JaLCDOI 10.18926/AMO/40007
FullText URL fulltext.pdf
Author Furumatsu, Takayuki| Ozaki, Toshifumi|
Abstract Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.
Keywords epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2010-06
Volume volume64
Issue issue3
Publisher Okayama University Medical School
Start Page 155
End Page 161
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20596126
Web of Science KeyUT 000279094300001
FullText URL fulltext20230703-01.pdf
Author Kamatsuki, Yusuke| Furumatsu, Takayuki| Hiranaka, Takaaki| Okazaki, Yuki| Kintaka, Keisuke| Kodama, Yuya| Miyazawa, Shinichi| Ozaki, Toshifumi|
Keywords Body mass index Medial meniscus Painful popping Posterior root tear Pullout repair
Note The version of record of this article, first published in International Orthopaedics, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00264-023-05848-0|
Published Date 2023-06-17
Publication Title International Orthopaedics
Volume volume47
Issue issue10
Publisher Springer Science and Business Media LLC
Start Page 2537
End Page 2545
ISSN 0341-2695
NCID AA0068148X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37329453
DOI 10.1007/s00264-023-05848-0
Web of Science KeyUT 001007187100001
Related Url isVersionOf https://doi.org/10.1007/s00264-023-05848-0
FullText URL fulltext.pdf
Author Kawada, Koki| Furumatsu, Takayuki| Tamura, Masanori| Xue, Haowei| Higashihara, Naohiro| Kintaka, Keisuke| Yokoyama, Yusuke| Ozaki, Toshifumi|
Published Date 2023-02
Publication Title Arthroscopy Techniques
Volume volume12
Issue issue2
Publisher Elsevier
Start Page e273
End Page e278
ISSN 2212-6287
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 THE AUTHORS.
File Version publisher
PubMed ID 36879867
DOI 10.1016/j.eats.2022.11.002
Web of Science KeyUT 000991859500001
Related Url isVersionOf https://doi.org/10.1016/j.eats.2022.11.002
FullText URL AP-SMART_fulltext.pdf AP-SMART_Table.pptx AP-SMART_Figure.pptx
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Kamatsuki, Kamatsuki| Sugiu, Kazuhisa| iyazawa, Shinichi| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Kodama, Yuya| Ozaki, Toshifumi|
Keywords Anterior cruciate ligament reconstruction Chondral damage Meniscal repair
Note This fulltext is available in Feb. 2022.|
Published Date 2020-04
Publication Title Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Volume volume20
Publisher Elsevier
Start Page 1
End Page 5
ISSN 22146873
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32042596
DOI 10.1016/j.asmart.2020.01.001
Web of Science KeyUT 000526087700001
Related Url isVersionOf https://doi.org/10.1016/j.asmart.2020.01.001
FullText URL JOS_015_Fulltext.pdf JOS_015_Figures.pptx
Author Okazaki, Yuki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Saito, Taichi| Ozaki, Toshifumi|
Published Date 2020-03-26
Publication Title Journal of Orthopaedic Science
Volume volume26
Issue issue2
Publisher Elsevier
Start Page 230
End Page 236
ISSN 09492658
NCID AA11052566
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Japanese Orthopaedic Association.
File Version author
PubMed ID 32223991
DOI 10.1016/j.jos.2020.02.015
Related Url isVersionOf https://doi.org/10.1016/j.jos.2020.02.015
JaLCDOI 10.18926/AMO/53910
FullText URL 69_6_355.pdf
Author Okada, Yukimasa| Furumatsu, Takayuki| Miyazawa, Shinichi| Tanaka, Takaaki| Fujii, Masataka| Ozaki, Toshifumi| Abe, Nobuhiro|
Abstract Venous thromboembolism (VTE) is a potential complication occurring after total knee arthroplasty (TKA). We investigated the incidence of VTE after TKA using contrast-enhanced computed tomography (CT), and assessed the efficacy of VTE prophylaxis (fondaparinux and enoxaparin). At our hospital, 189 patients (225 knees) underwent TKA between April 2007 and October 2011. The 225 knees were divided into a control group with no VTE prophylaxis (31 cases), a fondaparinux group (107 cases), and an enoxaparin group (87 cases). Contrast-enhanced CT screening for VTE was performed in all cases on day 5 or 6 after TKA. D-dimer levels were measured on day 5 after TKA, and were significantly lower in the fondaparinux (9.8±3.8) and enoxaparin groups (9.4±4.9) than in the control group (15.6±9.8) (p<0.001). However, no statistically significant difference in the incidence of VTE was observed among the groups (control, 61.3%;fondaparinux, 49.5%;enoxaparin, 50.6%). Prophylaxis was not effective for the prevention of VTE as detected by contrast-enhanced CT after TKA. CT should be performed after TKA, even when VTE prophylaxis is used.
Keywords venous thromboembolism contrast-enhanced computed tomography total knee arthroplasty fondaparinux enoxaparin
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-12
Volume volume69
Issue issue6
Publisher Okayama University Medical School
Start Page 355
End Page 359
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26690246
Web of Science KeyUT 000368434500005
JaLCDOI 10.18926/AMO/54806
FullText URL 70_6_441.pdf
Author Kashihara, Naoko| Furumatsu, Takayuki| Kodama, Yuya| Tanaka, Takaaki| Ozaki, Toshifumi|
Abstract Concurrent meniscal repair with anterior cruciate ligament (ACL) reconstruction has shown good clinical outcomes, but it has a considerable risk of progressing to post-traumatic osteoarthritis of the knee. Here we investigated postoperative changes in the position of the lateral meniscus (LM) and assessed the short-term clinical results after concurrent LM repair with ACL reconstruction. Twentyseven patients underwent LM repair of a peripheral longitudinal tear concomitant with ACL reconstruction. We evaluated the preoperative and postoperative values of the Lysholm score and anteroposterior instability. The length and width of the lateral tibial plateau were determined by radiographic images. The length, width, body width, extrusion, and height of the LM were measured in magnetic resonance images and compared between the preoperative and postoperative measurements. Our analysis revealed that concurrent LM repair with ACL reconstruction improved the shortterm clinical outcomes. Although the body width and height of the LM did not change, the postoperative LM extrusion and LM width were significantly increased after the surgery. The post-traumatic transposition of the LM may not be completely prevented by LM repair concomitant with ACL reconstruction.
Keywords lateral meniscus meniscal extrusion meniscal repair anterior cruciate ligament reconstruction
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 441
End Page 448
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003668
FullText URL fulltext20230125-1.pdf figures20230125-1.pdf tables20230125-1.pdf
Author Xue, Haowei| Furumatsu, Takayuki| Hiranaka, Takaaki| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Zhang, Ximing| Ozaki, Toshifumi|
Keywords Medial meniscus Pullout repair Meniscal extrusion Meniscal root tear Suture anchor Three-dimensional magnetic resonance imaging
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00264-022-05660-2| This full-text file will be available in Dec. 2023.|
Published Date 2022-12-28
Publication Title International Orthopaedics
Volume volume47
Issue issue10
Publisher Springer Science and Business Media LLC
Start Page 2391
End Page 2400
ISSN 0341-2695
NCID AA0068148X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) under exclusive licence to SICOT aisbl 2022
File Version author
PubMed ID 36575357
DOI 10.1007/s00264-022-05660-2
Web of Science KeyUT 000904067500001
Related Url isVersionOf https://doi.org/10.1007/s00264-022-05660-2
FullText URL fulltext.pdf
Author Kintaka, Keisuke| Furumatsu, Takayuki| Okazaki, Yuki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Kamatsuki, Yusuke| Ozaki, Toshifumi|
Keywords knee medial meniscus magnetic resonance imaging
Published Date 2021-09-01
Publication Title Journal of Orthopaedic Surgery
Volume volume29
Issue issue3
Publisher Sage Publications Ltd
Start Page 1
ISSN 1022-5536
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34775855
DOI 10.1177/23094990211049569
Web of Science KeyUT 000720343400001
Related Url isVersionOf https://doi.org/10.1177/23094990211049569
FullText URL Knee_27_3_701_708_fulltext.pdf Knee_27_3_701_708_abstract.pdf Knee_27_3_701_708_Figures.pptx
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Miyazawa, Shinichi| Okazaki, Yoshiki| Okazaki, Yuki| Takihira, Shota| Kodama, Yuya| Kamatsuki, Yusuke| Masuda, Shin| Saito, Taichi| Ozaki, Toshifumi|
Keywords Medial meniscus posterior root tear Transtibial pullout repair Modified Mason-Allen suture Two simple stitches Clinical outcomes
Note This fulltext is available in May 2021.|
Published Date 2020-05-11
Publication Title The Knee
Volume volume27
Issue issue3
Publisher Elsevier
Start Page 701
End Page 708
ISSN 0968-0160
NCID AA10996272
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Elsevier B.V.
File Version author
PubMed ID 32563426
DOI 10.1016/j.knee.2020.04.023
Web of Science KeyUT 000542165100013
Related Url isVersionOf https://doi.org/10.1016/j.knee.2020.04.023
FullText URL fulltext20210519-2.pdf figure20210519-2.pdf
Author Zhang, Ximing| Furumatsu, Takayuki| Okazaki, Yuki| Hiranaka, Takaaki| Xue, Haowei| Kintaka, Keisuke| Miyazawa, Shinichi| Ozaki, Toshifumi|
Keywords Medial meniscus posterior root remnant cells posterior horn cells collagen synthesis anti-angiogenic gene
Note This is an Accepted Manuscript of an article published by Informa UK Limited.
This fulltext is available in May 2022|
Published Date 2021-5-11
Publication Title Connective Tissue Research
Publisher Informa UK Limited
ISSN 0300-8207
NCID AA00615033
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
PubMed ID 33974473
DOI 10.1080/03008207.2021.1920935
Web of Science KeyUT 000649183200001
Related Url isVersionOf https://doi.org/10.1080/03008207.2021.1920935
Author Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi|
Published Date 2013-01
Publication Title International Orthopaedics
Volume volume37
Issue issue1
Content Type Journal Article
FullText URL fulltext.pdf
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Tanaka, Takaaki| Okazaki, Yuki| Kodama, Yuya| Kamatsuki, Yusuke| Masuda, Kenji| Seno, Noritaka| Ozaki, Toshifumi|
Keywords anterior cruciate ligament knee pullout suture screw fixation tibial eminence avulsion fracture
Published Date 2020-06-03
Publication Title Journal of Orthopaedic Surgery
Volume volume28
Issue issue2
Publisher SAGE Publications
Start Page 2309499020918681
ISSN 2309-4990
NCID AA11004541
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32489139
DOI 10.1177/2309499020918681
Web of Science KeyUT 000539749100001
Related Url isVersionOf https://doi.org/10.1177/2309499020918681
Author Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi|
Published Date 2010-11-12
Publication Title Biochemical and Biophysical Research Communications
Volume volume402
Issue issue2
Content Type Journal Article
FullText URL fulltext20221017-2.pdf fig2221017-2.pdf tables20221017-2.pdf
Author Furumatsu, Takayuki| Miyazawa, Shinichi| Kodama, Yuya| Kamatsuki, Yusuke| Okazaki, Yoshiki| Hiranaka, Takaaki| Okazaki, Yuki| Kintaka, Keisuke| Ozaki, Toshifumi|
Keywords Medial meniscus Posterior root tear MMPRT Transtibial pullout repair Clinical outcome
Note © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.knee.2022.08.010] .| This fulltext is available in Sep. 2023.|
Published Date 2022-10
Publication Title The Knee
Volume volume38
Publisher Elsevier BV
Start Page 141
End Page 147
ISSN 0968-0160
NCID AA11534443
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Elsevier B.V.
File Version author
PubMed ID 36058121
DOI 10.1016/j.knee.2022.08.010
Web of Science KeyUT 000863705700003
Related Url isVersionOf https://doi.org/10.1016/j.knee.2022.08.010
FullText URL fulltext.pdf
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yuki| Kintaka, Keisuke| Kamatsuki, Yusuke| Zhang, Ximing| Xue, Haowei| Hamada, Masanori| Ozaki, Toshifumi|
Keywords Medial meniscus Posterior root tear Clinical outcome Meniscal healing Suture material Pullout repair
Note The version of record of this article, first published in Knee Surgery & Related Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s43019-022-00167-x|
Published Date 2022-10-08
Publication Title Knee Surgery & Related Research
Volume volume34
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 39
ISSN 2234-2451
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36209256
DOI 10.1186/s43019-022-00167-x
Web of Science KeyUT 000865171800001
Related Url isVersionOf https://doi.org/10.1186/s43019-022-00167-x
FullText URL fulltext.pdf
Author Kuwahara, Miho| Kadoya, Koichi| Kondo, Sei| Fu, Shanqi| Miyake, Yoshiko| Ogo, Ayako| Ono, Mitsuaki| Furumatsu, Takayuki| Nakata, Eiji| Sasaki, Takako| Minagi, Shogo| Takigawa, Masaharu| Kubota, Satoshi| Hattori, Takako|
Keywords cellular communication network factor 3 CCN3 NOV primary chondrocytes aging oxidative stress senescence p21 p53 SASP
Published Date 2020-10-13
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue20
Publisher MDPI
Start Page 7556
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 33066270
DOI 10.3390/ijms21207556
Web of Science KeyUT 000585557400001
Related Url isVersionOf https://doi.org/10.3390/ijms21207556
JaLCDOI 10.18926/AMO/57717
FullText URL 73_6_523.pdf
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yoshiki| Kamatsuki, Yusuke| Masuda, Shin| Okazaki, Yuki| Takihira, Shota| Miyazawa, Shinichi| Nakata, Eiji| Ozaki, Toshifumi|
Abstract The case of an individual with a bilateral anterior cruciate ligament (ACL) tear combined with a medial meniscus (MM) posterior root tear is described. A 34-year-old Japanese man with bilateral ACL rupture that occurred > 10 years earlier was diagnosed with bilateral ACL tear combined with MM posterior root tear (MMPRT). We performed a transtibial pullout repair of the MMPRT with ACL reconstruction. The tibial tunnels for the MM posterior root repair and ACL reconstruction were created separately. Postoperatively, a good clinical outcome and meniscal healing were obtained. Our surgical technique may thus contribute to anatomical MM posterior root repair and ACL reconstruction.
Keywords bilateral anterior cruciate ligament tear medial meniscus posterior root tear pullout repair case report
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-12
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 523
End Page 528
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871335
Web of Science KeyUT 000503431400008
JaLCDOI 10.18926/AMO/66667
FullText URL 78_1_021.pdf
Author Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Kintaka, Keisuke| Higashihara, Naohiro| Kawada, Koki| Ozaki, Toshifumi|
Abstract The use of various strategies for arthroscopic meniscal repairs to save the meniscus and prevent the progression of knee osteoarthritis has gradually increased. We investigated the frequency of various arthroscopic treatments and the short-term clinical outcomes of symptomatic isolated medial meniscus (MM) injuries. This retrospective observational study included 193 patients (197 knees) who underwent arthroscopic meniscal treatment for isolated MM injuries between January 2016 and April 2019. Arthroscopic meniscal repairs were divided into two groups: transtibial pullout repairs of MM posterior root tears (MMPRTs) and arthroscopic meniscal repairs for other types of MM injuries. MMPRT pullout repair, other meniscal repairs, and partial meniscectomy were performed in 71.0%, 16.8%, and 12.2% of the knees, respectively. The ratio of women to men and the patient age were higher in the pullout-repair group than the meniscal-repair group. The Preoperative Knee Injury and Osteoarthritis Outcome Score subscale (as an index of daily living activities) was significantly lower in the pullout-repair group than the meniscus-repair group. However, no significant differences were observed in these scores among the two groups postoperatively. Our results suggest that familiarity with the diagnosis and treatment of MMPRTs is necessary for orthopedic surgeons to manage isolated MM injuries.
Keywords knee medial meniscus posterior root tear arthroscopy pullout repair
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 21
End Page 27
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419311
FullText URL IntOrthop_43_5_1239.pdf Tables.pdf Fig.pdf
Author Furumatsu, Takayuki| Miyazawa, Shinichi| Fujii, Masataka| Tanaka, Takaaki| Kodama, Yuya| Ozaki, Toshifumi|
Keywords Arthroscopic scoring Medial meniscus Meniscal healing Posterior root tear Transtibial pullout repair
Published Date 2018-08-01
Publication Title International Orthopaedics
Volume volume43
Issue issue5
Publisher Springer
Start Page 1239
End Page 1245
ISSN 03412695
NCID AA0068148X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30069591
DOI 10.1007/s00264-018-4071-z
Web of Science KeyUT 000466730800024
Related Url isVersionOf https://doi.org/10.1007/s00264-018-4071-z