ID | 55213 |
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Author |
Kudo, Ken-ichi
Hanafusa, Tadashi
Department of Radiation Research, Advanced Science Research CenterOkayama University
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Ono, Toshiro
Department of Radiation Research, Advanced Science Research CenterOkayama University
Kaken ID
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Abstract | Monoterpenes are naturally occurring hydrocarbons composed of two units of isoprenes. They exhibit antioxidant activity to scavenge reactive oxygen species, such as hydroxyl radicals. We investigated the potential of monoterpenes such as thymol, linalool, and menthol to act as radioprotectants. The proliferation of EL4 cells, a mouse lymphoma cell line, treated with linalool at a concentration of 500 μM or more was not affected by X-ray irradiation. Plasmid-nicking assay performed using formamidopyrimidine-DNA glycosylase showed that linalool prevented single strand breaks and oxidized purines on pUC19 plasmid DNA. These findings indicate that linalool has the ability to scavenge reactive oxygen species and is a potential radioprotector.
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Keywords | Monoterpenes
Linalool
X-ray irradiation
Reactive oxygen species
SSB
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Note | The final publication is available at Springer
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Published Date | 2017-07
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Publication Title |
Journal of Radioanalytical and Nuclear Chemistry
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Volume | volume313
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Issue | issue1
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Publisher | Springer
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Start Page | 169
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End Page | 174
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ISSN | 0236-5731
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NCID | AA11120189
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | author
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DOI | |
Related Url | https://doi.org/10.1007/s10967-017-5268-0
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