| Title Alternative | Current findings on familial hypobetalipoproteinemia |
|---|---|
| Author | Eguchi, Jun| Wada, Jun| |
| Keywords | 低脂血症 家族性低βリポタンパク血症 無βリポタンパク血症 カイロミクロン停滞病 |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2023-08-01 |
| Volume | volume135 |
| Issue | issue2 |
| Start Page | 81 |
| End Page | 84 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.135.81 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2023 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.135.81 |
| Author | Nakatsuka, Atsuko| Wada, Jun| Iseda, Izumi| Teshigawara, Sanae| Higashio, Kanji| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Hida, Kazuyuki| Eguchi, Jun| Horiguchi, Chikage Sato| Ogawa, Daisuke| Matsuki, Yasushi| Hiramatsu, Ryuji| Yagita, Hideo| Kakuta, Shigeru| Iwakura, Yoichiro| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Diabetes |
| Volume | volume61 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-10-22 |
| Publication Title | International Journal of Nephrology and Renovascular Disease |
| Volume | volume6 |
| Content Type | Journal Article |
| Author | Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-10-15 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue10 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Akihiro| Tone, Atsuhito| Watanabe, Mayu| Teshigawara, Sanae| Miyamoto, Satoshi| Eguchi, Jun| Nakatsuka, Atsuko| Shikata, Kenichi| Wada, Jun| |
| Keywords | Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP) |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.| |
| Published Date | 2019-09-16 |
| Publication Title | Diabetology International |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | Springer |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 2190-1678 |
| NCID | AA12503387 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32206479 |
| NAID | 40022198977 |
| DOI | 10.1007/s13340-019-00408-7 |
| Web of Science KeyUT | 000520711100004 |
| Related Url | isVersionOf https://doi.org/10.1007/s13340-019-00408-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuoka-Uchiyama, Natsumi| Uchida, Haruhito A.| Okamoto, Shugo| Onishi, Yasuhiro| Katayama, Katsuyoshi| Tsuchida-Nishiwaki, Mariko| Takeuchi, Hidemi| Takemoto, Rika| Hada, Yoshiko| Umebayashi, Ryoko| Kurooka, Naoko| Tsuji, Kenji| Eguchi, Jun| Nakajima, Hirofumi| Shikata, Kenichi| Wada, Jun| |
| Published Date | 2022-01-10 |
| Publication Title | Journal Of Diabetes Research |
| Volume | volume2022 |
| Publisher | Hindawi Ltd. |
| Start Page | 3157841 |
| ISSN | 2314-6745 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Natsumi Matsuoka-Uchiyama et al. |
| File Version | publisher |
| PubMed ID | 35047644 |
| DOI | 10.1155/2022/3157841 |
| Web of Science KeyUT | 000774919000001 |
| Related Url | isVersionOf https://doi.org/10.1155/2022/3157841 |
| Author | Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-01-22 |
| Publication Title | BMC Nephrology |
| Volume | volume14 |
| Content Type | Journal Article |
| Author | Teshigawara, Sanae| Wada, Jun| Hida, Kazuyuki| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Iseda, Izumi| Matsushita, Yuichi| Miyatake, Nobuyuki| McDonald, John F.| Hotta, Kikuko| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-07 |
| Publication Title | Journal of Clinical Endocrinology & Metabolism |
| Volume | volume97 |
| Issue | issue7 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/63717 |
|---|---|
| FullText URL | 76_3_235.pdf |
| Author | Tenta, Masafumi| Eguchi, Jun| Wada, Jun| |
| Abstract | The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity. |
| Keywords | adipose tissue skeletal muscle obesity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 245 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790353 |
| Web of Science KeyUT | 000823568300002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kurooka, Naoko| Eguchi, Jun| Wada, Jun| |
| Keywords | Dibaetes GPIHBP1 Lipoprotein lipase |
| Published Date | 2023-07-13 |
| Publication Title | Journal of Diabetes Investigation |
| Volume | volume14 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 1148 |
| End Page | 1156 |
| ISSN | 2040-1116 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37448184 |
| DOI | 10.1111/jdi.14056 |
| Web of Science KeyUT | 001024517600001 |
| Related Url | isVersionOf https://doi.org/10.1111/jdi.14056 |
| JaLCDOI | 10.18926/AMO/66927 |
|---|---|
| FullText URL | 78_2_185.pdf |
| Author | Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun| |
| Abstract | The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients. |
| Keywords | obesity type 2 diabetes COVID-19 vaccination |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 191 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| Author | Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-05-25 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-01-22 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue1 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mise, Koki| Imamura, Mariko| Yamaguchi, Satoshi| Watanabe, Mayu| Higuchi, Chigusa| Katayama, Akihiro| Miyamoto, Satoshi| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhiro| Ando, Shinichiro| Nunoue, Tomokazu| Yoshida, Michihiro| Yamada, Masao| Shikata, Kenichi| Wada, Jun| |
| Keywords | cardiovascular event diabetes lectins N-glycans urinary biomarkers |
| Published Date | 2021-05-24 |
| Publication Title | Frontiers In Cardiovascular Medicine |
| Volume | volume8 |
| Publisher | Frontiers Media SA |
| Start Page | 668059 |
| ISSN | 2297-055X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34109226 |
| NAID | 120007053373 |
| DOI | 10.3389/fcvm.2021.668059 |
| Web of Science KeyUT | 000658156400001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcvm.2021.668059 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Noriko| Watanabe, Mayu| Katayama, Akihiro| Noda, Yohei| Eguchi, Jun| Kataoka, Hitomi| Kagawa, Shunsuke| Wada, Jun| |
| Keywords | C-peptide diabetes mellitus immune checkpoint inhibitor insulin secretion |
| Published Date | 2021-09-07 |
| Publication Title | Clinical Case Reports |
| Volume | volume9 |
| Issue | issue9 |
| Publisher | Wiley |
| Start Page | e04574 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 34522382 |
| DOI | 10.1002/ccr3.4574 |
| Web of Science KeyUT | 000700003300112 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.4574 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nunoue, Tomokazu| Yamaguchi, Satoshi| Teshigawara, Sanae| Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Niki, Toshiro| Wada, Jun| |
| Published Date | 2021-03-16 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 5991 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33727589 |
| NAID | 120007004155 |
| DOI | 10.1038/s41598-021-85080-1 |
| Web of Science KeyUT | 000630512100015 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-85080-1 |
| Author | Nakatsuka, Atsuko| Matsuyama, Makoto| Yamaguchi, Satoshi| Katayama, Akihiro| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Ogawa, Daisuke| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Watanabe, Eijiro| Wada, Jun| |
|---|---|
| Published Date | 2016-02-17 |
| Publication Title | Scientific Reports |
| Volume | volume6 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kano, Yuzuki| Yamaguchi, Satoshi| Mise, Koki| Kawakita, Chieko| Onishi, Yasuhiro| Kurooka, Naoko| Sugawara, Ryosuke| Albuayjan, Haya Hamed Hassan| Nakatsuka, Atsuko| Eguchi, Jun| Wada, Jun| |
| Keywords | diabetes mellitus diabetic nephropathy metabolism obesity tubular epithelium |
| Published Date | 2023-12-08 |
| Publication Title | Kidney360 |
| Volume | volume5 |
| Issue | issue2 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Start Page | 182 |
| End Page | 194 |
| ISSN | 2641-7650 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 38062578 |
| DOI | 10.34067/kid.0000000000000333 |
| Web of Science KeyUT | 001178403800002 |
| Related Url | isVersionOf https://doi.org/10.34067/kid.0000000000000333 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun| |
| Keywords | Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology |
| Published Date | 2020-09-10 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 14928 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32913271 |
| DOI | 10.1038/s41598-020-71946-3 |
| Web of Science KeyUT | 000571915100049 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-71946-3 |
| JaLCDOI | 10.18926/AMO/65489 |
|---|---|
| FullText URL | 77_3_243.pdf |
| Author | Shibata, Yusuke| Eguchi, Jun| Wada, Jun| |
| Abstract | Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs. |
| Keywords | PPARγ brown adipose tissue thiazolidinediones |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357625 |
| Web of Science KeyUT | 001026279600002 |
