| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Healey, John| Ogura, Koichi| Yoshida, Aki| Kondo, Hiroya| Hata, Toshiaki| Kure, Miho| Tazawa, Hiroshi| Nakata, Eiji| Kunisada, Toshiyuki| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Keywords | sarcoma tumor-associated macrophage prognosis clinical trial immunotherapy |
| Published Date | 2021-03-03 |
| Publication Title | Cancers |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1086 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33802565 |
| NAID | 120007008531 |
| DOI | 10.3390/cancers13051086 |
| Web of Science KeyUT | 000627955600001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers13051086 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Haruyoshi| Fujimura, Atsushi| Huang, Rongsheng| Otani, Yusuke| Itano, Takuto| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter |
| Published Date | 2024-01-26 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 871 |
| End Page | 882 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38279513 |
| DOI | 10.1111/cas.16077 |
| Web of Science KeyUT | 001149722500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16077 |
| FullText URL | Int_Orthop_44_381.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Tsuda, Yusuke| Stevenson, Jonathan| Parry, Michael| Jeys, Lee| |
| Keywords | Chordoma Sacrum Surgery Margin width Radiotherapy |
| Note | This is a post-peer-review, pre-copyedit version of an article published in International Orthopaedics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00264-019-04460-5. This fulltext is available in Dec. 2020.| |
| Published Date | 2019-12-20 |
| Publication Title | International Orthopaedics |
| Volume | volume44 |
| Issue | issue2 |
| Publisher | Springer |
| Start Page | 381 |
| End Page | 389 |
| ISSN | 0341-2695 |
| NCID | AA0068148X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31863159 |
| DOI | 10.1007/s00264-019-04460-5 |
| Web of Science KeyUT | 000503665100004 |
| Related Url | isVersionOf https://doi.org/10.1007/s00264-019-04460-5 |
| FullText URL | EJSO_2020.06.020.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Stevenson, Jonathan| Parry, Michael| Tsuda, Yusuke| Kaneuchi, Yoichi| Jeys, Lee| |
| Keywords | Soft-tissue sarcoma Non-infiltrative subtype Margin Local recurrence Prognosis |
| Note | This is an Accepted Manuscript of an article published by European Society of Surgical Oncology.| |
| Published Date | 2020-06-18 |
| Publication Title | EJSO - European Journal of Surgical Oncology |
| Volume | volume47 |
| Issue | issue2 |
| Publisher | European Society of Surgical Oncology |
| Start Page | 429 |
| End Page | 435 |
| ISSN | 0748-7983 |
| NCID | AA10516435 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1016/j.ejso.2020.06.020 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejso.2020.06.020 |
| FullText URL | Bone_Joint_J_102B_8.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Tsuda, Yusuke| Le Nail, Louis-Romée| Evans, Scott| Gregory, Jonathan| Tillman, Roger| Abudu, Adesegun| |
| Published Date | 2020-07-31 |
| Publication Title | Bone and Joint Journal |
| Volume | volume102-B |
| Issue | issue8 |
| Publisher | British Editorial Society of Bone and Joint Surgery |
| Start Page | 1088 |
| End Page | 1094 |
| ISSN | 2049-4394 |
| NCID | AA12602094 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32731827 |
| DOI | 10.1302/0301-620X.102B8.BJJ-2020-0043.R1 |
| Web of Science KeyUT | 000561876000016 |
| Related Url | is VersionOf https://doi.org/10.1302/0301-620X.102B8.BJJ-2020-0043.R1 |
| FullText URL | EJSO_46_2_277.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Stevenson, Jonathan| Parry, Michael| Tsuda, Yusuke| Tsoi, Kim| Jeys, Lee| |
| Keywords | Soft-tissue sarcoma Myxofibrosarcoma Undifferentiated pleomorphic sarcoma Margin Prognosis |
| Published Date | 2019-10-08 |
| Publication Title | EJSO - European Journal of Surgical Oncolog |
| Volume | volume46 |
| Issue | issue2 |
| Publisher | European Society of Surgical Oncology |
| Start Page | 277 |
| End Page | 281 |
| ISSN | 0748-7983 |
| NCID | AA10516435 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31627932 |
| DOI | 10.1016/j.ejso.2019.10.005 |
| Web of Science KeyUT | 000515202000010 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejso.2019.10.005 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
