| JaLCDOI |
10.18926/AMO/47013
|
| FullText URL |
65_5_315.pdf
|
| Author |
Wang, Lei|
Kaku, Haruki|
Huang, Peng|
Xu, Kexin|
Yang, Kai|
Zhang, Jiheng|
Li, Ming|
Xie, Liping|
Wang, Xiaofeng|
Sakai, Akiko|
Watanabe, Masami|
Nasu, Yasutomo|
Shimizu, Kenji|
Kumon, Hiromi|
Na, Yanqun|
|
| Abstract |
Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR＝0.58, 95%CI:0.35-0.97, p＝0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR＝0.27, 95%CI:0.12-0.61, p＝0.002) and in patients with localized diseases (OR＝0.36, 95%CI:0.19-0.70, p＝0.003). However, no statistically significant difference was found in the subgroup with age ＞72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.
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| Keywords |
polymorphism
prostatic neoplasms
single nucleotide
susceptibility
WRN
|
| Amo Type |
Original Article
|
| Published Date |
2011-10
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| Publication Title |
Acta Medica Okayama
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| Volume |
volume65
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| Issue |
issue5
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| Publisher |
Okayama University Medical School
|
| Start Page |
315
|
| End Page |
323
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| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| Content Type |
Journal Article
|
| language |
英語
|
| Copyright Holders |
CopyrightⒸ 2011 by Okayama University Medical School
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| File Version |
publisher
|
| Refereed |
True
|
| PubMed ID |
22037267
|
| Web of Science KeyUT |
000296116400005
|
