| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Fujiwara, Tomohiro| Katayama, Haruyoshi| Itano, Takuto| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | malignant wounds soft tissue sarcoma microbiological analysis surgical site infection prognosis |
| Published Date | 2022-08-17 |
| Publication Title | Oncology Letters |
| Volume | volume24 |
| Issue | issue4 |
| Publisher | Spandidos Publications |
| Start Page | 345 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Nakata et al. |
| File Version | publisher |
| PubMed ID | 36072006 |
| DOI | 10.3892/ol.2022.13465 |
| Web of Science KeyUT | 000891420600001 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2022.13465 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hotta, Yoshifumi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Naniwa, Shuichi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Fujiwara, Tomohiro| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin |
| Published Date | 2024-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1443 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38338721 |
| DOI | 10.3390/ijms25031443 |
| Web of Science KeyUT | 001161430700001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms25031443 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takihira, Shota| Yamada, Daisuke| Osone, Tatsunori| Takao, Tomoka| Sakaguchi, Masakiyo| Hakozaki, Michiyuki| Itano, Takuto| Nakata, Eiji| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Ozaki, Toshifumi| Takarada, Takeshi| |
| Note | The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02632-8| |
| Published Date | 2024-03-06 |
| Publication Title | British Journal of Cancer |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0007-0920 |
| NCID | AA00574355 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38448751 |
| DOI | 10.1038/s41416-024-02632-8 |
| Web of Science KeyUT | 001180796100003 |
| Related Url | isVersionOf https://doi.org/10.1038/s41416-024-02632-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Haruyoshi| Fujimura, Atsushi| Huang, Rongsheng| Otani, Yusuke| Itano, Takuto| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter |
| Published Date | 2024-01-26 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 871 |
| End Page | 882 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38279513 |
| DOI | 10.1111/cas.16077 |
| Web of Science KeyUT | 001149722500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16077 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Nishida, Kenji| Yanai, Hiroyuki| Nakamura, Tomoki| Tanaka, Kazuhiro| Ozaki, Toshifumi| |
| Keywords | alveolar soft part sarcoma surgery chemotherapy targeted therapy immunotherapy |
| Published Date | 2023-08-25 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume53 |
| Issue | issue11 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 1009 |
| End Page | 1018 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37626447 |
| DOI | 10.1093/jjco/hyad102 |
| Web of Science KeyUT | 001080372000001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad102 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Published Date | 2024-02-20 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0298292 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
