JaLCDOI | 10.18926/AMO/32431 |
---|---|
FullText URL | fulltext.pdf |
Author | Kumon, Hiromi| Ohmori, Hiroyuki| Tanaka, Toshio| |
Abstract | A total of 252 bladder-washing and voided specimens from normal, and inflammatory and malignant lesions were examined by a direct mapping technique, i.e., a combined use of light (LM) and scanning electron microscopy (SEM). A newly-designed mesh, which consists of a piece of gelatine-covered, osmium-impregnated and polylysine-coated glass-slip with 42 compartments/25 mm2, was used in this study. This mesh permitted us to directly correlate LM and SEM images, which resulted in a shortening of the observation time. Malignancy of exfoliated urothelial cells has been determined on the basis of the presence or absence of pleomorphic microvilli as observed by SEM. Subsequently, a new "SEM grading" system for human urinary cytology was proposed. The direct mapping technique has enhanced the accuracy of the diagnosis over conventional methods, especially in cases of noninvasive, low-grade malignant tumors of the urinary bladder. |
Keywords | urinary cytology bladder cancer scanning electron microscopy |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1983-06 |
Volume | volume37 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 233 |
End Page | 250 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 6192688 |
Web of Science KeyUT | A1983QW75400007 |
JaLCDOI | 10.18926/AMO/32408 |
---|---|
FullText URL | fulltext.pdf |
Author | Kumon, Hiromi| Furukawa, Masato| Tsugawa, Masaya| Matsumura, Yosuke| Ohmori, Hiroyuki| Tanaka, Toshio| |
Abstract | We reported a 62-year-old man with malacoplakia of the prostate, and reviewed 49 cases of malacoplakia hitherto observed in Japan in which the lesions originated from the urogenital tract, except for one gastric case. E. Coli was emphasized as a possible causative agent for malacoplakia especially in the urogenital tract. The possible histiocytic origin of von Hansemann cells was stressed by demonstrating cytoplasmic processes and desmosomes in our prostatic case. An adjuvant use of cholinergic agents and ascorbic acid with chemotherapeutic agents was recommended for treating malacoplakia. |
Keywords | malacoplakia prostate von Hansemann cell |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1983-12 |
Volume | volume37 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 493 |
End Page | 501 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 6666677 |
Web of Science KeyUT | A1983RW62800005 |
JaLCDOI | 10.18926/AMO/32115 |
---|---|
FullText URL | fulltext.pdf |
Author | Araki, Tohru| Yokoyama, Teruhiko| Kumon, Hiromi| |
Abstract | We explored the effectiveness of loxoprofen sodium (loxoprofen), which is the most common non-steroidal anti-inflammatory drug (NSAID) in Japan, for patients with benign prostatic hyperplasia (BPH) complaining of nocturia. A total of 93 BPH patients aged 49-84 years were enrolled in the study. These patients had received standard drug therapy with alpha1-blocker for BPH, followed by anticholinergic drugs, hypnotics, tricyclic antidepressants, and/or antiduretic hormone, but they still complained about 2 or more episodes of nocturia. They each took a single 60-mg tablet of loxoprofen prior to sleeping at night for 14 days in addition to their BPH treatments. The effects were assessed by questionnaire before and after treatment as excellent (nocturia disappeared or decreased by 2 or more voids/night), improved (nocturia decreased by 1 void/night), unchanged, or worsened (nocturia increased). Nocturia improved or disappeared in 74.2% of patients: excellent, improved, unchanged, and worsened results were obtained in 37.6%, 36.6%, 21.5%, and 4.3% of patients, respectively. The effects were better in patients whose baseline nocturia was > 2 times than in those with a lesser frequency at enrollment (P = 0.04). Loxoprofen can be an effective and useful treatment option for patients with BPH complaining of refractory nocturia. |
Keywords | nocturia loxoprofen sodium non-steroidal anti-inflammatory drugs (NSAIDs) |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2004-02 |
Volume | volume58 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 45 |
End Page | 49 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 15157011 |
Web of Science KeyUT | 000189271100007 |
JaLCDOI | 10.18926/AMO/32106 |
---|---|
FullText URL | fulltext.pdf |
Author | Yokoyama, Teruhiko| Tsugawa, Masaya| Nagai, Atsushi| Kumon, Hiromi| |
Abstract | We retrospectively evaluated the subjective and objective treatment results of transurethral microwave thermotherapy (TUMT) for benign prostatic hyperplasia (BPH) and explored the difference in effectiveness between 30- and 60-min single treatments. From June 1997 through March 2003, 58 men with BPH underwent TUMT using the Targis device. Twenty-seven and 31 patients each received a single treatment of 60 or 30 min, respectively. Evaluations after treatment included a clinical determination of the International Prostate Symptom Score, urodynamic assessments by peak flow rate, and magnetic resonance imaging (MRI). In the 60-min treatment, the symptom score improved significantly, from 17.9 to 9.5 after 2 months. Similarly, there was a significant improvement in peak flow rate, from 6.7 to 11.2 ml/sec after 2 months. In the 30-min treatment, the symptom score also improved significantly, from 18.4 to 13.4 after 2 weeks. Similarly, there was a significant improvement in the peak flow rate, from 6.4 to 11.7 ml/sec after 1 month. MRI imaging showed necrosis of the prostate gland 2 weeks after either treatment. These results demonstrated that both the 60-min and the 30-min treatments were effective for patients with BPH. Moreover, the 30-min treatment led to quicker improvement than the 60-min treatment. Thus, a 30-min TUMT protocol is considered recommendable for this treatment. |
Keywords | prostate benign prostatic hyperplasia microwave thermotherapy MRI |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2004-06 |
Volume | volume58 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 151 |
End Page | 156 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 15471437 |
Web of Science KeyUT | 000222273300006 |
JaLCDOI | 10.18926/AMO/32090 |
---|---|
FullText URL | fulltext.pdf |
Author | Ando, Eiichi| Monden, Koichi| Mitsuhata, Ritsuko| Kariyama, Reiko| Kumon, Hiromi| |
Abstract | Staphylococci have been confirmed to form biofilms on various biomaterials. The purpose of this study was to investigate biofilm formation among methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with urinary tract infection (UTI) and to assess the relationship between biofilm-forming capacities and virulence determinants/clinical background. Over a 12-year period from 1990 through 2001, a total of 109 MRSA isolates were collected from patients (one isolate per patient) with UTI at the urology ward of Okayama University Hospital. We used the in vitro microtiter plate assay to quantify biofilm formation. We then investigated the presence of several virulence determinants by polymerase chain reaction assay and found eight determinants (tst, sec, hla, hlb, fnbA, clfA, icaA, and agrII) to be predominant among these isolates. Enhanced biofilm formation was confirmed in hla-, hlb-, and fnbA-positive MRSA isolates, both individually and in combination. Upon review of the associated medical records, we concluded that the biofilm-forming capacities of MRSA isolates from catheter-related cases were significantly greater than those from catheter-unrelated cases. The percentage of hla-, hlb-, and fnbA-positive isolates was higher among MRSA isolates from catheter-related cases than those from catheter-unrelated cases. Our studies suggest that MRSA colonization and infection of the urinary tract may be promoted by hla, hlb, and fnbA gene products. |
Keywords | methicillin-resistant Staphylococcus aureus urinary tract infection biofilm formation |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2004-08 |
Volume | volume58 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 207 |
End Page | 214 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 15551758 |
Web of Science KeyUT | 000223559700005 |
JaLCDOI | 10.18926/AMO/32084 |
---|---|
FullText URL | fulltext.pdf |
Author | Abarzua, Fernando| Monden, Koichi| Nagai, Atsushi| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | Ureteroscopy has evolved in many aspects, particularly in the flexibility and size of ureteroscopes. We have developed a new detachable access sheath to make ureteroscopic procedures more straight-forward and to reduce possible damage to delicate instruments used in the procedure. |
Keywords | ureteroscopy detachable accesss heath |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2004-08 |
Volume | volume58 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 215 |
End Page | 216 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 15551759 |
Web of Science KeyUT | 000223559700006 |
JaLCDOI | 10.18926/AMO/32050 |
---|---|
FullText URL | fulltext.pdf |
Author | Kumon, Hiromi| Morioka, Masaaki| Araki, Tohru| Matsumura, Yosuke| Ohmori, Hiroyuki| Tanaka, Toshio| |
Abstract | A case of extravesical malacoplakia, the first case in Japan, is described in detail. The patient was a 61-year-old woman with a right flank mass. Radiologically, the mass was thought to be of the renal origin. Surgically, however, the tumor was found attached not only to the cortical surface but extended to the retroperitoneum and psoas muscle. Pathological examination confirmed the lesion to be malacoplakia characterized by the presence of von Hansemann cells and Michaelis-Gutmann bodies. |
Keywords | malacoplakia retroperitomeum |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1979-12 |
Volume | volume33 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 455 |
End Page | 462 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 161471 |
NAID | 120002311746 |
JaLCDOI | 10.18926/AMO/31979 |
---|---|
FullText URL | fulltext.pdf |
Author | Seno, Yuko| Kariyama, Reiko| Mitsuhata, Ritsuko| Monden, Koichi| Kumon, Hiromi| |
Abstract | The potential relationships between biofilm formation and pathogenicity of Enterococcus faecalis in urinary tract infections (UTI) were investigated. Over a 12-year period from 1991 through 2002, a total of 352 E.faecalis isolates were collected from patients with complicated UTI (one isolate per patient) at the urology ward of Okayama University Hospital. We analyzed the prevalence and transferability of genes encoding virulence factors(asa1, esp, cylA, gelE /sprE )and antimicrobial resistance(aac(6') /aph(2'')). The production of biofilm, hemolysin and gelatinase by these isolates was also examined and the associated medical records of patients were retrospectively reviewed. Of 352 E. faecalis isolates, 315 possessed and/or genes. Of the 63 hemolysin- and 167 gelatinase-producing isolates, 59 and 94 isolates, respectively, possessed both asa1 and esp genes. E. faecalis isolates with both asa1 and esp genes formed biofilms at significantly higher rates than those with neither gene (P=0.038). The genes encoding asa1, cylA , and aac(6') /(aph(2'') were transferable and appeared to have accumulated in these isolates. The E. faecalis isolates possessing asa1 and/or esp genes were found from both catheter-related or -unrelated UTI. Our study indicates that E. faecalis isolates that have accumulated virulence genes are apt to form persistent biofilms in the urinary tracts. |
Keywords | Enterococcus faecalis urinary tract infection biofilm formation pathogenicity gene transfer |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2005-06 |
Volume | volume59 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 79 |
End Page | 87 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16049560 |
Web of Science KeyUT | 000230039100002 |
JaLCDOI | 10.18926/AMO/31978 |
---|---|
FullText URL | fulltext.pdf |
Author | Ozawa, Hideo| Nagai, Atsushi| Uematsu, Katsutoshi| Ohmori, Hiroyuki| Kumon, Hiromi| |
Abstract | We report a case in which retroperitoneoscopic pyelolithotomy was the procedure selected to treat a large stone in the upper urinary tract. A 71-year-old woman who had multiple cerebral infarction and dementia was admitted with a persistent high fever unresponsive to antibiotics. The diagnosis was pyelonephritis and urosepsis associated with ureteral calculus. A large calculus(3.0 x 2.0 cm)was found in the left ureter at the L3 level. She underwent nephrostomy of the left side. After the patient's general condition had improved, surgery was performed successfully with an uneventful recovery. The findings in this case confirm that retroperitoneoscopic surgery allows removal of a large stone in a single, minimally invasive procedures. |
Keywords | retroperitoneoscopic pyelolithotomy urinary stone laparoscopic surgery |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2005-06 |
Volume | volume59 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 109 |
End Page | 112 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16049564 |
Web of Science KeyUT | 000230039100006 |
JaLCDOI | 10.18926/AMO/31977 |
---|---|
FullText URL | fulltext.pdf |
Author | Mikuniya, Takeshi| Kato, Yoshihisa| Kariyama, Reiko| Monden, Koichi| Hikida, Muneo| Kumon, Hiromi| |
Abstract | Ulifloxacin is the active form of the prodrug prulifloxacin and shows a highly potent antipseudomonal activity. In this study, we examined the combined effect of fosfomycin and ulifloxacin against Pseudomonas aeruginosa (P. aeruginosa) growing in a biofilm using a modified Robbins device with artificial urine, and compared it to that of the combination of fosfomycin and ciprofloxacin or levofloxacin. An ATP bioluminescence assay was used to evaluate the antibacterial activity of the agents against sessile cells in a mature biofilm developed on a silicon disk. The total bioactivity of P. aeruginosa growing in a biofilm that had not been fully eradicated by fosfomycin or any of the fluoroquinolones alone at 10 times the MIC decreased after combination treatment with fosfomycin and fluoroquinolones. Morphological changes occurred in a time-dependent fashion; namely, swollen and/or rounding cells emerged within a couple of hours after combination treatment, marking the initial stage in the process leading to the destruction of the biofilms. We could not find any difference among the 3 fluoroquinolones with regard to their synergistic effects when administered with fosfomycin. The combination treatment of fosfomycin and fluoroquinolones with highly potent antipseudomonal activities was effective in eradicating sessile cells of P. aeruginosa in the biofilm and promises to be beneficial against biofilm-associated infectious diseases. |
Keywords | urinary tract infection Pseudomonas aeruginosa biofilm ulifloxacin fosfomycin |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2005-10 |
Volume | volume59 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 209 |
End Page | 216 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16286954 |
Web of Science KeyUT | 000232835600005 |
JaLCDOI | 10.18926/AMO/31976 |
---|---|
FullText URL | fulltext.pdf |
Author | Nagai, Atsushi| Tokuyama, Eijirou| Nanba, Yuzaburo| Tsutsui, Tetsuya| Kimata, Yoshihiro| Nakatsuka, Mikiya| Koshima, Isao| Saika, Takashi| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | The first case of sex reassignment surgery (SRS) in our hospital was performed in January 2001; as of February, 2005, 4 cases of MTF-SRS had been performed. In the 2 most recent cases, we used penile and scrotal skin flaps to avoid complications. The depth and width of the new vagina was made to be adequate for sexual intercourse. Future attention should be focused on devising a surgical technique that will help prevent the complications of partial necrosis of the epidermal skin and wound dehiscence. Although ours is only an initial experience, we describe our surgical technique herein. |
Keywords | gender identity disorder sex reassignment surgery male to female transsexual |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2005-10 |
Volume | volume59 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 231 |
End Page | 233 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16286961 |
Web of Science KeyUT | 000232835600008 |
JaLCDOI | 10.18926/AMO/31973 |
---|---|
FullText URL | fulltext.pdf |
Author | Edamura, Kohei| Saika, Takashi| Senoh, Takashi| Koizumi, Fumihito| Manabe, Daisuke| Ebara, Shin| Kaku, Haruki| Yokoyama, Teruhiko| Abarzua, Fernando| Nagai, Atsushi| Nasu, Yasutomo| Tsushima, Tomoyasu| Kumon, Hiromi| |
Abstract | This study was undertaken to reveal the trends of prostate cancer and the outcome of treatment modalities for each disease stage in patients in a single institute over a 10-year period. From January 1994 through December 2003, 420 consecutive patients with previously untreated and histologically confirmed prostate cancer were analyzed for annual distributions of disease stages and treatment modalities and for long-term clinical progression-free survival, prostate cancer-specific survival, and prostate-specific antigen (PSA) failure-free survival rates for each stage and treatment modality. Annual trends showed that the number of patients, especially those with clinically localized cancer, increased dramatically. The 5-year disease-specific survival rates for patients with clinically localized disease were 100 percent for all treatment modalities, including hormonal therapy alone. Patients with PSA levels less than 10 ng/ml showed an 81 percent 5-year PSA failure-free survival rate with radical prostatectomy. Stage C patients treated by surgery or radiation-based therapy with concomitant hormonal therapy obtained 93 percent and 100 percent cause-specific survival rates, respectively, and those treated by hormonal therapy alone showed a 79 percent rate. The number of patients with localized prostate cancer was increasing in this decade. While long-term hormonal therapy alone was highly efficient in controlling localized prostate cancer, radical therapies in conjunction with neo-adjuvant hormonal therapy produced better survival rates in cases of locally advanced disease. |
Keywords | prostate carcinoma long-term cohort retrospective outcome |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2005-10 |
Volume | volume59 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 195 |
End Page | 199 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16286958 |
Web of Science KeyUT | 000232835600003 |
JaLCDOI | 10.18926/AMO/31964 |
---|---|
FullText URL | fulltext.pdf |
Author | Nagai, Atsushi| Nasu, Yasutomo| Watanabe, Masami| Kusumi, Norihiro| Tsuboi, Hiromu| Kumon, Hiromi| |
Abstract | We investigated the usefulness of one-stage urethroplasty by the parameatal foreskin flap method (OUPF procedure), which is useful for repairing all types of hypospadias. Between June 1992 and March 2001, the OUPF procedure was performed on 18 patients with hypospadias: 10 patients with distal and 8 with proximal hypospadias. The follow-up periods ranged from 33-75 months, with an average of 52 months. The duration of surgery, the catheter indwelling period, and the postoperative complications of each patient were analyzed. The median age of the patients at the time of surgery was 3 years and 8 months. The length of surgery for OUPF II ranged from 150-230 min (average 186 min), and from 190-365 min (average 267 min) for OUPF IV. Postoperative complications were confirmed in 3 of the 18 patients (16.6%). Two patients had fistulas, and one had a meatal regression. The fistulas were successfully closed by the simple multilayered closure method. After adopting DuoDerm dressings instead of elastic bandages for protection of the wound, no fistulization occurred. DuoDerm dressings are useful in the healing of wounds without complications. To date, the longest follow-up period has been 75 months, and during that time there have been no late complications such as urethral stenosis or penile curvature. OUPF is a useful method in the treatment of hypospadias with a low incidence of early and late complications. |
Keywords | hypospadias one-stageure throplasty OUPF DuoDerm dressings |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2005-04 |
Volume | volume59 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 45 |
End Page | 48 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16049554 |
Web of Science KeyUT | 000228590000002 |
JaLCDOI | 10.18926/AMO/31956 |
---|---|
FullText URL | fulltext.pdf |
Author | Nagai, Atsushi| Kusumi, Norihiro| Tsuboi, Hiromu| Ishii, Kazushi| Saika, Takashi| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77 percent ) cases responded to 20 mcg of PGE1. Forty mcg of PGE was injected into the 15 non-responding cases, and 9 patients responded favorably. The overall effective rate was 58/64 (91 percent ). No major adverse effects were observed. |
Keywords | prostaglandin E1 intracavernous injection erectile dysfunction PDE5 inhibitors |
Amo Type | Short Communication |
Publication Title | Acta Medica Okayama |
Published Date | 2005-12 |
Volume | volume59 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 279 |
End Page | 280 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16418771 |
Web of Science KeyUT | 000234176600006 |
JaLCDOI | 10.18926/AMO/31847 |
---|---|
FullText URL | fulltext.pdf |
Author | Kobuke, Makoto| Saika, Takashi| Nakanishi, Yoshiko| Ebara, Shin| Manabe, Daisuke| Uesugi, Tatsuya| Nose, Hiroyuki| Arata, Ryoji| Tsushima, Tomoyasu| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | To determine health-related quality of life (HRQOL) after radical retropubic prostatectomy (RRP) or permanent prostate brachytherapy (BT), third party-conducted QOL surveys were prospectively compared. Between 2004 and 2005, 37 patients underwent RRP and 36 were treated with BT. A QOL survey consisting of the Medical Outcomes Study 36-Item Short Form (SF-36), the University of California, Los Angeles, Prostate Cancer Index (UCLA-PCI) and the International Prostate Symptoms Score (IPSS) was completed prospectively by a research coordinator at baseline, and at 1, 3, 6 and 12 months after treatment. The RRP patients scored well in general QOL except at 1 month after surgery, with their mental health better than at baseline by 6 months after surgery. Disease-specific QOL in RRP patients received a low score at 1 month for both urinary and sexual function, though urinary function rapidly recovered to baseline levels. BT patient QOL was not affected by the therapy except in the IPSS score. However, general and mental health scores in BT patients were inferior to those in RRP patients. This prospective study revealed differences in QOL after RRP and BT. These results will be helpful in making treatment decisions. |
Keywords | prostate cancer radical prostatectomy QOL brachytherapy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-06 |
Volume | volume63 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 129 |
End Page | 135 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19571899 |
Web of Science KeyUT | 000267388200002 |
JaLCDOI | 10.18926/AMO/31836 |
---|---|
FullText URL | fulltext.pdf |
Author | Wada, Koichiro| Kariyama, Reiko| Mitsuhata, Ritsuko| Uehara, Shinya| Watanabe, Toyohiko| Monden, Koichi| Kumon, Hiromi| |
Abstract | Urinary tract infections (UTIs) due to fluoroquinolone-insusceptible Escherichia coli have become increasingly common in recent years. We investigated the potential relationships between clinical measures to combat fluoroquinolone-insusceptible E. coli and experimental analyses on E. coli isolates. Over a 14-year period from 1994 through 2007, a total of 828 E. coli isolates were collected from patients (one isolate per patient) with UTI at the urology ward of Okayama University Hospital. We analyzed the mutations in quinolone resistance-determining regions of DNA gyrase (gyrA) and topoisomerase IV (parC). The production of biofilm by these isolates was also examined and the associated medical records were retrospectively reviewed. Seven of 189 (3.7%) strains from uncomplicated UTIs and 82 of 639 (12.8%) strains from complicated UTIs were insusceptible to fluoroquinolones. Amino acid replacements of type II topoisomerases were frequently observed at positions 83 and 87 in GyrA and at positions 80 and 84 in ParC. No significant difference in the biofilm-forming capabilities was observed between fluoroquinolone-susceptible and -insusceptible E. coli. Our study suggests that biofilm formation of fluoroquinolone-insusceptible E. coli isolates is not a major mechanism of resistance in patients with UTI. |
Keywords | fluoroquinolone Escherichia coli biofilm MICs QRDRs |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-10 |
Volume | volume63 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 263 |
End Page | 272 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19893602 |
Web of Science KeyUT | 000271132000006 |
JaLCDOI | 10.18926/AMO/31722 |
---|---|
FullText URL | fulltext.pdf |
Author | Nagai, Atsushi| Nasu, Yasutomo| Shirasaki, Yoshinori| Iguchi, Hiroki| Arata, Ryouji| Tsugawa, Masaya| Tsushima, Tomoyasu| Kumon, Hiromi| |
Abstract | We performed laparoscopic prostatectomy in seven cases with organ-confined prostate cancer. In 6 cases, the surgery was completed successfully and the mean operative time was 424 min. Volume of blood loss was 200 to 3,200 ml and catheterization lasted 6 to 37 days. No major complications were observed in 6 of the cases. In one case, open surgical conversion was necessary mainly due to a bladder injury. Although these were the first cases of laparoscopic prostatectomy in our institution, the technical difficulty and complexity of the surgery were moderate. We believe that laparoscopic radical prostatectomy will become a standard option for the treatment of organ-confined prostate cancer. |
Keywords | prosatatic cancer laparoscopy prostatectomy |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-02 |
Volume | volume56 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 51 |
End Page | 52 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 11873945 |
Web of Science KeyUT | 000174031300009 |
JaLCDOI | 10.18926/AMO/31693 |
---|---|
FullText URL | fulltext.pdf |
Author | Yokoyama, Teruhiko| Kumon, Hiromi| Smith, Christopher P| Somogyi, George T| Chancellor, Michael B| |
Abstract | Tremendous excitement has been generated by the use of botulinum toxin for the treatment of various types of urethral and bladder dysfunction over the past several years. Botulinum toxin is the most lethal naturally occurring toxin known to mankind. Why, then, would an urologist want to use this agent to poison the bladder or urethral sphincter? In this review article we will examine the mechanisms underlying the effects of botulinum toxin treatment. We will discuss the current use of this agent within the urologic community and will provide perspectives on future targets of botulinum toxin. |
Keywords | botulinum toxin urethra bladder |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-12 |
Volume | volume56 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 271 |
End Page | 277 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 12685855 |
Web of Science KeyUT | 000179959000001 |
JaLCDOI | 10.18926/AMO/31681 |
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FullText URL | fulltext.pdf |
Author | Iguchi, Hiroki| Watanabe, Masami| Kamitani, Akihiro| Nagai, Atsushi| Hosoya, Osamu| Tsutsui, Kimiko| Kumon, Hiromi| |
Abstract | Dynamin is a protein essential to endocytosis. Dynamin 2, a dynamin isoform, is expressed most intensely in testicular tissue; however, precise localization has never been studied. Therefore, we investigated the expression of dynamin 2 in rat testicular tissue using immunohistochemical methods, and discuss here the physiological function of this protein. Testicular tissues were obtained from Wistar rats at 10, 21 and 63 days of age. Immunohistochemistrical examination and Western blot analysis were conducted using dynamin 2 specific antibody. Western blot analysis showed that expression in 21- and 63-day-old rats was more intense than that in 10-day-old rats. Dynamin 2 expression was observed using immunohistochemical method in the seminiferous tubules of all rats. In the 63-day-old rats, the expression was intense, especially in spermatids in the earlier maturation stages and in spermatocytes, and was observed in Sertoli cells. However, in spermatids, the expression gradually declined as spermatids matured to spermatozoa. In the 21-day-old rats, the expression was evident in spermatocytes and Sertoli cells, but that in the 10-day-old rats was weak. Intense expression of dynamin 2 during spermatogenesis suggests that this protein plays an important role in this process. |
Keywords | dynamin 2 endocytosis spermatogenesis |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-08 |
Volume | volume56 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 205 |
End Page | 209 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 12199526 |
Web of Science KeyUT | 000177382600006 |
JaLCDOI | 10.18926/AMO/30950 |
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FullText URL | fulltext.pdf |
Author | Saika, Takashi| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Manabe, Daisuke| Ebara, Shin| Uehara, Shinya| Nasu, Yasutomo| Kumon, Hiromi| |
Abstract | To evaluate morbidity in Hybrid Radical Prostatectomy (HRP, hybridized laparoscopic and open retropubic radical prostatectomy). The operative and pathological outcomes obtained in 25 consecutive patients who underwent HRP were reviewed. The median operating time was 220min, median blood loss was 550ml, and no patient required an allogenic blood transfusion. No severe postoperative complications were observed. The surgical margin was positive in 12% of all patients, and in 1 patient with pT2 or less (4.5%). These results indicate that HRP is safe and may be able to combine the benefits of both laparoscopic and open procedures. |
Keywords | prostate cancer radical prostatectomy hybrid surgery morbidity positive surgical margin |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2008-12 |
Volume | volume62 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 379 |
End Page | 384 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
Web of Science KeyUT | 000262025000004 |