| JaLCDOI | 10.18926/AMO/30999 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Yabe, Yoshiro| Sakai, Akiko| Tanimura, Yoshie| Kuramitsu, Masae| Hitsumoto, Takako| Ishii, Kanji| Ueki, Hiroaki| |
| Abstract | Two distinct human papillomavirus (HPV) DNAs (MY-1 and MY-2) were molecularly cloned from the benign skin lesions of a patient with epidermodysplasia verruciformis. The restriction map of MY-1 was the same as that of HPV 3a. The map of MY-2 appeared to be different from those of any HPVs reported in the literature. MY-2 did not cross-hybridize with MY-1 or the DNAs of HPV types 1, 2 and 4 under stringent conditions. |
| Keywords | papillomavirus viral DNA molecular cloning restriction map epidermodysplasia verruciformis |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1988-08 |
| Volume | volume42 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 245 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 2845712 |
| Web of Science KeyUT | A1988P884600008 |
| JaLCDOI | 10.18926/AMO/62379 |
|---|---|
| FullText URL | 75_4_415.pdf |
| Author | Sun, Jingkai| Lin, Wenfeng| Wang, Qixu| Sakai, Akiko| Xue, Ruizhi| Watanabe, Masami| Liu, Chunxiao| Sadahira, Takuya| Nasu, Yasutomo| Xu, Abai| Huang, Peng| |
| Abstract | Human RAD17, as an agonist of checkpoint signaling, plays an essential role in mediating DNA damage. This hospital-based case-control study aimed to explore the association between RAD17 rs1045051, a missense sin-gle nucleotide polymorphism (SNP), and prostate cancer risk. Subjects were 358 prostate cancer patients and 314 cancer-free urology patients undergoing treatment at the Zhujiang Hospital of Southern Medical University in China. RAD17 gene polymorphism rs1045051 was evaluated by the SNaPshot method. Compared with the RAD17 gene polymorphism rs1045051 AA genotype, there was a higher risk of prostate cancer for the CC gen-otype (adjusted odds ratio [AOR] = 1.731, 95% confidence interval [95%CI] = 1.031−2.908, p = 0.038). Compared with the A allele, the C allele was significantly associated with the disease status (AOR = 1.302, 95%CI = 1.037−1.634, p = 0.023). All these findings indicate that in the SNP rs1045051, both the CC genotype and C allele may have a substantial influence on the prostate cancer risk. |
| Keywords | prostate cancer single-nucleotide polymorphisms cell cycle checkpoint rs1045051 RAD17 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-08 |
| Volume | volume75 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 415 |
| End Page | 421 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34511607 |
| Web of Science KeyUT | 000697944600002 |
| NAID | 120007146060 |
| JaLCDOI | 10.18926/AMO/47013 |
|---|---|
| FullText URL | 65_5_315.pdf |
| Author | Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun| |
| Abstract | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR＝0.58, 95%CI:0.35-0.97, p＝0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR＝0.27, 95%CI:0.12-0.61, p＝0.002) and in patients with localized diseases (OR＝0.36, 95%CI:0.19-0.70, p＝0.003). However, no statistically significant difference was found in the subgroup with age ＞72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects. |
| Keywords | polymorphism prostatic neoplasms single nucleotide susceptibility WRN |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-10 |
| Volume | volume65 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22037267 |
| Web of Science KeyUT | 000296116400005 |
| Author | Yasuda, Yukiko| Sakai, Akiko| Ito, Sachio| Sasai, Kaori| Yamamoto, Hiromasa| Matsubara, Nagahide| Ouchida, Mamoru| Katayama, Hiroshi| Shimizu, Kenji| |
|---|---|
| Published Date | 2017-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54826 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yasuda, Yukiko| Sakai, Akiko| Ito, Sachio| Sasai, Kaori| Ishizaki, Akisada| Okano, Yoshiya| Kawahara, Seito| Jitsumori, Yoshimi| Yamamoto, Hiromasa| Matsubara, Nagahide| Shimizu, Kenji| Katayama, Hiroshi| |
| Keywords | NINEIN centrosome single nucleotide polymorphism colon cancer tumor susceptibility |
| Published Date | 2020-8-27 |
| Publication Title | Biomedical Reports |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | Spandidos Publications |
| Start Page | 45 |
| ISSN | 2049-9434 |
| NCID | AA12610729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 32934817 |
| DOI | 10.3892/br.2020.1352 |
| Web of Science KeyUT | 000606302400011 |
| Related Url | isVersionOf https://doi.org/10.3892/br.2020.1352 |
