
NCID | AA12488319 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31317670 |
DOI | 10.1111/jdi.13116 |
Web of Science KeyUT | 000519857400011 |
Related Url | isVersionOf https://doi.org/10.1111/jdi.13116 |
Author | Nagase, Ryo| Kajitani, Nobuo| Shikata, Kenichi| Ogawa, Daisuke| Kodera, Ryo| Okada, Shinichi| Kido, Yuichi| Makino, Hirofumi| |
---|---|
Published Date | 2012-10 |
Publication Title | Clinical and Experimental Nephrology |
Volume | volume16 |
Issue | issue5 |
Content Type | Journal Article |
Author | Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi| |
---|---|
Note | This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.| |
Published Date | 2024-04-15 |
Publication Title | Nutrition and Cancer |
Publisher | Informa UK Limited |
ISSN | 0163-5581 |
NCID | AA00325612 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 38619145 |
DOI | 10.1080/01635581.2024.2340782 |
Web of Science KeyUT | 001202947500001 |
Related Url | isVersionOf https://doi.org/10.1080/01635581.2024.2340782 |
FullText URL | fulltext.pdf |
---|---|
Author | Mise, Koki| Imamura, Mariko| Yamaguchi, Satoshi| Watanabe, Mayu| Higuchi, Chigusa| Katayama, Akihiro| Miyamoto, Satoshi| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhiro| Ando, Shinichiro| Nunoue, Tomokazu| Yoshida, Michihiro| Yamada, Masao| Shikata, Kenichi| Wada, Jun| |
Keywords | cardiovascular event diabetes lectins N-glycans urinary biomarkers |
Published Date | 2021-05-24 |
Publication Title | Frontiers In Cardiovascular Medicine |
Volume | volume8 |
Publisher | Frontiers Media SA |
Start Page | 668059 |
ISSN | 2297-055X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
PubMed ID | 34109226 |
NAID | 120007053373 |
DOI | 10.3389/fcvm.2021.668059 |
Web of Science KeyUT | 000658156400001 |
Related Url | isVersionOf https://doi.org/10.3389/fcvm.2021.668059 |
JaLCDOI | 10.18926/AMO/32632 |
---|---|
FullText URL | fulltext.pdf |
Author | Ota, Zensuke| Shikata, Kenichi| Ota, Kosuke| |
Abstract | We developed a "tissue negative staining method" to observe the molecular-level ultrastructure in situ in any portion of the ultrathin sections routinely prepared for electron microscopy. This method was used in electron microscopy of the glomerular basement membranes (GBM). The GBM in patients with nephrotic syndrome was discovered to possess a tunnel structure, designated as "nephrotic tunnel", with lumen large enough to allow free passage of protein molecules. This tunnel seemed to be involved in the etiology of nephrotic syndrome. This new method appears to be applicable to a variety of purposes in biological studies. |
Keywords | mechanism proteinuria nephrotic syndrome electron microscopy negative staining |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1992-12 |
Volume | volume46 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 483 |
End Page | 487 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 1485544 |
Web of Science KeyUT | A1992KE49600012 |
JaLCDOI | 10.18926/AMO/52143 |
---|---|
FullText URL | 68_1_43.pdf |
Author | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
Abstract | The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p=0.7709, women:p=0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese. |
Keywords | proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification |
Amo Type | Short Communication |
Publication Title | Acta Medica Okayama |
Published Date | 2014-02 |
Volume | volume68 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 43 |
End Page | 46 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 24553488 |
Web of Science KeyUT | 000331592800007 |
JaLCDOI | 10.18926/AMO/46850 |
---|---|
FullText URL | 65_4_247.pdf |
Author | Watanabe, Naomi| Shikata, Kenichi| Shikata, Yasushi| Sarai, Kei| Omori, Kazuyoshi| Kodera, Ryo| Sato, Chikage| Wada, Jun| Makino, Hirofumi| |
Abstract | Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in glomerular endothelial cells under diabetic conditions. We examined the expression of ICAM-1 in the kidneys of experimental diabetic rats. Human glomerular endothelial cells (GE cells) were exposed to normal glucose concentration, high glucose concentration (HG), or high mannitol concentration (HM), and then the expression of the ICAM-1 protein and the phosphorylation of the 3 subfamilies of mitogen-activated protein kinase (MAPK) were determined using Western blot analysis. Next, to evaluate the involvement of MAPKs in HG- or HM-induced ICAM-1 expression, we preincubated GE cells with the inhibitors for ERK, p38 or JNK 1h prior to the application of glucose or mannitol. Expression of ICAM-1 was increased in the glomeruli of diabetic rats. Both HG and HM induced ICAM-1 expression and phosphorylation of ERK1/2, p38 and JNK in GE cells. Expression of ICAM-1 was significantly attenuated by inhibitors of ERK, p38 and JNK. We conclude that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions. |
Keywords | diabetic nephropathy ICAM-1 ERK p38 MAPK JNK |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2011-08 |
Volume | volume65 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 247 |
End Page | 257 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21860531 |
Web of Science KeyUT | 000294236700005 |
JaLCDOI | 10.18926/AMO/32856 |
---|---|
FullText URL | fulltext.pdf |
Author | Sumiyoshi, Kazuko| Kawata, Chieko| Shikata, Kenichi| Makino, Hirofumi| |
Abstract | The aim of this study was to clarify the factors influencing the dietary behavior of patients with diabetic nephropathy. One hundred twenty-two patients with type 2 diabetes were recruited from the outpatients of Okayama University Hospital in Okayama, Japan. We performed a cross-sectional study using a questionnaire including 206 items among 18 categories as follows:background factors, coping behavior (coping scale), degree of uncertainty in illness (uncertainty scale), and dietary behavior. The data were analyzed by correlation analysis, t-test, one-way analysis of variance, Pearson correlation analysis, and multiple regression analysis. We found that those patients with microalbuminuria alone tended to recognize more mild about their kidney status than those with macroalbuminuria and chronic renal failure. We also found that common factors influencing the dietary behavior of diabetic patients with and without nephropathy are as follows:1. coping with the problem (beta0.342, p0.01);2. anxiety about prognosis (beta0.344, p0.01);3. sex (beta0.234, p0.05);4. uncertainty regarding treatment (beta0.377, p0.01);5. negative coping (beta0.354, p0.01);and 6. employment status (beta0.367, p0.01). Coping and uncertainty in illness had a significant relation to positive support and lack of support. To maintain appropriate dietary behavior in diabetic patients, medical staff need to determine what the social supports are important for the patient, and also to ensure good communication among healthcare personnel as well as positive support for patients and families. |
Keywords | diabetic nephropathy dietary behavior coping uncertainty in illness social support |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2010-02 |
Volume | volume64 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 39 |
End Page | 47 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 20200583 |
Web of Science KeyUT | 000274868300006 |
JaLCDOI | 10.18926/AMO/30866 |
---|---|
FullText URL | fulltext.pdf |
Author | Ota, Zensuke| Kumagai, Isao| Shikata, Kenichi| Makino, Hirofumi| |
Abstract | Sprague-Dawley rats, 6 with aminonucleoside nephrosis and 6 controls, were intravenously injected with human liver ferritin isolated from post mortem liver, and their 24-h urine samples were examined for human ferritin by immunoradiometric assay. In rats with aminonucleoside nephrosis, the amount of excreted ferritin in urine was forty times greater than in control rats. Much more monomeric ferritin was excreted than that of polymeric ferritin. We are the first to have utilized human liver ferritin as a tracer to measure a minor amount of ferritin by a commercially available kit. Our present study seems to indicate a critical role for glomerular basement membrane as a size barrier. |
Keywords | glomerular permeabillity size barrier human liver ferritin immunoradiometricassay |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1989-12 |
Volume | volume43 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 363 |
End Page | 365 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 2624144 |
Web of Science KeyUT | A1989CG27400008 |
JaLCDOI | 10.18926/AMO/52789 |
---|---|
FullText URL | 68_4_235.pdf |
Author | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
Abstract | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
Keywords | microalbuminuria type 2 diabetes mellitus remission regression |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2014-08 |
Volume | volume68 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 235 |
End Page | 241 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25145409 |
Web of Science KeyUT | 000340687500005 |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
JaLCDOI | 10.18926/AMO/45272 |
---|---|
FullText URL | 65_2_129.pdf |
Author | Toyota, Noriko| Ogawa, Daisuke| Ishii, Keita| Hirata, Kyoji| Wada, Jun| Shikata, Kenichi| Makino, Hirofumi| |
Abstract | A 62-year-old woman with a history of poorly controlled type 2 diabetes mellitus was admitted to our hospital with a 3-week history of mild fever, vomiting, and anorexia. Abdominal computed tomography (CT) showed bilateral hydronephrosis and gas accumulation in the urinary bladder wall and left ureter. Laboratory tests showed leukocytosis and elevated C-reactive protein level. Urine culture showed heavy growth of Escherichia coli. The final diagnosis was emphysematous cystitis. The patient was treated with systemic antibiotics and drainage using a urethral catheter. The clinical and radiographic findings resolved rapidly, and she was discharged from the hospital on day 28. Emphysematous cystitis is a relatively rare urinary tract infection associated with gas formation, and has the potential for a serious outcome if untreated. Early detection by imaging studies such as CT is important in providing prompt treatment and favorable clinical outcome. |
Keywords | computed tomography diabetes mellitus emphysematous cystitis |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2011-04 |
Volume | volume65 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 129 |
End Page | 133 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21519371 |
Web of Science KeyUT | 000289818800009 |
FullText URL | fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf |
---|---|
Author | Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi| |
Keywords | Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling |
Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.| |
Published Date | 2022-09-25 |
Publication Title | Annals of Surgical Oncology |
Volume | volume30 |
Issue | issue2 |
Publisher | Springer Science and Business Media LLC |
Start Page | 1110 |
End Page | 1118 |
ISSN | 1068-9265 |
NCID | AA11016573 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Society of Surgical Oncology 2022 |
File Version | author |
PubMed ID | 36161371 |
DOI | 10.1245/s10434-022-12572-3 |
Web of Science KeyUT | 000858651900003 |
Related Url | isVersionOf https://doi.org/10.1245/s10434-022-12572-3 |
FullText URL | fulltext.pdf |
---|---|
Author | Uchida, Haruhito A.| Takatsuka, Tetsuharu| Hada, Yoshiko| Umebayashi, Ryoko| Takeuchi, Hidemi| Shikata, Kenichi| Subramanian, Venkateswaran| Daugherty, Alan| Wada, Jun| |
Keywords | edaravone angiotensin II abdominal aortic aneurysm atherosclerosis |
Published Date | 2022-08-14 |
Publication Title | Biomolecules |
Volume | volume12 |
Issue | issue8 |
Publisher | MDPI |
Start Page | 1117 |
ISSN | 2218-273X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the authors. |
File Version | publisher |
PubMed ID | 36009011 |
DOI | 10.3390/biom12081117 |
Web of Science KeyUT | 000846165000001 |
Related Url | isVersionOf https://doi.org/10.3390/biom12081117 |
FullText URL | fulltext.pdf |
---|---|
Author | Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun| |
Keywords | Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology |
Published Date | 2020-09-10 |
Publication Title | Scientific Reports |
Volume | volume10 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 14928 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 32913271 |
DOI | 10.1038/s41598-020-71946-3 |
Web of Science KeyUT | 000571915100049 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-020-71946-3 |
JaLCDOI | 10.18926/AMO/40510 |
---|---|
FullText URL | 64_5_339.pdf |
Author | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
Abstract | The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure(r=-0.306, p=0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women. |
Keywords | systolic blood pressure estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
Amo Type | Short Communication |
Publication Title | Acta Medica Okayama |
Published Date | 2010-10 |
Volume | volume64 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 339 |
End Page | 343 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 20975768 |
Web of Science KeyUT | 000283563300010 |
JaLCDOI | 10.18926/AMO/47261 |
---|---|
FullText URL | 65_6_363.pdf |
Author | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
Abstract | The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5±8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome components at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, almost all metabolic syndrome components were significantly improved. However, eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circumference (r=-0.232, p=0.0106). A decrease in abdominal circumference may be associated with improving eGFR in Japanese men. |
Keywords | abdominal circumference estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2011-12 |
Volume | volume65 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 363 |
End Page | 367 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 22189476 |
Web of Science KeyUT | 000298516900002 |
JaLCDOI | 10.18926/AMO/31126 |
---|---|
FullText URL | fulltext.pdf |
Author | Morioka, Shigeru| Makino, Hirofumi| Shikata, Kenichi| Ota, Zensuke| |
Abstract | To investigate the role of vitronectin in the progression of diabetic nephropathy, plasma concentrations of vitronectin were measured by enzyme-linked immunosorbent assay in patients with diabetes mellitus and compared with normal control subjects. In diabetic patients with normoalbuminuria and microalbuminuria, plasma concentrations of vitronectin were significantly higher than those of control subjects. Plasma concentrations of vitronectin in diabetic patients with chronic renal failure were significantly lower than those with normal renal function. There was a significant positive correlation between plasma concentration of vitronectin and blood platelet counts. In the early stage of diabetic nephropathy, vitronectin may be increased caused by synthesis from activated platelets. With progression of diabetic nephropathy, plasma vitronectin may be decreased because of accumulation in sclerotic glomeruli and arteriosclerotic lesions. In conclusion, the plasma concentration of vitronectin appears to be an important marker for the progression of diabetic nephropathy. |
Keywords | vitronectin(S-protein) diabetic nephropathy hypertension chronic renal failure enzyme-linked immunosorbent assay (ELISA) |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1994-06 |
Volume | volume48 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 137 |
End Page | 142 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 7524268 |
Web of Science KeyUT | A1994NV04300004 |