| JaLCDOI | 10.18926/AMO/31982 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Yumoto, Akihisa| Kusano, Kengo Fukushima| Nakamura, Kazufumi| Hashimoto, Katsushi| Aoki, Motokuni| Morishita, Ryuichi| Kaneda, Yasufumi| Ohe, Tohru| |
| Abstract | It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia. To investigate this possibility, we examined the antiarrhythmic effect of HGF gene therapy in rat acute and old myocardial infarction models. Myocardial ischemia was induced by ligation of the left descending coronary artery. Hemagglutinating virus of Japan (HVJ)-coated liposome containing HGF genes were injected directly into the myocardium fourteen days before programmed pacing. Ventricular fibrillation (VF)was induced by programmed pacing. The VF duration was reduced and the VF threshold increased after HGF gene therapy ( p< 0.01). Histological analyses revealed that the number of vessels in the ischemic border zone was greatly increased after HGF gene injection. These findings revealed that HGF gene therapy has an anti-arrhythmic effect after myocardial ischemia. |
| Keywords | ventricular arrhythmia HGF (hepatocyte growth factor) ischemia HVJ (hemagglutinating virus of Japan) |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2005-06 |
| Volume | volume59 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 73 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 16049559 |
| Web of Science KeyUT | 000230039100001 |
| JaLCDOI | 10.18926/AMO/32121 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Hisamatsu, Kenichi| Kusano, Kengo Fukushima| Morita, Hiroshi| Takenaka, Shiho| Nagase, Satoshi| Nakamura, Kazufumi| Emori, Tetsuro| Matsubara, Hiromi| Ohe, Tohru| |
| Abstract | We attempted to determine the usefulness of body surface mapping (BSM) for differentiating patients with Brugada syndrome (BS) from patients with asymptomatic Brugada syndrome (ABS). Electrocardiograms (ECG) and BSM were recorded in 7 patients with BS and 35 patients with ABS. Following the administration of Ic antiarrhythmic drugs, BSM was recorded in 5 patients with BS and 16 patients with ABS. The maximum amplitudes at J0, J20, J40 and J60 were compared between the 2 groups, as were 3-dimensional maps. The maximum amplitudes at J0, J20 and J60 under control conditions were larger in patients with BS than in patients with ABS (P < 0.05). A three-dimensional map of the ST segments under control conditions in patients with BS showed a higher peak of ST elevation in the median precordium compared to that for patients with ABS. Increases in ST elevation at J20, J40 and J60 following drug administration were greater in patients with BS than in patients with ABS (P < 0.05). Evaluation of the change in amplitude of the ST segment at E5 caused by Ic drug administration was also useful for differentiating between the 2 groups. In conclusion, BSM was useful for differentiating patients with BS from those with ABS. |
| Keywords | body surface map Brugada syndrome asymptomatic Brugada syndrome Ic antiarrhythmic drugs |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2004-02 |
| Volume | volume58 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 35 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 15157009 |
| Web of Science KeyUT | 000189271100005 |
| JaLCDOI | 10.18926/AMO/53519 |
|---|---|
| FullText URL | 69_3_129.pdf |
| Author | Akagi, Satoshi| Nakamura, Kazufumi| Matsubara, Hiromi| Ogawa, Aiko| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi| |
| Abstract | Pulmonary arterial hypertension (PAH) is characterized by elevation of pulmonary artery pressure caused by pulmonary vasoconstriction and vascular remodeling, which leads to right heart failure and death. Epoprostenol (prostaglandin I2) has a potent short-acting vasodilator property, and intravenous continuous epoprostenol is therefore used for treatment of PAH. Here we review evidence for the usefulness of intravenous continuous epoprostenol therapy in patients with PAH. Epoprostenol therapy is effective in idiopathic PAH patients and in patients with PAH associated with connective tissue disease, portal hypertension or congenital heart diseases, but it is not effective in patients with pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. High-dose epoprostenol therapy markedly improved hemodynamics in some patients with PAH, possibly due to reverse remodeling of pulmonary arteries. This therapy has several side effects and complications such as headache, hypotension and catheter-related infections. Intravenous continuous epoprostenol is an effective treatment, but there are still some problems to be resolved. |
| Keywords | pulmonary arterial hypertension epoprostenol high-dose complications side effects |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 136 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101188 |
| Web of Science KeyUT | 000356903000001 |
| JaLCDOI | 10.18926/AMO/54600 |
|---|---|
| FullText URL | 70_5_397.pdf |
| Author | Akagi, Satoshi| Nakamura, Kazufumi| Akagi, Teiji| Nakagawa, Koji| Takaya, Yoichi| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi| |
| Abstract | A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD. |
| Keywords | pulmonary hypertension atrial septal defect repair and treat transcatheter closure |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 397 |
| End Page | 400 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777434 |
| Web of Science KeyUT | 000388098700011 |
| JaLCDOI | 10.18926/AMO/61433 |
|---|---|
| FullText URL | 75_1_45.pdf |
| Author | Otsuka, Hiroaki| Miyoshi, Toru| Ejiri, Kentaro| Kohno, Kunihisa| Nakahama, Makoto| Doi, Masayuki| Munemasa, Mitsuru| Murakami, Masaaki| Nakamura, Kazufumi| Ito, Hiroshi| |
| Abstract | Remote ischemic preconditioning (RIPC) is a promising strategy for protecting against ischemic reperfusion injury. This study is a secondary analysis of a randomized study that aimed to evaluate the effect of RIPC on the early increase in serum creatinine (SCr) following percutaneous coronary intervention (PCI), which is associ-ated with contrast-induced acute kidney injury. Patients with stable angina undergoing elective PCI were assigned to control, RIPC, and continuous infusion of nicorandil (nicorandil) groups. The endpoint of this study was the incidence of the early increase in SCr, a predictor of contrast-induced acute kidney injury, which was defined as either a > 20% or absolute increase by 0.3 mg/dl of SCr levels after 24 h of PCI. This study included 220 patients for whom a dataset of SCr values was available. The incidence of the early increase in SCr was significantly lower in the RIPC than in the control (1.3% vs 10.8%, p = 0.03) group, but was not significantly different between the nicorandil and control groups. In multivariate analysis, RIPC remained a significant fac-tor associated with a reduction in the incidence of early increase in SCr. RIPC reduces the incidence of early increase in SCr in patients with stable angina following elective PCI. |
| Keywords | remote ischemic preconditioning stable angina serum creatinine acute kidney injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 45 |
| End Page | 53 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649613 |
| Author | 中村 一文| |
|---|---|
| Published Date | 1998-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Watanabe, Atsuyuki| Kusano Fukushima, Kengo| Morita, Hiroshi| Miura, Daiji| Sumida, Wakako| Hiramatsu, Shigeki| Banba, Kimikazu| Nishii, Nobuhiro| Nagase, Satoshi| Nakamura, Kazufumi| Sakuragi, Satoru| Ohe, Tohru| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 武田 昌也| 大塚 文男| 中村 一文| 稲垣 兼一| 鈴木 二郎| 三浦 大志| 藤尾 栄起| 松原 広己| 伊達 洋至| 大江 透| 槇野 博史| |
|---|---|
| Published Date | 2006-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume118 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 中村 一文| 草野 研吾| 垣下 幹夫| 三浦 綾| 久松 研一| 西井 伸洋| 伴場 主一| 渡邊 敦之| 藤尾 栄起| 宮地 克維| 永瀬 聡| 森田 宏| 斎藤 博則| 江森 哲郎| 浅沼 幹人| 宮崎 正博| 中村 陽一| 松原 広己| 伏見 和郎| 豊國 伸哉| 大江 透| |
|---|---|
| Published Date | 2004-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume116 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kobayashi, Makoto| Nakamura, Kazufumi| Kusano, Kengo Fukushima| Nakamura, Yoichi| Ohta-Ogo, Keiko| Nagase, Satoshi| Sakuragi, Satoru| Ohe, Tohru| |
|---|---|
| Published Date | 2008-06-22 |
| Publication Title | International Journal of Cardiology |
| Volume | volume126 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | 小川 愛子| 中村 一文| 松原 広己| 藤尾 栄起| 池田 哲也| 宮地 克維| 三浦 大志| 三浦 綾| 永瀬 聡| 草野 研吾| 伊達 洋至| 大江 透| |
|---|---|
| Published Date | 2007-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume118 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Nakamura, Kazufumi| Ito, Hiroshi| |
|---|---|
| Published Date | 2012-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nosaka, Kazumasa| Nakamura, Kazufumi| Kusano, Kengo| Toh, Norihisa| Tada, Takeshi| Miyoshi, Toru| Doi, Masayuki| Kohno, Kunihisa| Morita, Hiroshi| Ito, Hiroshi| |
|---|---|
| Published Date | 2013-08 |
| Publication Title | Congestive Heart Failure |
| Volume | volume19 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Wada, Tadashi| Nakahama, Makoto| Toda, Hironobu| Watanabe, Atsuyuki| Hashimoto, Katsushi| Terasaka, Ritsuko| Nakamura, Kazufumi| Yamada, Nobuyuki| Ito, Hiroshi| |
|---|---|
| Published Date | 2013 |
| Publication Title | ISRN Cardiology |
| Volume | volume2013 |
| Content Type | Journal Article |
| Author | Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-02-19 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Dan, Kazuhiro| Miyoshi, Toru| Ueeda, Masayuki| Ohtsuka, Hiroaki| Ugawa, Satoko| Ohnishi, Nobuhiko| Takaishi, Atsushi| Nakamura, Kazufumi| Kusano, Kengo| Ito, Hiroshi| |
|---|---|
| Published Date | 2012-09 |
| Publication Title | Circulation Journal |
| Volume | volume76 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Tokioka, Koji| Kusano, Kengo F.| Morita, Hiroshi| Miura, Daiji| Nishii, Nobuhiro| Nagase, Satoshi| Nakamura, Kazufumi| Kohno, Kunihisa| Ito, Hiroshi| Ohe, Tohru| |
|---|---|
| Published Date | 2014-05-27 |
| Publication Title | Journal of the American College of Cardiology |
| Volume | volume63 |
| Issue | issue20 |
| Content Type | Journal Article |
| FullText URL | HR42_5_752.pdf |
|---|---|
| Author | Nakamura, Kazufumi| Miyoshi, Toru| |
| Published Date | 2019-02-14 |
| Publication Title | Hypertension Research |
| Volume | volume42 |
| Issue | issue425 |
| Publisher | Nature Publishing Group |
| Start Page | 752 |
| End Page | 753 |
| ISSN | 0916-9636 |
| NCID | AA10847079 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30765877 |
| DOI | 10.1038/s41440-019-0225-7 |
| Web of Science KeyUT | 000467043700021 |
| Related Url | isVersionOf https://doi.org/10.1038/s41440-019-0225-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ejiri Kentaro| Akagi, Satoshi| Nakamura, Kazufumi| Amioka, Naofumi| Ichikawa, Keishi| Yagi, Takahito| Ito, Hiroshi| |
| Keywords | Rendu-Osler-Weber syndrome arteriovenous malformation pulmonary haemorrhage |
| Published Date | 2019-12-18 |
| Publication Title | Pulmonary Circulation |
| Volume | volume9 |
| Issue | issue4 |
| Publisher | SAGE Publications Inc |
| ISSN | 2045-8932 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019. |
| File Version | publisher |
| PubMed ID | 31903186 |
| DOI | 10.1177/2045894019896677 |
| Web of Science KeyUT | 000503484500001 |
| Related Url | isVersionOf https://doi.org/10.1177/2045894019896677 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Kazufumi| Akagi, Satoshi| Ejiri, Kentaro| Yoshida, Masashi| Miyoshi, Toru| Toh, Norihisa| Nakagawa, Koji| Takaya, Yoichi| Matsubara, Hiromi| Ito, Hiroshi| |
| Keywords | pulmonary arterial hypertension prostaglandin I-2 nitric oxide endothelin |
| Published Date | 2019-11-23 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue23 |
| Publisher | MDPI |
| Start Page | 5885 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31771203 |
| DOI | 10.3390/ijms20235885 |
| Web of Science KeyUT | 000504428300067 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20235885 |
