Matsukawa, Akihiro - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Role of Macrophages in Liver Fibrosis

JaLCDOI	10.18926/AMO/66664
FullText URL	78_1_001.pdf
Author	Sun, Cuiming\| Matsukawa, Akihiro\|
Abstract	Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis.
Keywords	ERK-MAPK SPRED2 fibrosis macrophages
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2024-02
Volume	volume78
Issue	issue1
Publisher	Okayama University Medical School
Start Page	1
End Page	8
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	38419308

Influence of the coronavirus disease 2019 pandemic on the post-graduate career paths of medical students: a cross-sectional study

FullText URL	fulltext.pdf
Author	Nishimura, Ayumu\| Miyoshi, Tomoko\| Otsuka, Fumio\| Matsukawa, Akihiro\|
Keywords	COVID-19 pandemic Medical students Career path Training hospitals
Note	The version of record of this article, first published in [Journal name], is available online at Publisher’s website: http://dx.doi.org/10.1186/s12909-023-05021-6\|
Published Date	2024-01-10
Publication Title	BMC Medical Education
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	55
ISSN	1472-6920
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024.
File Version	publisher
PubMed ID	38200534
DOI	10.1186/s12909-023-05021-6
Web of Science KeyUT	001140938300007
Related Url	isVersionOf https://doi.org/10.1186/s12909-023-05021-6

Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms

FullText URL	fulltext.pdf
Author	Matsumoto, Kazuyuki\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Takaki, Akinobu\| Takahara, Masahiro\| Kato, Hironari\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Matsukawa, Akihiro\| Okada, Hiroyuki\|
Keywords	Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry
Note	The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6\|
Published Date	2022-02-08
Publication Title	Journal of Gastrointestinal Surgery
Volume	volume26
Issue	issue6
Publisher	Springer Science and Business Media LLC
Start Page	1213
End Page	1223
ISSN	1091-255X
NCID	AA11494553
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35137343
DOI	10.1007/s11605-021-05197-6
Web of Science KeyUT	000752761400001
Related Url	isVersionOf https://doi.org/10.1007/s11605-021-05197-6

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells

FullText URL	fulltext.pdf
Author	Gao, Tong\| Yang, Xu\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Wang, Tianyi\| Tomonobu, Nahoko\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	cancer stem cells epithelial-mesenchymal transition ERK1/2-MAPK tumorigenesis
Published Date	2023-03-05
Publication Title	International Journal of Molecular Sciences
Volume	volume24
Issue	issue5
Publisher	MDPI
Start Page	4996
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36902429
DOI	10.3390/ijms24054996
Web of Science KeyUT	000947675000001
Related Url	isVersionOf https://doi.org/10.3390/ijms24054996

Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators

FullText URL	fulltext.pdf
Author	Wang, Yuze\| Ohara, Toshiaki\| Chen, Yuehua\| Hamada, Yusuke\| Li, Chunning\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	triple-negative breast cancer iron metabolism iron chelator phosphoinositide-3-kinase-protein kinase heterogeneity metastasis
Published Date	2023-01-12
Publication Title	Cancers
Volume	volume15
Issue	issue2
Publisher	MDPI
Start Page	468
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36672419
DOI	10.3390/cancers15020468
Web of Science KeyUT	000914513700001
Related Url	isVersionOf https://doi.org/10.3390/cancers15020468

Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung

FullText URL	fulltext.pdf
Author	Nakata, Kentaro\| Okazaki, Mikio\| Sakaue, Tomohisa\| Kinoshita, Rie\| Komoda, Yuhei\| Shimizu, Dai\| Yamamoto, Haruchika\| Tanaka, Shin\| Suzawa, Ken\| Shien, Kazuhiko\| Miyoshi, Kentaroh\| Yamamoto, Hiromasa\| Ohara, Toshiaki\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Matsukawa, Akihiro\| Sakaguchi, Masakiyo\| Toyooka, Shinichi\|
Keywords	ischemia reperfusion injury S100A8/A9 lung transplantation damage-associated molecule patterns
Published Date	2022-11-10
Publication Title	Bioengineering
Volume	volume9
Issue	issue11
Publisher	MDPI
Start Page	673
ISSN	2306-5354
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	36354584
DOI	10.3390/bioengineering9110673
Web of Science KeyUT	000880897200001
Related Url	isVersionOf https://doi.org/10.3390/bioengineering9110673

Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer

FullText URL	fulltext.pdf
Author	Li, Chunning\| Yoshimura, Teizo\| Tian, Miao\| Wang, Yuze\| Kondo, Takamasa\| Yamamoto, Ken-Ichi\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Matsukawa, Akihiro\|
Keywords	Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment
Published Date	2022-09-12
Publication Title	Breast Cancer Research
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	60
ISSN	1465-5411
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36096830
DOI	10.1186/s13058-022-01557-5
Web of Science KeyUT	000853036400001
Related Url	isVersionOf https://doi.org/10.1186/s13058-022-01557-5

Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways

FullText URL	fulltext.pdf
Author	Miyahara, Hiroyuki\| Hasegawa, Kosei\| Yashiro, Masato\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\| Tsukahara, Hirokazu\|
Published Date	2022-03-21
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	4819
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35314758
DOI	10.1038/s41598-022-08791-z
Web of Science KeyUT	000771589000002
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-08791-z

Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder

FullText URL	fulltext.pdf
Author	Oda, Shinsuke\| Fujisawa, Masayoshi\| Li, Chunning\| Ito, Toshihiro\| Yamaguchi, Takahiro\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Published Date	2021-11-24
Publication Title	Plos One
Volume	volume16
Issue	issue11
Publisher	Public Library Science
Start Page	e0254289
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Oda et al.
File Version	publisher
PubMed ID	34818323
DOI	10.1371/journal.pone.0254289
Web of Science KeyUT	000747234800004
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0254289

Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4(+) and CD8(+) T cells

FullText URL	fulltext.pdf
Author	Sun, Cuiming\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Liu, Qiuying\| Cao, Chen\| Yang, Xu\| Yoshimura, Teizo\| Kunkel, Steven L.\| Matsukawa, Akihiro\|
Keywords	Liver damage MAPK Signal transduction and regulation Gene-modified mice Spred2
Published Date	2022-01
Publication Title	Journal Of Advanced Research
Volume	volume35
Publisher	Elsevier
Start Page	71
End Page	86
ISSN	2090-1232
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	35003795
DOI	10.1016/j.jare.2021.03.014
Web of Science KeyUT	000736947300007
Related Url	isVersionOf https://doi.org/10.1016/j.jare.2021.03.014

Crosstalk between Cancer Cells and Fibroblasts for the Production of Monocyte Chemoattractant Protein-1 in the Murine 4T1 Breast Cancer

FullText URL	fulltext.pdf
Author	Imamura, Mayu\| Li, Tiantian\| Li, Chunning\| Fujisawa, Masayoshi\| Mukaida, Naofumi\| Matsukawa, Akihiro\| Yoshimura, Teizo\|
Keywords	breast cancer chemokine lung metastasis fibroblasts macrophages tumor microenvironment
Published Date	2021-10-22
Publication Title	Current Issues In Molecular Biology
Volume	volume43
Issue	issue3
Publisher	MDPI
Start Page	1726
End Page	1740
ISSN	1467-3037
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	34698088
DOI	10.3390/cimb43030122
Web of Science KeyUT	000735852200001
Related Url	isVersionOf https://doi.org/10.3390/cimb43030122

PolyI:C suppresses TGF-β1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells

FullText URL	fulltext20210824-3.pdf
Author	Yamaguchi, Takahiro\| Yoshimura, Teizo\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Tong, Gao\| Matsukawa, Akihiro\|
Keywords	Toll-like receptors cell migration metastasis epithelial mesenchymal transformation
Note	This is a post-peer-review, pre-copyedit version of an article published in Molecular Biology Reports. The final authenticated version is available online at: https://doi.org/10.1007/s11033-021-06625-1\|
Published Date	2021-8-14
Publication Title	Molecular Biology Reports
Publisher	Springer Science and Business Media LLC
ISSN	0301-4851
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	34390443
DOI	10.1007/s11033-021-06625-1
Web of Science KeyUT	000684897400002
Related Url	isVersionOf https://doi.org/10.1007/s11033-021-06625-1

Utility of gastric biopsy in diagnosing IgG4‐related gastrointestinal disease

FullText URL	fulltext.pdf Figures.pdf Tables_Figure_legends.pdf
Author	Uchino, Kaori\| Notohara, Kenji\| Uehara, Takeshi\| Kuraishi, Yasuhiro\| Itakura, Junya\| Matsukawa, Akihiro\|
Keywords	biopsy feasibility studies gastric mucosa gastritis IgG4 IgG4‐related disease immunoglobulin G4 immunohistochemistry plasma cells
Note	This is the peer reviewed version of the following article: Kaori Uchino et. al. Utility of gastric biopsy in diagnosing IgG4‐related gastrointestinal disease. Pathology International (2020), which has been published in final form at [https://doi.org/10.1111/pin.13059. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This fulltext is available in Jan. 2022.\|
Published Date	2020-12-30
Publication Title	Pathology International
Volume	volume71
Issue	issue2
Publisher	Wiley
Start Page	124
End Page	134
ISSN	1320-5463
NCID	AA10984364
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	33378576
DOI	10.1111/pin.13059
Web of Science KeyUT	000603493000001
Related Url	isVersionOf https://doi.org/10.1111/pin.13059

Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin

FullText URL	fulltext.pdf
Author	Kawara, Akina\| Mizuta, Ryo\| Fujisawa, Masayoshi\| Ito, Toshihiro\| Li, Chunning\| Nakamura, Kaoru\| Sun, Cuiming\| Kuwabara, Masaki\| Kitabatake, Masahiro\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Cell signalling Mechanisms of disease
Published Date	2020-10-05
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature
Start Page	16490
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	33020583
DOI	10.1038/s41598-020-73752-3
Web of Science KeyUT	000577291800001
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-73752-3

Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression

FullText URL	fulltext.pdf
Author	Moh-Moh-Aung, Aye\| Fujisawa, Masayoshi\| Ito, Sachio\| Katayama, Hiroshi\| Ohara, Toshiaki\| Ota, Yoko\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Molecular medicine Tumour angiogenesis
Published Date	2020-06-26
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature
Start Page	10418
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	32591615
DOI	10.1038/s41598-020-67425-4
Web of Science KeyUT	000545967200015
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-67425-4

Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case

JaLCDOI	10.18926/AMO/58275
FullText URL	74_2_159.pdf
Author	Thar Htet San\| Ota, Yoko\| Fushimi, Soichiro\| Fujisawa, Masayoshi\| Yanai, Hiroyuki\| Toda, Hiroko\| Kunitomo, Tadayoshi\| Kodama, Keisuke\| Matsukawa, Akihiro\|
Abstract	Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (～97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.
Keywords	juvenile granulosa cell tumor late recurrence adult granulosa cell tumor
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2020-04
Volume	volume74
Issue	issue2
Publisher	Okayama University Medical School
Start Page	159
End Page	163
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	32341591
Web of Science KeyUT	000528278500010
NAID	120006839454

Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse

FullText URL	fulltext.pdf
Author	Hirano, Yutaka\| Sugimoto, Seiichiro\| Yamamoto, Sumiharu\| Okada, Masanori\| Otani, Shinji\| Ohara, Toshiaki\| Yamane, Masaomi\| Matsukawa, Akihiro\| Oto, Takahiro\| Toyooka, Shinichi\|
Keywords	Brain dead donor Donation after cardiac death Lung transplantation Organ preservation Rejection
Note	This is a post-peer-review, pre-copyedit version of an article published in General Thoracic and Cardiovascular Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-019-01181-9.\|
Published Date	2019-07-31
Publication Title	General Thoracic and Cardiovascular Surgery
Volume	volume68
Issue	issue1
Publisher	Springer
Start Page	57
End Page	62
ISSN	1863-6705
NCID	AA12201344
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	31367969
DOI	10.1007/s11748-019-01181-9
Web of Science KeyUT	000511499200009
Related Url	isVersionOf https://doi.org/10.1007/s11748-019-01181-9

Cancer Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor Is Dispensable for the Progression of 4T1 Murine Breast Cancer

FullText URL	fulltext.pdf
Author	Yoshimura, Teizo\| Nakamura, Kaoru\| Li, Chunning\| Fujisawa, Masayoshi\| Shiina, Tsuyoshi\| Imamura, Mayu\| Li, Tiantian\| Mukaida, Naofumi\| Matsukawa, Akihiro\|
Keywords	macrophages chemokines cytokines inflammation tumor microenvironment breast cancer
Published Date	2019-12-16
Publication Title	International Journal of Molecular Sciences
Volume	volume20
Issue	issue24
Publisher	MDPI
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 by the authors.
File Version	publisher
PubMed ID	31888216
DOI	10.3390/ijms20246342
Web of Science KeyUT	000506840100235
Related Url	isVersionOf https://doi.org/10.3390/ijms20246342

Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury

FullText URL	fulltext.pdf
Author	Yamane, Kentaro\| Misawa, Haruo\| Takigawa, Tomoyuki\| Ito, Yoshihiro\| Ozaki, Toshifumi\| Matsukawa, Akihiro\|
Keywords	hepatocyte growth factor spinal cord injury neural regeneration
Published Date	2019-12-02
Publication Title	International Journal of Molecular Sciences
Volume	volume20
Issue	issue23
Publisher	MDPI
Start Page	6078
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 by the authors.
File Version	publisher
PubMed ID	31810304
DOI	10.3390/ijms20236078
Web of Science KeyUT	000504428300260
Related Url	isVersionOf https://doi.org/10.3390/ijms20236078

A Surgical Instructor Training Course for the Next Generation

JaLCDOI	10.18926/AMO/57956
FullText URL	74_1_73.pdf
Author	Yamane, Masaomi\| Mandai, Yasuhiro\| Ino, Hideo\| Matsukawa, Akihiro\| Toyooka, Shinichi\|
Abstract	In 2016, Gunma University Hospital’s Medical Accident Investigation Committee released a report reiterating the necessity of medical education and the need for surgeons to master non-technical skills. We designed a 17-h training course for surgical instructors, designed to teach participants how to sufficiently educate surgeon trainees and encourage their professional identity formation. A post-training survey showed that participants improved their awareness, and their behavioral changes led to favorable team performances. We then began offering a 3-h workshop focusing on the participants’ experiences. We propose that the training course using participant narratives is required and effective to establish surgeons’ self-reflection and professional identity as surgeons.
Keywords	professional identity instructor training narrative
Amo Type	Short Communication
Publication Title	Acta Medica Okayama
Published Date	2020-02
Volume	volume74
Issue	issue1
Publisher	Okayama University Medical School
Start Page	73
End Page	76
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	32099252
Web of Science KeyUT	000516606200011
NAID	120006795623