JaLCDOI 10.18926/AMO/53556
FullText URL 69_4_205.pdf
Author Okada, Yoshiki| Endo, Hirosuke| Mitani, Shigeru| Fujiwara, Kazuo| Tetsunaga, Tomonori| Kagawa, Yohei| Fujii, Yosuke| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15オ, 9.0オ, 6.0オ, and 6.4オ, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0オ), minor bleeding in 2 cases (2.0オ), persistent wound drainage in 3 cases (3.0オ), and eruption in 1 case (1.0オ). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0オ) and progression of anemia in 1 case (1.0オ). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases.
Keywords total hip arthroplasty venous thromboembolism anticoagulant prophylaxis complications
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-08
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 205
End Page 212
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289911
Web of Science KeyUT 000365519100003
Related Url http://doi.org/10.18926/AMO/53680
JaLCDOI 10.18926/AMO/53680
FullText URL 69_5_325.pdf
Author Okada, Yoshiki| Endo, Hirosuke| Mitani, Shigeru| Fujiwara, Kazuo| Tetsunaga, Tomonori| Kagawa, Yohei| Fujii, Yosuke| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15%, 9.0%, 6.0%, and 6.4%, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0%), minor bleeding in 2 cases (2.0%), persistent wound drainage in 3 cases (3.0%), and eruption in 1 case (1.0%). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0%) and progression of anemia in 1 case (1.0%). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases.
Keywords total hip arthroplasty venous thromboembolism anticoagulant prophylaxis complications
Amo Type Erratum
Publication Title Acta Medica Okayama
Published Date 2015-10
Volume volume69
Issue issue5
Publisher Okayama University Medical School
Start Page 325
End Page 325
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26490031
Related Url http://doi.org/10.18926/AMO/53556
JaLCDOI 10.18926/AMO/54807
FullText URL 70_6_449.pdf
Author Watanabe, Noriyuki| Sugimoto, Yoshihisa| Tanaka, Masato| Mazaki, Tetsuro| Arataki, Shinya| Takigawa, Tomoyuki| Kataoka, Masaki| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract Metastatic epidural spinal cord compression (MESCC) is a common complication in patients with a malignant tumor, but it is difficult to decide the proper time to perform the necessary surgery. Here we analyzed the prognostic factors for postoperative walking ability. We retrospectively reviewed the cases of 112 MESCC patients treated surgically at our institute and divided them into ambulatory (n= 88) and non-ambulatory (n=24) groups based on their American Spinal Injury Association (ASIA) Impairment Scale grades at the final follow-up. We also classified the patients preoperatively using the revised Tokuhashi score. We assessed the correlation between preoperative or intraoperative factors and postoperative walking ability in both groups. Of the 10 patients classified preoperatively as grade A or B, 2 (20 ) were ambulatory at the final follow-up. Of the 102 patients classified preoperatively as grade C, D or E, 86 (84 ) were ambulatory at the final follow-up (p<0.001). There were no significant differences between the groups in the average total Tokuhashi score. Our analysis revealed that the severity of paralysis significantly affects neurological recovery in patients with MESCC. Patients with MESCC should receive surgery before the preoperative ASIA Impairment Scale grade falls below grade C.
Keywords metastatic epidural spinal cord compression American Spinal Injury Association Impairment Scale Tokuhashi score walking ability prognostic factor
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 449
End Page 453
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003669
FullText URL JOS_24_2_337.pdf
Author Fujiwara, Tomohiro| Kunisada, Toshiyuki| Takeda, Ken| Hasei, Joe| Nakata, Eiji| Mochizuki, Yusuke| Kiyono, Masahiro| Yoshida, Aki| Ozaki, Toshifumi|
Published Date 2019-03
Publication Title Journal of Orthopaedic Science
Volume volume24
Issue issue2
Publisher Elsevier
Start Page 337
End Page 341
ISSN 0949-2658
NCID AA11627828
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2018 The Japanese Orthopaedic Association.
File Version author
PubMed ID 30857616
DOI 10.1016/j.jos.2018.09.017
Web of Science KeyUT 000460662100026
Related Url isVersionOf https://doi.org/10.1016/j.jos.2018.09.017
FullText URL JOS_24_2_377.pdf
Author Omori, Toshinori| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Takeda, Ken| Hasei, Joe| Yoshida, Aki| Yanai, Hiroyuki| Ozaki, Toshifumi|
Published Date 2019-03
Publication Title Journal of Orthopaedic Science
Volume volume24
Issue issue2
Publisher Elsevier
Start Page 377
End Page 381
ISSN 0949-2658
NCID AA11627828
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2016 The Japanese Orthopaedic Association
File Version author
PubMed ID 28187993
DOI 10.1016/j.jos.2016.12.011
Web of Science KeyUT 000460662100033
Related Url isVersionOf https://doi.org/10.1016/j.jos.2016.12.011
FullText URL CORR477_8_1892.pdf
Author Kunisada, Toshiyuki| Fujiwara, Tomohiro| Hasei, Joe| Nakata, Eiji| Senda, Masuo| Ozaki, Toshifumi|
Published Date 2019-08
Publication Title Clinical Orthopaedics and Related Research
Volume volume477
Issue issue8
Publisher Lippincott, Williams & Wilkins
Start Page 1892
End Page 1901
ISSN 0009-921X
NCID AA00607942
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30985613
DOI 10.1097/CORR.0000000000000764
Web of Science KeyUT 000509664400024
Related Url isVersionOf https://doi.org/10.1097/CORR.0000000000000764
FullText URL fulltext.pdf Tables.pdf Fig1.tif Fig2.tif Supplementary Tables.pdf Supplementary Fig.pdf
Author Yamamoto, Hiromasa| Namba, Kei| Yamamoto, Haruchika| Toji, Tomohiro| Soh, Junichi| Shien, Kazuhiko| Suzawa, Ken| Kurosaki, Takeshi| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Kunisada, Toshiyuki| Oto, Takahiro| Toyooka, Shinichi|
Keywords Metastatic lung tumor Sarcoma Metastasectomy Survival rate Neutrophil-to-lymphocyte ratio (NLR)
Note This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-02093-5. |
Published Date 2020-08-03
Publication Title Surgery Today
Publisher Springer
ISSN 0941-1291
NCID AA10824685
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32747982
DOI 10.1007/s00595-020-02093-5
Web of Science KeyUT 000555382600001
Related Url isVersionOf https://doi.org/10.1007/s00595-020-02093-5
FullText URL fulltext.pdf Suppl. Info.pdf Suppl. Tables.xlsx
Author Morita, Takuya| Fujiwara, Tomohiro| Yoshida, Aki| Uotani, Koji| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Keywords Sarcoma Translational research
Published Date 2020-06-10
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature
Start Page 9414
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32523124
DOI 10.1038/s41598-020-66120-8
Web of Science KeyUT 000560478900030
Related Url isVersionOf https://doi.org/10.1038/s41598-020-66120-8
FullText URL fulltext.pdf
Author Nakata, Eiji| Sugihara, Shinsuke| Sugawara, Yoshifumi| Nakahara, Ryuichi| Furumatsu, Takayuki| Tetsunaga, Tomonori| Kunisada, Toshiyuki| Nakanishi, Kazuo| Ozaki, Toshifumi|
Keywords bone metastasis multidisciplinary treatment skeletal-related event malignant spinal cord compression neurological deficit
Published Date 2020-02-20
Publication Title Oncology Letters
Volume volume19
Issue issue4
Publisher Spandidos Publications
Start Page 3137
End Page 3144
ISSN 1792-1074
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Nakata et al.
File Version publisher
PubMed ID 32218864
DOI 10.3892/ol.2020.11415
Web of Science KeyUT 000523763900064
Related Url isVersionOf https://doi.org/10.3892/ol.2020.11415
FullText URL fulltext.pdf
Author Joko, Ryoji| Yamada, Daisuke| Nakamura, Masahiro| Yoshida, Aki| Takihira, Shota| Takao, Tomoka| Lu, Ming| Sato, Kohei| Ito, Tatsuo| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| Takarada, Takeshi|
Keywords PRRX1 Osteosarcoma Tumor malignancy Invasion Drug resistance Connectivity map analysis
Published Date 2021-01
Publication Title Translational Oncology
Volume volume14
Issue issue1
Publisher Elsevier
Start Page 100960
ISSN 1936-5233
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 33395745
DOI 10.1016/j.tranon.2020.100960
Web of Science KeyUT 000604582300006
Related Url isVersionOf https://doi.org/10.1016/j.tranon.2020.100960
FullText URL fulltext.pdf
Author Kunisada, Toshiyuki| Hasei, Joe| Fujiwara, Tomohiro| Nakata, Eiji| Yokoo, Suguru| Demiya, Koji| Ozaki, Toshifumi|
Published Date 2020-12-09
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 21578
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33299043
DOI 10.1038/s41598-020-78409-9
Web of Science KeyUT 000608956800002
Related Url isVersionOf https://doi.org/10.1038/s41598-020-78409-9
FullText URL fulltext.pdf
Author Fujiwara, Tomohiro| Healey, John| Ogura, Koichi| Yoshida, Aki| Kondo, Hiroya| Hata, Toshiaki| Kure, Miho| Tazawa, Hiroshi| Nakata, Eiji| Kunisada, Toshiyuki| Fujiwara, Toshiyoshi| Ozaki, Toshifumi|
Keywords sarcoma tumor-associated macrophage prognosis clinical trial immunotherapy
Published Date 2021-03-03
Publication Title Cancers
Volume volume13
Issue issue5
Publisher MDPI
Start Page 1086
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33802565
NAID 120007008531
DOI 10.3390/cancers13051086
Web of Science KeyUT 000627955600001
Related Url isVersionOf https://doi.org/10.3390/cancers13051086
FullText URL fulltext.pdf
Author Yokoo, Suguru| Fujiwara, Tomohiro| Yoshida, Aki| Uotani, Koji| Morita, Takuya| Kiyono, Masahiro| Hasei, Joe| Nakata, Eiji| Kunisada, Toshiyuki| Iwata, Shintaro| Yonemoto, Tsukasa| Ueda, Koji| Ozaki, Toshifumi|
Keywords liquid biopsy synovial sarcoma monocarboxylate transporter 1 extracellular vesicles non-invasive biomarker
Published Date 2021-04-11
Publication Title Cancers
Volume volume13
Issue issue8
Publisher MDPI
Start Page 1823
ISSN 2072-6694
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33920416
NAID 120007037389
DOI 10.3390/cancers13081823
Web of Science KeyUT 000644023400001
Related Url isVersionOf https://doi.org/10.3390/cancers13081823
FullText URL fulltext.pdf
Author Ise, Masato| Nakata, Eiji| Katayama, Yoshimi| Hamada, Masanori| Kunisada, Toshiyuki| Fujiwara, Tomohiro| Nakahara, Ryuichi| Takihira, Shouta| Sato, Kohei| Akezaki, Yoshiteru| Senda, Masuo| Ozaki, Toshifumi|
Keywords psychological distress distress and impact thermometer bone and soft tissue tumor surgery
Published Date 2021-05-01
Publication Title Healthcare
Volume volume9
Issue issue5
Publisher MDPI
Start Page 566
ISSN 2227-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
NAID 120007042388
DOI 10.3390/healthcare9050566
Web of Science KeyUT 000654015500001
Related Url isVersionOf https://doi.org/10.3390/healthcare9050566
FullText URL fulltext.pdf
Author Omori, Toshinori| Tazawa, Hiroshi| Yamakawa, Yasuaki| Osaki, Shuhei| Hasei, Joe| Sugiu, Kazuhisa| Komatsubara, Tadashi| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Gastric yolk sac Tumor-like carcinoma Adenocarcinoma; Alpha-fetoprotein
Published Date 2021-04-22
Publication Title PLoS ONE
Volume volume16
Issue issue4
Publisher Public Library Science
Start Page e0250643
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Omori et al.
File Version publisher
PubMed ID 33886686
NAID 120007045007
DOI 10.1371/journal.pone.0250643
Web of Science KeyUT 000644138300019
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0250643
FullText URL fulltext20210628-1.pdf Figure_20210628-1.pdf Supple_Figure_20210628-1.pdf Supple_Table_20210628-1.pdf
Author Sugiu, Kazuhisa| Tazawa, Hiroshi| Hasei, Joe| Yamakawa, Yasuaki| Omori, Toshinori| Komatsubara, Tadashi| Mochizuki, Yusuke| Kondo, Hiroya| Osaki, Shuhei| Fujiwara, Tomohiro| Yoshida, Aki| Kunisada, Toshiyuki| Ueda, Koji| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Osteosarcoma Chemoresistance MDR1 Oncolytic adenovirus p53
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-021-04310-5|
Published Date 2021-6-10
Publication Title Cancer Chemotherapy and Pharmacology
Volume volume88
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 513
End Page 524
ISSN 0344-5704
NCID AA00598397
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 34114067
DOI 10.1007/s00280-021-04310-5
Web of Science KeyUT 000659839700002
Related Url isVersionOf https://doi.org/10.1007/s00280-021-04310-5
Author Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Published Date 2013-03
Publication Title Molecular Cancer Therapeutics
Volume volume12
Issue issue3
Content Type Journal Article
Author Yoneda, Yasushi| Ito, Sachio| Kunisada, Toshiyuki| Morimoto, Yuki| Kanzaki, Hirotaka| Yoshida, Aki| Shimizu, Kenji| Ozaki, Toshifumi| Ouchida, Mamoru|
Published Date 2013-10-09
Publication Title PLoS ONE
Volume volume8
Issue issue10
Content Type Journal Article
FullText URL fulltext.pdf figures.pdf SuppleFigures.pdf
Author Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7.|
Published Date 2020-11-05
Publication Title Cancer Immunology, Immunotherapy
Volume volume70
Publisher Springer
Start Page 1405
End Page 1417
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33151368
DOI 10.1007/s00262-020-02774-7
Web of Science KeyUT 000586350500002
Related Url isVersionOf https://doi.org/10.1007/s00262-020-02774-7
FullText URL fulltext.pdf
Author Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| Kawai, Akira|
Keywords Alveolar soft part sarcoma Survival Surgery Chemotherapy Pazopanib
Published Date 2022-08-15
Publication Title BMC Cancer
Volume volume22
Issue issue1
Publisher BMC
Start Page 891
ISSN 1471-2407
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35971085
DOI 10.1186/s12885-022-09968-5
Web of Science KeyUT 000840842400002
Related Url isVersionOf https://doi.org/10.1186/s12885-022-09968-5