Eguchi, Jun - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

FullText URL	fulltext.pdf
Author	Nakatsuka, Atsuko\| Yamaguchi, Satoshi\| Eguchi, Jun\| Kakuta, Shigeru\| Iwakura, Yoichiro\| Sugiyama, Hitoshi\| Wada, Jun\|
Published Date	2021-03-19
Publication Title	Communications Biology
Volume	volume4
Issue	issue1
Publisher	Nature
Start Page	373
ISSN	2399-3642
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	33742129
DOI	10.1038/s42003-021-01902-y
NAID	120007004153
Web of Science KeyUT	000631555700003
Related Url	isVersionOf https://doi.org/10.1038/s42003-021-01902-y

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

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Author	Yamaguchi, Satoshi\| Zhang, Dongxiao\| Katayama, Akihiro\| Kurooka, Naoko\| Sugawara, Ryosuke\| Albuayjan, Haya Hamed Hassan\| Nakatsuka, Atsuko\| Eguchi, Jun\| Wada, Jun\|
Keywords	non-coding RNAs microRNA adipose tissues Adipogenesis mTORC1
Published Date	2022-01-03
Publication Title	Frontiers In Endocrinology
Volume	volume12
Publisher	Frontiers Media SA
Start Page	750261
ISSN	1664-2392
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Yamaguchi, Zhang, Katayama, Kurooka, Sugawara, Albuayjan, Nakatsuka, Eguchi and Wada.
File Version	publisher
PubMed ID	35046889
DOI	10.3389/fendo.2021.750261
Web of Science KeyUT	000745695800001
Related Url	isVersionOf https://doi.org/10.3389/fendo.2021.750261

Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis

Author	Katayama, Akihiro\| Nakatsuka, Atsuko\| Eguchi, Jun\| Murakami, Kazutoshi\| Teshigawara, Sanae\| Kanzaki, Motoko\| Nunoue, Tomokazu\| Hida, Kazuyuki\| Wada, Nozomu\| Yasunaka, Tetsuya\| Ikeda, Fusao\| Takaki, Akinobu\| Yamamoto, Kazuhide\| Kiyonari, Hiroshi\| Makino, Hirofumi\| Wada, Jun\|
Published Date	2015
Publication Title	Scientific reports
Volume	volume5
Content Type	Journal Article

Brown Adipose Tissue PPARγ Is Required for the Insulin-Sensitizing Action of Thiazolidinediones

JaLCDOI	10.18926/AMO/65489
FullText URL	77_3_243.pdf
Author	Shibata, Yusuke\| Eguchi, Jun\| Wada, Jun\|
Abstract	Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs.
Keywords	PPARγ brown adipose tissue thiazolidinediones
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2023-06
Volume	volume77
Issue	issue3
Publisher	Okayama University Medical School
Start Page	243
End Page	254
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2023 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	37357625
Web of Science KeyUT	001026279600002

Dysfunction of CD8+PD-1+T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

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Author	Nojima, Ichiro\| Eikawa, Shingo\| Tomonobu, Nahoko\| Hada, Yoshiko\| Kajitani, Nobuo\| Teshigawara, Sanae\| Miyamoto, Satoshi\| Tone, Atsuhito\| Uchida, Haruhito A.\| Nakatsuka, Atsuko\| Eguchi, Jun\| Shikata, Kenichi\| Udono, Heiichiro\| Wada, Jun\|
Keywords	Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology
Published Date	2020-09-10
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature Research
Start Page	14928
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	32913271
DOI	10.1038/s41598-020-71946-3
Web of Science KeyUT	000571915100049
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-71946-3

HOMA-beta independently predicts survival in patients with advanced cancer on treatment with immune checkpoint inhibitors

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Author	Watanabe, Mayu\| Eguchi, Jun\| Takamoto, Atsushi\| Kanzaki, Hiromitsu\| Noda, Yohei\| Kagawa, Syunsuke\| Wada, Jun\|
Keywords	anti-PD1 immune checkpoint inhibitors insulin secretory capacity cancer prognosis insulin secretion glucose metabolism markers
Published Date	2024-12-11
Publication Title	Frontiers in Endocrinology
Volume	volume15
Publisher	Frontiers Media
Start Page	1439705
ISSN	1664-2392
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 Watanabe, Eguchi, Takamoto, Kanzaki, Noda, Kagawa and Wada.
File Version	publisher
PubMed ID	39722806
DOI	10.3389/fendo.2024.1439705
Web of Science KeyUT	001382975000001
Related Url	isVersionOf https://doi.org/10.3389/fendo.2024.1439705

Inhibition of Amino Acids Influx into Proximal Tubular Cells Improves Lysosome Function in Diabetes

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Author	Kano, Yuzuki\| Yamaguchi, Satoshi\| Mise, Koki\| Kawakita, Chieko\| Onishi, Yasuhiro\| Kurooka, Naoko\| Sugawara, Ryosuke\| Albuayjan, Haya Hamed Hassan\| Nakatsuka, Atsuko\| Eguchi, Jun\| Wada, Jun\|
Keywords	diabetes mellitus diabetic nephropathy metabolism obesity tubular epithelium
Published Date	2023-12-08
Publication Title	Kidney360
Volume	volume5
Issue	issue2
Publisher	Ovid Technologies (Wolters Kluwer Health)
Start Page	182
End Page	194
ISSN	2641-7650
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	Copyright © 2023 The Author(s).
File Version	publisher
PubMed ID	38062578
DOI	10.34067/kid.0000000000000333
Web of Science KeyUT	001178403800002
Related Url	isVersionOf https://doi.org/10.34067/kid.0000000000000333

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis

Author	Nakatsuka, Atsuko\| Matsuyama, Makoto\| Yamaguchi, Satoshi\| Katayama, Akihiro\| Eguchi, Jun\| Murakami, Kazutoshi\| Teshigawara, Sanae\| Ogawa, Daisuke\| Wada, Nozomu\| Yasunaka, Tetsuya\| Ikeda, Fusao\| Takaki, Akinobu\| Watanabe, Eijiro\| Wada, Jun\|
Published Date	2016-02-17
Publication Title	Scientific Reports
Volume	volume6
Content Type	Journal Article

Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2

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Author	Nunoue, Tomokazu\| Yamaguchi, Satoshi\| Teshigawara, Sanae\| Katayama, Akihiro\| Nakatsuka, Atsuko\| Eguchi, Jun\| Niki, Toshiro\| Wada, Jun\|
Published Date	2021-03-16
Publication Title	Scientific Reports
Volume	volume11
Issue	issue1
Publisher	Nature
Start Page	5991
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	33727589
DOI	10.1038/s41598-021-85080-1
NAID	120007004155
Web of Science KeyUT	000630512100015
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-85080-1

Longitudinal observation of insulin secretory ability before and after the onset of immune checkpoint inhibitor-induced diabetes mellitus: A report of two cases

FullText URL	fulltext.pdf
Author	Fujiwara, Noriko\| Watanabe, Mayu\| Katayama, Akihiro\| Noda, Yohei\| Eguchi, Jun\| Kataoka, Hitomi\| Kagawa, Shunsuke\| Wada, Jun\|
Keywords	C-peptide diabetes mellitus immune checkpoint inhibitor insulin secretion
Published Date	2021-09-07
Publication Title	Clinical Case Reports
Volume	volume9
Issue	issue9
Publisher	Wiley
Start Page	e04574
ISSN	2050-0904
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	34522382
DOI	10.1002/ccr3.4574
Web of Science KeyUT	000700003300112
Related Url	isVersionOf https://doi.org/10.1002/ccr3.4574

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2)

FullText URL	fulltext.pdf
Author	Mise, Koki\| Imamura, Mariko\| Yamaguchi, Satoshi\| Watanabe, Mayu\| Higuchi, Chigusa\| Katayama, Akihiro\| Miyamoto, Satoshi\| Uchida, Haruhito A.\| Nakatsuka, Atsuko\| Eguchi, Jun\| Hida, Kazuyuki\| Nakato, Tatsuaki\| Tone, Atsuhito\| Teshigawara, Sanae\| Matsuoka, Takashi\| Kamei, Shinji\| Murakami, Kazutoshi\| Shimizu, Ikki\| Miyashita, Katsuhiro\| Ando, Shinichiro\| Nunoue, Tomokazu\| Yoshida, Michihiro\| Yamada, Masao\| Shikata, Kenichi\| Wada, Jun\|
Keywords	cardiovascular event diabetes lectins N-glycans urinary biomarkers
Published Date	2021-05-24
Publication Title	Frontiers In Cardiovascular Medicine
Volume	volume8
Publisher	Frontiers Media SA
Start Page	668059
ISSN	2297-055X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	34109226
DOI	10.3389/fcvm.2021.668059
NAID	120007053373
Web of Science KeyUT	000658156400001
Related Url	isVersionOf https://doi.org/10.3389/fcvm.2021.668059

Nuclear Hormone Receptor Expression in Mouse Kidney and Renal Cell Lines

Author	Ogawa, Daisuke\| Eguchi, Jun\| Wada, Jun\| Terami, Naoto\| Hatanaka, Takashi\| Tachibana, Hiromi\| Nakatsuka, Atsuko\| Sato Horiguchi, Chikage\| Nishii, Naoko\| Makino, Hirofumi\|
Published Date	2014-01-22
Publication Title	PLOS ONE
Volume	volume9
Issue	issue1
Content Type	Journal Article

Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy

Author	Watanabe, Mayu\| Nakatsuka, Atsuko\| Murakami, Kazutoshi\| Inoue, Kentaro\| Terami, Takahiro\| Higuchi, Chigusa\| Katayama, Akihiro\| Teshigawara, Sanae\| Eguchi, Jun\| Ogawa, Daisuke\| Watanabe, Eijiro\| Wada, Jun\| Makino, Hirofumi\|
Published Date	2014-05-25
Publication Title	PLOS ONE
Volume	volume9
Issue	issue3
Content Type	Journal Article

Plasma angiotensin-converting enzyme 2 (ACE2) is a marker for renal outcome of diabetic kidney disease (DKD) (U-CARE study 3)

FullText URL	fulltext.pdf
Author	Ueno, Asami\| Onishi, Yasuhiro\| Mise, Koki\| Yamaguchi, Satoshi\| Kanno, Ayaka\| Nojima, Ichiro\| Higuchi, Chigusa\| Uchida, Haruhito A.\| Shikata, Kenichi\| Miyamoto, Satoshi\| Nakatsuka, Atsuko\| Eguchi, Jun\| Hida, Kazuyuki\| Katayama, Akihiro\| Watanabe, Mayu\| Nakato, Tatsuaki\| Tone, Atsuhito\| Teshigawara, Sanae\| Matsuoka, Takashi\| Kamei, Shinji\| Murakami, Kazutoshi\| Shimizu, Ikki\| Miyashita, Katsuhito\| Ando, Shinichiro\| Nunoue, Tomokazu\| Wada, Jun\|
Published Date	2024-05
Publication Title	BMJ Open Diabetes Research and Care
Volume	volume12
Issue	issue3
Publisher	BMJ Publishing Group
Start Page	e004237
ISSN	2052-4897
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Author(s) (or their employer(s)) 2024.
File Version	publisher
PubMed ID	38816205
DOI	10.1136/bmjdrc-2024-004237
Web of Science KeyUT	001236385500001
Related Url	isVersionOf https://doi.org/10.1136/bmjdrc-2024-004237

Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study

JaLCDOI	10.18926/AMO/66927
FullText URL	78_2_185.pdf
Author	Takahashi, Hiroko\| Eguchi, Jun\| Watanabe, Mayu\| Nakayama, Masanori\| Wada, Jun\|
Abstract	The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
Keywords	obesity type 2 diabetes COVID-19 vaccination
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2024-04
Volume	volume78
Issue	issue2
Publisher	Okayama University Medical School
Start Page	185
End Page	191
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	38688836
Web of Science KeyUT	001227932200002

Role of galectin-9 in the development of gestational diabetes mellitus

FullText URL	fulltext.pdf
Author	Albuayjan, Haya Hamed Hassan\| Watanabe, Mayu\| Sugawara, Ryosuke\| Katsuyama, Eri\| Mise, Koki\| Oi, Yukiko\| Kanno, Ayaka\| Yang, BoXuan\| Tahara, Toshihisa\| Nojima, Ichiro\| Nakatsuka, Atsuko\| Eguchi, Jun\| Maki, Jota\| Eto, Eriko\| Hayata, Kei\| Masuyama, Hisashi\| Wada, Jun\|
Published Date	2025-05-30
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	18981
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40447728
DOI	10.1038/s41598-025-03879-8
Web of Science KeyUT	001499629300002
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-03879-8

Role of glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in hypertriglyceridemia and diabetes

FullText URL	fulltext.pdf
Author	Kurooka, Naoko\| Eguchi, Jun\| Wada, Jun\|
Keywords	Dibaetes GPIHBP1 Lipoprotein lipase
Published Date	2023-07-13
Publication Title	Journal of Diabetes Investigation
Volume	volume14
Issue	issue10
Publisher	Wiley
Start Page	1148
End Page	1156
ISSN	2040-1116
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 The Authors.
File Version	publisher
PubMed ID	37448184
DOI	10.1111/jdi.14056
Web of Science KeyUT	001024517600001
Related Url	isVersionOf https://doi.org/10.1111/jdi.14056

Roles of Transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle

JaLCDOI	10.18926/AMO/63717
FullText URL	76_3_235.pdf
Author	Tenta, Masafumi\| Eguchi, Jun\| Wada, Jun\|
Abstract	The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity.
Keywords	adipose tissue skeletal muscle obesity
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2022-06
Volume	volume76
Issue	issue3
Publisher	Okayama University Medical School
Start Page	235
End Page	245
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2022 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	35790353
Web of Science KeyUT	000823568300002

Serum Vaspin Concentrations Are Closely Related to Insulin Resistance, and rs77060950 at SERPINA12 Genetically Defines Distinct Group with Higher Serum Levels in Japanese Population

Author	Teshigawara, Sanae\| Wada, Jun\| Hida, Kazuyuki\| Nakatsuka, Atsuko\| Eguchi, Jun\| Murakami, Kazutoshi\| Kanzaki, Motoko\| Inoue, Kentaro\| Terami, Takahiro\| Katayama, Akihiro\| Iseda, Izumi\| Matsushita, Yuichi\| Miyatake, Nobuyuki\| McDonald, John F.\| Hotta, Kikuko\| Makino, Hirofumi\|
Published Date	2012-07
Publication Title	Journal of Clinical Endocrinology & Metabolism
Volume	volume97
Issue	issue7
Content Type	Journal Article

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease

Author	Kurose, Yuko\| Wada, Jun\| Kanzaki, Motoko\| Teshigawara, Sanae\| Nakatsuka, Atsuko\| Murakami, Kazutoshi\| Inoue, Kentaro\| Terami, Takahiro\| Katayama, Akihiro\| Watanabe, Mayu\| Higuchi, Chigusa\| Eguchi, Jun\| Miyatake, Nobuyuki\| Makino, Hirofumi\|
Published Date	2013-01-22
Publication Title	BMC Nephrology
Volume	volume14
Content Type	Journal Article