| JaLCDOI | 10.18926/AMO/32897 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Matsukawa, Akihiro| |
| Abstract | The innate immune system provides immediate defense against infection and serves as the first line of host defense during infection. In innate immunity, leukocytes such as neutrophils and macrophages recognize and respond to pathogens in a non-specific manner. Therefore, the recruitment and activation of leukocytes are essential in innate immunity, and are governed by a variety of chemical mediators including cytokines. Cytokines are generally divided into 2 types, termed type-1 and type-2 cytokines. Type-1 cytokines are important in local host defense, while type-2 cytokines play a protective role when inflammatory response spreads to the body. These cytokines exert their biological functions through the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1/3/4/6 are transcription factors that mediate IFNgamma/IL-10/IL-12/IL-13 cytokine signaling, respectively. Evidence indicates that STAT proteins have a significant impact on innate immunity during sepsis. This review focuses on recent understandings in the regulation of innate immunity by STAT proteins during sepsis and septic shock. The suppressor of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing cytoplasmic proteins that complete a negative feedback loop to attenuate signal transduction from cytokines that act through the JAK/STAT pathway. The participation of SOCS proteins in sepsis is also discussed. |
| Keywords | cytokines innate immunity sepsis SOCS STAT |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2007-10 |
| Volume | volume61 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 239 |
| End Page | 245 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 17971840 |
| Web of Science KeyUT | 000250431700001 |
| JaLCDOI | 10.18926/AMO/51867 |
|---|---|
| FullText URL | 67_5_311.pdf |
| Author | Nishida, Keiichiro| Hashizume, Hiroyuki| Matsukawa, Akihiro| Hashizume, Kenzo| Shimamura, Yasunori| Torigoe, Yasuyuki| Ozaki, Toshifumi| |
| Abstract | We report a case of 4th metacarpal head collapse of a 19-year-old healthy man. MRI revealed T1 low and T2 high regions in the collapsed 4th metacarpal head, as well as in the right 3rd and left 4th metacarpal head. Our initial diagnosis was occult compression fracture due to avascular necrosis, known as Dieterich's disease. However, pathological findings of surgically resected right 4th metacarpal head were compatible with transient osteoporosis and metacarpal head fracture followed by active tissue repair. The autologous osteochondral transplants from costchondral junction survived and maintained their size and shape even at 10-year follow-up. |
| Keywords | occult compression fracture metacarpal head avascular necrosis osteochondral autograft |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-10 |
| Volume | volume67 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 311 |
| End Page | 317 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24145731 |
| Web of Science KeyUT | 000325836100005 |
| JaLCDOI | 10.18926/AMO/57946 |
|---|---|
| FullText URL | 74_1_1.pdf |
| Author | Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro| |
| Abstract | Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. |
| Keywords | cancer stem cell stemness iron chelation chemotherapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099242 |
| Web of Science KeyUT | 000516606200001 |
| NAID | 120006795613 |
| JaLCDOI | 10.18926/AMO/57956 |
|---|---|
| FullText URL | 74_1_73.pdf |
| Author | Yamane, Masaomi| Mandai, Yasuhiro| Ino, Hideo| Matsukawa, Akihiro| Toyooka, Shinichi| |
| Abstract | In 2016, Gunma University Hospital’s Medical Accident Investigation Committee released a report reiterating the necessity of medical education and the need for surgeons to master non-technical skills. We designed a 17-h training course for surgical instructors, designed to teach participants how to sufficiently educate surgeon trainees and encourage their professional identity formation. A post-training survey showed that participants improved their awareness, and their behavioral changes led to favorable team performances. We then began offering a 3-h workshop focusing on the participants’ experiences. We propose that the training course using participant narratives is required and effective to establish surgeons’ self-reflection and professional identity as surgeons. |
| Keywords | professional identity instructor training narrative |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 73 |
| End Page | 76 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099252 |
| Web of Science KeyUT | 000516606200011 |
| NAID | 120006795623 |
| JaLCDOI | 10.18926/AMO/58275 |
|---|---|
| FullText URL | 74_2_159.pdf |
| Author | Thar Htet San| Ota, Yoko| Fushimi, Soichiro| Fujisawa, Masayoshi| Yanai, Hiroyuki| Toda, Hiroko| Kunitomo, Tadayoshi| Kodama, Keisuke| Matsukawa, Akihiro| |
| Abstract | Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (～97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested. |
| Keywords | juvenile granulosa cell tumor late recurrence adult granulosa cell tumor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 159 |
| End Page | 163 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341591 |
| Web of Science KeyUT | 000528278500010 |
| NAID | 120006839454 |
| Author | 松川 昭博| |
|---|---|
| Published Date | 2006-09-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume118 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Mominoki, Katsumi| Takashima, Rumi| Matsukawa, Akihiro| |
|---|---|
| Published Date | 2011-05 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume27 |
| Content Type | Article |
| Author | Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | Critical Care Medicine |
| Volume | volume41 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| Yodoi, Junji| Morishima, Tsuneo| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Wakabayashi, Hiroshi| Ito, Toshihiro| Fushimi, Soichiro| Nakashima, Yuki| Itakura, Jyunya| Liu, Qiuying| Win, Min Min| Sun, Cuiming| Chen, Cao| Sato, Miwa| Mino, Megumi| Ogino, Tetsuya| Makino, Hirofumi| Yoshimura, Akihiko| Matsukawa, Akihiro| |
|---|---|
| Published Date | 2012-09 |
| Publication Title | Clinical Immunology |
| Volume | volume144 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Shiozaki, Yasuyuki| Kitajima, Takashi| Mazaki, Tetsuro| Yoshida, Aki| Tanaka, Masato| Umezawa, Akihiro| Nakamura, Mariko| Yoshida, Yasuhiro| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro| |
|---|---|
| Published Date | 2013-04 |
| Publication Title | International Journal of Nanomedicine |
| Volume | volume8 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Mazaki, Tetsuro| Shiozaki, Yasuyuki| Yamane, Kentaro| Yoshida, Aki| Nakamura, Mariko| Yoshida, Yasuhiro| Zhou, Di| Kitajima, Takashi| Tanaka, Masato| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro| |
|---|---|
| Published Date | 2014-03-25 |
| Publication Title | Scientific Reports |
| Volume | volume4 |
| Content Type | Journal Article |
| Author | Yoshimura, Teizo| Howard, O. M. Zack| Ito, Toshihiro| Kuwabara, Masaki| Matsukawa, Akihiro| Chen, Keqiang| Liu, Ying| Liu, Mingyong| Oppenheim, Joost J.| Wang, Ji Ming| |
|---|---|
| Published Date | 2013-03-18 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue3 |
| Content Type | Journal Article |
| FullText URL | JGastroenterol_54_11_1019.pdf Table.pdf Figure 1.jpg Figure 2.jpg Figure 3A.tif Figure 3B.tif supplemental figure 1.jpg |
|---|---|
| Author | Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Tanaka, Noriyuki| Kato, Hironari| Horiguchi, Shigeru| Yoshida, Ryuichi| Umeda, Yuzo| Fushimi, Soichiro| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki| |
| Keywords | Immunohistochemistry PD-L1 Pancreatic cancer |
| Note | This fulltext will be available in Apr 2020| |
| Published Date | 2019-04-29 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume54 |
| Issue | issue11 |
| Start Page | 1019 |
| End Page | 1028 |
| ISSN | 09441174 |
| NCID | AA10988015 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31032528 |
| DOI | 10.1007/s00535-019-01586-6 |
| Web of Science KeyUT | 000492169400008 |
| Related Url | isVersionOf https://doi.org/10.1007/s00535-019-01586-6 |
| FullText URL | cancers_11_2_177.pdf |
|---|---|
| Author | Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi| |
| Keywords | cancer stem cells combination therapy iron stemness |
| Published Date | 2019-02-03 |
| Publication Title | Cancers |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 177 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors |
| File Version | publisher |
| PubMed ID | 30717462 |
| DOI | 10.3390/cancers11020177 |
| Web of Science KeyUT | 000460747200051 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers11020177 |
| FullText URL | FI_10_17.pdf |
|---|---|
| Author | Ohkura, Takahiro| Yoshimura, Teizo| Fujisawa, Masayoshi| Ohara, Toshiaki| Marutani, Rie| Usami, Kaya| Matsukawa, Akihiro| |
| Keywords | Ras/Raf/ERK/MAPK Spred2 adipocyte inflammation macrophage obesity |
| Published Date | 2019-01-22 |
| Publication Title | Frontiers in Immunology |
| Volume | volume10 |
| Publisher | Frontiers Media S.A |
| Start Page | 17 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2019 Authors |
| File Version | publisher |
| PubMed ID | 30723473 |
| DOI | 10.3389/fimmu.2019.00017 |
| Web of Science KeyUT | 000456196900002 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2019.00017 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamane, Kentaro| Misawa, Haruo| Takigawa, Tomoyuki| Ito, Yoshihiro| Ozaki, Toshifumi| Matsukawa, Akihiro| |
| Keywords | hepatocyte growth factor spinal cord injury neural regeneration |
| Published Date | 2019-12-02 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue23 |
| Publisher | MDPI |
| Start Page | 6078 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31810304 |
| DOI | 10.3390/ijms20236078 |
| Web of Science KeyUT | 000504428300260 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20236078 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshimura, Teizo| Nakamura, Kaoru| Li, Chunning| Fujisawa, Masayoshi| Shiina, Tsuyoshi| Imamura, Mayu| Li, Tiantian| Mukaida, Naofumi| Matsukawa, Akihiro| |
| Keywords | macrophages chemokines cytokines inflammation tumor microenvironment breast cancer |
| Published Date | 2019-12-16 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue24 |
| Publisher | MDPI |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31888216 |
| DOI | 10.3390/ijms20246342 |
| Web of Science KeyUT | 000506840100235 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20246342 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirano, Yutaka| Sugimoto, Seiichiro| Yamamoto, Sumiharu| Okada, Masanori| Otani, Shinji| Ohara, Toshiaki| Yamane, Masaomi| Matsukawa, Akihiro| Oto, Takahiro| Toyooka, Shinichi| |
| Keywords | Brain dead donor Donation after cardiac death Lung transplantation Organ preservation Rejection |
| Note | This is a post-peer-review, pre-copyedit version of an article published in General Thoracic and Cardiovascular Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-019-01181-9.| |
| Published Date | 2019-07-31 |
| Publication Title | General Thoracic and Cardiovascular Surgery |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 1863-6705 |
| NCID | AA12201344 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31367969 |
| DOI | 10.1007/s11748-019-01181-9 |
| Web of Science KeyUT | 000511499200009 |
| Related Url | isVersionOf https://doi.org/10.1007/s11748-019-01181-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Moh-Moh-Aung, Aye| Fujisawa, Masayoshi| Ito, Sachio| Katayama, Hiroshi| Ohara, Toshiaki| Ota, Yoko| Yoshimura, Teizo| Matsukawa, Akihiro| |
| Keywords | Molecular medicine Tumour angiogenesis |
| Published Date | 2020-06-26 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 10418 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32591615 |
| DOI | 10.1038/s41598-020-67425-4 |
| Web of Science KeyUT | 000545967200015 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-67425-4 |
