start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=6 article-no= start-page=455 end-page=460 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Isoflurane Induces Transient Impairment of Retention of Spatial Working Memory in Rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats. en-copyright= kn-copyright= en-aut-name=TaninoMasaaki en-aut-sei=Tanino en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KobayashiMotomu en-aut-sei=Kobayashi en-aut-mei=Motomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SasakiToshihiro en-aut-sei=Sasaki en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakataKen en-aut-sei=Takata en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakedaYoshimasa en-aut-sei=Takeda en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MizobuchiSatoshi en-aut-sei=Mizobuchi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagaiTaku en-aut-sei=Nagai en-aut-mei=Taku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MorimatsuHiroshi en-aut-sei=Morimatsu en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Anesthesiology and Intensive Care Medicine, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Division of Anesthesiology, Department of Surgery Related, Kobe University Graduate School of Medicine kn-affil= affil-num=7 en-affil=Okayama University kn-affil= affil-num=8 en-affil=Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine kn-affil= affil-num=9 en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=postoperative cognitive dysfunction kn-keyword=postoperative cognitive dysfunction en-keyword=isoflurane kn-keyword=isoflurane en-keyword=spatial working memory kn-keyword=spatial working memory en-keyword=retention kn-keyword=retention en-keyword=delayed spatial win-shift task kn-keyword=delayed spatial win-shift task END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=12 article-no= start-page=1647 end-page=1653 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Feasibility study of immediate pharyngeal cooling initiation in cardiac arrest patients after arrival at the emergency room en-subtitle= kn-subtitle= en-abstract= kn-abstract=AIM: Cooling the pharynx and upper oesophagus would be more advantageous for rapid induction of therapeutic hypothermia since the carotid arteries run in their vicinity. The aim of this study was to determine the effects of pharyngeal cooling on brain temperature and the safety and feasibility for patients under resuscitation. METHODS: Witnessed non-traumatic cardiac arrest patients (n=108) were randomized to receive standard care with (n=53) or without pharyngeal cooling (n=55). In the emergency room, pharyngeal cooling was initiated before or shortly after return of spontaneous circulation by perfusing physiological saline (5 °C) into a pharyngeal cuff for 120 min. RESULTS: There was a significant decrease in tympanic temperature at 40 min after arrival (P=0.02) with a maximum difference between the groups at 120 min (32.9 ± 1.2°C, pharyngeal cooling group vs. 34.1 ± 1.3°C, control group; P<0.001). The return of spontaneous circulation (70% vs. 65%, P=0.63) and rearrest (38% vs. 47%, P=0.45) rates were not significantly different based on the initiation of pharyngeal cooling. No post-treatment mechanical or cold-related injury was observed on the pharyngeal epithelium by macroscopic observation. The thrombocytopaenia incidence was lower in the pharyngeal cooling group (P=0.001) during the 3-day period after arrival. The cumulative survival rate at 1 month was not significantly different between the two groups. CONCLUSIONS: Initiation of pharyngeal cooling before or immediately after the return of spontaneous circulation is safe and feasible. Pharyngeal cooling can rapidly decrease tympanic temperature without adverse effects on circulation or the pharyngeal epithelium. en-copyright= kn-copyright= en-aut-name=TakedaYoshimasa en-aut-sei=Takeda en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawashimaTakahisa en-aut-sei=Kawashima en-aut-mei=Takahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KiyotaKazuya en-aut-sei=Kiyota en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OdaShigeto en-aut-sei=Oda en-aut-mei=Shigeto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MorimotoNaoki en-aut-sei=Morimoto en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KobataHitoshi en-aut-sei=Kobata en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IsobeHisashi en-aut-sei=Isobe en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HondaMitsuru en-aut-sei=Honda en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujimiSatoshi en-aut-sei=Fujimi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OndaJun en-aut-sei=Onda en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ISeishi en-aut-sei=I en-aut-mei=Seishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=SakamotoTetsuya en-aut-sei=Sakamoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshikawaMasami en-aut-sei=Ishikawa en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=NakanoHiroshi en-aut-sei=Nakano en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=SadamitsuDaikai en-aut-sei=Sadamitsu en-aut-mei=Daikai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KishikawaMasanobu en-aut-sei=Kishikawa en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=KinoshitaKosaku en-aut-sei=Kinoshita en-aut-mei=Kosaku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=YokoyamaTomoharu en-aut-sei=Yokoyama en-aut-mei=Tomoharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=HaradaMasahiro en-aut-sei=Harada en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=KitauraMichio en-aut-sei=Kitaura en-aut-mei=Michio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=IchiharaKiyoshi en-aut-sei=Ichihara en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=HashimotoHiroshi en-aut-sei=Hashimoto en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=TsujiHidekazu en-aut-sei=Tsuji en-aut-mei=Hidekazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=NaganoOsamu en-aut-sei=Nagano en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=KatayamaHiroshi en-aut-sei=Katayama en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name=UjikeYoshihito en-aut-sei=Ujike en-aut-mei=Yoshihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= affil-num=1 en-affil= kn-affil=Department of Anesthesiology, Okayama University Medical School affil-num=2 en-affil= kn-affil=Department of Emergency and Critical Care Medicine, Iseikai Hospital affil-num=3 en-affil= kn-affil=Tertiary Emergency Medical Center, Saitama Red-Cross Hospital affil-num=4 en-affil= kn-affil=Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine affil-num=5 en-affil= kn-affil=Emergency and Critical Care Center, Tsuyama Central Hospital affil-num=6 en-affil= kn-affil=Osaka Mishima Emergency Critical Care Center affil-num=7 en-affil= kn-affil=Department of Emergency Diagnosis and Treatment, Himeji Medical Center affil-num=8 en-affil= kn-affil=Emergency and Critical Care Center, Toho University Faculty of Medicine affil-num=9 en-affil= kn-affil=Critical Care and Trauma Center, Osaka General Medical Center affil-num=10 en-affil= kn-affil=Department of Neurosurgery, Kitakyushu Yugawa Hospital affil-num=11 en-affil= kn-affil=Department of Emergency Medicine, Japanese Red Cross Kumamoto Hospital affil-num=12 en-affil= kn-affil=Trauma and Resuscitation Center, Teikyo University School of Medicine affil-num=13 en-affil= kn-affil=Emergency Department, Kure Kyosai Hospital affil-num=14 en-affil= kn-affil=Emergency Department, Okazaki City Hospital affil-num=15 en-affil= kn-affil=Emergency and Critical Care Center, Osaka Medical Center affil-num=16 en-affil= kn-affil=Emergency and Critical Care Center, Saiseikai Fukuoka General Hospital affil-num=17 en-affil= kn-affil=Emergency and Critical Care Center, Nihon University Itabashi Hospital affil-num=18 en-affil= kn-affil=Emergency and Critical Care Medicine, Tokyo Medical University Hachioji Medical Center affil-num=19 en-affil= kn-affil=Emergency and Critical Care Center, Kumamoto Medical Center affil-num=20 en-affil= kn-affil=Department of Emergency and Critical Care Medicine, Kagawa Rosai Hospital affil-num=21 en-affil= kn-affil=Department of Clinical Laboratory Science, Yamaguchi University Graduate School of Medicine affil-num=22 en-affil= kn-affil=Daiken Medical Co. affil-num=23 en-affil= kn-affil=Daiken Medical Co. affil-num=24 en-affil= kn-affil=Department of Human Ecology, Okayama University Graduate School of Environmental and Life Science affil-num=25 en-affil= kn-affil=Department of Disaster and Emergency Medicine, Kochi University Medical School affil-num=26 en-affil= kn-affil=Department of Anesthesiology and Intensive Care Medicine, Kawasaki Medical School affil-num=27 en-affil= kn-affil=Department of Emergency and Critical Care Medicine, Okayama University Medical School affil-num=28 en-affil= kn-affil=Department of Anesthesiology, Okayama University Medical School en-keyword=Brain ischaemia kn-keyword=Brain ischaemia en-keyword=Cardiac arrest kn-keyword=Cardiac arrest en-keyword=Intra-arrest cooling kn-keyword=Intra-arrest cooling en-keyword=Pharynx kn-keyword=Pharynx en-keyword=Selective cooling kn-keyword=Selective cooling en-keyword=Therapeutic hypothermia kn-keyword=Therapeutic hypothermia END start-ver=1.4 cd-journal=joma no-vol=2012 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=2012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Incidence and Prognostic Value of Hypochloremia in Critically Ill Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98-106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6%, normochloremia 74.6%, and hypochloremia 8.8%. The hypochloremic group was significantly alkalemic (P < 0.0001) and has significantly higher apparent strong ion difference (SIDa) (P < 0.0001) compared to the two other groups. The hypochloremic group had significantly longer stays in the ICU and hospital (P < 0.0001) with higher mortality (P < 0.0001). However, multiple regression analysis showed that chloride was not an independent factor of poorer outcome. In conclusion, the acid-base characteristics of the hypochloremic patients were alkalemia coexisting with higher SIDa. And although it was not an independent prognostic factor, hypochloremia was related to poorer outcome in critically ill settings. en-copyright= kn-copyright= en-aut-name=TaniMakiko en-aut-sei=Tani en-aut-mei=Makiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimatsuHiroshi en-aut-sei=Morimatsu en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakatsuFumiaki en-aut-sei=Takatsu en-aut-mei=Fumiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ Hosp, Dept Anesthesiol & Resuscitol affil-num=2 en-affil= kn-affil=Okayama Univ Hosp, Perioperat Management Ctr affil-num=3 en-affil= kn-affil=Okayama Univ, Sch Med affil-num=4 en-affil= kn-affil=Okayama Univ Hosp, Dept Anesthesiol & Resuscitol END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=5 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Biliverdin Administration on Acute Lung Injury Induced by Hemorrhagic Shock and Resuscitation in Rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hemorrhagic shock and resuscitation induces pulmonary inflammation that leads to acute lung injury. Biliverdin, a metabolite of heme catabolism, has been shown to have potent cytoprotective, anti-inflammatory, and anti-oxidant effects. This study aimed to examine the effects of intravenous biliverdin administration on lung injury induced by hemorrhagic shock and resuscitation in rats. Biliverdin or vehicle was administered to the rats 1 h before sham or hemorrhagic shock-inducing surgery. The sham-operated rats underwent all surgical procedures except bleeding. To induce hemorrhagic shock, rats were bled to achieve a mean arterial pressure of 30 mmHg that was maintained for 60 min, followed by resuscitation with shed blood. Histopathological changes in the lungs were evaluated by histopathological scoring analysis. Inflammatory gene expression was determined by Northern blot analysis, and oxidative DNA damage was assessed by measuring 8-hydroxy-2' deoxyguanosine levels in the lungs. Hemorrhagic shock and resuscitation resulted in prominent histopathological damage, including congestion, edema, cellular infiltration, and hemorrhage. Biliverdin administration prior to hemorrhagic shock and resuscitation significantly ameliorated these lung injuries as judged by histopathological improvement. After hemorrhagic shock and resuscitation, inflammatory gene expression of tumor necrosis factor-alpha and inducible nitric oxide synthase were increased by 18- and 8-fold, respectively. Inflammatory gene expression significantly decreased when biliverdin was administered prior to hemorrhagic shock and resuscitation. Moreover, after hemorrhagic shock and resuscitation, lung 8-hydroxy-2' deoxyguanosine levels in mitochondrial DNA expressed in the pulmonary interstitium increased by 1.5-fold. Biliverdin administration prior to hemorrhagic shock and resuscitation decreased mitochondrial 8-hydroxy-2' deoxyguanosine levels to almost the same level as that in the control animals. We also confirmed that biliverdin administration after hemorrhagic shock and resuscitation had protective effects on lung injury. Our findings suggest that biliverdin has a protective role, at least in part, against hemorrhagic shock and resuscitation-induced lung injury through anti-inflammatory and anti-oxidant mechanisms. en-copyright= kn-copyright= en-aut-name=KosakaJunko en-aut-sei=Kosaka en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimatsuHiroshi en-aut-sei=Morimatsu en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiToru en-aut-sei=Takahashi en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimizuHiroko en-aut-sei=Shimizu en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawanishiSusumu en-aut-sei=Kawanishi en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OmoriEmiko en-aut-sei=Omori en-aut-mei=Emiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=EndoYasumasa en-aut-sei=Endo en-aut-mei=Yasumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TamakiNaofumi en-aut-sei=Tamaki en-aut-mei=Naofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Prevent Dent affil-num=8 en-affil= kn-affil=Univ Tokushima, Grad Sch, Dept Prevent Dent, Inst Hlth Biosci affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Prevent Dent affil-num=10 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=1 article-no= start-page=37 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Achievements and Next Themes of Dental Section of Perioperative Management Center in Okayama University Hospital at 5 Months after Establishment kn-title=岡山大学病院周術期管理センター(歯科部門)設立後5ヵ月間の活動内容および今後の展開 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamanakaReiko en-aut-sei=Yamanaka en-aut-mei=Reiko kn-aut-name=山中玲子 kn-aut-sei=山中 kn-aut-mei=玲子 aut-affil-num=1 ORCID= en-aut-name=SogaYoshihiko en-aut-sei=Soga en-aut-mei=Yoshihiko kn-aut-name=曽我賢彦 kn-aut-sei=曽我 kn-aut-mei=賢彦 aut-affil-num=2 ORCID= en-aut-name=NawachiKumiko en-aut-sei=Nawachi en-aut-mei=Kumiko kn-aut-name=縄稚久美子 kn-aut-sei=縄稚 kn-aut-mei=久美子 aut-affil-num=3 ORCID= en-aut-name=YanagiYoshinobu en-aut-sei=Yanagi en-aut-mei=Yoshinobu kn-aut-name=柳文修 kn-aut-sei=柳 kn-aut-mei=文修 aut-affil-num=4 ORCID= en-aut-name=KodamaNaoki en-aut-sei=Kodama en-aut-mei=Naoki kn-aut-name=兒玉直紀 kn-aut-sei=兒玉 kn-aut-mei=直紀 aut-affil-num=5 ORCID= en-aut-name=NakataTakashi en-aut-sei=Nakata en-aut-mei=Takashi kn-aut-name=中田貴 kn-aut-sei=中田 kn-aut-mei=貴 aut-affil-num=6 ORCID= en-aut-name=MiuraRumi en-aut-sei=Miura en-aut-mei=Rumi kn-aut-name=三浦留美 kn-aut-sei=三浦 kn-aut-mei=留美 aut-affil-num=7 ORCID= en-aut-name=HagawaMisao en-aut-sei=Hagawa en-aut-mei=Misao kn-aut-name=羽川操 kn-aut-sei=羽川 kn-aut-mei=操 aut-affil-num=8 ORCID= en-aut-name=TakeuchiTetsuo en-aut-sei=Takeuchi en-aut-mei=Tetsuo kn-aut-name=竹内哲男 kn-aut-sei=竹内 kn-aut-mei=哲男 aut-affil-num=9 ORCID= en-aut-name=YamaneMieko en-aut-sei=Yamane en-aut-mei=Mieko kn-aut-name=山根美榮子 kn-aut-sei=山根 kn-aut-mei=美榮子 aut-affil-num=10 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name=森田学 kn-aut-sei=森田 kn-aut-mei=学 aut-affil-num=11 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name=高柴正悟 kn-aut-sei=高柴 kn-aut-mei=正悟 aut-affil-num=12 ORCID= en-aut-name=AsamiJun-ichi en-aut-sei=Asami en-aut-mei=Jun-ichi kn-aut-name=浅海淳一 kn-aut-sei=浅海 kn-aut-mei=淳一 aut-affil-num=13 ORCID= en-aut-name=MinagiShogo en-aut-sei=Minagi en-aut-mei=Shogo kn-aut-name=皆木省吾 kn-aut-sei=皆木 kn-aut-mei=省吾 aut-affil-num=14 ORCID= en-aut-name=YoshiyamaMasahiro en-aut-sei=Yoshiyama en-aut-mei=Masahiro kn-aut-name=吉山昌宏 kn-aut-sei=吉山 kn-aut-mei=昌宏 aut-affil-num=15 ORCID= en-aut-name=ShimonoTsutomu en-aut-sei=Shimono en-aut-mei=Tsutomu kn-aut-name=下野勉 kn-aut-sei=下野 kn-aut-mei=勉 aut-affil-num=16 ORCID= en-aut-name=KubokiTakuo en-aut-sei=Kuboki en-aut-mei=Takuo kn-aut-name=窪木拓男 kn-aut-sei=窪木 kn-aut-mei=拓男 aut-affil-num=17 ORCID= en-aut-name=SasakiAkira en-aut-sei=Sasaki en-aut-mei=Akira kn-aut-name=佐々木朗 kn-aut-sei=佐々木 kn-aut-mei=朗 aut-affil-num=18 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name=森田潔 kn-aut-sei=森田 kn-aut-mei=潔 aut-affil-num=19 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=2 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=3 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=4 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=5 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=6 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=7 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=8 en-affil= kn-affil=岡山大学病院医療技術部歯科衛生士室 affil-num=9 en-affil= kn-affil=岡山大学病院医療技術部歯科技工室 affil-num=10 en-affil= kn-affil=岡山大学病院周術期管理センター(歯科部門) affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科予防歯科学分野 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科歯周病態学分野 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科歯科放射線学分野 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科咬合・有床義歯補綴学分野 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科歯科保存修復学分野 affil-num=16 en-affil= kn-affil=岡山大学病院医療技術部歯科衛生士室 affil-num=17 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科インプラント再生補綴学分野 affil-num=18 en-affil= kn-affil=岡山大学病院副病院長 affil-num=19 en-affil= kn-affil=岡山大学病院病院長 END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=3 article-no= start-page=292 end-page=298 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201307 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Quantitative evaluation of the neuroprotective effects of a short-acting β-adrenoceptor antagonist at a clinical dose on forebrain ischemia in gerbils: effects of esmolol on ischemic depolarization and histologic outcome of hippocampal CA1. en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND: Neuroprotective effects of esmolol in laboratory and clinical settings have been reported. The present study was designed to quantitatively evaluate the neuroprotective effects of esmolol using logistic regression curves and extracellular potentials. MATERIALS AND METHODS: In 42 gerbils, bilateral occlusion of common carotid arteries was performed for 3, 5, or 7 minutes (n=7 in each group). In treated animals, esmolol (200 ?g/kg/min) was administered for 90 minutes, 30 minutes before the onset of ischemia. Direct current potentials were measured in the bilateral CA1 regions, in which histologic evaluation was performed 5 days later. Relations of neuronal damage with ischemic duration and duration of ischemic depolarization were determined using logistic regression curves. RESULTS: There was no significant difference in onset time between the 2 groups (the control group vs. the esmolol group: 1.65±0.46 vs. 1.68±0.45 min, P=0.76), and significant differences in durations of ischemic depolarization were not observed with any ischemic duration. However, logistic regression curves indicated that esmolol has a neuroprotective effect from 2.95 to 7.66 minutes of ischemic depolarization (P<0.05), and esmolol prolonged the duration of ischemic depolarization causing 50% neuronal damage from 4.97 to 6.34 minutes (P<0.05). Logistic regression curves also indicated that esmolol has a neuroprotective effect from 3.77 to 7.74 minutes of ischemic duration (P<0.05), and esmolol prolonged the ischemic duration causing 50% neuronal damage from 4.26 to 4.91 minutes (P<0.05). en-copyright= kn-copyright= en-aut-name=DanuraTetsuya en-aut-sei=Danura en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakedaYoshimasa en-aut-sei=Takeda en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShiraishiKensuke en-aut-sei=Shiraishi en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MizoueRyoichi en-aut-sei=Mizoue en-aut-mei=Ryoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoSachiko en-aut-sei=Sato en-aut-mei=Sachiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Anesthesiology and Resuscitology, Okayama University Medical School affil-num=2 en-affil= kn-affil=Department of Anesthesiology and Resuscitology, Okayama University Medical School affil-num=3 en-affil= kn-affil=Department of Anesthesiology, Maizuru Kyosai Hospital affil-num=4 en-affil= kn-affil=Department of Anesthesiology and Resuscitology, Okayama University Medical School affil-num=5 en-affil= kn-affil=Department of Anesthesiology and Resuscitology, Okayama University Medical School affil-num=6 en-affil= kn-affil=Department of Anesthesiology and Resuscitology, Okayama University Medical School affil-num=7 en-affil= kn-affil=Department of Anesthesiology and Resuscitology, Okayama University Medical School en-keyword=esmolol kn-keyword=esmolol en-keyword=[beta]-adrenoceptor kn-keyword=[beta]-adrenoceptor en-keyword=ischemic depolarization kn-keyword=ischemic depolarization en-keyword=neuroprotective effect kn-keyword=neuroprotective effect en-keyword=brain ischemia. kn-keyword=brain ischemia. END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=3 article-no= start-page=431 end-page=432 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201207 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=気管挿管における口腔内偶発症防止対策の必要性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=縄稚久美子 kn-aut-sei=縄稚 kn-aut-mei=久美子 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=曽我賢彦 kn-aut-sei=曽我 kn-aut-mei=賢彦 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山中玲子 kn-aut-sei=山中 kn-aut-mei=玲子 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=足羽孝子 kn-aut-sei=足羽 kn-aut-mei=孝子 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊藤真理 kn-aut-sei=伊藤 kn-aut-mei=真理 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐藤真千子 kn-aut-sei=佐藤 kn-aut-mei=真千子 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=窪木拓男 kn-aut-sei=窪木 kn-aut-mei=拓男 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=森田潔 kn-aut-sei=森田 kn-aut-mei=潔 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院周術期管理センター affil-num=2 en-affil= kn-affil=岡山大学病院周術期管理センター affil-num=3 en-affil= kn-affil=岡山大学病院周術期管理センター affil-num=4 en-affil= kn-affil=岡山大学病院周術期管理センター affil-num=5 en-affil= kn-affil=岡山大学病院周術期管理センター affil-num=6 en-affil= kn-affil=岡山大学病院周術期管理センター affil-num=7 en-affil= kn-affil=岡山大学病院クラウンブリッジ補綴科 affil-num=8 en-affil= kn-affil=岡山大学病院周術期管理センター en-keyword=dental injury kn-keyword=dental injury en-keyword=perioperative management kn-keyword=perioperative management en-keyword=complication kn-keyword=complication END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=6 article-no= start-page=435 end-page=442 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Propofol on Left Ventricular Mechanoenergetics in the Excised Cross-circulated Canine Heart en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although propofol is commonly used for general anesthesia, its direct effects on left ventricular (LV) contractility and energetics remain unknown. Accordingly, we studied the effects of intracoronary propofol on excised cross-circulated canine hearts using the framework of the Emax (a contractility index)-PVA (systolic pressure-volume area, a measure of total mechanical energy)-Vo2 (myocardial oxygen consumption per beat) relationship. We obtained 1) the Vo2-PVA relationship of isovolumic contractions with varied LV volumes at a constant Emax, 2) the Vo2-PVA relationship with varied LV volumes at a constant intracoronary concentration of propofol, and 3) the Vo2-PVA relationship under increased intracoronary concentrations of either propofol or CaCl2 at a constant LV volume to assess the cardiac mechanoenergetic effects of propofol. We found that propofol decreased Emax dose-dependently. The slope of the linear Vo2-PVA relationship (oxygen cost of PVA) remained unchanged by propofol. The PVA-independent Vo2-Emax relationship (oxygen cost of Emax) was the same for propofol and Ca2＋. In conclusion, propofol showed a direct negative inotropic effect on LV. At its clinical concentrations, decreases in contractility by propofol were relatively small. Propofol shows mechanoenergetic effects on the LV that are similar to those of Ca2＋ blockers or ?-antagonists?i.e., it exerts negative inotropic effects without changing the oxygen costs of Emax and PVA. en-copyright= kn-copyright= en-aut-name=FujinakaWaso en-aut-sei=Fujinaka en-aut-mei=Waso kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimizuJuichiro en-aut-sei=Shimizu en-aut-mei=Juichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IribeGentaro en-aut-sei=Iribe en-aut-mei=Gentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ImaokaTakeshi en-aut-sei=Imaoka en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OshimaYu en-aut-sei=Oshima en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KiyookaTakahiko en-aut-sei=Kiyooka en-aut-mei=Takahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MohriaSatoshi en-aut-sei=Mohria en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=anesthesia kn-keyword=anesthesia en-keyword=heart kn-keyword=heart en-keyword=contractility kn-keyword=contractility en-keyword=myocardial oxygen consumption kn-keyword=myocardial oxygen consumption END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=285 end-page=289 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model en-subtitle= kn-subtitle= en-abstract= kn-abstract=Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required. en-copyright= kn-copyright= en-aut-name=MizobuchiSatoshi en-aut-sei=Mizobuchi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuokaYoshikazu en-aut-sei=Matsuoka en-aut-mei=Yoshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ObataNorihiko en-aut-sei=Obata en-aut-mei=Norihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KakuRyuji en-aut-sei=Kaku en-aut-mei=Ryuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ItanoYoshitaro en-aut-sei=Itano en-aut-mei=Yoshitaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TomotsukaNaoto en-aut-sei=Tomotsuka en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TaniguchiArata en-aut-sei=Taniguchi en-aut-mei=Arata kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishieHiroyuki en-aut-sei=Nishie en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KanzakiHirotaka en-aut-sei=Kanzaki en-aut-mei=Hirotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OuchidaMamoru en-aut-sei=Ouchida en-aut-mei=Mamoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MoritaKiyoshi en-aut-sei=Morita en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=5 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=6 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=7 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=8 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine affil-num=9 en-affil= kn-affil=Department of Biomedical Sciences, Cedars-sinai Medical Center affil-num=10 en-affil= kn-affil=Departments of Molecular Genetics, Okayama University Graduate School of Medicine affil-num=11 en-affil= kn-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine en-keyword=beta-blocker kn-keyword=beta-blocker en-keyword=landiolol kn-keyword=landiolol en-keyword=formalin kn-keyword=formalin en-keyword=pain behavior kn-keyword=pain behavior en-keyword=c-fos kn-keyword=c-fos END