Ohara, Toshiaki - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses

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Author	Chen, Yuehua\| Ohara, Toshiaki\| Hamada, Yusuke\| Wang, Yuze\| Tian, Miao\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Colorectal cancer Microsatellite stable Hypoxia-inducible factor Immune checkpoint inhibitors
Note	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04067-3\|
Published Date	2025-05-09
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume74
Issue	issue7
Publisher	Springer
Start Page	192
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40343532
DOI	10.1007/s00262-025-04067-3
Web of Science KeyUT	001485530100001
Related Url	isVersionOf https://doi.org/10.1007/s00262-025-04067-3

Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone

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Author	Yagi, Tomohiko\| Kagawa, Shunsuke\| Nogi, Shohei\| Taniguchi, Atsuki\| Yoshimoto, Masashi\| Suemori, Kanto\| Nagai, Yasuo\| Fujita, Shuto\| Kuroda, Shinji\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Teraishi, Fuminori\| Takagi, Kosei\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Cancer-associated fibroblasts Neutrophil Anti-fibrotic agent Pirfenidone
Published Date	2025-02-04
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume74
Issue	issue3
Publisher	Springer
Start Page	96
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	39904796
DOI	10.1007/s00262-025-03946-z
Web of Science KeyUT	001413348800005
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Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer

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Author	Mitsui, Ema\| Kikuchi, Satoru\| Okura, Tomohiro\| Tazawa, Hiroshi\| Une, Yuta\| Nishiwaki, Noriyuki\| Kuroda, Shinji\| Noma, Kazuhiro\| Kagawa, Shunsuke\| Ohara, Toshiaki\| Ohtsuka, Junko\| Ohki, Rieko\| Fujiwara, Toshiyoshi\|
Keywords	Peritoneal metastasis Gastric cancer Interleukin-6 Cancer-associated fibroblasts Interleukin-6 receptor antibody
Published Date	2025-01-25
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Nature Portfolio
Start Page	3267
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	39863722
DOI	10.1038/s41598-025-88033-0
Web of Science KeyUT	001406498300020
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-88033-0

Loss of Nr4a1 ameliorates endothelial cell injury and vascular leakage in lung transplantation from circulatory-death donor

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Author	Kawana, Shinichi\| Okazaki, Mikio\| Sakaue, Tomohisa\| Hashimoto, Kohei\| Nakata, Kentaro\| Choshi, Haruki\| Tanaka, Shin\| Miyoshi, Kentaroh\| Ohtani, Shinji\| Ohara, Toshiaki\| Sugimoto, Seiichiro\| Matsukawa, Akihiro\| Toyooka, Shinichi\|
Keywords	lung transplantation ischemia-reperfusion injury donation after circulatory death nuclear receptor subfamily 4 group A member 1 endothelial cell
Published Date	2024-10-05
Publication Title	The Journal of Heart and Lung Transplantation
Volume	volume44
Issue	issue2
Publisher	Elsevier
Start Page	249
End Page	260
ISSN	1053-2498
NCID	AA10796579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Authors.
File Version	publisher
PubMed ID	39369968
DOI	10.1016/j.healun.2024.09.028
Web of Science KeyUT	001416964100001
Related Url	isVersionOf https://doi.org/10.1016/j.healun.2024.09.028

Senescent Fibroblasts Potentiate Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells via IL-8–mediated Crosstalk

FullText URL	fulltext20240701-01.pdf fig20240701-01.pdf
Author	LI, YUNCHENG\| TAZAWA, HIROSHI\| NAGAI, YASUO\| FUJITA, SHUTO\| OKURA, TOMOHIRO\| SHOJI, RYOHEI\| YAMADA, MOTOHIKO\| KIKUCHI, SATORU\| KURODA, SHINJI\| OHARA, TOSHIAKI\| NOMA, KAZUHIRO\| NISHIZAKI, MASAHIKO\| KAGAWA, SHUNSUKE\| FUJIWARA, TOSHIYOSHI\|
Keywords	Gastric cancer peritoneal metastasis senescent fibroblast IL-8 CXCR1/2
Note	This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.\| This fulltext file will be available in Dec. 2024.\|
Published Date	2024-05-31
Publication Title	Anticancer Research
Volume	volume44
Issue	issue6
Publisher	International Institute of Anticancer Research
Start Page	2497
End Page	2509
ISSN	0250-7005
NCID	AA10625860
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 International Institute of Anticancer Research (Dr. George J. Delinasios)
File Version	author
PubMed ID	38821603
DOI	10.21873/anticanres.17056
Web of Science KeyUT	001249685300009
Related Url	isVersionOf https://doi.org/10.21873/anticanres.17056

SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes

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Author	Wang, Tianyi\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	autophagy mitophagy SPRED proteins MAPK/ERK mTOR hepatocellular carcinoma
Published Date	2024-06-06
Publication Title	International Journal of Molecular Sciences
Volume	volume25
Issue	issue11
Publisher	MDPI
Start Page	6269
ISSN	1661-6596
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2024 by the authors.
File Version	publisher
DOI	10.3390/ijms25116269
Web of Science KeyUT	001245555700001
Related Url	isVersionOf https://doi.org/10.3390/ijms25116269

The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer

FullText URL	fulltext.pdf
Author	Swe, Hnin‐Wint‐Wint\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Komatsubara, Yu\| Yoshimura, Teizo\| Shien, Tadahiko\| Matsukawa, Akihiro\|
Keywords	angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis
Published Date	2024-05-31
Publication Title	Pathology International
Volume	volume74
Issue	issue7
Publisher	Wiley
Start Page	394
End Page	407
ISSN	1320-5463
NCID	AA10984364
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	38818885
DOI	10.1111/pin.13442
Web of Science KeyUT	001235649700001
Related Url	isVersionOf https://doi.org/10.1111/pin.13442

Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma

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Author	Eain, Htoo Shwe\| Kawai, Hotaka\| Nakayama, Masaaki\| Oo, May Wathone\| Ohara, Toshiaki\| Fukuhara, Yoko\| Takabatake, Kiyofumi\| Shan, Quisheng\| Soe, Yamin\| Ono, Kisho\| Nakano, Keisuke\| Mizukawa, Nobuyoshi\| Iida, Seiji\| Nagatsuka, Hitoshi\|
Published Date	2024-05-22
Publication Title	JCI Insight
Volume	volume9
Issue	issue10
Publisher	American Society for Clinical Investigation
Start Page	e174618
ISSN	2379-3708
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024, Eain et al.
File Version	publisher
PubMed ID	38775151
DOI	10.1172/jci.insight.174618
Web of Science KeyUT	001230441500001
Related Url	isVersionOf https://doi.org/10.1172/jci.insight.174618

PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer

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Author	Kawasaki, Kento\| Noma, Kazuhiro\| Kato, Takuya\| Ohara, Toshiaki\| Tanabe, Shunsuke\| Takeda, Yasushige\| Matsumoto, Hijiri\| Nishimura, Seitaro\| Kunitomo, Tomoyoshi\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Kashima, Hajime\| Maeda, Naoaki\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Shirakawa, Yasuhiro\| Fujiwara, Toshiyoshi\|
Keywords	Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors
Note	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2\|
Published Date	2023-09-05
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume72
Issue	issue11
Publisher	Springer Science and Business Media LLC
Start Page	3787
End Page	3802
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	37668710
DOI	10.1007/s00262-023-03531-2
Web of Science KeyUT	001062743200002
Related Url	isVersionOf https://doi.org/10.1007/s00262-023-03531-2

Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic Streptococcus mutans

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Author	Shinoda-Ito, Yuki\| Omori, Kazuhiro\| Ito, Takashi\| Nakayama, Masaaki\| Ikeda, Atsushi\| Ito, Masahiro\| Ohara, Toshiaki\| Takashiba, Shogo\|
Keywords	antimicrobial iron chelator oral infection Streptococcus mutans super-polyphenols
Published Date	2023-10-24
Publication Title	Antibiotics
Volume	volume12
Issue	issue11
Publisher	MDPI
Start Page	1562
ISSN	2079-6382
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37998764
DOI	10.3390/antibiotics12111562
Web of Science KeyUT	001109390500001
Related Url	isVersionOf https://doi.org/10.3390/antibiotics12111562

Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms

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Author	Matsumoto, Kazuyuki\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Takaki, Akinobu\| Takahara, Masahiro\| Kato, Hironari\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Matsukawa, Akihiro\| Okada, Hiroyuki\|
Keywords	Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry
Note	The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6\|
Published Date	2022-02-08
Publication Title	Journal of Gastrointestinal Surgery
Volume	volume26
Issue	issue6
Publisher	Springer Science and Business Media LLC
Start Page	1213
End Page	1223
ISSN	1091-255X
NCID	AA11494553
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35137343
DOI	10.1007/s11605-021-05197-6
Web of Science KeyUT	000752761400001
Related Url	isVersionOf https://doi.org/10.1007/s11605-021-05197-6

Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models

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Author	Komoto, Satoshi\| Noma, Kazuhiro\| Kato, Takuya\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Sato, Hiroaki\| Katsura, Yuki\| Kashima, Hajime\| Kikuchi, Satoru\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date	2023-05-30
Publication Title	Cancers
Volume	volume15
Issue	issue11
Publisher	MDPI
Start Page	2971
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37296933
DOI	10.3390/cancers15112971
Web of Science KeyUT	001006082400001
Related Url	isVersionOf https://doi.org/10.3390/cancers15112971

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells

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Author	Gao, Tong\| Yang, Xu\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Wang, Tianyi\| Tomonobu, Nahoko\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	cancer stem cells epithelial-mesenchymal transition ERK1/2-MAPK tumorigenesis
Published Date	2023-03-05
Publication Title	International Journal of Molecular Sciences
Volume	volume24
Issue	issue5
Publisher	MDPI
Start Page	4996
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36902429
DOI	10.3390/ijms24054996
Web of Science KeyUT	000947675000001
Related Url	isVersionOf https://doi.org/10.3390/ijms24054996

Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators

FullText URL	fulltext.pdf
Author	Wang, Yuze\| Ohara, Toshiaki\| Chen, Yuehua\| Hamada, Yusuke\| Li, Chunning\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	triple-negative breast cancer iron metabolism iron chelator phosphoinositide-3-kinase-protein kinase heterogeneity metastasis
Published Date	2023-01-12
Publication Title	Cancers
Volume	volume15
Issue	issue2
Publisher	MDPI
Start Page	468
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36672419
DOI	10.3390/cancers15020468
Web of Science KeyUT	000914513700001
Related Url	isVersionOf https://doi.org/10.3390/cancers15020468

Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer

FullText URL	fulltext20221215-1.pdf figures20221215-1.pdf Supple_Figures20221215-1.pdf Supple_Table20221215-1.pdf
Author	Kajiwara, Yoshinori\| Tazawa, Hiroshi\| Yamada, Motohiko\| Kanaya, Nobuhiko\| Fushimi, Takuro\| Kikuchi, Satoru\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Yoshida, Ryuichi\| Umeda, Yuzo\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	Pancreatic cancer Chemoresistance MDSC GM-CSF Oncolytic virus
Note	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00262-022-03334-x\| This full-text of the article will be available in Nov. 2023.\|
Published Date	2022-11-27
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume72
Issue	issue5
Publisher	Springer Science and Business Media LLC
Start Page	1285
End Page	1300
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version	author
PubMed ID	36436021
DOI	10.1007/s00262-022-03334-x
Web of Science KeyUT	000889040300003
Related Url	isVersionOf https://doi.org/10.1007/s00262-022-03334-x

Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

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Author	Sato, Hiroaki\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kawasaki, Kento\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Komoto, Satoshi\| Kashima, Hajime\| Katsura, Yuki\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2022-11-23
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	20152
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	36418422
DOI	10.1038/s41598-022-24313-3
Web of Science KeyUT	000887936300054
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-24313-3

Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung

FullText URL	fulltext.pdf
Author	Nakata, Kentaro\| Okazaki, Mikio\| Sakaue, Tomohisa\| Kinoshita, Rie\| Komoda, Yuhei\| Shimizu, Dai\| Yamamoto, Haruchika\| Tanaka, Shin\| Suzawa, Ken\| Shien, Kazuhiko\| Miyoshi, Kentaroh\| Yamamoto, Hiromasa\| Ohara, Toshiaki\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Matsukawa, Akihiro\| Sakaguchi, Masakiyo\| Toyooka, Shinichi\|
Keywords	ischemia reperfusion injury S100A8/A9 lung transplantation damage-associated molecule patterns
Published Date	2022-11-10
Publication Title	Bioengineering
Volume	volume9
Issue	issue11
Publisher	MDPI
Start Page	673
ISSN	2306-5354
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36354584
DOI	10.3390/bioengineering9110673
Web of Science KeyUT	000880897200001
Related Url	isVersionOf https://doi.org/10.3390/bioengineering9110673

Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer

FullText URL	fulltext.pdf
Author	Li, Chunning\| Yoshimura, Teizo\| Tian, Miao\| Wang, Yuze\| Kondo, Takamasa\| Yamamoto, Ken-Ichi\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Matsukawa, Akihiro\|
Keywords	Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment
Published Date	2022-09-12
Publication Title	Breast Cancer Research
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	60
ISSN	1465-5411
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36096830
DOI	10.1186/s13058-022-01557-5
Web of Science KeyUT	000853036400001
Related Url	isVersionOf https://doi.org/10.1186/s13058-022-01557-5

Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of cancer

FullText URL	fulltext.pdf
Author	Ogawa, Toshihiro\| Kikuchi, Satoru\| Tabuchi, Motoyasu\| Mitsui, Ema\| Une, Yuta\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Published Date	2022-06-16
Publication Title	Molecular Therapy-Oncolytics
Volume	volume25
Publisher	Cell Press
Start Page	249
End Page	261
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	35615263
DOI	10.1016/j.omto.2022.04.009
Web of Science KeyUT	000800437000008
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2022.04.009

Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways

FullText URL	fulltext.pdf
Author	Miyahara, Hiroyuki\| Hasegawa, Kosei\| Yashiro, Masato\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\| Tsukahara, Hirokazu\|
Published Date	2022-03-21
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	4819
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35314758
DOI	10.1038/s41598-022-08791-z
Web of Science KeyUT	000771589000002
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-08791-z