| JaLCDOI | 10.18926/AMO/49259 |
|---|---|
| FullText URL | 67_1_65.pdf |
| Author | Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi| |
| Abstract | Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects. |
| Keywords | bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-02 |
| Volume | volume67 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23439511 |
| Web of Science KeyUT | 000316829900009 |
| JaLCDOI | 10.18926/AMO/49670 |
|---|---|
| FullText URL | 67_2_113.pdf |
| Author | Sugimoto, Yoshihisa| Tanaka, Masato| Gobara, Hideo| Misawa, Haruo| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | We report on 2 patients who experienced injury to one of their lumbar arteries related to pedicle screw misplacement. In this report, the lumbar pedicle screw holes were made laterally with resultant injury to the lumbar artery. During surgery, arterial bleeding was controlled with pressure and gauze; however, the patients experienced vital shock after surgery. Vital shock ensued and they were rescued by catheter embolization. If patients receiving lumbar instrumentation surgery experience severe anemia or vital shock postoperatively, the surgeon should assume lumbar artery injury as a differential diagnosis. |
| Keywords | catheter embolization complication lumbar artery injury pedicle screw |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-04 |
| Volume | volume67 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 113 |
| End Page | 116 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23603928 |
| Web of Science KeyUT | 000317801700006 |
| FullText URL | fulltext20230703-01.pdf |
|---|---|
| Author | Kamatsuki, Yusuke| Furumatsu, Takayuki| Hiranaka, Takaaki| Okazaki, Yuki| Kintaka, Keisuke| Kodama, Yuya| Miyazawa, Shinichi| Ozaki, Toshifumi| |
| Keywords | Body mass index Medial meniscus Painful popping Posterior root tear Pullout repair |
| Note | The version of record of this article, first published in International Orthopaedics, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00264-023-05848-0| |
| Published Date | 2023-06-17 |
| Publication Title | International Orthopaedics |
| Volume | volume47 |
| Issue | issue10 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 2537 |
| End Page | 2545 |
| ISSN | 0341-2695 |
| NCID | AA0068148X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37329453 |
| DOI | 10.1007/s00264-023-05848-0 |
| Web of Science KeyUT | 001007187100001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00264-023-05848-0 |
| FullText URL | fulltext20230120-2.pdf fig20230120-2.pdf |
|---|---|
| Author | Hiranaka, Takaaki| Furumatsu, Takayuki| Yokoyama, Yusuke| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Kawada, Koki| Xue, Haowei| Hamada, Masanori| Ozaki, Toshifumi| |
| Keywords | Medial meniscus posterior root tear Magnetic resonance imaging Medial meniscus extrusion Pullout repair Type 2 tear |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00167-022-07293-9| |
| Published Date | 2022-12-25 |
| Publication Title | Knee Surgery, Sports Traumatology, Arthroscopy |
| Volume | volume31 |
| Issue | issue6 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 2323 |
| End Page | 2330 |
| ISSN | 0942-2056 |
| NCID | AA10973641 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2022 |
| File Version | author |
| PubMed ID | 36566386 |
| DOI | 10.1007/s00167-022-07293-9 |
| Web of Science KeyUT | 000903833100001 |
| Related Url | isVersionOf https://doi.org/ |
| FullText URL | fulltext20230125-1.pdf figures20230125-1.pdf tables20230125-1.pdf |
|---|---|
| Author | Xue, Haowei| Furumatsu, Takayuki| Hiranaka, Takaaki| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Zhang, Ximing| Ozaki, Toshifumi| |
| Keywords | Medial meniscus Pullout repair Meniscal extrusion Meniscal root tear Suture anchor Three-dimensional magnetic resonance imaging |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00264-022-05660-2| This full-text file will be available in Dec. 2023.| |
| Published Date | 2022-12-28 |
| Publication Title | International Orthopaedics |
| Volume | volume47 |
| Issue | issue10 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 2391 |
| End Page | 2400 |
| ISSN | 0341-2695 |
| NCID | AA0068148X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) under exclusive licence to SICOT aisbl 2022 |
| File Version | author |
| PubMed ID | 36575357 |
| DOI | 10.1007/s00264-022-05660-2 |
| Web of Science KeyUT | 000904067500001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00264-022-05660-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Saito, Taichi| Nakamichi, Ryo| Nakahara, Ryuichi| Nishida, Keiichiro| Ozaki, Toshifumi| |
| Keywords | hand surgery rehabilitation open surgical release trigger finger |
| Published Date | 2023-11-20 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume12 |
| Issue | issue22 |
| Publisher | MDPI |
| Start Page | 7187 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 38002801 |
| DOI | 10.3390/jcm12227187 |
| Web of Science KeyUT | 001123419500001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm12227187 |
| Author | Hiranaka, Takaaki| Furumatsu, Takayuki| Yokoyama, Yusuke| Higashihara, Naohiro| Tamura, Masanori| Kawada, Koki| Ozaki, Toshifumi| |
|---|---|
| Keywords | clinical outcomes medial meniscus posterior root tears transtibial pullout repair weight change |
| Note | This is the peer reviewed version of the following article: [Hiranaka, T., Furumatsu, T., Yokoyama, Y., Higashihara, N., Tamura, M., Kawada, K. et al. (2024) Weight loss enhances meniscal healing following transtibial pullout repair for medial meniscus posterior root tears. Knee Surgery, Sports Traumatology, Arthroscopy, 32, 143–150. https://doi.org/10.1002/ksa.12037], which has been published in final form at [https://doi.org/10.1002/ksa.12037]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jan. 2025.| |
| Published Date | 2024-01 |
| Publication Title | Knee Surgery, Sports Traumatology, Arthroscopy |
| Volume | volume32 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | 143 |
| End Page | 150 |
| ISSN | 0942-2056 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 European Society of Sports Traumatology, Knee Surgery and Arthroscopy. |
| File Version | author |
| DOI | 10.1002/ksa.12037 |
| Web of Science KeyUT | 001135876700001 |
| Related Url | isVersionOf https://doi.org/10.1002/ksa.12037 |
| FullText URL | KSSTA_fulltext.pdf KSSTA_Tables.pptx KSSTA_Figures.pptx |
|---|---|
| Author | Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yuki| Yamawaki, Tadashi| Okazaki, Yoshiki| Kodama, Yuya| Kamatsuki, Yusuke| Ozaki, Toshifumi| |
| Keywords | Medial meniscus Posterior root tear Bilateral injury Predictor Medial tibial slope Sensitivity and specificity |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Knee Surgery, Sports Traumatology, Arthroscopy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00167-020-06079-1. This fulltext is available in June 2021.| |
| Published Date | 2020-06-01 |
| Publication Title | Knee Surgery, Sports Traumatology, Arthroscopy |
| Volume | volume29 |
| Publisher | Springer |
| Start Page | 1052 |
| End Page | 1057 |
| ISSN | 0942-2056 |
| NCID | AA10973641 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32488369 |
| DOI | 10.1007/s00167-020-06079-1 |
| Web of Science KeyUT | 000538465000003 |
| Related Url | isVersionOf https://doi.org/10.1007/s00167-020-06079-1 |
| FullText URL | OTSR_106_3.pdf OTSR_106_3_Figures.pptx |
|---|---|
| Author | Okazaki, Yuki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Okazaki, Yoshiki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Miyazawa, Shinichi| Ozaki, Toshifumi| |
| Keywords | Anterior cruciate ligament Lateral meniscus Posterior root tear Transtibial pullout repair Meniscus extrusion |
| Published Date | 2020-04-08 |
| Publication Title | Orthopaedics & Traumatology: Surgery & Research |
| Volume | volume106 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 469 |
| End Page | 473 |
| ISSN | 1877-0568 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32278734 |
| DOI | 10.1016/j.otsr.2019.10.022 |
| Web of Science KeyUT | 000539660200014 |
| Related Url | isVersionOf https://doi.org/10.1016/j.otsr.2019.10.022 |
| Author | Hiranaka, Takaaki| Furumatsu, Takayuki| Yokoyama, Yusuke| Higashihara, Naohiro| Tamura, Masanori| Kawada, Koki| Xue, Haowei| Ozaki, Toshifumi| |
|---|---|
| Keywords | intercondylar notch width intercondylar osteophyte medial meniscus posterior root tear transtibial pullout repair |
| Note | This is the pre-peer reviewed version of the following article: [Hiranaka, T., Furumatsu, T., Yokoyama, Y., Higashihara, N., Tamura, M., Kawada, K. et al. (2024) Intercondylar notch width and osteophyte width impact meniscal healing and clinical outcomes following transtibial pullout repair of medial meniscus posterior root tears. Knee Surgery, Sports Traumatology, Arthroscopy, 32, 116–123. https://doi.org/10.1002/ksa.12032], which has been published in final form at [https://doi.org/10.1002/ksa.12032]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| This fulltext file will be available in Jan. 2025.| |
| Published Date | 2024-01-04 |
| Publication Title | Knee Surgery, Sports Traumatology, Arthroscopy |
| Volume | volume32 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | 116 |
| End Page | 123 |
| ISSN | 0942-2056 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 European Society of Sports Traumatology, Knee Surgery and Arthroscopy. |
| File Version | author |
| PubMed ID | 38226691 |
| DOI | 10.1002/ksa.12032 |
| Web of Science KeyUT | 001135891400001 |
| Related Url | isVersionOf https://doi.org/10.1002/ksa.12032 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Higashihara, Naohiro| Kawada, Koki| Ozaki, Toshifumi| |
| Keywords | Knee injuries Arthroscopy Meniscus Root tear |
| Note | The version of record of this article, first published in Knee Surgery & Related Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s43019-023-00206-1| |
| Published Date | 2024-02-08 |
| Publication Title | Knee Surgery & Related Research |
| Volume | volume36 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 8 |
| ISSN | 2234-2451 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38331953 |
| DOI | 10.1186/s43019-023-00206-1 |
| Web of Science KeyUT | 001160637100001 |
| Related Url | isVersionOf https://doi.org/10.1186/s43019-023-00206-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hotta, Yoshifumi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Naniwa, Shuichi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Fujiwara, Tomohiro| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin |
| Published Date | 2024-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1443 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38338721 |
| DOI | 10.3390/ijms25031443 |
| Web of Science KeyUT | 001161430700001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms25031443 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takihira, Shota| Yamada, Daisuke| Osone, Tatsunori| Takao, Tomoka| Sakaguchi, Masakiyo| Hakozaki, Michiyuki| Itano, Takuto| Nakata, Eiji| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Ozaki, Toshifumi| Takarada, Takeshi| |
| Note | The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02632-8| |
| Published Date | 2024-03-06 |
| Publication Title | British Journal of Cancer |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0007-0920 |
| NCID | AA00574355 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38448751 |
| DOI | 10.1038/s41416-024-02632-8 |
| Web of Science KeyUT | 001180796100003 |
| Related Url | isVersionOf https://doi.org/10.1038/s41416-024-02632-8 |
| JaLCDOI | 10.18926/AMO/66159 |
|---|---|
| FullText URL | 77_6_655.pdf |
| Author | Endo, Hirosuke| Yamada, Kazuki| Tetsunaga, Tomonori| Namba, Yoshifumi| Sugimoto, Yoshihisa| Mitani, Shigeru| Nakata, Eiji| Ozaki, Toshifumi| |
| Abstract | Most patients with developmental dysplasia of the hip (DDH) now receive closed-reduction treatment within 6 months after birth. The long-term outcomes of patients with late-detection DDH have remained unclear. We reviewed the clinical records of 18 patients who underwent Colonna capsular arthroplasty (n=8) or closed reduction (n=10) for developmental dysplasia of the hip as infants or young children and underwent total hip arthroplasty approximately in midlife. Both the Colonna capsular arthroplasty and closed reduction groups achieved good clinical results after total hip arthroplasty. However, the operating time was longer and the improvements of hip range of motion and clinical score were significantly worse in the Colonna capsular arthroplasty group than in the closed reduction group. |
| Keywords | developmental hip dysplasia long-term follow-up closed reduction Colonna capsular arthroplasty total hip arthroplasty |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 655 |
| End Page | 663 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145941 |
| Web of Science KeyUT | 001164631200012 |
| JaLCDOI | 10.18926/AMO/65973 |
|---|---|
| FullText URL | 77_5_511.pdf |
| Author | Sato, Kohei| Tsuji, Hironori| Yorimitsu, Masanori| Uehara, Takenori| Okazaki, Yuki| Takao, Shinichiro| Hata, Toshiaki| Fukuoka, Shiro| Noda, Tomoyuki| Kanda, Hideyuki| Ozaki, Toshifumi| |
| Abstract | Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either “gait disturbance” or “independent gait”. Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required. |
| Keywords | sarcopenia nutrition geriatric hip fracture psoas muscle index controlling nutritional status score |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 511 |
| End Page | 516 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899262 |
| Web of Science KeyUT | 001108661600008 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamichi, Ryo| Saito, Taichi| Shimamura, Yasunori| Hamada, Masanori| Nishida, Keiichiro| Ozaki, Toshifumi| |
| Keywords | Carpal tunnel syndrome Mini-open Endoscopy Patient-oriented evaluation |
| Note | The version of record of this article, first published in BMC Musculoskeletal Disorders, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12891-023-07151-w| |
| Published Date | 2024-04-01 |
| Publication Title | BMC Musculoskeletal Disorders |
| Volume | volume25 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 251 |
| ISSN | 1471-2474 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38561698 |
| DOI | 10.1186/s12891-023-07151-w |
| Web of Science KeyUT | 001195650000009 |
| Related Url | isVersionOf https://doi.org/10.1186/s12891-023-07151-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Haruyoshi| Fujimura, Atsushi| Huang, Rongsheng| Otani, Yusuke| Itano, Takuto| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter |
| Published Date | 2024-01-26 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 871 |
| End Page | 882 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38279513 |
| DOI | 10.1111/cas.16077 |
| Web of Science KeyUT | 001149722500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16077 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Nishida, Kenji| Yanai, Hiroyuki| Nakamura, Tomoki| Tanaka, Kazuhiro| Ozaki, Toshifumi| |
| Keywords | alveolar soft part sarcoma surgery chemotherapy targeted therapy immunotherapy |
| Published Date | 2023-08-25 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume53 |
| Issue | issue11 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 1009 |
| End Page | 1018 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37626447 |
| DOI | 10.1093/jjco/hyad102 |
| Web of Science KeyUT | 001080372000001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad102 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Published Date | 2024-02-20 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0298292 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
