フルテキストURL | fulltext.pdf |
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著者 | Shikata, Kenichi| Kodera, Ryo| Utsunomiya, Kazunori| Koya, Daisuke| Nishimura, Rimei| Miyamoto, Satoshi| Tajima, Naoko| the JDCP study group| |
キーワード | Diabetic nephropathy Diabetic kidney disease Japan Diabetes Complication and its Prevention study |
発行日 | 2020-05-17 |
出版物タイトル | Journal of Diabetes Investigation |
巻 | 11巻 |
号 | 2号 |
出版者 | Wiley |
開始ページ | 325 |
終了ページ | 332 |
ISSN | 2040-1116 |
NCID | AA12488319 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2019 The Authors. |
論文のバージョン | publisher |
PubMed ID | 31317670 |
DOI | 10.1111/jdi.13116 |
Web of Science KeyUT | 000519857400011 |
関連URL | isVersionOf https://doi.org/10.1111/jdi.13116 |
著者 | Nagase, Ryo| Kajitani, Nobuo| Shikata, Kenichi| Ogawa, Daisuke| Kodera, Ryo| Okada, Shinichi| Kido, Yuichi| Makino, Hirofumi| |
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発行日 | 2012-10 |
出版物タイトル | Clinical and Experimental Nephrology |
巻 | 16巻 |
号 | 5号 |
資料タイプ | 学術雑誌論文 |
著者 | Hanzawa, Shunya| Kikuchi, Satoru| Kuroda, Shinji| Shoji, Ryohei| Kashima, Hajime| Matsumi, Yuki| Takahashi, Ayako| Kakiuchi, Yoshihiko| Takagi, Kosei| Tanabe, Shunsuke| Noma, Kazuhiro| Kagawa, Shunsuke| Shikata, Kenichi| Fujiwara, Toshiyoshi| |
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備考 | This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 15 Apr 2024, available at: https://doi.org/10.1080/01635581.2024.2340782.| This fulltext file will be available in Apr. 2025.| |
発行日 | 2024-04-15 |
出版物タイトル | Nutrition and Cancer |
出版者 | Informa UK Limited |
ISSN | 0163-5581 |
NCID | AA00325612 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
論文のバージョン | author |
PubMed ID | 38619145 |
DOI | 10.1080/01635581.2024.2340782 |
Web of Science KeyUT | 001202947500001 |
関連URL | isVersionOf https://doi.org/10.1080/01635581.2024.2340782 |
フルテキストURL | fulltext.pdf |
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著者 | Mise, Koki| Imamura, Mariko| Yamaguchi, Satoshi| Watanabe, Mayu| Higuchi, Chigusa| Katayama, Akihiro| Miyamoto, Satoshi| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhiro| Ando, Shinichiro| Nunoue, Tomokazu| Yoshida, Michihiro| Yamada, Masao| Shikata, Kenichi| Wada, Jun| |
キーワード | cardiovascular event diabetes lectins N-glycans urinary biomarkers |
発行日 | 2021-05-24 |
出版物タイトル | Frontiers In Cardiovascular Medicine |
巻 | 8巻 |
出版者 | Frontiers Media SA |
開始ページ | 668059 |
ISSN | 2297-055X |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2021 by the authors. |
論文のバージョン | publisher |
PubMed ID | 34109226 |
NAID | 120007053373 |
DOI | 10.3389/fcvm.2021.668059 |
Web of Science KeyUT | 000658156400001 |
関連URL | isVersionOf https://doi.org/10.3389/fcvm.2021.668059 |
JaLCDOI | 10.18926/AMO/32632 |
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フルテキストURL | fulltext.pdf |
著者 | Ota, Zensuke| Shikata, Kenichi| Ota, Kosuke| |
抄録 | We developed a "tissue negative staining method" to observe the molecular-level ultrastructure in situ in any portion of the ultrathin sections routinely prepared for electron microscopy. This method was used in electron microscopy of the glomerular basement membranes (GBM). The GBM in patients with nephrotic syndrome was discovered to possess a tunnel structure, designated as "nephrotic tunnel", with lumen large enough to allow free passage of protein molecules. This tunnel seemed to be involved in the etiology of nephrotic syndrome. This new method appears to be applicable to a variety of purposes in biological studies. |
キーワード | mechanism proteinuria nephrotic syndrome electron microscopy negative staining |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1992-12 |
巻 | 46巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 483 |
終了ページ | 487 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 1485544 |
Web of Science KeyUT | A1992KE49600012 |
JaLCDOI | 10.18926/AMO/52143 |
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フルテキストURL | 68_1_43.pdf |
著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
抄録 | The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p=0.7709, women:p=0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese. |
キーワード | proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification |
Amo Type | Short Communication |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-02 |
巻 | 68巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 43 |
終了ページ | 46 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 24553488 |
Web of Science KeyUT | 000331592800007 |
JaLCDOI | 10.18926/AMO/46850 |
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フルテキストURL | 65_4_247.pdf |
著者 | Watanabe, Naomi| Shikata, Kenichi| Shikata, Yasushi| Sarai, Kei| Omori, Kazuyoshi| Kodera, Ryo| Sato, Chikage| Wada, Jun| Makino, Hirofumi| |
抄録 | Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in glomerular endothelial cells under diabetic conditions. We examined the expression of ICAM-1 in the kidneys of experimental diabetic rats. Human glomerular endothelial cells (GE cells) were exposed to normal glucose concentration, high glucose concentration (HG), or high mannitol concentration (HM), and then the expression of the ICAM-1 protein and the phosphorylation of the 3 subfamilies of mitogen-activated protein kinase (MAPK) were determined using Western blot analysis. Next, to evaluate the involvement of MAPKs in HG- or HM-induced ICAM-1 expression, we preincubated GE cells with the inhibitors for ERK, p38 or JNK 1h prior to the application of glucose or mannitol. Expression of ICAM-1 was increased in the glomeruli of diabetic rats. Both HG and HM induced ICAM-1 expression and phosphorylation of ERK1/2, p38 and JNK in GE cells. Expression of ICAM-1 was significantly attenuated by inhibitors of ERK, p38 and JNK. We conclude that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions. |
キーワード | diabetic nephropathy ICAM-1 ERK p38 MAPK JNK |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-08 |
巻 | 65巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 247 |
終了ページ | 257 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 21860531 |
Web of Science KeyUT | 000294236700005 |
JaLCDOI | 10.18926/AMO/32856 |
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フルテキストURL | fulltext.pdf |
著者 | Sumiyoshi, Kazuko| Kawata, Chieko| Shikata, Kenichi| Makino, Hirofumi| |
抄録 | The aim of this study was to clarify the factors influencing the dietary behavior of patients with diabetic nephropathy. One hundred twenty-two patients with type 2 diabetes were recruited from the outpatients of Okayama University Hospital in Okayama, Japan. We performed a cross-sectional study using a questionnaire including 206 items among 18 categories as follows:background factors, coping behavior (coping scale), degree of uncertainty in illness (uncertainty scale), and dietary behavior. The data were analyzed by correlation analysis, t-test, one-way analysis of variance, Pearson correlation analysis, and multiple regression analysis. We found that those patients with microalbuminuria alone tended to recognize more mild about their kidney status than those with macroalbuminuria and chronic renal failure. We also found that common factors influencing the dietary behavior of diabetic patients with and without nephropathy are as follows:1. coping with the problem (beta0.342, p0.01);2. anxiety about prognosis (beta0.344, p0.01);3. sex (beta0.234, p0.05);4. uncertainty regarding treatment (beta0.377, p0.01);5. negative coping (beta0.354, p0.01);and 6. employment status (beta0.367, p0.01). Coping and uncertainty in illness had a significant relation to positive support and lack of support. To maintain appropriate dietary behavior in diabetic patients, medical staff need to determine what the social supports are important for the patient, and also to ensure good communication among healthcare personnel as well as positive support for patients and families. |
キーワード | diabetic nephropathy dietary behavior coping uncertainty in illness social support |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-02 |
巻 | 64巻 |
号 | 1号 |
出版者 | Okayama University Medical School |
開始ページ | 39 |
終了ページ | 47 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20200583 |
Web of Science KeyUT | 000274868300006 |
JaLCDOI | 10.18926/AMO/30866 |
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フルテキストURL | fulltext.pdf |
著者 | Ota, Zensuke| Kumagai, Isao| Shikata, Kenichi| Makino, Hirofumi| |
抄録 | Sprague-Dawley rats, 6 with aminonucleoside nephrosis and 6 controls, were intravenously injected with human liver ferritin isolated from post mortem liver, and their 24-h urine samples were examined for human ferritin by immunoradiometric assay. In rats with aminonucleoside nephrosis, the amount of excreted ferritin in urine was forty times greater than in control rats. Much more monomeric ferritin was excreted than that of polymeric ferritin. We are the first to have utilized human liver ferritin as a tracer to measure a minor amount of ferritin by a commercially available kit. Our present study seems to indicate a critical role for glomerular basement membrane as a size barrier. |
キーワード | glomerular permeabillity size barrier human liver ferritin immunoradiometricassay |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1989-12 |
巻 | 43巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 363 |
終了ページ | 365 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 2624144 |
Web of Science KeyUT | A1989CG27400008 |
JaLCDOI | 10.18926/AMO/52789 |
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フルテキストURL | 68_4_235.pdf |
著者 | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
抄録 | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
キーワード | microalbuminuria type 2 diabetes mellitus remission regression |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2014-08 |
巻 | 68巻 |
号 | 4号 |
出版者 | Okayama University Medical School |
開始ページ | 235 |
終了ページ | 241 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 25145409 |
Web of Science KeyUT | 000340687500005 |
関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
JaLCDOI | 10.18926/AMO/45272 |
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フルテキストURL | 65_2_129.pdf |
著者 | Toyota, Noriko| Ogawa, Daisuke| Ishii, Keita| Hirata, Kyoji| Wada, Jun| Shikata, Kenichi| Makino, Hirofumi| |
抄録 | A 62-year-old woman with a history of poorly controlled type 2 diabetes mellitus was admitted to our hospital with a 3-week history of mild fever, vomiting, and anorexia. Abdominal computed tomography (CT) showed bilateral hydronephrosis and gas accumulation in the urinary bladder wall and left ureter. Laboratory tests showed leukocytosis and elevated C-reactive protein level. Urine culture showed heavy growth of Escherichia coli. The final diagnosis was emphysematous cystitis. The patient was treated with systemic antibiotics and drainage using a urethral catheter. The clinical and radiographic findings resolved rapidly, and she was discharged from the hospital on day 28. Emphysematous cystitis is a relatively rare urinary tract infection associated with gas formation, and has the potential for a serious outcome if untreated. Early detection by imaging studies such as CT is important in providing prompt treatment and favorable clinical outcome. |
キーワード | computed tomography diabetes mellitus emphysematous cystitis |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-04 |
巻 | 65巻 |
号 | 2号 |
出版者 | Okayama University Medical School |
開始ページ | 129 |
終了ページ | 133 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 21519371 |
Web of Science KeyUT | 000289818800009 |
フルテキストURL | fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf |
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著者 | Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi| |
キーワード | Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling |
備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.| |
発行日 | 2022-09-25 |
出版物タイトル | Annals of Surgical Oncology |
巻 | 30巻 |
号 | 2号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 1110 |
終了ページ | 1118 |
ISSN | 1068-9265 |
NCID | AA11016573 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Society of Surgical Oncology 2022 |
論文のバージョン | author |
PubMed ID | 36161371 |
DOI | 10.1245/s10434-022-12572-3 |
Web of Science KeyUT | 000858651900003 |
関連URL | isVersionOf https://doi.org/10.1245/s10434-022-12572-3 |
フルテキストURL | fulltext.pdf |
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著者 | Uchida, Haruhito A.| Takatsuka, Tetsuharu| Hada, Yoshiko| Umebayashi, Ryoko| Takeuchi, Hidemi| Shikata, Kenichi| Subramanian, Venkateswaran| Daugherty, Alan| Wada, Jun| |
キーワード | edaravone angiotensin II abdominal aortic aneurysm atherosclerosis |
発行日 | 2022-08-14 |
出版物タイトル | Biomolecules |
巻 | 12巻 |
号 | 8号 |
出版者 | MDPI |
開始ページ | 1117 |
ISSN | 2218-273X |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2022 by the authors. |
論文のバージョン | publisher |
PubMed ID | 36009011 |
DOI | 10.3390/biom12081117 |
Web of Science KeyUT | 000846165000001 |
関連URL | isVersionOf https://doi.org/10.3390/biom12081117 |
フルテキストURL | fulltext.pdf |
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著者 | Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun| |
キーワード | Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology |
発行日 | 2020-09-10 |
出版物タイトル | Scientific Reports |
巻 | 10巻 |
号 | 1号 |
出版者 | Nature Research |
開始ページ | 14928 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2020 |
論文のバージョン | publisher |
PubMed ID | 32913271 |
DOI | 10.1038/s41598-020-71946-3 |
Web of Science KeyUT | 000571915100049 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-020-71946-3 |
JaLCDOI | 10.18926/AMO/40510 |
---|---|
フルテキストURL | 64_5_339.pdf |
著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
抄録 | The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure(r=-0.306, p=0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women. |
キーワード | systolic blood pressure estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
Amo Type | Short Communication |
出版物タイトル | Acta Medica Okayama |
発行日 | 2010-10 |
巻 | 64巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 339 |
終了ページ | 343 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2010 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 20975768 |
Web of Science KeyUT | 000283563300010 |
JaLCDOI | 10.18926/AMO/47261 |
---|---|
フルテキストURL | 65_6_363.pdf |
著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
抄録 | The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5±8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome components at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, almost all metabolic syndrome components were significantly improved. However, eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circumference (r=-0.232, p=0.0106). A decrease in abdominal circumference may be associated with improving eGFR in Japanese men. |
キーワード | abdominal circumference estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2011-12 |
巻 | 65巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 363 |
終了ページ | 367 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 22189476 |
Web of Science KeyUT | 000298516900002 |
JaLCDOI | 10.18926/AMO/31126 |
---|---|
フルテキストURL | fulltext.pdf |
著者 | Morioka, Shigeru| Makino, Hirofumi| Shikata, Kenichi| Ota, Zensuke| |
抄録 | To investigate the role of vitronectin in the progression of diabetic nephropathy, plasma concentrations of vitronectin were measured by enzyme-linked immunosorbent assay in patients with diabetes mellitus and compared with normal control subjects. In diabetic patients with normoalbuminuria and microalbuminuria, plasma concentrations of vitronectin were significantly higher than those of control subjects. Plasma concentrations of vitronectin in diabetic patients with chronic renal failure were significantly lower than those with normal renal function. There was a significant positive correlation between plasma concentration of vitronectin and blood platelet counts. In the early stage of diabetic nephropathy, vitronectin may be increased caused by synthesis from activated platelets. With progression of diabetic nephropathy, plasma vitronectin may be decreased because of accumulation in sclerotic glomeruli and arteriosclerotic lesions. In conclusion, the plasma concentration of vitronectin appears to be an important marker for the progression of diabetic nephropathy. |
キーワード | vitronectin(S-protein) diabetic nephropathy hypertension chronic renal failure enzyme-linked immunosorbent assay (ELISA) |
Amo Type | Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 1994-06 |
巻 | 48巻 |
号 | 3号 |
出版者 | Okayama University Medical School |
開始ページ | 137 |
終了ページ | 142 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 7524268 |
Web of Science KeyUT | A1994NV04300004 |