| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Published Date | 2024-02-20 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0298292 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Nishida, Kenji| Yanai, Hiroyuki| Nakamura, Tomoki| Tanaka, Kazuhiro| Ozaki, Toshifumi| |
| Keywords | alveolar soft part sarcoma surgery chemotherapy targeted therapy immunotherapy |
| Published Date | 2023-08-25 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume53 |
| Issue | issue11 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 1009 |
| End Page | 1018 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37626447 |
| DOI | 10.1093/jjco/hyad102 |
| Web of Science KeyUT | 001080372000001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad102 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takihira, Shota| Yamada, Daisuke| Osone, Tatsunori| Takao, Tomoka| Sakaguchi, Masakiyo| Hakozaki, Michiyuki| Itano, Takuto| Nakata, Eiji| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Ozaki, Toshifumi| Takarada, Takeshi| |
| Note | The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02632-8| |
| Published Date | 2024-03-06 |
| Publication Title | British Journal of Cancer |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0007-0920 |
| NCID | AA00574355 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38448751 |
| DOI | 10.1038/s41416-024-02632-8 |
| Web of Science KeyUT | 001180796100003 |
| Related Url | isVersionOf https://doi.org/10.1038/s41416-024-02632-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Haruyoshi| Fujimura, Atsushi| Huang, Rongsheng| Otani, Yusuke| Itano, Takuto| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter |
| Published Date | 2024-01-26 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 871 |
| End Page | 882 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38279513 |
| DOI | 10.1111/cas.16077 |
| Web of Science KeyUT | 001149722500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16077 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Fujiwara, Tomohiro| Katayama, Haruyoshi| Itano, Takuto| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | malignant wounds soft tissue sarcoma microbiological analysis surgical site infection prognosis |
| Published Date | 2022-08-17 |
| Publication Title | Oncology Letters |
| Volume | volume24 |
| Issue | issue4 |
| Publisher | Spandidos Publications |
| Start Page | 345 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Nakata et al. |
| File Version | publisher |
| PubMed ID | 36072006 |
| DOI | 10.3892/ol.2022.13465 |
| Web of Science KeyUT | 000891420600001 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2022.13465 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Kawai, Hotaka| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Inoue, Hirofumi| Futagawa, Mashu| Katayama, Haruyoshi| Itano, Takuto| Ozaki, Toshifumi| |
| Keywords | giant cell tumor of bone malignant transformation p53 denosumab molecular targeted therapy |
| Published Date | 2022-07-19 |
| Publication Title | Oncology Letters |
| Volume | volume24 |
| Issue | issue3 |
| Publisher | Spandidos Publications |
| Start Page | 319 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Nakata et al. |
| File Version | publisher |
| PubMed ID | 35949597 |
| DOI | 10.3892/ol.2022.13439 |
| Web of Science KeyUT | 000840512400001 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2022.13439 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakahara, Ryuichi| Katayama, Haruyoshi| Itano, Takuto| Ozaki, Toshifumi| |
| Keywords | Soft tissue sarcomas Forearm Function Prognosis |
| Note | The version of record of this article, first published in Journal of Orthopaedic Surgery and Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13018-023-04088-7| |
| Published Date | 2023-08-14 |
| Publication Title | Journal of Orthopaedic Surgery and Research |
| Volume | volume18 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 599 |
| ISSN | 1749-799X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37580775 |
| DOI | 10.1186/s13018-023-04088-7 |
| Web of Science KeyUT | 001049196400001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13018-023-04088-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| Kawai, Akira| |
| Keywords | Alveolar soft part sarcoma Survival Surgery Chemotherapy Pazopanib |
| Published Date | 2022-08-15 |
| Publication Title | BMC Cancer |
| Volume | volume22 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 891 |
| ISSN | 1471-2407 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35971085 |
| DOI | 10.1186/s12885-022-09968-5 |
| Web of Science KeyUT | 000840842400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-022-09968-5 |
| FullText URL | fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf |
|---|---|
| Author | Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53 |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5| |
| Published Date | 2021-6-10 |
| Publication Title | Cancer Chemotherapy and Pharmacology |
| Volume | volume88 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 513 |
| End Page | 524 |
| ISSN | 0344-5704 |
| NCID | AA00598397 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 34114067 |
| DOI | 10.1007/s00280-021-04310-5 |
| Web of Science KeyUT | 000659839700002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00280-021-04310-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Omori, Toshinori| Tazawa, Hiroshi| Yamakawa, Yasuaki| Osaki, Shuhei| Hasei, Joe| Sugiu, Kazuhisa| Komatsubara, Tadashi| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein |
| Published Date | 2021-04-22 |
| Publication Title | PLoS ONE |
| Volume | volume16 |
| Issue | issue4 |
| Publisher | Public Library Science |
| Start Page | e0250643 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Omori et al. |
| File Version | publisher |
| PubMed ID | 33886686 |
| NAID | 120007045007 |
| DOI | 10.1371/journal.pone.0250643 |
| Web of Science KeyUT | 000644138300019 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0250643 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ise, Masato| Nakata, Eiji| Katayama, Yoshimi| Hamada, Masanori| Kunisada, Toshiyuki| Fujiwara, Tomohiro| Nakahara, Ryuichi| Takihira, Shouta| Sato, Kohei| Akezaki, Yoshiteru| Senda, Masuo| Ozaki, Toshifumi| |
| Keywords | psychological distress distress and impact thermometer bone and soft tissue tumor surgery |
| Published Date | 2021-05-01 |
| Publication Title | Healthcare |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 566 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| NAID | 120007042388 |
| DOI | 10.3390/healthcare9050566 |
| Web of Science KeyUT | 000654015500001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare9050566 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yokoo, Suguru| Fujiwara, Tomohiro| Yoshida, Aki| Uotani, Koji| Morita, Takuya| Kiyono, Masahiro| Hasei, Joe| Nakata, Eiji| Kunisada, Toshiyuki| Iwata, Shintaro| Yonemoto, Tsukasa| Ueda, Koji| Ozaki, Toshifumi| |
| Keywords | liquid biopsy synovial sarcoma monocarboxylate transporter 1 extracellular vesicles non-invasive biomarker |
| Published Date | 2021-04-11 |
| Publication Title | Cancers |
| Volume | volume13 |
| Issue | issue8 |
| Publisher | MDPI |
| Start Page | 1823 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33920416 |
| NAID | 120007037389 |
| DOI | 10.3390/cancers13081823 |
| Web of Science KeyUT | 000644023400001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers13081823 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Healey, John| Ogura, Koichi| Yoshida, Aki| Kondo, Hiroya| Hata, Toshiaki| Kure, Miho| Tazawa, Hiroshi| Nakata, Eiji| Kunisada, Toshiyuki| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Keywords | sarcoma tumor-associated macrophage prognosis clinical trial immunotherapy |
| Published Date | 2021-03-03 |
| Publication Title | Cancers |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1086 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33802565 |
| NAID | 120007008531 |
| DOI | 10.3390/cancers13051086 |
| Web of Science KeyUT | 000627955600001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers13051086 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kunisada, Toshiyuki| Hasei, Joe| Fujiwara, Tomohiro| Nakata, Eiji| Yokoo, Suguru| Demiya, Koji| Ozaki, Toshifumi| |
| Published Date | 2020-12-09 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 21578 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 33299043 |
| DOI | 10.1038/s41598-020-78409-9 |
| Web of Science KeyUT | 000608956800002 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-78409-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Joko, Ryoji| Yamada, Daisuke| Nakamura, Masahiro| Yoshida, Aki| Takihira, Shota| Takao, Tomoka| Lu, Ming| Sato, Kohei| Ito, Tatsuo| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| Takarada, Takeshi| |
| Keywords | PRRX1 Osteosarcoma Tumor malignancy Invasion Drug resistance Connectivity map analysis |
| Published Date | 2021-01 |
| Publication Title | Translational Oncology |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 100960 |
| ISSN | 1936-5233 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 33395745 |
| DOI | 10.1016/j.tranon.2020.100960 |
| Web of Science KeyUT | 000604582300006 |
| Related Url | isVersionOf https://doi.org/10.1016/j.tranon.2020.100960 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Sugihara, Shinsuke| Sugawara, Yoshifumi| Nakahara, Ryuichi| Furumatsu, Takayuki| Tetsunaga, Tomonori| Kunisada, Toshiyuki| Nakanishi, Kazuo| Ozaki, Toshifumi| |
| Keywords | bone metastasis multidisciplinary treatment skeletal-related event malignant spinal cord compression neurological deficit |
| Published Date | 2020-02-20 |
| Publication Title | Oncology Letters |
| Volume | volume19 |
| Issue | issue4 |
| Publisher | Spandidos Publications |
| Start Page | 3137 |
| End Page | 3144 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Nakata et al. |
| File Version | publisher |
| PubMed ID | 32218864 |
| DOI | 10.3892/ol.2020.11415 |
| Web of Science KeyUT | 000523763900064 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2020.11415 |
| FullText URL | fulltext.pdf figures.pdf SuppleFigures.pdf |
|---|---|
| Author | Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Keywords | Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8 |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7.| |
| Published Date | 2020-11-05 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume70 |
| Publisher | Springer |
| Start Page | 1405 |
| End Page | 1417 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33151368 |
| DOI | 10.1007/s00262-020-02774-7 |
| Web of Science KeyUT | 000586350500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00262-020-02774-7 |
| FullText URL | fulltext.pdf Suppl. Info.pdf Suppl. Tables.xlsx |
|---|---|
| Author | Morita, Takuya| Fujiwara, Tomohiro| Yoshida, Aki| Uotani, Koji| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | Sarcoma Translational research |
| Published Date | 2020-06-10 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 9414 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32523124 |
| DOI | 10.1038/s41598-020-66120-8 |
| Web of Science KeyUT | 000560478900030 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-66120-8 |
| FullText URL | fulltext.pdf Tables.pdf Fig1.tif Fig2.tif Supplementary Tables.pdf Supplementary Fig.pdf |
|---|---|
| Author | Yamamoto, Hiromasa| Namba, Kei| Yamamoto, Haruchika| Toji, Tomohiro| Soh, Junichi| Shien, Kazuhiko| Suzawa, Ken| Kurosaki, Takeshi| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Kunisada, Toshiyuki| Oto, Takahiro| Toyooka, Shinichi| |
| Keywords | Metastatic lung tumor Sarcoma Metastasectomy Survival rate Neutrophil-to-lymphocyte ratio (NLR) |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-02093-5. | |
| Published Date | 2020-08-03 |
| Publication Title | Surgery Today |
| Publisher | Springer |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32747982 |
| DOI | 10.1007/s00595-020-02093-5 |
| Web of Science KeyUT | 000555382600001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-020-02093-5 |
