JaLCDOI 10.18926/AMO/60371
フルテキストURL 74_4_327.pdf
著者 Yamamoto, Ken-ichi| Kagawa, Hiroko| Arimoto, Sakae| Tan, Xian Wen| Yasui, Kento| Oshiki, Toshiyuki| Sakaguchi, Masakiyo|
抄録 An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.
キーワード plastic wrap plasticizer, cytotoxicity, liver cells in vitro
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-08
74巻
4号
出版者 Okayama University Medical School
開始ページ 327
終了ページ 334
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32843764
Web of Science KeyUT 000562508700008
NAID 120006880210
レファレンス Parker L: We Made plastic. We depend on it. Now Weʼre drowning in it. National Geographic (2018) 233: 40-87.| Tanaka K and Takada H: Microplastic fragments and microbeads in digestive tracts of planktivorous fish from urban coastal waters. Sci Rep (2016) 6: 34351.| Jeong CB, Kang HM, Lee MC, Kim DH, Han J, Hwang DS, Souissi S, Lee SJ, Shin KH, Park HG and Lee JS: Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana. Sci Rep (2017) 7: 41323.| Lithner D, Nordensvan I and Dave G: Comparative acute toxicity of leachates from plastic products made of polypropylene, olyethylene, PVC, acrylonitrile-butadiene-styrene, and epoxy to Daphnia magna. Environ Sci Pollut Res Int (2012) 19: 1763-1772.| Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, Van Look KJ and Tyler CR: A critical analysis of the biological impacts of plasticizers on wildlife. Philos Trans R Soc Lond B Biol Sci (2009) 364 (1526): 2047-2062.| Doi I, Namba M and Sato J: Establishment and some biological characteristics of human hepatoma cell lines. Gann (1975) 66: 385-392.| Maron DM and Ames BN: Revised methods for the Salmonella mutagenicity test. Mutat Res (1983) 113: 173-215.| Yamada M, Matsui K, Sofuni T and Nohmi T: New tester strains of Salmonella typhimurium lacking O6-methylguanine DNA methyltransferases and highly sensitive to mutagenic alkylating agents. Mutat Res (1997) 381: 15-24.| Blackshear PE, Pandiri AR, Nagai H, Bhusari S, Hong HH, Ton TV, Clayton NP, Wyde M, Shochley KR, Peddada SD, Gerrish KE, Sills RC and Hoenerhoff MJ: Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways. Toxicol Pathol (2015) 43 (2): 171-185.| Hayes S, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC and Hoenerhoff MJ: Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice are Characterized by Oxidative Stress and TP53 Pathway Dysregulation. Toxicol Pathol (2016) 44: 71-87.|
著者 押木 俊之|
発行日 2011-02
出版物タイトル 化学経済
58巻
2号
資料タイプ 一般雑誌記事
著者 Oshiki, Toshiyuki|
出版物タイトル
資料タイプ その他
著者 押木 俊之|
出版物タイトル
資料タイプ その他
著者 押木 俊之|
出版物タイトル
資料タイプ その他
著者 押木 俊之|
出版物タイトル
資料タイプ その他
著者 Muranaka, Makoto| Hyodo, Isao| Okumura, Wataru| Oshiki, Toshiyuki|
発行日 2011-04-30
出版物タイトル Catalysis Today
164巻
1号
資料タイプ 学術雑誌論文
著者 押木 俊之|
発行日 2007-09-12
出版物タイトル
資料タイプ 会議発表論文
著者 押木 俊之|
発行日 2007-03-24
出版物タイトル
資料タイプ 会議発表論文
著者 押木 俊之| 石塚 章斤|
発行日 2007-06-05
出版物タイトル
資料タイプ 会議発表論文