| JaLCDOI | 10.18926/AMO/53524 |
|---|---|
| FullText URL | 69_3_173.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Ohara, Toshiaki| Kashima, Hajime| Maeda, Naoaki| Tanabe, Shunsuke| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position. |
| Keywords | chyle leak thoracic duct thoracoscopy prone position |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 173 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101193 |
| Web of Science KeyUT | 000356903000006 |
| JaLCDOI | 10.18926/AMO/54421 |
|---|---|
| FullText URL | 70_3_213.pdf |
| Author | Kikuchi, Satoru| Kagawa, Shunsuke| Ohara, Toshiaki| Kubota, Tetsushi| Kuwada, Kazuya| Kagawa, Tetsuya| Kuroda, Shinji| Shirakawa, Yasuhiro| Nishizaki, Masahiko| Fujiwara, Toshiyoshi| |
| Abstract | A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence. |
| Keywords | dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-06 |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 216 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27339211 |
| Web of Science KeyUT | 000379406100009 |
| JaLCDOI | 10.18926/AMO/57946 |
|---|---|
| FullText URL | 74_1_1.pdf |
| Author | Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro| |
| Abstract | Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. |
| Keywords | cancer stem cell stemness iron chelation chemotherapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099242 |
| Web of Science KeyUT | 000516606200001 |
| NAID | 120006795613 |
| JaLCDOI | 10.18926/AMO/60880 |
|---|---|
| FullText URL | 74_6_505.pdf |
| Author | Ohara, Toshiaki| Sakurama, Kazufumi| Hiramatsu, Satoshi| |
| Abstract | Vascular-access interventions are necessary for the continuation of hemodialysis, and they are performed under X-ray guidance. During interventions, patients’ accidental falls from the bed are a serious problem, and spe-cialized fixation systems for hemodialysis patients to prevent their falls from the bed have been lacking. We developed a new fixation plate made of polypropylene homopolymer and tested its ability to prevent such falls retrospectively. This plate, which we named the ‘vascular-access intervention assistance plate,’ offers functional features such as the concurrent fixation of the body and either arm and an arm space with serrations for fixing a forearm strap. We performed computer simulations to examine the strength of the plate, and we evaluated the efficacy of fall prevention by reviewing patients’ medical records. The results demonstrated that the functional design of the plate provides good operability via accurate concurrent fixations of the body and arm. The com-puter simulation analysis results indicated the plate’s sufficient strength. The medical records analysis revealed three accidental falls before the plate’s introduction (401 patients, 1,437 interventions), and none after plate introduction (683 patients, 1,872 interventions). Accidental falls were significantly prevented by use of the plate (p < 0.05). The dementia rate and type of procedure were not significantly different between the patients who fell and those who did not. This vascular-access intervention assisted plate provides good operability and safety by preventing accidental falls among hemodialysis patients. |
| Keywords | hemodialysis fall accident incident vascular access |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 505 |
| End Page | 511 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361870 |
| Web of Science KeyUT | 000601203600006 |
| NAID | 120006948959 |
| Author | Ohara, Toshiaki| 櫻間 教文| 唐井 利昌| |
|---|---|
| Publication Title | |
| Content Type | Others |
| FullText URL | JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg |
|---|---|
| Author | Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki| |
| Keywords | Immunohistochemistry PD-L1 Pancreatic cancer |
| Note | This fulltext will be available in Apr 2020| |
| Published Date | 2019-04-29 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume54 |
| Issue | issue11 |
| Start Page | 1019 |
| End Page | 1028 |
| ISSN | 09441174 |
| NCID | AA10988015 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31032528 |
| DOI | 10.1007/s00535-019-01586-6 |
| Web of Science KeyUT | 000492169400008 |
| Related Url | isVersionOf https://doi.org/10.1007/s00535-019-01586-6 |
| FullText URL | cancers_11_2_177.pdf |
|---|---|
| Author | Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi| |
| Keywords | cancer stem cells combination therapy iron stemness |
| Published Date | 2019-02-03 |
| Publication Title | Cancers |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 177 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors |
| File Version | publisher |
| PubMed ID | 30717462 |
| DOI | 10.3390/cancers11020177 |
| Web of Science KeyUT | 000460747200051 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers11020177 |
| Author | Ieda, Takeshi| Tazawa, Hiroshi| Okabayashi, Hiroki| Yano, Shuya| Shigeyasu, Kunitoshi| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Kishimoto, Hiroyuki| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Saitou, Takashi| Imamura, Takeshi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2019-11-8 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 16378 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 31705021 |
| DOI | 10.1038/s41598-019-52816-z |
| Web of Science KeyUT | 000495372900001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-52816-z |
| FullText URL | OL18_3_2756.pdf |
|---|---|
| Author | Seno, Akimasa| Murakami, Chikae| El‑Aarag, Bishoy| Iwasaki, Yoshiaki| Ohara, Toshiaki| Seno, Masaharu| |
| Keywords | cancer stem cell conditioned medium mouse embryonic stem cells |
| Published Date | 2019-09 |
| Publication Title | Oncology Letters |
| Volume | volume18 |
| Issue | issue3 |
| Publisher | Spandidos Publications |
| Start Page | 2756 |
| End Page | 2762 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Seno et al. |
| File Version | publisher |
| PubMed ID | 31452753 |
| DOI | 10.3892/ol.2019.10614 |
| Web of Science KeyUT | 000487675500075 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2019.10614 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirano, Yutaka| Sugimoto, Seiichiro| Yamamoto, Sumiharu| Okada, Masanori| Otani, Shinji| Ohara, Toshiaki| Yamane, Masaomi| Matsukawa, Akihiro| Oto, Takahiro| Toyooka, Shinichi| |
| Keywords | Brain dead donor Donation after cardiac death Lung transplantation Organ preservation Rejection |
| Note | This is a post-peer-review, pre-copyedit version of an article published in General Thoracic and Cardiovascular Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-019-01181-9.| |
| Published Date | 2019-07-31 |
| Publication Title | General Thoracic and Cardiovascular Surgery |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 1863-6705 |
| NCID | AA12201344 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31367969 |
| DOI | 10.1007/s11748-019-01181-9 |
| Web of Science KeyUT | 000511499200009 |
| Related Url | isVersionOf https://doi.org/10.1007/s11748-019-01181-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Moh-Moh-Aung, Aye| Fujisawa, Masayoshi| Ito, Sachio| Katayama, Hiroshi| Ohara, Toshiaki| Ota, Yoko| Yoshimura, Teizo| Matsukawa, Akihiro| |
| Keywords | Molecular medicine Tumour angiogenesis |
| Published Date | 2020-06-26 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 10418 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32591615 |
| DOI | 10.1038/s41598-020-67425-4 |
| Web of Science KeyUT | 000545967200015 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-67425-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katsube, Ryoichi| Noma, Kazuhiro| Ohara, Toshiaki| Nishiwaki, Noriyuki| Kobayashi, Teruki| Komoto, Satoshi| Sato, Hiroaki| Kashima, Hajime| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi| |
| Published Date | 2021-01-18 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 1693 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33462372 |
| DOI | 10.1038/s41598-021-81465-4 |
| Web of Science KeyUT | 000612156600008 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-81465-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohara, Toshiaki| Ikeda, Hiroshi| Sugitani, Yoshiki| Suito, Hiroshi| Huynh, Viet Quang Huy| Kinomura, Masaru| Haraguchi, Soichiro| Sakurama, Kazufumi| |
| Keywords | anemia artificial intelligence chronic kidney disease erythropoiesis-stimulating agents hemodialysis iron |
| Published Date | 2021-02-22 |
| Publication Title | International Journal of Medical Sciences |
| Volume | volume18 |
| Issue | issue8 |
| Publisher | Ivyspring International Publisher |
| Start Page | 1831 |
| End Page | 1839 |
| ISSN | 1449-1907 |
| NCID | AA1197928X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The author(s). |
| File Version | publisher |
| DOI | 10.7150/ijms.53298 |
| Related Url | isVersionOf https://www.medsci.org/v18p1831.htm |
| FullText URL | fulltext20210824-3.pdf |
|---|---|
| Author | Yamaguchi, Takahiro| Yoshimura, Teizo| Ohara, Toshiaki| Fujisawa, Masayoshi| Tong, Gao| Matsukawa, Akihiro| |
| Keywords | Toll-like receptors cell migration metastasis epithelial mesenchymal transformation |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Molecular Biology Reports. The final authenticated version is available online at: https://doi.org/10.1007/s11033-021-06625-1| |
| Published Date | 2021-8-14 |
| Publication Title | Molecular Biology Reports |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0301-4851 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 34390443 |
| DOI | 10.1007/s11033-021-06625-1 |
| Web of Science KeyUT | 000684897400002 |
| Related Url | isVersionOf https://doi.org/10.1007/s11033-021-06625-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sun, Cuiming| Fujisawa, Masayoshi| Ohara, Toshiaki| Liu, Qiuying| Cao, Chen| Yang, Xu| Yoshimura, Teizo| Kunkel, Steven L.| Matsukawa, Akihiro| |
| Keywords | Liver damage MAPK Signal transduction and regulation Gene-modified mice Spred2 |
| Published Date | 2022-01 |
| Publication Title | Journal Of Advanced Research |
| Volume | volume35 |
| Publisher | Elsevier |
| Start Page | 71 |
| End Page | 86 |
| ISSN | 2090-1232 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 35003795 |
| DOI | 10.1016/j.jare.2021.03.014 |
| Web of Science KeyUT | 000736947300007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jare.2021.03.014 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oo, May Wathone| Kawai, Hotaka| Takabatake, Kiyofumi| Tomida, Shuta| Eguchi, Takanori| Ono, Kisho| Shan, Qiusheng| Ohara, Toshiaki| Yoshida, Saori| Omori, Haruka| Sukegawa, Shintaro| Nakano, Keisuke| Okamoto, Kuniaki| Sasaki, Akira| Nagatsuka, Hitoshi| |
| Published Date | 2022-01-11 |
| Publication Title | JCI Insight |
| Volume | volume7 |
| Issue | issue1 |
| Publisher | American Society for Clinical Investigation |
| Start Page | e148960 |
| ISSN | 2379-3708 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022, Oo et al. |
| File Version | publisher |
| PubMed ID | 34874922 |
| DOI | 10.1172/jci.insight.148960 |
| Web of Science KeyUT | 000743257400001 |
| Related Url | isVersionOf https://doi.org/10.1172/jci.insight.148960 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hassan, Ghmkin| Ohara, Toshiaki| Afify, Said M.| Kumon, Kazuki| Zahra, Maram H.| Fu, Xiaoying| Al Kadi, Mohamad| Seno, Akimasa| Salomon, David S.| Seno, Masaharu| |
| Keywords | Cancer stem cells iPSCs Conversion Plasticity Tumorigenesis Pancreatic cancer microenvironments |
| Published Date | 2022-01-21 |
| Publication Title | Journal Of Experimental ＆ Clinical Cancer Research |
| Volume | volume41 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 29 |
| ISSN | 1756-9966 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021. |
| File Version | publisher |
| PubMed ID | 35063003 |
| DOI | 10.1186/s13046-021-02167-3 |
| Web of Science KeyUT | 000745504400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s13046-021-02167-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyahara, Hiroyuki| Hasegawa, Kosei| Yashiro, Masato| Ohara, Toshiaki| Fujisawa, Masayoshi| Yoshimura, Teizo| Matsukawa, Akihiro| Tsukahara, Hirokazu| |
| Published Date | 2022-03-21 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4819 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35314758 |
| DOI | 10.1038/s41598-022-08791-z |
| Web of Science KeyUT | 000771589000002 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-08791-z |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Published Date | 2022-06-16 |
| Publication Title | Molecular Therapy-Oncolytics |
| Volume | volume25 |
| Publisher | Cell Press |
| Start Page | 249 |
| End Page | 261 |
| ISSN | 2372-7705 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 35615263 |
| DOI | 10.1016/j.omto.2022.04.009 |
| Web of Science KeyUT | 000800437000008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omto.2022.04.009 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Li, Chunning| Yoshimura, Teizo| Tian, Miao| Wang, Yuze| Kondo, Takamasa| Yamamoto, Ken-Ichi| Fujisawa, Masayoshi| Ohara, Toshiaki| Sakaguchi, Masakiyo| Matsukawa, Akihiro| |
| Keywords | Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment |
| Published Date | 2022-09-12 |
| Publication Title | Breast Cancer Research |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 60 |
| ISSN | 1465-5411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 36096830 |
| DOI | 10.1186/s13058-022-01557-5 |
| Web of Science KeyUT | 000853036400001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13058-022-01557-5 |
