Ohara, Toshiaki - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms

FullText URL	fulltext.pdf
Author	Matsumoto, Kazuyuki\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Takaki, Akinobu\| Takahara, Masahiro\| Kato, Hironari\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Matsukawa, Akihiro\| Okada, Hiroyuki\|
Keywords	Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry
Note	The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6\|
Published Date	2022-02-08
Publication Title	Journal of Gastrointestinal Surgery
Volume	volume26
Issue	issue6
Publisher	Springer Science and Business Media LLC
Start Page	1213
End Page	1223
ISSN	1091-255X
NCID	AA11494553
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35137343
DOI	10.1007/s11605-021-05197-6
Web of Science KeyUT	000752761400001
Related Url	isVersionOf https://doi.org/10.1007/s11605-021-05197-6

Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models

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Author	Komoto, Satoshi\| Noma, Kazuhiro\| Kato, Takuya\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Sato, Hiroaki\| Katsura, Yuki\| Kashima, Hajime\| Kikuchi, Satoru\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date	2023-05-30
Publication Title	Cancers
Volume	volume15
Issue	issue11
Publisher	MDPI
Start Page	2971
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37296933
DOI	10.3390/cancers15112971
Web of Science KeyUT	001006082400001
Related Url	isVersionOf https://doi.org/10.3390/cancers15112971

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells

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Author	Gao, Tong\| Yang, Xu\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Wang, Tianyi\| Tomonobu, Nahoko\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	cancer stem cells epithelial-mesenchymal transition ERK1/2-MAPK tumorigenesis
Published Date	2023-03-05
Publication Title	International Journal of Molecular Sciences
Volume	volume24
Issue	issue5
Publisher	MDPI
Start Page	4996
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36902429
DOI	10.3390/ijms24054996
Web of Science KeyUT	000947675000001
Related Url	isVersionOf https://doi.org/10.3390/ijms24054996

Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators

FullText URL	fulltext.pdf
Author	Wang, Yuze\| Ohara, Toshiaki\| Chen, Yuehua\| Hamada, Yusuke\| Li, Chunning\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	triple-negative breast cancer iron metabolism iron chelator phosphoinositide-3-kinase-protein kinase heterogeneity metastasis
Published Date	2023-01-12
Publication Title	Cancers
Volume	volume15
Issue	issue2
Publisher	MDPI
Start Page	468
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36672419
DOI	10.3390/cancers15020468
Web of Science KeyUT	000914513700001
Related Url	isVersionOf https://doi.org/10.3390/cancers15020468

Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer

FullText URL	fulltext20221215-1.pdf figures20221215-1.pdf Supple_Figures20221215-1.pdf Supple_Table20221215-1.pdf
Author	Kajiwara, Yoshinori\| Tazawa, Hiroshi\| Yamada, Motohiko\| Kanaya, Nobuhiko\| Fushimi, Takuro\| Kikuchi, Satoru\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Yoshida, Ryuichi\| Umeda, Yuzo\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	Pancreatic cancer Chemoresistance MDSC GM-CSF Oncolytic virus
Note	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00262-022-03334-x\| This full-text of the article will be available in Nov. 2023.\|
Published Date	2022-11-27
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume72
Issue	issue5
Publisher	Springer Science and Business Media LLC
Start Page	1285
End Page	1300
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version	author
PubMed ID	36436021
DOI	10.1007/s00262-022-03334-x
Web of Science KeyUT	000889040300003
Related Url	isVersionOf https://doi.org/10.1007/s00262-022-03334-x

Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

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Author	Sato, Hiroaki\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kawasaki, Kento\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Komoto, Satoshi\| Kashima, Hajime\| Katsura, Yuki\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2022-11-23
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	20152
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	36418422
DOI	10.1038/s41598-022-24313-3
Web of Science KeyUT	000887936300054
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-24313-3

Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung

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Author	Nakata, Kentaro\| Okazaki, Mikio\| Sakaue, Tomohisa\| Kinoshita, Rie\| Komoda, Yuhei\| Shimizu, Dai\| Yamamoto, Haruchika\| Tanaka, Shin\| Suzawa, Ken\| Shien, Kazuhiko\| Miyoshi, Kentaroh\| Yamamoto, Hiromasa\| Ohara, Toshiaki\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Matsukawa, Akihiro\| Sakaguchi, Masakiyo\| Toyooka, Shinichi\|
Keywords	ischemia reperfusion injury S100A8/A9 lung transplantation damage-associated molecule patterns
Published Date	2022-11-10
Publication Title	Bioengineering
Volume	volume9
Issue	issue11
Publisher	MDPI
Start Page	673
ISSN	2306-5354
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36354584
DOI	10.3390/bioengineering9110673
Web of Science KeyUT	000880897200001
Related Url	isVersionOf https://doi.org/10.3390/bioengineering9110673

Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer

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Author	Li, Chunning\| Yoshimura, Teizo\| Tian, Miao\| Wang, Yuze\| Kondo, Takamasa\| Yamamoto, Ken-Ichi\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Matsukawa, Akihiro\|
Keywords	Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment
Published Date	2022-09-12
Publication Title	Breast Cancer Research
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	60
ISSN	1465-5411
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36096830
DOI	10.1186/s13058-022-01557-5
Web of Science KeyUT	000853036400001
Related Url	isVersionOf https://doi.org/10.1186/s13058-022-01557-5

Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of cancer

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Author	Ogawa, Toshihiro\| Kikuchi, Satoru\| Tabuchi, Motoyasu\| Mitsui, Ema\| Une, Yuta\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Published Date	2022-06-16
Publication Title	Molecular Therapy-Oncolytics
Volume	volume25
Publisher	Cell Press
Start Page	249
End Page	261
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	35615263
DOI	10.1016/j.omto.2022.04.009
Web of Science KeyUT	000800437000008
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2022.04.009

Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways

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Author	Miyahara, Hiroyuki\| Hasegawa, Kosei\| Yashiro, Masato\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\| Tsukahara, Hirokazu\|
Published Date	2022-03-21
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	4819
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35314758
DOI	10.1038/s41598-022-08791-z
Web of Science KeyUT	000771589000002
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-08791-z

Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways

FullText URL	fulltext.pdf
Author	Hassan, Ghmkin\| Ohara, Toshiaki\| Afify, Said M.\| Kumon, Kazuki\| Zahra, Maram H.\| Fu, Xiaoying\| Al Kadi, Mohamad\| Seno, Akimasa\| Salomon, David S.\| Seno, Masaharu\|
Keywords	Cancer stem cells iPSCs Conversion Plasticity Tumorigenesis Pancreatic cancer microenvironments
Published Date	2022-01-21
Publication Title	Journal Of Experimental ＆ Clinical Cancer Research
Volume	volume41
Issue	issue1
Publisher	BMC
Start Page	29
ISSN	1756-9966
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021.
File Version	publisher
PubMed ID	35063003
DOI	10.1186/s13046-021-02167-3
Web of Science KeyUT	000745504400002
Related Url	isVersionOf https://doi.org/10.1186/s13046-021-02167-3

Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment

FullText URL	fulltext.pdf
Author	Oo, May Wathone\| Kawai, Hotaka\| Takabatake, Kiyofumi\| Tomida, Shuta\| Eguchi, Takanori\| Ono, Kisho\| Shan, Qiusheng\| Ohara, Toshiaki\| Yoshida, Saori\| Omori, Haruka\| Sukegawa, Shintaro\| Nakano, Keisuke\| Okamoto, Kuniaki\| Sasaki, Akira\| Nagatsuka, Hitoshi\|
Published Date	2022-01-11
Publication Title	JCI Insight
Volume	volume7
Issue	issue1
Publisher	American Society for Clinical Investigation
Start Page	e148960
ISSN	2379-3708
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022, Oo et al.
File Version	publisher
PubMed ID	34874922
DOI	10.1172/jci.insight.148960
Web of Science KeyUT	000743257400001
Related Url	isVersionOf https://doi.org/10.1172/jci.insight.148960

Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4(+) and CD8(+) T cells

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Author	Sun, Cuiming\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Liu, Qiuying\| Cao, Chen\| Yang, Xu\| Yoshimura, Teizo\| Kunkel, Steven L.\| Matsukawa, Akihiro\|
Keywords	Liver damage MAPK Signal transduction and regulation Gene-modified mice Spred2
Published Date	2022-01
Publication Title	Journal Of Advanced Research
Volume	volume35
Publisher	Elsevier
Start Page	71
End Page	86
ISSN	2090-1232
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	35003795
DOI	10.1016/j.jare.2021.03.014
Web of Science KeyUT	000736947300007
Related Url	isVersionOf https://doi.org/10.1016/j.jare.2021.03.014

PolyI:C suppresses TGF-β1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells

FullText URL	fulltext20210824-3.pdf
Author	Yamaguchi, Takahiro\| Yoshimura, Teizo\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Tong, Gao\| Matsukawa, Akihiro\|
Keywords	Toll-like receptors cell migration metastasis epithelial mesenchymal transformation
Note	This is a post-peer-review, pre-copyedit version of an article published in Molecular Biology Reports. The final authenticated version is available online at: https://doi.org/10.1007/s11033-021-06625-1\|
Published Date	2021-8-14
Publication Title	Molecular Biology Reports
Publisher	Springer Science and Business Media LLC
ISSN	0301-4851
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	34390443
DOI	10.1007/s11033-021-06625-1
Web of Science KeyUT	000684897400002
Related Url	isVersionOf https://doi.org/10.1007/s11033-021-06625-1

Artificial intelligence supported anemia control system (AISACS) to prevent anemia in maintenance hemodialysis patients

FullText URL	fulltext.pdf
Author	Ohara, Toshiaki\| Ikeda, Hiroshi\| Sugitani, Yoshiki\| Suito, Hiroshi\| Huynh, Viet Quang Huy\| Kinomura, Masaru\| Haraguchi, Soichiro\| Sakurama, Kazufumi\|
Keywords	anemia artificial intelligence chronic kidney disease erythropoiesis-stimulating agents hemodialysis iron
Published Date	2021-02-22
Publication Title	International Journal of Medical Sciences
Volume	volume18
Issue	issue8
Publisher	Ivyspring International Publisher
Start Page	1831
End Page	1839
ISSN	1449-1907
NCID	AA1197928X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The author(s).
File Version	publisher
DOI	10.7150/ijms.53298
Related Url	isVersionOf https://www.medsci.org/v18p1831.htm

Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

FullText URL	fulltext.pdf
Author	Katsube, Ryoichi\| Noma, Kazuhiro\| Ohara, Toshiaki\| Nishiwaki, Noriyuki\| Kobayashi, Teruki\| Komoto, Satoshi\| Sato, Hiroaki\| Kashima, Hajime\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2021-01-18
Publication Title	Scientific Reports
Volume	volume11
Issue	issue1
Publisher	Nature Research
Start Page	1693
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	33462372
DOI	10.1038/s41598-021-81465-4
Web of Science KeyUT	000612156600008
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-81465-4

New Vascular-Access Intervention Assistance Plate Provides Good Operability and Safety by Preventing Accidental Falls: First Experience of 1,872 Cases

JaLCDOI	10.18926/AMO/60880
FullText URL	74_6_505.pdf
Author	Ohara, Toshiaki\| Sakurama, Kazufumi\| Hiramatsu, Satoshi\|
Abstract	Vascular-access interventions are necessary for the continuation of hemodialysis, and they are performed under X-ray guidance. During interventions, patients’ accidental falls from the bed are a serious problem, and spe-cialized fixation systems for hemodialysis patients to prevent their falls from the bed have been lacking. We developed a new fixation plate made of polypropylene homopolymer and tested its ability to prevent such falls retrospectively. This plate, which we named the ‘vascular-access intervention assistance plate,’ offers functional features such as the concurrent fixation of the body and either arm and an arm space with serrations for fixing a forearm strap. We performed computer simulations to examine the strength of the plate, and we evaluated the efficacy of fall prevention by reviewing patients’ medical records. The results demonstrated that the functional design of the plate provides good operability via accurate concurrent fixations of the body and arm. The com-puter simulation analysis results indicated the plate’s sufficient strength. The medical records analysis revealed three accidental falls before the plate’s introduction (401 patients, 1,437 interventions), and none after plate introduction (683 patients, 1,872 interventions). Accidental falls were significantly prevented by use of the plate (p < 0.05). The dementia rate and type of procedure were not significantly different between the patients who fell and those who did not. This vascular-access intervention assisted plate provides good operability and safety by preventing accidental falls among hemodialysis patients.
Keywords	hemodialysis fall accident incident vascular access
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2020-12
Volume	volume74
Issue	issue6
Publisher	Okayama University Medical School
Start Page	505
End Page	511
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33361870
Web of Science KeyUT	000601203600006
NAID	120006948959

Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression

FullText URL	fulltext.pdf
Author	Moh-Moh-Aung, Aye\| Fujisawa, Masayoshi\| Ito, Sachio\| Katayama, Hiroshi\| Ohara, Toshiaki\| Ota, Yoko\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Molecular medicine Tumour angiogenesis
Published Date	2020-06-26
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature
Start Page	10418
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	32591615
DOI	10.1038/s41598-020-67425-4
Web of Science KeyUT	000545967200015
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-67425-4

Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse

FullText URL	fulltext.pdf
Author	Hirano, Yutaka\| Sugimoto, Seiichiro\| Yamamoto, Sumiharu\| Okada, Masanori\| Otani, Shinji\| Ohara, Toshiaki\| Yamane, Masaomi\| Matsukawa, Akihiro\| Oto, Takahiro\| Toyooka, Shinichi\|
Keywords	Brain dead donor Donation after cardiac death Lung transplantation Organ preservation Rejection
Note	This is a post-peer-review, pre-copyedit version of an article published in General Thoracic and Cardiovascular Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-019-01181-9.\|
Published Date	2019-07-31
Publication Title	General Thoracic and Cardiovascular Surgery
Volume	volume68
Issue	issue1
Publisher	Springer
Start Page	57
End Page	62
ISSN	1863-6705
NCID	AA12201344
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	31367969
DOI	10.1007/s11748-019-01181-9
Web of Science KeyUT	000511499200009
Related Url	isVersionOf https://doi.org/10.1007/s11748-019-01181-9

A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs

JaLCDOI	10.18926/AMO/57946
FullText URL	74_1_1.pdf
Author	Chen, Yuehua\| Ohara, Toshiaki\| Xing, Boyi\| Qi, Jiping\| Noma, Kazuhiro\| Matsukawa, Akihiro\|
Abstract	Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.
Keywords	cancer stem cell stemness iron chelation chemotherapy
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2020-02
Volume	volume74
Issue	issue1
Publisher	Okayama University Medical School
Start Page	1
End Page	6
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	32099242
Web of Science KeyUT	000516606200001
NAID	120006795613