| FullText URL | JRNC_313_1_169.pdf |
|---|---|
| Author | Kudo, Ken-ichi| Hanafusa, Tadashi| Ono, Toshiro| |
| Keywords | Monoterpenes Linalool X-ray irradiation Reactive oxygen species SSB |
| Note | The final publication is available at Springer| |
| Published Date | 2017-07 |
| Publication Title | Journal of Radioanalytical and Nuclear Chemistry |
| Volume | volume313 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 169 |
| End Page | 174 |
| ISSN | 0236-5731 |
| NCID | AA11120189 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1007/s10967-017-5268-0 |
| Related Url | https://doi.org/10.1007/s10967-017-5268-0 |
| JaLCDOI | 10.18926/AMO/55204 |
|---|---|
| FullText URL | 71_3_219.pdf |
| Author | Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira| |
| Abstract | Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery. |
| Keywords | oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-06 |
| Volume | volume71 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 226 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28655941 |
| Author | Nishiyama, Yuichi| Hanafusa, Tadashi| Yamashita, Jun| Yamamoto, Yoko| Ono, Toshiro| |
|---|---|
| Published Date | 2015-06-20 |
| Publication Title | Journal of Radioanalytical and Nuclear Chemistry |
| Content Type | Journal Article |
| Author | Hanafusa, Tadashi| Mohamed, Ali Eldib Ali| Kitaoka, Kenta| Ohue, Yoshihiro| Nakayama, Eiichi| Ono, Toshiro| |
|---|---|
| Published Date | 2011-02-01 |
| Publication Title | Cancer Letters |
| Volume | volume301 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/45267 |
|---|---|
| FullText URL | 65_2_91.pdf |
| Author | Nagamatsu, Tomohiro| Sakoda, Akihiro| Kataoka, Takahiro| Ono, Toshiro| Yamaoka, Kiyonori| |
| Abstract | No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics. |
| Keywords | tobacco radionuclides smoking intake radiation exposure |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-04 |
| Volume | volume65 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 91 |
| End Page | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21519366 |
| Web of Science KeyUT | 000289818800004 |
| JaLCDOI | 10.18926/AMO/31119 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Nishioka, Keiko| Saito, Chisato| Nagano, Toshiaki| Okano, Mitsuhiro| Nakagawa, Fumio| Nishioka, Satoko| Masuda, Yu| Ono, Toshiro| |
| Abstract | To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P < 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite. |
| Keywords | mite allergen skin test nasal provoration test allergen rhinitis |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1994-10 |
| Volume | volume48 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 282 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 7863799 |
| Web of Science KeyUT | A1994PP23600008 |
| JaLCDOI | 10.18926/AMO/31114 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Nishioka, Keiko| Saito, Chisato| Nagano, Toshiaki| Okano, Mitsuhiro| Nakagawa, Fumio| Nishioka, Satoko| Masuda, Yu| Ono, Toshiro| |
| Abstract | To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P < 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite. |
| Keywords | mite allergen skin test nasal provoration test allergen rhinitis |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1994-10 |
| Volume | volume48 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 282 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 7863799 |
| Web of Science KeyUT | A1994PP23600008 |
| Author | Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio| |
|---|---|
| Published Date | 2005-01-20 |
| Publication Title | BMC Cancer |
| Volume | volume5 |
| Content Type | Journal Article |
| Author | Nagamatsu, Tomohiro| Hanamoto, Katsumi| Ono, Toshiro| Yamaoka, Kiyonori| |
|---|---|
| Published Date | 2005-12 |
| Publication Title | 環境制御 |
| Volume | volume27 |
| Content Type | Departmental Bulletin Paper |
| Author | Nagamatsu, Tomohiro| Hanafusa, Tadashi| Kinno, Ikuo| Sakoda, Akihiro| Hanamoto, Katsumi| Yamaoka, Kiyonori| Ono, Toshiro| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | 環境制御 |
| Volume | volume30 |
| Content Type | Journal Article |
| Author | Kubota, Naohiro| Potjanapimon, Chaiwat| Fukuda, Fumio| Fujiia, Yuichiro| Ono, Toshiro| Kurafuji, Yuki| Ogoro, Atsuo| Kunugi, Yukihiro| Kobayashi, Kazushi| Shigehara, Izumi| Yamashita, Hiroyuki| Fujishima, Hiroyuki| |
|---|---|
| Published Date | 2009-02 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume98 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | 小野 俊朗| |
|---|---|
| Published Date | 2002-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume114 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | 小野 俊朗| |
|---|---|
| Published Date | 2005-05-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume115 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nakagawa, Kazuhiko| Noguchi, Yuji| Okumura, Hideo| Sato, Shuichiro| Tanaka, Motoyuki| Shimono, Michihide| Ali Eldib, Ali Mohamed| Aoe, Motoi| Ono, Toshiro| Uenaka, Akiko| Ohara, Nobuya| Yoshino, Tadashi| Yamashita, Kazuki| Tsunoda, Tsukasa| Shimizu, Nobuyoshi| Nakayama, Eiichi| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
