| JaLCDOI | 10.18926/15202 |
|---|---|
| Title Alternative | Recent trend of research on the nongenotoxic mechanisms of chemical carcinogenesis |
| FullText URL | 014_1_001_014.pdf |
| Author | Yamaoka, Kiyonori| Hanamoto, Katsumi| Ina, Yasuhiro| Kataoka, Takahiro| Kawabe, Atsusi| Sano, Masanobu| Ujifuku, Ayako| |
| Abstract | 本総説は,筆者らが進めている｢低線量放射線の健康への影響と医療への応用｣に関する研究に資するために調査した,化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向の概要についてまとめたものである｡即ち,非遺伝毒性的発がんにおける細胞増殖,シトクロムP450誘導,酸化的ストレス,および遺伝子発現のそれぞれの役割,並びに量的な応答性について言及した｡また,後成的発がんにおけるアポトーシス,およびギャップ結合による情報伝達のそれぞれの役割についても触れた｡その結果,非遺伝毒性的な発がん物質の作用の様式とメカニズムやこれによる後成的な影響などについては解明さ れつつあり,特に,これらの発がん物質がゲノムDNAに対し直接的な相互作用,突然変異,修飾などを行う発がん物質とは機能的に異なった作用をすることが明らかになった｡また,これらは放射線発がんなど低線量放射線の健康への影響などについて研究する上で,重要な知見となっていることもわかった。 |
| Keywords | 化学発がん (chemical carcinogenesis) 非遺伝毒性 (nongenotoxicity) 後成説 (epigenesis) 酸化的ストレス (oxidative stress) ギャップ結合 (gap junction) |
| Publication Title | 岡山大学医学部保健学科紀要 |
| Published Date | 2003-12-25 |
| Volume | volume14 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 14 |
| ISSN | 1345-0948 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307816 |
| Author | Yamaoka, Kiyonori| Kataoka, Takahiro| Nomura, Takaharu| Taguchi, Takehito| Wang, Da-Hong| Mori, Shuji| Hanamoto, Katsumi| Kira, Shohei| |
|---|---|
| Published Date | 2004-05-07 |
| Publication Title | Journal of Radiation Research |
| Volume | volume45 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yamaoka, Kiyonori| Mitsunobu, Fumihiro| Kojima, Shuji| Shibakura, Misako| Kataoka, Takahiro| Hanamoto, Katsumi| Tanizaki, Yoshiro| |
|---|---|
| Published Date | 2005-04-01 |
| Publication Title | Journal of Radiation Research |
| Volume | volume46 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2007-11-21 |
| Publication Title | Journal of Radiation Research |
| Volume | volume48 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| |
|---|---|
| Published Date | 2008-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Nakagawa, Shinya| Kataoka, Takahiro| Sakoda, Akihiro| Ishimori, Yuu| Hanamoto, Katsumi| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2008-04-25 |
| Publication Title | RADIOISOTOPES |
| Volume | volume57 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Nakagawa, Shinya| Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Sakoda, Akihiro| Nomura, Takaharu| Wang, Da-Hong| Kawabe, Atsushi| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2008-07 |
| Publication Title | Journal of Clinical Biochemistry and Nutrition |
| Volume | volume43 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Mizuguchi, Yuko| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2009-09 |
| Publication Title | Journal of Clinical Biochemistry and Nutrition |
| Volume | volume45 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/45267 |
|---|---|
| FullText URL | 65_2_91.pdf |
| Author | Nagamatsu, Tomohiro| Sakoda, Akihiro| Kataoka, Takahiro| Ono, Toshiro| Yamaoka, Kiyonori| |
| Abstract | No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics. |
| Keywords | tobacco radionuclides smoking intake radiation exposure |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-04 |
| Volume | volume65 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 91 |
| End Page | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21519366 |
| Web of Science KeyUT | 000289818800004 |
| Author | Kataoka, Takahiro| Sakoda, Akihiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Toyota, Teruaki| Nishiyama, Yuichi| Yamato, Keiko| Ishimori, Yuu| Kawabe, Atsushi| Hanamoto, Katsumi| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2011-07 |
| Publication Title | Radiation Protection Dosimetry |
| Volume | volume146 |
| Issue | issue1-3 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Sakoda, Akihiro| Ishimori, Yuu| Toyota, Teruaki| Nishiyama, Yuichi| Tanaka, Hiroshi| Mitsunobu, Fumihiro| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2011-11-22 |
| Publication Title | Journal of Radiation Research |
| Volume | volume52 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Nishiyama, Yuichi| Toyota, Teruaki| Yoshimoto, Masaaki| Sakoda, Akihiro| Ishimori, Yuu| Aoyama, Yutaka| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | Inflammation |
| Volume | volume34 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Toyota, Teruaki| Kataoka, Takahiro| Nishiyama, Yuichi| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012 |
| Publication Title | Mediators of Inflammation |
| Volume | volume2012 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Tokunaga, Rikizo| Sakoda, Akihiro| Kawabe, Atsushi| Hanamoto, Katsumi| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012-01-27 |
| Publication Title | RADIOISOTOPES |
| Volume | volume61 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yoshimoto, Masaaki| Kataoka, Takahiro| Toyota, Teruaki| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012-02-01 |
| Publication Title | Inflammation |
| Volume | volume35 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012-02-09 |
| Publication Title | ISRN Endocrinology |
| Volume | volume2012 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Nishiyama, Yuichi| Yamato, Keiko| Monden, Mayuko| Ishimori, Yuu| Nomura, Takaharu| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012-04-01 |
| Publication Title | Inflammation |
| Volume | volume35 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nishiyama, Yuichi| Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Ishimori, Yuu| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012-05-29 |
| Publication Title | RADIOISOTOPES |
| Volume | volume61 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Nishiyama, Yuichi| Yamato, Keiko| Teraoka, Junichi| Morii, Yuji| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012-07-31 |
| Publication Title | Journal of Radiation Research |
| Volume | volume53 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Kataoka, Takahiro| Yamato, Keiko| Nishiyama, Yuichi| Morii, Yuji| Etani, Reo| Takata, Yuji| Hanamoto, Katsumi| Kawabe, Atsuishi| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2012-10 |
| Publication Title | Renal Failure |
| Volume | volume34 |
| Issue | issue9 |
| Content Type | Journal Article |
