| Author | Nishiyama, Yuichi| Hanafusa, Tadashi| Yamashita, Jun| Yamamoto, Yoko| Ono, Toshiro| |
|---|---|
| Published Date | 2015-06-20 |
| Publication Title | Journal of Radioanalytical and Nuclear Chemistry |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/32656 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Hada, Hajime| Koide, Norio| Hanafusa, Tadashi| Sakaguchi, Kosaku| Shinji, Toshiyuki| Sasaki, Shunsuke| Oka, Takahiko| Takayama, Niro| Yumoto, Yasuhiro| Tsuji, Takao| |
| Abstract | We detected an antibody to HCV envelope protein (E1) in sera of patients with HCV-related chronic liver diseases (20 patients with chronic hepatitis and 5 patients with liver cirrhosis) by Western blotting using the fusion protein of E1 envelope protein and beta-galactosidase as an antigen. The antibody to HCV E1 (anti-HCV E1) was detected in 8 (42%) of 19 patients positive for HCV-RNA (16 were positive and 3 were negative for antibody to C100-3) and in 1 (17%) of 6 patients negative for HCV-RNA but positive for antibody to C100-3. HCV-RNA was detected in 8 (89%) of 9 anti-HCV E1 positive sera. The value of alanine aminotransferase was significantly higher in patients positive for anti-HCV E1 than in patients negative for the antibody. Although an antibody to the envelope protein of HCV is suspected to be one of the candidates of virus-neutralizing antibodies, our results suggest this hypothesis appears to be unlikely. |
| Keywords | hepatitis C virus envelope antibody Western blotting |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1992-10 |
| Volume | volume46 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 367 |
| End Page | 370 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1279946 |
| Web of Science KeyUT | A1992JX49500007 |
| Author | Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio| |
|---|---|
| Published Date | 2005-01-20 |
| Publication Title | BMC Cancer |
| Volume | volume5 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujimura, Atsushi| Yasui, Seiji| Igawa, Kazuyo| Ueda, Ai| Watanabe, Kaori| Hanafusa, Tadashi| Ichikawa, Yasuaki| Yoshihashi, Sachiko| Tsuchida, Kazuki| Kamiya, Atsunori| Furuya, Shuichi| |
| Keywords | boron neutron capture therapy (BNCT) BSH-polyR CD44 translational machinery bioinformatics |
| Published Date | 2020-09-23 |
| Publication Title | Cells |
| Volume | volume9 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 2149 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32977522 |
| DOI | 10.3390/cells9102149 |
| Web of Science KeyUT | 000584223000001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells9102149 |
| FullText URL | JRNC_313_1_169.pdf |
|---|---|
| Author | Kudo, Ken-ichi| Hanafusa, Tadashi| Ono, Toshiro| |
| Keywords | Monoterpenes Linalool X-ray irradiation Reactive oxygen species SSB |
| Note | The final publication is available at Springer| |
| Published Date | 2017-07 |
| Publication Title | Journal of Radioanalytical and Nuclear Chemistry |
| Volume | volume313 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 169 |
| End Page | 174 |
| ISSN | 0236-5731 |
| NCID | AA11120189 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1007/s10967-017-5268-0 |
| Related Url | https://doi.org/10.1007/s10967-017-5268-0 |
| Author | Hanafusa, Tadashi| Mohamed, Ali Eldib Ali| Kitaoka, Kenta| Ohue, Yoshihiro| Nakayama, Eiichi| Ono, Toshiro| |
|---|---|
| Published Date | 2011-02-01 |
| Publication Title | Cancer Letters |
| Volume | volume301 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Shigehira, Takafumi| Hanafusa, Tadashi| Igawa, Kazuyo| Kasai, Tomonari| Furuya, Shuichi| Nishimori, Hisakazu| Maeda, Yoshinobu| Michiue, Hiroyuki| Fujimura, Atsushi| |
|---|---|
| Keywords | boron agents boron neutron capture therapy simulation study |
| Note | This is the peer reviewed version of the following article: Shigehira, T., Hanafusa, T., Igawa, K., Kasai, T., Furuya, S., Nishimori, H., Maeda, Y., Michiue, H., Fujimura, A., Particle and Heavy Ion Transport Code System-Based Microdosimetry for the Development of Boron Agents for Boron Neutron Capture Therapy. Adv. Theory Simul. 2023, 2300163. https://doi.org/10.1002/adts.202300163, which has been published in final form at https://doi.org/10.1002/adts.202300163. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Apr. 2024.| |
| Published Date | 2023-04-28 |
| Publication Title | Advanced Theory and Simulations |
| Publisher | Wiley |
| Start Page | 2300163 |
| ISSN | 2513-0390 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Wiley-VCH GmbH |
| File Version | author |
| DOI | 10.1002/adts.202300163 |
| Web of Science KeyUT | 000978086700001 |
| Related Url | isVersionOf https://doi.org/10.1002/adts.202300163 |
| Author | 花房 直志| |
|---|---|
| Published Date | 1989-03-28 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| JaLCDOI | 10.18926/AMO/32196 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Hada, Hajime| Koide, Norio| Takabatake, Hiroyuki| Hanafusa, Tadashi| Tsuji, Takao| |
| Abstract | It has been reported that the envelope region located at the 3' portion of the structural protein coding region is one of the most variable regions at both nucleotide and amino acid sequence levels in the hepatitis C virus (HCV) genome. We cloned HCV cDNA fragments of an envelope protein coding region (HCVNK), which were derived from serum of a Japanese patient with hepatocellular carcinoma and were amplified by polymerase chain reaction. After determining the nucleotide sequence, deduced amino acid sequence of the envelope protein region was compared with those of six HCV strains already published (HCJ1, HCVUS, HCJ4, HCVJH, HCVJ and HCVBK). Homology analysis among the strains revealed that the seven strains were classified into two subtypes; a US subtype (HCJ1 and HCVUS) and a Japanese subtype (HCJ4, HCVJH, HCVJ, HCVBK and HCVNK), since percentage homologies between two subtypes (70.3-77.3%) were significantly lower than those within each subtype (83.9-93.5%). Detailed analysis of the amino acid sequences also indicates that the region at aa246-aa258, tentatively named intersubtype variable region-1, may distinguish the US subtype from the Japanese subtype. |
| Keywords | hapatitis C virus envelope DNA sequecing homology intersubtype variable region |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1991-10 |
| Volume | volume45 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 347 |
| End Page | 355 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1661558 |
| Web of Science KeyUT | A1991GN53800009 |
| FullText URL | 48_320.pdf |
|---|---|
| Author | Yumoto, Yasuhiro| Hanafusa, Tadashi| Nagamatsu, Tomohiro| Okada, Shigeru| |
| Keywords | low level radioactive sample (LLRS) low energy β-emitter Imaging Plate experimental incineration system |
| Published Date | 1999-05-15 |
| Publication Title | Radioisotopes |
| Volume | volume48 |
| Issue | issue5 |
| Publisher | 日本アイソトープ協会 |
| Start Page | 320 |
| End Page | 326 |
| ISSN | 00338303 |
| NCID | AN00351589 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| NAID | 10002684844 |
| FullText URL | 46_443.pdf |
|---|---|
| Author | 湯本 泰弘| 花房 直志| 永松 知洋| 岡田 茂| |
| Keywords | low level radioactive sample (LLRS) experimental incineration system for LLRS |
| Published Date | 1997-7-15 |
| Publication Title | Radioisotopes |
| Volume | volume46 |
| Issue | issue7 |
| Publisher | 日本アイソト-プ協会 |
| Start Page | 443 |
| End Page | 449 |
| ISSN | 00338303 |
| NCID | AN00351589 |
| Content Type | Journal Article |
| language | Japanese |
| OAI-PMH Set | 岡山大学 |
| NAID | 10003721742 |
| Author | Nagamatsu, Tomohiro| Hanafusa, Tadashi| Kinno, Ikuo| Sakoda, Akihiro| Hanamoto, Katsumi| Yamaoka, Kiyonori| Ono, Toshiro| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | 環境制御 |
| Volume | volume30 |
| Content Type | Journal Article |
