JaLCDOI 10.18926/15202
Title Alternative Recent trend of research on the nongenotoxic mechanisms of chemical carcinogenesis
FullText URL 014_1_001_014.pdf
Author Yamaoka, Kiyonori| Hanamoto, Katsumi| Ina, Yasuhiro| Kataoka, Takahiro| Kawabe, Atsusi| Sano, Masanobu| Ujifuku, Ayako|
Abstract 本総説は,筆者らが進めている「低線量放射線の健康への影響と医療への応用」に関する研究に資するために調査した,化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向の概要についてまとめたものである。即ち,非遺伝毒性的発がんにおける細胞増殖,シトクロムP450誘導,酸化的ストレス,および遺伝子発現のそれぞれの役割,並びに量的な応答性について言及した。また,後成的発がんにおけるアポトーシス,およびギャップ結合による情報伝達のそれぞれの役割についても触れた。その結果,非遺伝毒性的な発がん物質の作用の様式とメカニズムやこれによる後成的な影響などについては解明さ れつつあり,特に,これらの発がん物質がゲノムDNAに対し直接的な相互作用,突然変異,修飾などを行う発がん物質とは機能的に異なった作用をすることが明らかになった。また,これらは放射線発がんなど低線量放射線の健康への影響などについて研究する上で,重要な知見となっていることもわかった。
Abstract Alternative To elucidate the health effects by low dose radiation, we reviewed the recent trend of research on the epigenetic mechanisms of chemical carcinogenesis. The following view were obtained. It has become apparent that chemical and physical agents that induce cancer may do so through different cellular and molecular mechanisms. Investigators, recognizing the apparent differences in the ways compounds participate in the carcinogenesis process, coined the phrases "genotoxic" and "epigenetic" in describing activities of chemicals and physical agents that induced cancer. The term "nongenotoxic" has to some extent replaced "epigenetic" and thus, classification of chemical carcinogens has been frequently delegated to either the genotoxic or nongenotoxic categories. Moreover, while much work remains in the understanding of the modes and mechanisms of action of nongenotoxic carcinogens and the epigenetic effects of these agents, it is apparent that this category of chemicals are functionally different than those compounds which directly interact, mutate, and modify genomic DNA.
Keywords 化学発がん (chemical carcinogenesis) 非遺伝毒性 (nongenotoxicity) 後成説 (epigenesis) 酸化的ストレス (oxidative stress) ギャップ結合 (gap junction)
Publication Title 岡山大学医学部保健学科紀要
Published Date 2003-12-25
Volume volume14
Issue issue1
Start Page 1
End Page 14
ISSN 1345-0948
language 日本語
File Version publisher
NAID 120002307816
Author Nakagawa, Shinya| Kataoka, Takahiro| Sakoda, Akihiro| Ishimori, Yuu| Hanamoto, Katsumi| Yamaoka, Kiyonori|
Published Date 2008-04-25
Publication Title RADIOISOTOPES
Volume volume57
Issue issue4
Content Type Journal Article
Author Kataoka, Takahiro| Tokunaga, Rikizo| Sakoda, Akihiro| Kawabe, Atsushi| Hanamoto, Katsumi| Yamaoka, Kiyonori|
Published Date 2012-01-27
Publication Title RADIOISOTOPES
Volume volume61
Issue issue1
Content Type Journal Article
FullText URL fulltext.pdf
Author Kataoka, Takahiro| Shuto, Hina| Yano, Junki| Naoe, Shota| Ishida, Tsuyoshi| Nakada, Tetsuya| Yamato, Keiko| Hanamoto, Katsumi| Nomura, Takaharu| Yamaoka, Kiyonori|
Keywords X-irradiation forced swim test antioxidants brain oxidative stress
Published Date 2020-04-29
Publication Title Journal of Radiation Research
Volume volume61
Issue issue4
Publisher OXFORD UNIV PRESS
Start Page 517
End Page 523
ISSN 0449-3060
NCID AA00705792
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © Crown copyright 2020.
File Version publisher
PubMed ID 32346734
DOI 10.1093/jrr/rraa022
Web of Science KeyUT 000593101500002
Related Url isVersionOf https://doi.org/10.1093/jrr/rraa022
Author Yamaoka, Kiyonori| Mitsunobu, Fumihiro| Kojima, Shuji| Shibakura, Misako| Kataoka, Takahiro| Hanamoto, Katsumi| Tanizaki, Yoshiro|
Published Date 2005-04-01
Publication Title Journal of Radiation Research
Volume volume46
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/61896
FullText URL 75_2_169.pdf
Author Nakada, Tetsuya| Kataoka, Takahiro| Nomura, Takaharu| Shuto, Hina| Yano, Junki| Naoe, Shota| Hanamoto, Katsumi| Yamaoka, Kiyonori|
Abstract The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent.
Keywords low-dose-rate γ-irradiation forced swim test antioxidant oxidative stress
Amo Type Original Article
Published Date 2021-04
Publication Title Acta Medica Okayama
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 169
End Page 175
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953424
NAID 120007029890
Author Kataoka, Takahiro|
Published Date 2008-03-25
Publication Title
Content Type Thesis or Dissertation
Author Kataoka, Takahiro| Sakoda, Akihiro| Ishimori, Yuu| Toyota, Teruaki| Nishiyama, Yuichi| Tanaka, Hiroshi| Mitsunobu, Fumihiro| Yamaoka, Kiyonori|
Published Date 2011-11-22
Publication Title Journal of Radiation Research
Volume volume52
Issue issue6
Content Type Journal Article
Author Kataoka, Takahiro| Sakoda, Akihiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Toyota, Teruaki| Nishiyama, Yuichi| Yamato, Keiko| Ishimori, Yuu| Kawabe, Atsushi| Hanamoto, Katsumi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2011-07
Publication Title Radiation Protection Dosimetry
Volume volume146
Issue issue1-3
Content Type Journal Article
FullText URL fulltext.pdf
Author Kataoka, Takahiro| Shuto, Hina| Naoe, Shota| Yano, Junki| Kanzaki, Norie| Sakoda, Akihiro| Tanaka, Hiroshi| Hanamoto, Katsumi| Mitsunobu, Fumihiro| Terato, Hiroaki| Yamaoka, Kiyonori|
Keywords radon oxidative DNA damage Mn-superoxide dismutase (SOD) 8-oxoguanine DNA glycosylase
Published Date 2021-08-09
Publication Title Journal of Radiation Research
Volume volume62
Issue issue5
Publisher Oxford University Press
Start Page 861
End Page 867
ISSN 0449-3060
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 34370027
DOI 10.1093/jrr/rrab069
Web of Science KeyUT 000700078300014
Related Url isVersionOf https://doi.org/10.1093/jrr/rrab069
Author Kataoka, Takahiro| Nishiyama, Yuichi| Toyota, Teruaki| Yoshimoto, Masaaki| Sakoda, Akihiro| Ishimori, Yuu| Aoyama, Yutaka| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2011-12-01
Publication Title Inflammation
Volume volume34
Issue issue6
Content Type Journal Article
Author Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Nishiyama, Yuichi| Yamato, Keiko| Monden, Mayuko| Ishimori, Yuu| Nomura, Takaharu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-04-01
Publication Title Inflammation
Volume volume35
Issue issue2
Content Type Journal Article
Author Nakagawa, Shinya| Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Sakoda, Akihiro| Nomura, Takaharu| Wang, Da-Hong| Kawabe, Atsushi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2008-07
Publication Title Journal of Clinical Biochemistry and Nutrition
Volume volume43
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2007-11-21
Publication Title Journal of Radiation Research
Volume volume48
Issue issue6
Content Type Journal Article
Author Yamaoka, Kiyonori| Kataoka, Takahiro| Nomura, Takaharu| Taguchi, Takehito| Wang, Da-Hong| Mori, Shuji| Hanamoto, Katsumi| Kira, Shohei|
Published Date 2004-05-07
Publication Title Journal of Radiation Research
Volume volume45
Issue issue1
Content Type Journal Article
Author Yoshimoto, Masaaki| Kataoka, Takahiro| Toyota, Teruaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-02-01
Publication Title Inflammation
Volume volume35
Issue issue1
Content Type Journal Article
Author Toyota, Teruaki| Kataoka, Takahiro| Nishiyama, Yuichi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012
Publication Title Mediators of Inflammation
Volume volume2012
Content Type Journal Article
Author Nishiyama, Yuichi| Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Ishimori, Yuu| Yamaoka, Kiyonori|
Published Date 2012-05-29
Publication Title RADIOISOTOPES
Volume volume61
Issue issue5
Content Type Journal Article
FullText URL fulltext.pdf Erratum.pdf
Author Kataoka, Takahiro| Kanzaki, Norie| Sakoda, Akihiro| Shuto, Hina| Yano, Junki| Naoe, Shota| Tanaka, Hiroshi| Hanamoto, Katsumi| Terato, Hiroaki| Mitsunobu, Fumihiro| Yamaoka, Kiyonori|
Keywords radon redox state oxidative stress antioxidative function principal component analysis
Published Date 2021-01-27
Publication Title Journal of Radiation Research
Volume volume62
Issue issue3
Publisher Oxford Univ Press
Start Page 390
End Page 400
ISSN 0449-3060
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 33503655
NAID 120007042386
DOI 10.1093/jrr/rraa129
Web of Science KeyUT 000648970300003
Related Url isVersionOf https://doi.org/10.1093/jrr/rraa129
FullText URL fulltext.pdf
Author Kobashi, Yusuke| Kataoka, Takahiro| Kanzaki, Norie| Ishida, Tsuyoshi| Sakoda, Akihiro| Tanaka, Hiroshi| Ishimori, Yuu| Mitsunobu, Fumihiro| Yamaoka, Kiyonori|
Keywords Radon Thoron Oxidative stress Antioxidative function
Note This is an Accepted Manuscript of an article published by Springer.|
Published Date 2020-04-22
Publication Title Radiation and Environmental Biophysics
Volume volume59
Issue issue3
Publisher Springer
ISSN 0301634X
NCID AA00800192
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32322961
DOI 10.1007/s00411-020-00843-0
Web of Science KeyUT 000528077400001
Related Url isVersionOf https://doi.org/10.1007/s00411-020-00843-0