Ohara, Toshiaki - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

SPRED2 suppresses the stemness of hepatocellular carcinoma through the p53/miR-506-3p/KLF4 pathway

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Author	Gao, Tong\| Ito, Sachio\| Moh-Moh-Aung, Aye\| Wang, Tianyi\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	SPRED2 p53 KLF4 miR-506-3p stemness
Published Date	2026-01-20
Publication Title	Cancer Biology & Medicine
Publisher	China Anti-cancer Association
ISSN	2095-3941
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2026 The Authors.
File Version	publisher
PubMed ID	41560328
DOI	10.20892/j.issn.2095-3941.2025.0247
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Enhancement of drug delivery through fibroblast activation protein–targeted near-infrared photoimmunotherapy

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Author	Nishimura, Seitaro\| Noma, Kazuhiro\| Matsumoto, Tasuku\| Takeda, Yasushige\| Takahashi, Tatsuya\| Matsumoto, Hijiri\| Kawasaki, Kento\| Kawai, Hotaka\| Kunitomo, Tomoyoshi\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Kashima, Hajime\| Kato, Takuya\| Kikuchi, Satoru\| Tanabe, Shunsuke\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Shirakawa, Yasuhiro\| Choyke, Peter L.\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2025-12-22
Publication Title	JCI Insight
Volume	volume10
Issue	issue24
Publisher	American Society for Clinical Investigation
Start Page	e195776
ISSN	2379-3708
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025, Nishimura et al.
File Version	publisher
PubMed ID	41424387
DOI	10.1172/jci.insight.195776
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SPRED2 controls the severity of cisplatin-induced acute kidney injury by inhibiting ERK activation and TNFα production in mice

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Author	Yang, Xu\| He, Jiali\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Kunkel, Steven L.\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Cisplatin ERK Macrophage SPRED2 TNFα
Published Date	2026-02
Publication Title	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume	volume1873
Issue	issue2
Publisher	Elsevier BV
Start Page	120091
ISSN	0167-4889
NCID	AA1050609X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
PubMed ID	41330472
DOI	10.1016/j.bbamcr.2025.120091
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p53-armed oncolytic adenovirus induces apoptosis in pancreatic cancer-associated stellate cells via macropinocytosis

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Author	Nishiyama, Takeyoshi\| Tazawa, Hiroshi\| Nagai, Yasuo\| Shoji, Ryohei\| Kajiwara, Yoshinori\| Hashimoto, Naoyuki\| Takahashi, Yosuke\| Kikuchi, Satoru\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Yoshida, Ryuichi\| Umeda, Yuzo\| Tanaka, Hiroyoshi Y.\| Kano, Mitsunobu R.\| Masamune, Atsushi\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2025-11-28
Publication Title	Cancer Gene Therapy
Publisher	Springer Science and Business Media LLC
ISSN	0929-1903
NCID	AA11052453
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41315733
DOI	10.1038/s41417-025-00989-3
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Tertiary Lymphoid Structures Are Associated with Favorable Clinical Outcomes and Negatively Correlated with Cancer-Associated Fibroblasts in Esophageal Cancer

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Author	Kunitomo, Tomoyoshi\| Noma, Kazuhiro\| Nishiwaki, Noriyuki\| Nishimura, Seitaro\| Takeda, Yasushige\| Matsumoto, Hijiri\| Takahashi, Tatsuya\| Kawasaki, Kento\| Akai, Masaaki\| Maeda, Naoaki\| Kikuchi, Satoru\| Tanabe, Shunsuke\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Shirakawa, Yasuhiro\| Fujiwara, Toshiyoshi\|
Keywords	tertiary lymphoid structures (TLSs) cancer-associated fibroblasts (CAFs) esophageal cancer tumor microenvironment prognosis
Published Date	2025-10-17
Publication Title	Cancers
Volume	volume17
Issue	issue20
Publisher	MDPI AG
Start Page	3351
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	41154405
DOI	10.3390/cancers17203351
Web of Science KeyUT	001602403800001
Related Url	isVersionOf https://doi.org/10.3390/cancers17203351

Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells

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Author	Su Pwint, Nang Thee\| Li, Chunning\| Gao, Tong\| Wang, Yuze\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	breast cancer SPRED2 neurofibromatosis type 1 neurofibromin RAS/RAF/ERK
Published Date	2025-10-16
Publication Title	International Journal of Molecular Sciences
Volume	volume26
Issue	issue20
Publisher	MDPI AG
Start Page	10072
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
DOI	10.3390/ijms262010072
Related Url	isVersionOf https://doi.org/10.3390/ijms262010072

Periodontitis associated with Porphyromonas gingivalis infection is a risk factor for infertility through uterine hypertrophy

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Author	Kamei-Nagata, Chiaki\| Omori, Kazuhiro\| Sako, Hidefumi\| Sakaida, Kyosuke\| Nakayama, Masa-aki\| Ohara, Toshiaki\| Mandai, Hiroki\| Kubota-Takamori, Moyuka\| Kiyama, Fumiko\| Ishii, Takayuki\| Hirai, Kimito\| Ikeda, Atsushi\| Takeuchi-Hatanaka, Kazu\| Shinoda-Ito, Yuki\| Tai-Tokuzen, Masako\| Sakamoto, Ai\| Kiyokawa, Machiko\| Yamanishi, Tomomi\| Oda, Takashi\| Takigawa, Masayuki\| Yamamoto, Tadashi\| Miyake, Takahito\| Takashiba, Shogo\|
Keywords	Infertility Periodontitis Porphyromonas gingivalis Chronic inflammation Uterus Sex hormone receptor
Published Date	2025-10-07
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	34964
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41057450
DOI	10.1038/s41598-025-18992-x
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Cancer-associated fibroblast-derived SOD3 enhances lymphangiogenesis to drive metastasis in lung adenocarcinoma

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Author	Oo, May Wathone\| Hikita, Takao\| Mashima, Tomoha\| Torigata, Kosuke\| Thu, Yin Min\| Habu, Tomohiro\| Kawai, Hotaka\| Ohara, Toshiaki\| Tomida, Shuta\| Ito, Sachio\| Suzawa, Ken\| Nagatsuka, Hitoshi\| Toyooka, Shinichi\| Nakayama, Masanori\|
Keywords	Cancer-associated fibroblast Superoxide dismutase 3 Lymphangiogenesis Angiogenesis Metastasis Lung adenocarcinoma
Note	The version of record of this article, first published in Angiogenesis, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10456-025-10005-9\|
Published Date	2025-09-30
Publication Title	Angiogenesis
Volume	volume28
Issue	issue4
Publisher	Springer Science and Business Media LLC
Start Page	51
ISSN	1573-7209
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41028519
DOI	10.1007/s10456-025-10005-9
Related Url	isVersionOf https://doi.org/10.1007/s10456-025-10005-9

Pseudohypoxia induced by iron chelator activates tumor immune response in lung cancer

Author	Hamada, Yusuke\| Ohara, Toshiaki\| Chen, Yuehua\| Terada, Manato\| Wang, Yuze\| Kawai, Hotaka\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Lung cancer iron hypoxia-inducible factor immune checkpoint inhibitors
Note	This is an Accepted Manuscript of an article published by Taylor & Francis in Free Radical Research on 30 Aug 2025, available at: https://doi.org/10.1080/10715762.2025.2551030.\| This fulltext file will be available in Aug. 2026.\|
Published Date	2025-08-30
Publication Title	Free Radical Research
Publisher	Informa UK Limited
ISSN	1071-5762
NCID	AA11001805
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	40850320
DOI	10.1080/10715762.2025.2551030
Web of Science KeyUT	001560636600001
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Tumor Microvessels with Specific Morphology as a Prognostic Factor in Esophageal Squamous Cell Carcinoma

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Author	Tun, Hnin Thida\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Nishimura, Seitaro\| Kunitomo, Tomoyoshi\| Noma, Kazuhiro\| Matsukawa, Akihiro\|
Keywords	Esophageal neoplasms Angiogenesis Microvessel density Pericytes VEGF-A Immunohistochemistry Prognosis
Published Date	2025-07-10
Publication Title	Annals of Surgical Oncology
Publisher	Springer Science and Business Media LLC
ISSN	1068-9265
NCID	AA11016573
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40640482
DOI	10.1245/s10434-025-17747-2
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HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses

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Author	Chen, Yuehua\| Ohara, Toshiaki\| Hamada, Yusuke\| Wang, Yuze\| Tian, Miao\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Colorectal cancer Microsatellite stable Hypoxia-inducible factor Immune checkpoint inhibitors
Note	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04067-3\|
Published Date	2025-05-09
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume74
Issue	issue7
Publisher	Springer
Start Page	192
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40343532
DOI	10.1007/s00262-025-04067-3
Web of Science KeyUT	001485530100001
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Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone

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Author	Yagi, Tomohiko\| Kagawa, Shunsuke\| Nogi, Shohei\| Taniguchi, Atsuki\| Yoshimoto, Masashi\| Suemori, Kanto\| Nagai, Yasuo\| Fujita, Shuto\| Kuroda, Shinji\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Teraishi, Fuminori\| Takagi, Kosei\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Cancer-associated fibroblasts Neutrophil Anti-fibrotic agent Pirfenidone
Published Date	2025-02-04
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume74
Issue	issue3
Publisher	Springer
Start Page	96
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	39904796
DOI	10.1007/s00262-025-03946-z
Web of Science KeyUT	001413348800005
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Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer

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Author	Mitsui, Ema\| Kikuchi, Satoru\| Okura, Tomohiro\| Tazawa, Hiroshi\| Une, Yuta\| Nishiwaki, Noriyuki\| Kuroda, Shinji\| Noma, Kazuhiro\| Kagawa, Shunsuke\| Ohara, Toshiaki\| Ohtsuka, Junko\| Ohki, Rieko\| Fujiwara, Toshiyoshi\|
Keywords	Peritoneal metastasis Gastric cancer Interleukin-6 Cancer-associated fibroblasts Interleukin-6 receptor antibody
Published Date	2025-01-25
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Nature Portfolio
Start Page	3267
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	39863722
DOI	10.1038/s41598-025-88033-0
Web of Science KeyUT	001406498300020
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Loss of Nr4a1 ameliorates endothelial cell injury and vascular leakage in lung transplantation from circulatory-death donor

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Author	Kawana, Shinichi\| Okazaki, Mikio\| Sakaue, Tomohisa\| Hashimoto, Kohei\| Nakata, Kentaro\| Choshi, Haruki\| Tanaka, Shin\| Miyoshi, Kentaroh\| Ohtani, Shinji\| Ohara, Toshiaki\| Sugimoto, Seiichiro\| Matsukawa, Akihiro\| Toyooka, Shinichi\|
Keywords	lung transplantation ischemia-reperfusion injury donation after circulatory death nuclear receptor subfamily 4 group A member 1 endothelial cell
Published Date	2024-10-05
Publication Title	The Journal of Heart and Lung Transplantation
Volume	volume44
Issue	issue2
Publisher	Elsevier
Start Page	249
End Page	260
ISSN	1053-2498
NCID	AA10796579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Authors.
File Version	publisher
PubMed ID	39369968
DOI	10.1016/j.healun.2024.09.028
Web of Science KeyUT	001416964100001
Related Url	isVersionOf https://doi.org/10.1016/j.healun.2024.09.028

Senescent Fibroblasts Potentiate Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells via IL-8–mediated Crosstalk

FullText URL	fulltext20240701-01.pdf fig20240701-01.pdf
Author	LI, YUNCHENG\| TAZAWA, HIROSHI\| NAGAI, YASUO\| FUJITA, SHUTO\| OKURA, TOMOHIRO\| SHOJI, RYOHEI\| YAMADA, MOTOHIKO\| KIKUCHI, SATORU\| KURODA, SHINJI\| OHARA, TOSHIAKI\| NOMA, KAZUHIRO\| NISHIZAKI, MASAHIKO\| KAGAWA, SHUNSUKE\| FUJIWARA, TOSHIYOSHI\|
Keywords	Gastric cancer peritoneal metastasis senescent fibroblast IL-8 CXCR1/2
Note	This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.\| This fulltext file will be available in Dec. 2024.\|
Published Date	2024-05-31
Publication Title	Anticancer Research
Volume	volume44
Issue	issue6
Publisher	International Institute of Anticancer Research
Start Page	2497
End Page	2509
ISSN	0250-7005
NCID	AA10625860
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 International Institute of Anticancer Research (Dr. George J. Delinasios)
File Version	author
PubMed ID	38821603
DOI	10.21873/anticanres.17056
Web of Science KeyUT	001249685300009
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SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes

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Author	Wang, Tianyi\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	autophagy mitophagy SPRED proteins MAPK/ERK mTOR hepatocellular carcinoma
Published Date	2024-06-06
Publication Title	International Journal of Molecular Sciences
Volume	volume25
Issue	issue11
Publisher	MDPI
Start Page	6269
ISSN	1661-6596
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2024 by the authors.
File Version	publisher
DOI	10.3390/ijms25116269
Web of Science KeyUT	001245555700001
Related Url	isVersionOf https://doi.org/10.3390/ijms25116269

The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer

FullText URL	fulltext.pdf
Author	Swe, Hnin‐Wint‐Wint\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Komatsubara, Yu\| Yoshimura, Teizo\| Shien, Tadahiko\| Matsukawa, Akihiro\|
Keywords	angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis
Published Date	2024-05-31
Publication Title	Pathology International
Volume	volume74
Issue	issue7
Publisher	Wiley
Start Page	394
End Page	407
ISSN	1320-5463
NCID	AA10984364
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	38818885
DOI	10.1111/pin.13442
Web of Science KeyUT	001235649700001
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Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma

FullText URL	fulltext.pdf
Author	Eain, Htoo Shwe\| Kawai, Hotaka\| Nakayama, Masaaki\| Oo, May Wathone\| Ohara, Toshiaki\| Fukuhara, Yoko\| Takabatake, Kiyofumi\| Shan, Quisheng\| Soe, Yamin\| Ono, Kisho\| Nakano, Keisuke\| Mizukawa, Nobuyoshi\| Iida, Seiji\| Nagatsuka, Hitoshi\|
Published Date	2024-05-22
Publication Title	JCI Insight
Volume	volume9
Issue	issue10
Publisher	American Society for Clinical Investigation
Start Page	e174618
ISSN	2379-3708
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024, Eain et al.
File Version	publisher
PubMed ID	38775151
DOI	10.1172/jci.insight.174618
Web of Science KeyUT	001230441500001
Related Url	isVersionOf https://doi.org/10.1172/jci.insight.174618

PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

FullText URL	fulltext.pdf
Author	Kawasaki, Kento\| Noma, Kazuhiro\| Kato, Takuya\| Ohara, Toshiaki\| Tanabe, Shunsuke\| Takeda, Yasushige\| Matsumoto, Hijiri\| Nishimura, Seitaro\| Kunitomo, Tomoyoshi\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Kashima, Hajime\| Maeda, Naoaki\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Shirakawa, Yasuhiro\| Fujiwara, Toshiyoshi\|
Keywords	Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors
Note	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2\|
Published Date	2023-09-05
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume72
Issue	issue11
Publisher	Springer Science and Business Media LLC
Start Page	3787
End Page	3802
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	37668710
DOI	10.1007/s00262-023-03531-2
Web of Science KeyUT	001062743200002
Related Url	isVersionOf https://doi.org/10.1007/s00262-023-03531-2

Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic Streptococcus mutans

FullText URL	fulltext.pdf
Author	Shinoda-Ito, Yuki\| Omori, Kazuhiro\| Ito, Takashi\| Nakayama, Masaaki\| Ikeda, Atsushi\| Ito, Masahiro\| Ohara, Toshiaki\| Takashiba, Shogo\|
Keywords	antimicrobial iron chelator oral infection Streptococcus mutans super-polyphenols
Published Date	2023-10-24
Publication Title	Antibiotics
Volume	volume12
Issue	issue11
Publisher	MDPI
Start Page	1562
ISSN	2079-6382
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37998764
DOI	10.3390/antibiotics12111562
Web of Science KeyUT	001109390500001
Related Url	isVersionOf https://doi.org/10.3390/antibiotics12111562