ID | 34230 |
FullText URL | |
Author |
Kobayashi, Makoto
Kusano, Kengo Fukushima
Nakamura, Yoichi
Ohta-Ogo, Keiko
Nagase, Satoshi
Sakuragi, Satoru
Ohe, Tohru
|
Abstract | Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM. |
Keywords | cardiomyopathy
immunohistochemistry
monocyte
|
Note | Published with permission from the copyright holder.
This is a author's copy,as published in International Journal of Cardiology, 2008 Vol.126 Issue.3 pp.427-429 Publisher URL: http://dx.doi.org/10.1016/j.ijcard.2007.01.109 Direct access to Thomson Web of Science record Copyright © 2008 Elsevier Ireland Ltd. |
Published Date | 2008-06-22
|
Publication Title |
International Journal of Cardiology
|
Volume | volume126
|
Issue | issue3
|
Start Page | 427
|
End Page | 429
|
Content Type |
Journal Article
|
language |
English
|
Refereed |
True
|
DOI | |
Web of Science KeyUT | |
Submission Path | cardiovascular_diseases/2
|