JaLCDOI 10.18926/AMO/66160
FullText URL 77_6_665.pdf
Author Sakurai, Atsunobu| Uka, Mayu| Iguchi, Toshihiro| Tomita, Koji| Matsui, Yusuke| Kakiuchi, Yoshihiko| Kuroda, Shinji| Fujiwara, Toshiyoshi| Hiraki, Takao|
Abstract We report the case details of a 65-year-old Japanese man with an omental abscess that was discovered 43 days after he underwent a laparoscopic proximal gastrectomy for gastric cancer. His chief complaint was mild abdominal pain that had persisted for several days. The abscess was diagnosed as a rare postoperative complication. We hesitated to perform a reoperation given the invasiveness of general anesthesia and surgery, plus the possibility of postoperative adhesions and because the patient’s general condition was stable and he had only mild abdominal pain. Percutaneous drainage using a 10.2-F catheter was performed with the patient under conscious sedation and computed tomography–fluoroscopy guidance, with no complications. After the procedure, the size of the abscess cavity was remarkably reduced, and 23 days later the catheter was withdrawn.
Keywords drainage omental abscess omental infarction proximal gastrectomy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 665
End Page 669
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145942
Web of Science KeyUT 001164631200013
FullText URL fulltext20231030-01.pdf fig20231030-01.pdf table20231030-01.pdf suppl20231030-01.pdf
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Choda, Yasuhiro| Otsuka, Shinya| Ueyama, Satoshi| Tanaka, Norimitsu| Muraoka, Atsushi| Hato, Shinji| Kamikawa, Yasuaki| Fujiwara, Toshiyoshi|
Keywords Double -flap technique Gastric cancer Prognostic factor Prognostic nutritional index Proximal gastrectomy
Note © 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Sep. 2024.|
Published Date 2023-10
Publication Title Surgical Oncology
Volume volume50
Publisher Elsevier BV
Start Page 101990
ISSN 0960-7404
NCID AA10850448
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier Ltd.
File Version author
PubMed ID 37717376
DOI 10.1016/j.suronc.2023.101990
Web of Science KeyUT 001082185900001
Related Url isVersionOf https://doi.org/10.1016/j.suronc.2023.101990
FullText URL fulltext.pdf
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Gastric cancer (GC) elderly stage IA comorbidity Charlson comorbidity index (CCI)
Published Date 2022-10
Publication Title Journal of Gastrointestinal Oncology
Volume volume13
Issue issue5
Publisher AME Publishing Company
Start Page 2178
End Page 2185
ISSN 2078-6891
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Journal of Gastrointestinal Oncology.
File Version publisher
PubMed ID 36388703
DOI 10.21037/jgo-22-527
Web of Science KeyUT 000864732300001
Related Url isVersionOf https://doi.org/10.21037/jgo-22-527
FullText URL fulltext20230720-02.pdf fig20230720-02.pdf suppl_table20230720-02.pdf suppl_fig20230720-02.pdf
Author Yoshimoto, Masashi| Kagawa, Shunsuke| Kajioka, Hiroki| Taniguchi, Atsuki| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Yagi, Tomohiko| Nogi, Shohei| Teraishi, Fuminori| Shigeyasu, Kunitoshi| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jul. 2024.|
Published Date 2023-07-28
Publication Title Cancer Letters
Volume volume567
Publisher Elsevier BV
Start Page 216260
ISSN 0304-3835
NCID AA00598513
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 37295551
DOI 10.1016/j.canlet.2023.216260
Web of Science KeyUT 001020524700001
Related Url isVersionOf https://doi.org/10.1016/j.canlet.2023.216260
FullText URL fulltext.pdf
Author Kashima, Hajime| Kikuchi, Satoru| Kuroda, Shinji| Fujiwara, Toshiyoshi|
Keywords lecs local resection esophagogastric junction hiatal hernia laparoscopic surgery leiomyoma gastric submucosal tumor
Published Date 2023-04-20
Publication Title Cureus
Volume volume15
Issue issue4
Publisher Springer
Start Page e37902
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Kashima et al.
File Version publisher
PubMed ID 37223198
DOI 10.7759/cureus.37902
Web of Science KeyUT 000995995400012
Related Url isVersionOf https://doi.org/10.7759/cureus.37902
JaLCDOI 10.18926/AMO/64368
FullText URL 77_1_91.pdf
Author Takahashi, Toshiaki| Kakiuchi, Yoshihiko| Kikuch, Satoru| Kuroda, Shinji| Takeda, Sho| Shigeyasu, Kunitoshi| Kondo, Yoshitaka| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract An annular pancreas is a rare anomaly of the pancreas, defined as pancreatic tissue that totally or partly encircles the duodenum, usually the descending portion. A 76-year-old man who was diagnosed with gastric cancer cT3N0M0 Stage IIB underwent laparoscopic distal gastrectomy with D2 lymph node dissection. Intraoperatively, the dorsal half of the duodenal bulb was seen to be half surrounded by the pancreas, and a non-typical annular pancreas was diagnosed. Because of the risk to the pancreas, it was considered impossible to perform anastomosis by a linear stapler as in the usual laparoscopic procedure. Therefore, we performed laparoscopically assisted distal gastrectomy and Billroth-I reconstruction using a circular stapler, and the surgery was completed without difficulties. His postoperative course was good despite the development of a pancreatic fistula, which was an International Study Group for Pancreas Fistula biochemical leak. Some APs can be diagnosed preoperatively, but the rarer subtypes such as ours are more difficult to visualize on imaging. In gastrectomy, it is both oncologically important and technically challenging to perform lymph node dissection around the pancreas. In this case with an especially proximal pancreas, a circular stapler was considered better suited for gastroduodenal anastomosis and required a broader field than that afforded by laparoscopy. A case of non-typical annular pancreas diagnosed during laparoscopic gastric surgery is described.
Keywords annular pancreas gastric cancer laparoscopic distal gastrectomye
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 91
End Page 95
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849152
Web of Science KeyUT 000952978000002
FullText URL fulltext.pdf
Author Kakiuchi, Yoshihiko| Kikuchi, Satoru| Kuroda, Shinji| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Remnant gastric cancer Prognostic factor Tumor-infiltrating lymphocytes CD8(+) T cell Tumor immunity
Published Date 2022-11-30
Publication Title World Journal Of Surgical Oncology
Volume volume20
Issue issue1
Publisher BMC
Start Page 374
ISSN 1477-7819
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36451224
DOI 10.1186/s12957-022-02853-2
Web of Science KeyUT 000892980100002
Related Url isVersionOf https://doi.org/10.1186/s12957-022-02853-2
FullText URL fulltext.pdf
Author Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2022-12-15
Publication Title Molecular Therapy - Oncolytics
Volume volume27
Publisher Cell Press
Start Page 3
End Page 13
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 36212775
DOI 10.1016/j.omto.2022.09.003
Web of Science KeyUT 000870232500001
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.09.003
FullText URL fulltext20221020-1.pdf figure20221020-1.pdf table20221020-1.pdf ASO_Takata_Supplementary.pdf
Author Takata, Nobuo| Kikuchi, Satoru| Kuroda, Shinji| Tanabe, Shunsuke| Maeda, Naoaki| Noma, Kazuhiro| Takahashi, Ayako| Umeda, Yuzo| Shikata, Kenichi| Ozaki, Kazuhide| Fujiwara, Toshiyoshi|
Keywords Gastric cancer Gastrectomy Body weight loss Skeletal muscle loss Nutritional counseling
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1245/s10434-022-12572-3| This fulltext is available in Sep. 2023.|
Published Date 2022-09-25
Publication Title Annals of Surgical Oncology
Volume volume30
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 1110
End Page 1118
ISSN 1068-9265
NCID AA11016573
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Society of Surgical Oncology 2022
File Version author
PubMed ID 36161371
DOI 10.1245/s10434-022-12572-3
Web of Science KeyUT 000858651900003
Related Url isVersionOf https://doi.org/10.1245/s10434-022-12572-3
FullText URL fulltext.pdf
Author Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2022-06-16
Publication Title Molecular Therapy-Oncolytics
Volume volume25
Publisher Cell Press
Start Page 249
End Page 261
ISSN 2372-7705
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35615263
DOI 10.1016/j.omto.2022.04.009
Web of Science KeyUT 000800437000008
Related Url isVersionOf https://doi.org/10.1016/j.omto.2022.04.009
JaLCDOI 10.18926/AMO/63425
FullText URL 76_2_203.pdf
Author Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression.
Keywords esophageal cancer EMT TGF-β oncolytic adenovirus E1A
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-04
Volume volume76
Issue issue2
Publisher Okayama University Medical School
Start Page 203
End Page 215
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35503449
Web of Science KeyUT 000792291900003
FullText URL fulltext20220131-2.pdf
Author Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Takeda, Sho| Kikuchi, Satoru| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Gastric cancer D2 lymphadenectomy Suprapancreatic lymphadenectomy Posterior hepatic plexus Distal gastrectomy
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00423-022-02437-4|
Published Date 2022-1-12
Publication Title Langenbeck's Archives of Surgery
Volume volume407
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 871
End Page 877
ISSN 1435-2443
NCID AA11211080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
File Version author
PubMed ID 35022835
DOI 10.1007/s00423-022-02437-4
Web of Science KeyUT 000741939500003
Related Url isVersionOf https://doi.org/10.1007/s00423-022-02437-4
FullText URL fulltext20211210-1.pdf
Author Hamada, Kenta| Kawahara, Yoshiro| Tanimoto, Takayoshi| Ohto, Akimitsu| Toda, Akira| Aida, Toshiaki| Yamasaki, Yasushi| Gotoda, Tatsuhiro| Ogawa, Taiji| Abe, Makoto| Okanoue, Shotaro| Takei, Kensuke| Kikuchi, Satoru| Kuroda, Shinji| Fujiwara, Toshiyoshi| Okada, Hiroyuki|
Keywords Artificial intelligence convolutional neural network early gastric cancer endoscopic image invasion depth
Note This is the peer reviewed version of the following article: [Hamada, K., Kawahara, Y., Tanimoto, T., Ohto, A., Toda, A., Aida, T., Yamasaki, Y., Gotoda, T., Ogawa, T., Abe, M., Okanoue, S., Takei, K., Kikuchi, S., Kuroda, S., Fujiwara, T., and Okada, H. (2021) Application of convolutional neural networks for evaluating the depth of invasion of early gastric cancer based on endoscopic images, Journal of Gastroenterology and Hepatology], which has been published in final form at [https://doi.org/10.1111/jgh.15725]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
Published Date 2021-11-25
Publication Title Journal of Gastroenterology and Hepatology
Publisher Wiley
Start Page 1
ISSN 0815-9319
NCID AA10727383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
File Version author
PubMed ID 34713495
DOI 10.1111/jgh.15725
Web of Science KeyUT 000722466600001
Related Url isVersionOf https://doi.org/10.1111/jgh.15725
FullText URL fulltext20211015-3.pdf figure20211015-3.pdf Suppl_Information20211015-3.pdf
Author Kakiuchi, Yoshihiko| Kuroda, Shinji| Kanaya, Nobuhiko| Kumon, Kento| Tsumura, Tomoko| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Hamada, Yuki| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Exosome Abscopal effect Oncolytic adenovirus Local treatment Systemic delivery Drug delivery system
Note © 2021 The American Society of Gene and Cell Therapy. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ymthe.2021.05.015] .|
Published Date 2021-05-21
Publication Title Molecular Therapy
Volume volume29
Issue issue10
Publisher The American Society of Gene and Cell Therapy
Start Page 2920
End Page 2930
ISSN 15250016
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The American Society of Gene and Cell Therapy.
File Version author
PubMed ID 34023506
DOI 10.1016/j.ymthe.2021.05.015
Web of Science KeyUT 000708324600008
Related Url isVersionOf https://doi.org/10.1016/j.ymthe.2021.05.015
FullText URL fulltext20210831-3.pdf
Author Shirakawa, Yasuhiro| Tazawa, Hiroshi| Tanabe, Shunsuke| Kanaya, Nobuhiko| Noma, Kazuhiro| Koujima, Takeshi| Kashima, Hajime| Kato, Takuya| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Katsui, Kuniaki| Kanazawa, Susumu| Urata, Yasuo| Fujiwara, Toshiyoshi|
Keywords Telomerase adenovirus radiotherapy esophageal cancer immunotherapy
Note © 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .|
Published Date 2021-8
Publication Title European Journal of Cancer
Volume volume153
Publisher Elsevier BV
Start Page 98
End Page 108
ISSN 0959-8049
NCID AA1075407X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Elsevier Ltd.
File Version author
PubMed ID 34153720
DOI 10.1016/j.ejca.2021.04.043
Web of Science KeyUT 000686051300013
Related Url isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043
FullText URL fulltext20210608-1.pdf highlights20210608-1.pdf figure20210608-1.pdf table20210608-1.pdf supplement20210608-1.pdf
Author Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kuwada, Kazuya| Tsumura, Tomoko| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi|
Note This is an Accepted Manuscript of an article published by Elsevier BV. © 2021 IJS Publishing Group Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ijsu.2021.105946] . |
Published Date 2021-5
Publication Title International Journal of Surgery
Volume volume89
Publisher Elsevier BV
Start Page 105946
ISSN 1743-9191
NCID AA12063080
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 IJS Publishing Group Ltd.
File Version author
PubMed ID 33892160
DOI 10.1016/j.ijsu.2021.105946
Web of Science KeyUT 000651625600016
Related Url isVersionOf https://doi.org/10.1016/j.ijsu.2021.105946
FullText URL fulltext20210607-4.pdf table1-20210607-4.pdf table2-20210607-4.pdf figure-20210607-4.pdf
Author Kikuchi, Satoru| Kagawa, Tetsuya| Kuroda, Shinji| Nishizaki, Masahiko| Takata, Nobuo| Kuwada, Kazuya| Shoji, Ryohei| Kakiuchi, Yoshihiko| Mitsuhashi, Toshiharu| Umeda, Yuzo| Noma, Kazuhiro| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Keywords Endoscopic surgical skill quantification system Qualified surgeon Laparoscopic distal gastrectomy Gastric cancer Cumulative sum analysis
Note This is a post-peer-review, pre-copyedit version of an article published in [Surgery Today]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-021-02309-2|
Published Date 2021-5-29
Publication Title Surgery Today
Volume volume51
Publisher Springer Science and Business Media LLC
Start Page 1978
End Page 1984
ISSN 0941-1291
NCID AA10824685
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Springer Nature Singapore Pte Ltd. 2021
File Version author
PubMed ID 34050804
DOI 10.1007/s00595-021-02309-2
Web of Science KeyUT 000655944300001
Related Url isVersionOf https://doi.org/10.1007/s00595-021-02309-2
FullText URL fulltext20210608.pdf
Author Umeda, Hibiki| Kikuchi, Satoru| Kuroda, Shinji| Yano, Shuya| Tanaka, Takehiro| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Umeda, Yuzo| Fujiwara, Toshiyoshi|
Keywords Gastric yolk sac Tumor-like carcinoma Adenocarcinoma Alpha-fetoprotein
Published Date 2021-05-06
Publication Title Surgical Case Reports
Volume volume7
Issue issue1
Publisher Springer
Start Page 111
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 33956241
DOI 10.1186/s40792-021-01199-3
NAID 120007045008
Web of Science KeyUT 000656467700001
Related Url isVersionOf https://doi.org/10.1186/s40792-021-01199-3
JaLCDOI 10.18926/AMO/61906
FullText URL 75_2_231.pdf
Author Endo, Motochika| Yano, Shuya| Asano, Hiroaki| Takeda, Sho| Hamada, Yuki| Kondo, Yoshitaka| Kuroda, Shinji| Shigeyasu, Kunitoshi| Kikuchi, Satoru| Tanaka, Takehiro| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
Keywords primary gastrointestinal melanoma laparoscopic surgery immune checkpoint antibody-blockade inhibitor
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 231
End Page 238
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953431
NAID 120007029881
FullText URL fulltext.pdf
Author Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
Published Date 2021-01-28
Publication Title BMC Cancer
Volume volume21
Issue issue1
Publisher BMC
Start Page 102
ISSN 1471-2407
NCID AA12034763
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33509150
DOI 10.1186/s12885-021-07816-6
Web of Science KeyUT 000615987400002
Related Url isVersionOf https://doi.org/10.1186/s12885-021-07816-6