FullText URL | fulltext.pdf |
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Author | Thu, Yin Min| Suzawa, Ken| Tomida, Shuta| Ochi, Kosuke| Tsudaka, Shimpei| Takatsu, Fumiaki| Date, Keiichi| Matsuda, Naoki| Iwata, Kazuma| Nakata, Kentaro| Shien, Kazuhiko| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Toyooka, Shinichi| |
Published Date | 2024-05-17 |
Publication Title | PLoS ONE |
Volume | volume19 |
Issue | issue5 |
Publisher | Public Library of Science |
Start Page | e0300644 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2024 Thu et al. |
File Version | publisher |
PubMed ID | 38758826 |
DOI | 10.1371/journal.pone.0300644 |
Web of Science KeyUT | 001227109100078 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0300644 |
FullText URL | fulltext.pdf |
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Author | Sasakura, Minori| Urakami, Hitoshi| Tachibana, Kota| Ikeda, Kenta| Hasui, Ken-Ichi| Matsuda, Yoshihiro| Sunagawa, Ko| Ennishi, Daisuke| Tomida, Shuta| Morizane, Shin| |
Keywords | AP-1 inhibitor Atopic dermatitis Baricitinib T-5224 Topical application |
Published Date | 2024-04 |
Publication Title | Allergology International |
Volume | volume73 |
Issue | issue2 |
Publisher | Japanese Society of Allergology |
Start Page | 323 |
End Page | 331 |
ISSN | 1323-8930 |
NCID | AA11091750 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2024 Japanese Society of Allergology. |
File Version | publisher |
PubMed ID | 38350816 |
DOI | 10.1016/j.alit.2023.12.006 |
Web of Science KeyUT | 001220243500001 |
Related Url | isVersionOf https://doi.org/10.1016/j.alit.2023.12.006 |
FullText URL | fulltext20240213-01.pdf |
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Author | Urata, Tomohiro| Naoi, Yusuke| Jiang, Aixiang| Boyle, Merrill| Sunami, Kazutaka| Imai, Toshi| Nawa, Yuichiro| Hiramatsu, Yasushi| Yamamoto, Kazuhiko| Fujii, Soichiro| Yoshida, Isao| Yano, Tomofumi| Chijimatsu, Ryota| Murakami, Hiroyuki| Ikeuchi, Kazuhiro| Kobayashi, Hiroki| Tani, Katsuma| Ujiie, Hideki| Inoue, Hirofumi| Tomida, Shuta| Yamamoto, Akira| Kondo, Takumi| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Sawada, Keisuke| Momose, Shuji| Tamaru, Jun-ichi| Nishikori, Asami| Sato, Yasuharu| Yoshino, Tadashi| Maeda, Yoshinobu| Scott, David W.| Ennishi, Daisuke| |
Published Date | 2023-12-14 |
Publication Title | Blood Advances |
Volume | volume7 |
Issue | issue24 |
Publisher | American Society of Hematology |
Start Page | 7459 |
End Page | 7470 |
ISSN | 2473-9529 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by The American Society of Hematology. |
File Version | publisher |
PubMed ID | 37552496 |
DOI | 10.1182/bloodadvances.2023010402 |
Web of Science KeyUT | 001141306600001 |
Related Url | isVersionOf https://doi.org/10.1182/bloodadvances.2023010402 |
FullText URL | fulltext.pdf |
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Author | Tomioka, Yasuaki| Sugimoto, Seiichiro| Yamamoto, Haruchika| Tomida, Shuta| Shiotani, Toshio| Tanaka, Shin| Shien, Kazuhiko| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Yamamoto, Hiromasa| Okazaki, Mikio| Yamane, Masaomi| Toyooka, Shinichi| |
Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-36143-y| |
Published Date | 2023-06-01 |
Publication Title | Scientific Reports |
Volume | volume13 |
Issue | issue1 |
Publisher | nature portfolio |
Start Page | 8912 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023 |
File Version | publisher |
PubMed ID | 37264212 |
DOI | 10.1038/s41598-023-36143-y |
Web of Science KeyUT | 001000430300041 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-023-36143-y |
JaLCDOI | 10.18926/AMO/65502 |
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FullText URL | 77_3_323.pdf |
Author | Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao| |
Abstract | In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases. |
Keywords | comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-06 |
Volume | volume77 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 323 |
End Page | 330 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37357634 |
Web of Science KeyUT | 001025850000001 |
FullText URL | fulltext.pdf |
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Author | Sekito, Takanori| Wada, Koichiro| Ishii, Ayano| Iwata, Takehiro| Matsubara, Takehiro| Tomida, Shuta| Watanabe, Masami| Araki, Motoo| Sadahira, Takuya| |
Keywords | cystitis vagina microbiota Lactobacillus urinary tract infection |
Published Date | 2023-05-18 |
Publication Title | Frontiers in Microbiology |
Volume | volume14 |
Publisher | Frontiers Media |
Start Page | 1187479 |
ISSN | 1664-302X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Sekito, Wada, Ishii, Iwata, Matsubara, Tomida, Watanabe, Araki and Sadahira. |
File Version | publisher |
PubMed ID | 37275169 |
DOI | 10.3389/fmicb.2023.1187479 |
Web of Science KeyUT | 000998008400001 |
Related Url | isVersionOf https://doi.org/10.3389/fmicb.2023.1187479 |
FullText URL | fulltext.pdf |
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Author | Ochi, Kosuke| Suzawa, Ken| Thu, Yin Min| Takatsu, Fumiaki| Tsudaka, Shimpei| Zhu, Yidan| Nakata, Kentaro| Takeda, Tatsuaki| Shien, Kazuhiko| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Okamoto, Yoshiharu| Tomida, Shuta| Toyooka, Shinichi| |
Keywords | cancer-associated fibroblast drug resistance tranilast |
Published Date | 2022-07-24 |
Publication Title | Cancer Science |
Volume | volume2022 |
Publisher | Wiley |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 35871750 |
DOI | 10.1111/cas.15502 |
Web of Science KeyUT | 000840374000001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.15502 |
FullText URL | fulltext.pdf |
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Author | Namba, Kei| Suzawa, Ken| Shien, Kazuhiko| Miura, Akihiro| Takahashi, Yuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Tomida, Shuta| Tanaka, Shin| Miyoshi, Kentaroh| Otani, Shinji| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Soh, Junichi| Yamane, Masaomi| Toyooka, Shinichi| |
Published Date | 2022-05-04 |
Publication Title | Scientific Reports |
Volume | volume12 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 7297 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022 |
File Version | publisher |
PubMed ID | 35508484 |
DOI | 10.1038/s41598-022-11064-4 |
Web of Science KeyUT | 000790941900040 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-022-11064-4 |
FullText URL | fulltext.pdf |
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Author | Higo, Hisao| Ohashi, Kadoaki| Tomida, Shuta| Okawa, Sachi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Senoo, Satoru| Makimoto, Go| Ninomiya, Kiichiro| Nakasuka, Takamasa| Nishii, Kazuya| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Toyooka, Shinichi| Kiura, Katsuyuki| |
Keywords | Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy |
Published Date | 2022-02-07 |
Publication Title | Respiratory Research |
Volume | volume23 |
Issue | issue1 |
Publisher | BMC |
Start Page | 20 |
ISSN | 1465-993X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022. |
File Version | publisher |
PubMed ID | 35130915 |
DOI | 10.1186/s12931-022-01940-y |
Web of Science KeyUT | 000752386100002 |
Related Url | isVersionOf https://doi.org/10.1186/s12931-022-01940-y |
FullText URL | fulltext.pdf |
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Author | Oo, May Wathone| Kawai, Hotaka| Takabatake, Kiyofumi| Tomida, Shuta| Eguchi, Takanori| Ono, Kisho| Shan, Qiusheng| Ohara, Toshiaki| Yoshida, Saori| Omori, Haruka| Sukegawa, Shintaro| Nakano, Keisuke| Okamoto, Kuniaki| Sasaki, Akira| Nagatsuka, Hitoshi| |
Published Date | 2022-01-11 |
Publication Title | JCI Insight |
Volume | volume7 |
Issue | issue1 |
Publisher | American Society for Clinical Investigation |
Start Page | e148960 |
ISSN | 2379-3708 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022, Oo et al. |
File Version | publisher |
PubMed ID | 34874922 |
DOI | 10.1172/jci.insight.148960 |
Web of Science KeyUT | 000743257400001 |
Related Url | isVersionOf https://doi.org/10.1172/jci.insight.148960 |
FullText URL | fulltext.pdf |
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Author | Nakamura, Makoto| Meguri, Yusuke| Ikegawa, Shuntaro| Kondo, Takumi| Sumii, Yuichi| Fukumi, Takuya| Iwamoto, Miki| Sando, Yasuhisa| Sugiura, Hiroyuki| Asada, Noboru| Ennishi, Daisuke| Tomida, Shuta| Fukuda-Kawaguchi, Emi| Ishii, Yasuyuki| Maeda, Yoshinobu| Matsuoka, Ken-Ichi| |
Published Date | 2021-06-23 |
Publication Title | Scientific Reports |
Volume | volume11 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 13125 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2021 |
File Version | publisher |
PubMed ID | 34162921 |
DOI | 10.1038/s41598-021-92526-z |
Web of Science KeyUT | 000669995600012 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-021-92526-z |
FullText URL | fulltext.pdf |
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Author | Inoue, Hirofumi| Tomida, Shuta| Horiguchi, Shigeru| Kato, Hironari| Matsuoka, Hiromi| Sanehira, Etsuko| Matsuoka, Masashi| Yanai, Hiroyuki| Hirasawa, Akira| Toyooka, Shinichi| |
Keywords | cancer genomic profiling tests formalin‐fixed paraffin‐embedded (FFPE) tumor tissue genomic DNA extraction |
Note | This is the peer reviewed version of the following article: Hirofumi Inoue et. al. Best practices for the extraction of genomic DNA from formalin‐fixed paraffin‐embedded tumor tissue for cancer genomic profiling tests. Pathology International (2021), which has been published in final form at https://doi.org/10.1111/pin.13086. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This fulltext is available in March 2022.| |
Published Date | 2021-03-03 |
Publication Title | Pathology International |
Volume | volume71 |
Publisher | Wiley |
Start Page | 360 |
End Page | 364 |
ISSN | 1320-5463 |
NCID | AA10984364 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 33657250 |
DOI | 10.1111/pin.13086 |
Web of Science KeyUT | 000624843200001 |
Related Url | isVersionOf https://doi.org/10.1111/pin.13086 |
JaLCDOI | Training Medical Staff with Basic Skills for Data Science in Genomic Medicine |
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FullText URL | fulltext.pdf |
Author | Tomida, Shuta| Morita, Mizuki| Yamashita, Noriyuki| Hirasawa, Akira| Toyooka, Shinichi| |
Keywords | genomic medicine tumor mutation burden biomedical data science bioinformatics |
Published Date | 2020-05-01 |
Publication Title | YAKUGAKU ZASSHI |
Volume | volume140 |
Issue | issue5 |
Publisher | 日本薬学会 |
Start Page | 657 |
End Page | 661 |
ISSN | 0031-6903 |
NCID | AN00284903 |
Content Type | Journal Article |
language | Japanese |
OAI-PMH Set | 岡山大学 |
Copyright Holders | 日本薬学会 |
File Version | publisher |
PubMed ID | 32378667 |
DOI | 10.1248/yakushi.19-00217-2 |
Web of Science KeyUT | 000596822500010 |
Related Url | isVersionOf https://doi.org/10.1248/yakushi.19-00217-2 |
FullText URL | fulltext.pdf |
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Author | Nishii, Kazuya| Ohashi, Kadoaki| Tamura, Tomoki| Ninomiya, Kiichiro| Matsubara, Takehiro| Senoo, Satoru| Kano, Hirohisa| Watanabe, Hiromi| Oda, Naohiro| Makimoto, Go| Higo, Hisao| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Yamamoto, Hiromasa | Tomida, Shuta| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | non-small cell lung cancer epidermal growth factor receptor mutations droplet digital PCR exhaled breath condensate EGFR-TKIs |
Published Date | 2020-12 |
Publication Title | Oncology Letters |
Volume | volume20 |
Issue | issue6 |
Publisher | Spandidos Publications |
Start Page | 393 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 33193853 |
DOI | 10.3892/ol.2020.12256 |
Web of Science KeyUT | 000595649300005 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2020.12256 |
FullText URL | fulltext.pdf figure1.tif figure2.tif figure3.tif spfigure1.tif spfigure2.tif SupTable1.xlsx |
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Author | Ochi, Kosuke| Suzawa, Ken| Tomida, Shuta| Shien, Kazuhiko| Takano, Jui| Miyauchi, Shunsaku| Takeda, Tatsuaki| Miura, Akihiro| Araki, Kota| Nakata, Kentaro| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Yamane, Masaomi| Azuma, Kazuo| Okamoto, Yoshiharu| Toyooka, Shinichi| |
Keywords | Monensin Epithelial-mesenchymal transition Non-small cell lung cancer Drug repositioning Drug resistance |
Note | This fulltext is available in Jul. 2021.| |
Published Date | 2020-08-27 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume529 |
Issue | issue3 |
Publisher | Academic Press |
Start Page | 760 |
End Page | 765 |
ISSN | 0006-291X |
NCID | AA00564395 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32736704 |
DOI | 10.1016/j.bbrc.2020.06.077 |
Web of Science KeyUT | 000555780500037 |
Related Url | iaVersionOf https://doi.org/10.1016/j.bbrc.2020.06.077 |
Author | Isoshima, Daichi| Yamashiro, Keisuke| Matsunaga, Kazuyuki| Taniguchi, Makoto| Matsubara, Takehiro| Tomida, Shuta| Ota, Shinzo| Sato, Michiyoshi| Shimoe, Yutaka| Kohriyama, Tatsuo| Arias, Zulema| Omori, Kazuhiro| Yamamoto, Tadashi| Takashiba, Shogo| |
---|---|
Keywords | Microbiome Atherosclerosis Periodontitis Next-generating sequencing Oral bacteria |
Note | metadata only access| |
Published Date | 2020-05-19 |
Publication Title | Odontology |
Volume | volume109 |
Publisher | Springer |
Start Page | 239 |
End Page | 249 |
ISSN | 16181247 |
NCID | AA11580928 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | none |
PubMed ID | 32430725 |
DOI | 10.1007/s10266-020-00524-w |
Web of Science KeyUT | 000534632400001 |
Related Url | isVersionOf https://doi.org/10.1007/s10266-020-00524-w |
FullText URL | fulltext.pdf |
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Author | Matsubara, Takehiro| Soh, Junichi| Morita, Mizuki| Uwabo, Takahiro| Tomida, Shuta| Fujiwara, Toshiyoshi| Kanazawa, Susumu| Toyooka, Shinichi| Hirasawa, Akira| |
Published Date | 2020-02-27 |
Publication Title | BioMed Research International |
Volume | volume2020 |
Publisher | Hindawi |
Start Page | 9349132 |
ISSN | 2314-6133 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Takehiro Matsubara et al. |
File Version | publisher |
PubMed ID | 32185225 |
DOI | 10.1155/2020/9349132 |
Web of Science KeyUT | 000522222100002 |
Related Url | isVersionOf https://doi.org/10.1155/2020/9349132 |
FullText URL | fulltext.pdf |
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Author | Takeda, Tatsuaki| Yamamoto, Hiromasa| Suzawa, Ken| Tomida, Shuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Miura, Akihiro| Namba, Kei| Shien, Kazuhiko| Soh, Junichi| Shien, Tadahiko| Kitamura, Yoshihisa| Sendo, Toshiaki| Toyooka, Shinichi| |
Keywords | breast cancer drug resistance lung cancer neratinib YES1 |
Published Date | 2019-12-19 |
Publication Title | Cancer Science |
Volume | volume111 |
Issue | issue3 |
Publisher | Wiley |
Start Page | 849 |
End Page | 856 |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31856375 |
DOI | 10.1111/cas.14289 |
Web of Science KeyUT | 000507433400001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.14289 |
FullText URL | fulltext.pdf |
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Author | Yoshioka, Takahiro| Shien, Kazuhiko| Takeda, Tatsuaki| Takahashi, Yuta| Kurihara, Eisuke| Ogoshi, Yusuke| Namba, Kei| Torigoe, Hidejiro| Sato, Hiroki| Tomida, Shuta| Yamamoto, Hiromasa| Soh, Junichi| Fujiwara, Toshiyoshi| Toyooka, Shinichi| |
Keywords | afatinib gastric cancer HER2 MET YES1 |
Published Date | 2019-06-04 |
Publication Title | Cancer Science |
Volume | volume110 |
Issue | issue8 |
Publisher | Wiley Open Access |
Start Page | 2549 |
End Page | 2557 |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31162771 |
DOI | 10.1111/cas.14089 |
Web of Science KeyUT | 000478616800022 |
Related Url | isVersionOf https://doi.org/10.1111/cas.14089 |
FullText URL | J_Thorac_Oncol_201907017.pdf |
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Author | Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Nishii, Kazuya| Matsubara, Takehiro| Kayatani, Hiroe| Higo, Hisao| Ninomiya, Kiichiro| Sato, Akiko| Watanabe, Hiromi| Kano, Hirohisa| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Takata, Minoru| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | ALK G1202R Alectinib Amphiregulin MET NSCLC |
Published Date | 2019-07-30 |
Publication Title | Journal of Thoracic Oncology |
Volume | volume14 |
Issue | issue11 |
Publisher | Elsevier |
Start Page | 2009 |
End Page | 2018 |
ISSN | 15560864 |
NCID | AA12058455 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. |
File Version | author |
PubMed ID | 31374369 |
DOI | 10.1016/j.jtho.2019.07.017 |
Web of Science KeyUT | 000492678300025 |
Related Url | isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017 |