| JaLCDOI |
10.18926/AMO/60371
|
| FullText URL |
74_4_327.pdf
|
| Author |
Yamamoto, Ken-ichi|
Kagawa, Hiroko|
Arimoto, Sakae|
Tan, Xian Wen|
Yasui, Kento|
Oshiki, Toshiyuki|
Sakaguchi, Masakiyo|
|
| Abstract |
An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.
|
| Keywords |
plastic wrap
plasticizer,
cytotoxicity,
liver cells
in vitro
|
| Amo Type |
Original Article
|
| Publication Title |
Acta Medica Okayama
|
| Published Date |
2020-08
|
| Volume |
volume74
|
| Issue |
issue4
|
| Publisher |
Okayama University Medical School
|
| Start Page |
327
|
| End Page |
334
|
| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| Content Type |
Journal Article
|
| language |
English
|
| Copyright Holders |
CopyrightⒸ 2020 by Okayama University Medical School
|
| File Version |
publisher
|
| Refereed |
True
|
| PubMed ID |
32843764
|
| Web of Science KeyUT |
000562508700008
|
| NAID |
120006880210
|
