| JaLCDOI | 10.18926/AMO/54808 |
|---|---|
| FullText URL | 70_6_455.pdf |
| Author | Tanino, Masaaki| Kobayashi, Motomu| Sasaki, Toshihiro| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi| Nagai, Taku| Morimatsu, Hiroshi| |
| Abstract | Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats. |
| Keywords | postoperative cognitive dysfunction isoflurane spatial working memory retention delayed spatial win-shift task |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-12 |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 455 |
| End Page | 460 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003670 |
| Author | Takeda, Yoshimasa| Kawashima, Takahisa| Kiyota, Kazuya| Oda, Shigeto| Morimoto, Naoki| Kobata, Hitoshi| Isobe, Hisashi| Honda, Mitsuru| Fujimi, Satoshi| Onda, Jun| I, Seishi| Sakamoto, Tetsuya| Ishikawa, Masami| Nakano, Hiroshi| Sadamitsu, Daikai| Kishikawa, Masanobu| Kinoshita, Kosaku| Yokoyama, Tomoharu| Harada, Masahiro| Kitaura, Michio| Ichihara, Kiyoshi| Hashimoto, Hiroshi| Tsuji, Hidekazu| Yorifuji, Takashi| Nagano, Osamu| Katayama, Hiroshi| Ujike, Yoshihito| Morita, Kiyoshi| |
|---|---|
| Published Date | 2014-12 |
| Publication Title | Resuscitation |
| Volume | volume85 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Tani, Makiko| Morimatsu, Hiroshi| Takatsu, Fumiaki| Morita, Kiyoshi| |
|---|---|
| Published Date | 2012 |
| Publication Title | The Scientific World Journal |
| Volume | volume2012 |
| Content Type | Journal Article |
| Author | Kosaka, Junko| Morimatsu, Hiroshi| Takahashi, Toru| Shimizu, Hiroko| Kawanishi, Susumu| Omori, Emiko| Endo, Yasumasa| Tamaki, Naofumi| Morita, Manabu| Morita, Kiyoshi| |
|---|---|
| Published Date | 2013-05-07 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Yamanaka, Reiko| Soga, Yoshihiko| Nawachi, Kumiko| Yanagi, Yoshinobu| Kodama, Naoki| Nakata, Takashi| Miura, Rumi| Hagawa, Misao| Takeuchi, Tetsuo| Yamane, Mieko| Morita, Manabu| Takashiba, Shogo| Asami, Jun-ichi| Minagi, Shogo| Yoshiyama, Masahiro| Shimono, Tsutomu| Kuboki, Takuo| Sasaki, Akira| Morita, Kiyoshi| |
|---|---|
| Published Date | 2009-06 |
| Publication Title | 岡山歯学会雑誌 |
| Volume | volume28 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Danura, Tetsuya| Takeda, Yoshimasa| Shiraishi, Kensuke| Naito, Hiromichi| Mizoue, Ryoichi| Sato, Sachiko| Morita, Kiyoshi| |
|---|---|
| Published Date | 2013-07 |
| Publication Title | Journal of Neurosurgical Anesthesiology |
| Volume | volume25 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | 縄稚 久美子| 曽我 賢彦| 山中 玲子| 足羽 孝子| 伊藤 真理| 佐藤 真千子| 窪木 拓男| 森田 潔| |
|---|---|
| Published Date | 2012-07 |
| Publication Title | 日本集中治療医学会雑誌 |
| Volume | volume19 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/49039 |
|---|---|
| FullText URL | 66_6_435.pdf |
| Author | Fujinaka, Waso| Shimizu, Juichiro| Iribe, Gentaro| Imaoka, Takeshi| Oshima, Yu| Kiyooka, Takahiko| Morita, Kiyoshi| Mohria, Satoshi| |
| Abstract | Although propofol is commonly used for general anesthesia, its direct effects on left ventricular (LV) contractility and energetics remain unknown. Accordingly, we studied the effects of intracoronary propofol on excised cross-circulated canine hearts using the framework of the Emax (a contractility index)-PVA (systolic pressure-volume area, a measure of total mechanical energy)-Vo2 (myocardial oxygen consumption per beat) relationship. We obtained 1) the Vo2-PVA relationship of isovolumic contractions with varied LV volumes at a constant Emax, 2) the Vo2-PVA relationship with varied LV volumes at a constant intracoronary concentration of propofol, and 3) the Vo2-PVA relationship under increased intracoronary concentrations of either propofol or CaCl2 at a constant LV volume to assess the cardiac mechanoenergetic effects of propofol. We found that propofol decreased Emax dose-dependently. The slope of the linear Vo2-PVA relationship (oxygen cost of PVA) remained unchanged by propofol. The PVA-independent Vo2-Emax relationship (oxygen cost of Emax) was the same for propofol and Ca2＋. In conclusion, propofol showed a direct negative inotropic effect on LV. At its clinical concentrations, decreases in contractility by propofol were relatively small. Propofol shows mechanoenergetic effects on the LV that are similar to those of Ca2＋ blockers or ß-antagonists—i.e., it exerts negative inotropic effects without changing the oxygen costs of Emax and PVA. |
| Keywords | anesthesia heart contractility myocardial oxygen consumption |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-12 |
| Volume | volume66 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 435 |
| End Page | 442 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23254577 |
| Web of Science KeyUT | 000312966100002 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/49732 |
| JaLCDOI | 10.18926/AMO/48569 |
|---|---|
| FullText URL | 66_3_285.pdf |
| Author | Mizobuchi, Satoshi| Matsuoka, Yoshikazu| Obata, Norihiko| Kaku, Ryuji| Itano, Yoshitaro| Tomotsuka, Naoto| Taniguchi, Arata| Nishie, Hiroyuki| Kanzaki, Hirotaka| Ouchida, Mamoru| Morita, Kiyoshi| |
| Abstract | Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required. |
| Keywords | beta-blocker landiolol formalin pain behavior c-fos |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 289 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729110 |
| Web of Science KeyUT | 000305669700013 |
