Author Rai, Kammei| Takigawa, Nagio| Ito, Sachio| Kashihara, Hiromi| Ichihara, Eiki| Yasuda, Tatsuji| Shimizu, Kenji| Tanimoto, Mitsune| Kiura, Katsuyuki|
Published Date 2012-12-03
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue3
Content Type Journal Article
Author Rai, Kammei| Takigawa, Nagio| Ito, Sachio| Kashihara, Hiromi| Ichihara, Eiki| Yasuda, Tatsuji| Shimizu, Kenji| Tanimoto, Mitsune| Kiura, Katsuyuki|
Published Date 2011-09
Publication Title Molecular Cancer Therapeutics
Volume volume10
Issue issue9
Content Type Journal Article
Author Kubo, Toshio| Takigawa, Nagio| Osawa, Masahiro| Harada, Daijiro| Ninomiya, Takashi| Ochi, Nobuaki| Ichihara, Eiki| Yamane, Hiromichi| Tanimoto, Mitsune| Kiura, Katsuyuki|
Published Date 2013-01
Publication Title Cancer Science
Volume volume104
Issue issue1
Content Type Journal Article
Author Harada, Daijiro| Takigawa, Nagio| Ochi, Nobuaki| Ninomiya, Takashi| Yasugi, Masayuki| Kubo, Toshio| Takeda, Hiromasa| Ichihara, Eiki| Ohashi, Kadoaki| Takata, Saburo| Tanimoto, Mitsune| Kiura, Katsuyuki|
Published Date 2012-10
Publication Title Cancer Science
Volume volume103
Issue issue10
Content Type Journal Article
JaLCDOI 10.18926/AMO/54499
FullText URL 70_4_243.pdf
Author Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki|
Abstract Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p<0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation.
Keywords vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 243
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549668
Web of Science KeyUT 000384748600003
JaLCDOI 10.18926/AMO/55446
FullText URL 71_5_453.pdf
Author Taniguchi, Akihiko| Miyahara, Nobuaki| Oda, Naohiro| Morichika, Daisuke| Ichihara, Eiki| Oze, Isao| Tanimoto, Yasushi| Ichikawa, Hirohisa| Fujii, Utako| Tanimoto, Mitsune| Kanehiro, Arihiko| Kiura, Katsuyuki|
Abstract Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication. The primary endpoint is the rate of mild-to-severe COPD exacerbation. The results of this study will clarify whether bisoprolol can prevent exacerbation in COPD patients without heart failure.
Keywords chronic obstructive pulmonary disease β-blocker bisoprolol exacerbation heart failure
Amo Type Clinical Study Protocol
Publication Title Acta Medica Okayama
Published Date 2017-10
Volume volume71
Issue issue5
Publisher Okayama University Medical School
Start Page 453
End Page 457
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 29042706
FullText URL J_Thorac_Oncol_201907017.pdf
Author Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Nishii, Kazuya| Matsubara, Takehiro| Kayatani, Hiroe| Higo, Hisao| Ninomiya, Kiichiro| Sato, Akiko| Watanabe, Hiromi| Kano, Hirohisa| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Takata, Minoru| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords ALK G1202R Alectinib Amphiregulin MET NSCLC
Published Date 2019-07-30
Publication Title Journal of Thoracic Oncology
Volume volume14
Issue issue11
Publisher Elsevier
Start Page 2009
End Page 2018
ISSN 15560864
NCID AA12058455
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
File Version author
PubMed ID 31374369
DOI 10.1016/j.jtho.2019.07.017
Web of Science KeyUT 000492678300025
Related Url isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017
JaLCDOI 10.18926/AMO/58271
FullText URL 74_2_129.pdf
Author Fukuma, Shogo| Shinya, Takayoshi| Soh, Junichi| Fukuhara, Ryuichiro| Ogawa, Nanako| Higaki, Fumiyo| Tanaka, Takehiro| Ichihara, Eiki| Hiraki, Takao| Toyooka, Shinichi| Kanazawa, Susumu|
Abstract The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types.
Keywords differentiation dynamic computed tomography primary lung cancer enhancement pattern
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 135
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341587
Web of Science KeyUT 000528278500006
NAID 120006839450
FullText URL fulltext.pdf
Author Matsuoka, Natsumi| Tsuji, Kenji| Ichihara, Eiki| Hara, Takayuki| Fukushima, Kazuhiko| Toma, Kishio| Kitamura, Shinji| Inagaki, Kenichi| Sugiyama, Hitoshi| Wada, Jun|
Keywords Pembrolizumab Hypothyroidism Creatinine Cystatin C
Published Date 2020-03-31
Publication Title BMC Nephrology
Volume volume21
Publisher BMC
Start Page 113
ISSN 1471-2369
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32234009
DOI 10.1186/s12882-020-01775-z
Web of Science KeyUT 000522961400004
Related Url isVersionOf https://doi.org/10.1186/s12882-020-01775-z
FullText URL fulltext.pdf
Author Kano, Hirohisa| Ichihara, Eiki| Harada, Daijiro| Inoue, Koji| Kayatani, Hiroe| Hosokawa, Shinobu| Kishino, Daizo| Watanabe, Kazuhiko| Ochi, Nobuaki| Oda, Naohiro| Hara, Naofumi| Ninomiya, Kiichiro| Hotta, Katsuyuki| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords immune checkpoint inhibitor non-small cell-lung cancer PD-L1 pembrolizumab poor performance status
Published Date 2020-07-29
Publication Title Cancer Science
Volume volume111
Issue issue10
Publisher Wiley
Start Page 3739
End Page 3746
ISSN 1347-9032
NCID AA11808050
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32726470
DOI 10.1111/cas.14590
Web of Science KeyUT 000562490200001
Related Url isVersionOf https://doi.org/10.1111/cas.14590
JaLCDOI 10.18926/AMO/60802
FullText URL 74_5_423.pdf
Author Hirabae, Atsuko| Ichihara, Eiki| Sunami, Ryota| Ota, Moeko| Iwamoto, Yoshitaka| Maeda, Yoshinobu| Kiura, Katsuyuki|
Abstract We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replacement of almost the entire liver with cancer over a period of 5 weeks.
Keywords lung cancer immune checkpoint inhibitors pembrolizumab hyperprogression
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 423
End Page 425
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106698
Web of Science KeyUT 000581970100007
NAID 120006892928
FullText URL fulltext.pdf
Author Ichihara, Eiki| Miyahara, Nobuaki| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords lung cancer interstitial pneumonia
Published Date 2020-01-15
Publication Title Internal Medicine
Volume volume59
Issue issue2
Publisher 日本内科学会
Start Page 163
End Page 167
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 31534086
NAID 130007785095
DOI 10.2169/internalmedicine.3481-19
Web of Science KeyUT 000507577600002
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.3481-19
FullText URL fulltext.pdf
Author Watanabe, Hiromi| Ichihara, Eiki| Kayatani, Hiroe| Makimoto, Go| Ninomiya, Kiichiro| Nishii, Kazuya| Higo, Hisao| Ando, Chihiro| Okawa, Sachi| Nakasuka, Takamasa| Kano, Hirohisa| Hara, Naofumi| Hirabae, Atsuko| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Published Date 2021-01-07
Publication Title Cancer science
Publisher Wiley
ISSN 1347-9032
NCID AA11808050
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
PubMed ID 33410241
NAID 120007008532
DOI 10.1111/cas.14801
Web of Science KeyUT 000630136900001
Related Url isVersionOf https://doi.org/10.1111/cas.14801
FullText URL fulltext20210810-3.pdf
Author Nishii, Kazuya| Ohashi, Kadoaki| Watanabe, Hiromi| Makimoto, Go| Nakasuka, Takamasa| Higo, Hisao| Ninomiya, Kiichiro| Kato, Yuka| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords epidermal growth factor receptor osimertinib bevacizumab cetuximab hypoxia‑inducible factor‑1α transforming growth factor‑α
Published Date 2021-7-7
Publication Title Oncology Letters
Volume volume22
Issue issue3
Publisher Spandidos Publications
Start Page 639
ISSN 1792-1074
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Nishii et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
File Version publisher
DOI 10.3892/ol.2021.12900
Web of Science KeyUT 000678494600001
Related Url isVersionOf https://doi.org/10.3892/ol.2021.12900
FullText URL fulltext.pdf
Author Okawa, Sachi| Rai, Kammei| Fujii, Nobuharu| Gion, Yuka| Ninomiya, Kiichiro| Kato, Yuka| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Ohashi, Kadoaki| Miyahara, Nobuaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords EGFR IgG4-related disease marginal zone lymphoma osimertinib
Published Date 2021-09-01
Publication Title Internal Medicine
Volume volume60
Issue issue17
Publisher The Japanese Society of Internal Medicine
Start Page 2831
End Page 2837
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33775999
DOI 10.2169/internalmedicine.6470-20
Web of Science KeyUT 000695856000020
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6470-20
FullText URL fulltext.pdf
Author Higo, Hisao| Ohashi, Kadoaki| Tomida, Shuta| Okawa, Sachi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Senoo, Satoru| Makimoto, Go| Ninomiya, Kiichiro| Nakasuka, Takamasa| Nishii, Kazuya| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Toyooka, Shinichi| Kiura, Katsuyuki|
Keywords Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy
Published Date 2022-02-07
Publication Title Respiratory Research
Volume volume23
Issue issue1
Publisher BMC
Start Page 20
ISSN 1465-993X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35130915
DOI 10.1186/s12931-022-01940-y
Web of Science KeyUT 000752386100002
Related Url isVersionOf https://doi.org/10.1186/s12931-022-01940-y
FullText URL fulltext.pdf
Author Ando, Eri| Nakasuka, Takamasa| Kubo, Toshio| Taniguchi, Akihiko| Ninomiya, Kiichiro| Kato, Yuka| Ichihara, Eiki| Ohashi, Kadoaki| Rai, Kammei| Hotta, Katsuyuki| Yamane, Masaomi| Miyahara, Nobuaki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords pulmonary aspergilloma allergic bronchopulmonary aspergillosis disaster
Published Date 2022-02-01
Publication Title Internal Medicine
Volume volume61
Issue issue3
Publisher JAPAN SOC INTERNAL MEDICINE
Start Page 379
End Page 383
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 34373373
DOI 10.2169/internalmedicine.7124-21
Web of Science KeyUT 000752787300015
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.7124-21
FullText URL fulltext.pdf
Author Makimoto, Go| Shimonishi, Atsushi| Ohashi, Kadoaki| Ninomiya, Kiichiro| Higo, Hisao| Kato, Yuka| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords MET Tepotinib Non-small-cell lung cancer
Published Date 2022
Publication Title Case Reports In Oncology
Volume volume15
Issue issue2
Publisher Karger
Start Page 494
End Page 498
ISSN 1662-6575
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35702678
DOI 10.1159/000524326
Web of Science KeyUT 000864085100005
Related Url isVersionOf https://doi.org/10.1159/000524326
FullText URL fulltext.pdf
Author Nishimura, Tomoka| Ichihara, Eiki| Yokoyama, Toshihide| Inoue, Koji| Tamura, Tomoki| Sato, Ken| Oda, Naohiro| Kano, Hirohisa| Kishino, Daizo| Kawai, Haruyuki| Inoue, Masaaki| Ochi, Nobuaki| Fujimoto, Nobukazu| Ichikawa, Hirohisa| Ando, Chihiro| Hotta, Katsuyuki| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords pleural effusion non-small cell carcinoma immune checkpoint inhibitors
Published Date 2022-12-14
Publication Title Cancers
Volume volume14
Issue issue24
Publisher MDPI
Start Page 6184
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36551668
DOI 10.3390/cancers14246184
Web of Science KeyUT 000900618600001
Related Url isVersionOf https://doi.org/10.3390/cancers14246184
Author Nakasuka, Takamasa| Ohashi, Kadoaki| Nishii, Kazuya| Hirabae, Atsuko| Okawa, Sachi| Tomonobu, Nahoko| Takada, Kenji| Ando, Chihiro| Watanabe, Hiromi| Makimoto, Go| Ninomiya, Kiichiro| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Kumon, Hiromi| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords EGFR mutation Non-small cell lung cancer Antitumor immunity Non-inflamed tumor Ad-SGE-REIC Gene therapy PD-1
Note ©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.lungcan.2023.01.018.| This fulltext file will be available in Apr. 2024.|
Published Date 2023-04
Publication Title Lung Cancer
Volume volume178
Publisher Elsevier BV
Start Page 1
End Page 10
ISSN 0169-5002
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 36753780
DOI 10.1016/j.lungcan.2023.01.018
Web of Science KeyUT 000931976300001
Related Url isVersionOf https://doi.org/10.1016/j.lungcan.2023.01.018