小野俊朗

In vitro analysis of radioprotective effect of monoterpenes

フルテキストURL	JRNC_313_1_169.pdf
著者	Kudo, Ken-ichi\| Hanafusa, Tadashi\| Ono, Toshiro\|
キーワード	Monoterpenes Linalool X-ray irradiation Reactive oxygen species SSB
備考	The final publication is available at Springer\|
発行日	2017-07
出版物タイトル	Journal of Radioanalytical and Nuclear Chemistry
巻	313巻
号	1号
出版者	Springer
開始ページ	169
終了ページ	174
ISSN	0236-5731
NCID	AA11120189
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.1007/s10967-017-5268-0
関連URL	https://doi.org/10.1007/s10967-017-5268-0

The Immunological Impact of Chemotherapy on the Tumor Microenvironment of Oral Squamous Cell Carcinoma

JaLCDOI	10.18926/AMO/55204
フルテキストURL	71_3_219.pdf
著者	Takakura, Hiroaki\| Domae, Shohei\| Ono, Toshiro\| Sasaki, Akira\|
抄録	Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
キーワード	oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2017-06
巻	71巻
号	3号
出版者	Okayama University Medical School
開始ページ	219
終了ページ	226
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	28655941

Adsorption and removal of strontium in aqueous solution by synthetic hydroxyapatite

著者	Nishiyama, Yuichi\| Hanafusa, Tadashi\| Yamashita, Jun\| Yamamoto, Yoko\| Ono, Toshiro\|
発行日	2015-06-20
出版物タイトル	Journal of Radioanalytical and Nuclear Chemistry
資料タイプ	学術雑誌論文

Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies

著者	Hanafusa, Tadashi\| Mohamed, Ali Eldib Ali\| Kitaoka, Kenta\| Ohue, Yoshihiro\| Nakayama, Eiichi\| Ono, Toshiro\|
発行日	2011-02-01
出版物タイトル	Cancer Letters
巻	301巻
号	1号
資料タイプ	学術雑誌論文

An Assessment of Radioactivity Levels of 210Pb and 40K in Tobacco and Radiation Exposure from Smoking

JaLCDOI	10.18926/AMO/45267
フルテキストURL	65_2_91.pdf
著者	Nagamatsu, Tomohiro\| Sakoda, Akihiro\| Kataoka, Takahiro\| Ono, Toshiro\| Yamaoka, Kiyonori\|
抄録	No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
キーワード	tobacco radionuclides smoking intake radiation exposure
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2011-04
巻	65巻
号	2号
出版者	Okayama University Medical School
開始ページ	91
終了ページ	95
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	21519366
Web of Science KeyUT	000289818800004

Allergens of the house dust mite, Dermatophagoides pteronyssinus, in patients with mite allergic rhinitis: a clinical investigation by intracutaneous skin tests and nasal provocation tests.

JaLCDOI	10.18926/AMO/31119
フルテキストURL	fulltext.pdf
著者	Nishioka, Keiko\| Saito, Chisato\| Nagano, Toshiaki\| Okano, Mitsuhiro\| Nakagawa, Fumio\| Nishioka, Satoko\| Masuda, Yu\| Ono, Toshiro\|
抄録	To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P < 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.
キーワード	mite allergen skin test nasal provoration test allergen rhinitis
Amo Type	Article
出版物タイトル	Acta Medica Okayama
発行日	1994-10
巻	48巻
号	5号
出版者	Okayama University Medical School
開始ページ	279
終了ページ	282
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
論文のバージョン	publisher
査読	有り
PubMed ID	7863799
Web of Science KeyUT	A1994PP23600008

Allergens of the house dust mite, Dermatophagoides pteronyssinus, in patients with mite allergic rhinitis: a clinical investigation by intracutaneous skin tests and nasal provocation tests.

JaLCDOI	10.18926/AMO/31114
フルテキストURL	fulltext.pdf
著者	Nishioka, Keiko\| Saito, Chisato\| Nagano, Toshiaki\| Okano, Mitsuhiro\| Nakagawa, Fumio\| Nishioka, Satoko\| Masuda, Yu\| Ono, Toshiro\|
抄録	To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P < 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.
キーワード	mite allergen skin test nasal provoration test allergen rhinitis
Amo Type	Article
出版物タイトル	Acta Medica Okayama
発行日	1994-10
巻	48巻
号	5号
出版者	Okayama University Medical School
開始ページ	279
終了ページ	282
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
論文のバージョン	publisher
査読	有り
PubMed ID	7863799
Web of Science KeyUT	A1994PP23600008

Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation

著者	Hanafusa, Tadashi\| Shinji, Toshiyuki\| Shiraha, Hidenori\| Nouso, Kazuhiro\| Iwasaki, Yoshiaki\| Yumoto, Eichiro\| Ono, Toshiro\| Koide, Norio\|
発行日	2005-01-20
出版物タイトル	BMC Cancer
巻	5巻
資料タイプ	学術雑誌論文

埋蔵文化財発掘調査および建設工事が環境放射線に及ぼす影響に関する基礎的検討

著者	永松知洋\| 花元克巳\| 小野俊朗\| 山岡聖典\|
発行日	2005-12
出版物タイトル	環境制御
巻	27巻
資料タイプ	紀要論文

岡山大学における核燃料物質の安全管理のための劣化ウランと天然ウランの鑑別について

著者	永松知洋\| 花房直志\| 金野郁雄\| 迫田晃弘\| 花元克巳\| 山岡聖典\| 小野俊朗\|
発行日	2008-12
出版物タイトル	環境制御
巻	30巻
資料タイプ	学術雑誌論文

積算温度によるブドウの芽の休眠完了予測

著者	久保田尚浩\| ポジャナピモンチャイワット\| 福田文夫\| 藤井雄一郎\| 小野俊朗\| 倉藤祐輝\| 尾頃敦郎\| 功刀幸博\| 小林和司\| 茂原泉\| 山下裕之\| 藤島宏之\|
発行日	2009-02
出版物タイトル	岡山大学農学部学術報告
巻	98巻
号	1号
資料タイプ	紀要論文

ＳＥＲＥＸ法によるマウス移植腫瘍の抗原解析

著者	小野俊朗\|
発行日	2002-09-30
出版物タイトル	岡山医学会雑誌
巻	114巻
号	2号
資料タイプ	学術雑誌論文

プロアクロシン結合タンパク sp32 前駆体のヒトホモログ遺伝子の同定とがん・精巣 (CT) 抗原－岡山大学医学賞（林原賞）を受賞して－

著者	小野俊朗\|
発行日	2005-05-30
出版物タイトル	岡山医学会雑誌
巻	115巻
号	1号
資料タイプ	学術雑誌論文

非小細胞肺癌における癌・精巣抗原XAGE-1の発現と免疫応答の解析

著者	中川和彦\| 野口雄司\| 奥村英雄\| 佐藤修一郎\| 田中志幸\| 下野玄英\| アリ・エルディブアリモハメド\| 青江基\| 小野俊朗\| 上中明子\| 大原信哉\| 吉野正\| 山下和城\| 角田司\| 清水信義\| 中山睿一\|
発行日	2007-09-03
出版物タイトル	岡山医学会雑誌
巻	119巻
号	2号
資料タイプ	学術雑誌論文

小野 俊朗