start-ver=1.4
cd-journal=joma
no-vol=313
cd-vols=
no-issue=1
article-no=
start-page=169
end-page=174
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201707
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=In vitro analysis of radioprotective effect of monoterpenes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Monoterpenes are naturally occurring hydrocarbons composed of two units of isoprenes. They exhibit antioxidant activity to scavenge reactive oxygen species, such as hydroxyl radicals. We investigated the potential of monoterpenes such as thymol, linalool, and menthol to act as radioprotectants. The proliferation of EL4 cells, a mouse lymphoma cell line, treated with linalool at a concentration of 500 μM or more was not affected by X-ray irradiation. Plasmid-nicking assay performed using formamidopyrimidine-DNA glycosylase showed that linalool prevented single strand breaks and oxidized purines on pUC19 plasmid DNA. These findings indicate that linalool has the ability to scavenge reactive oxygen species and is a potential radioprotector.
en-copyright=
kn-copyright=
en-aut-name=KudoKen-ichi
en-aut-sei=Kudo
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
affil-num=1
en-affil=
kn-affil=
affil-num=2
en-affil=Department of Radiation Research, Advanced Science Research CenterOkayama University
kn-affil=
affil-num=3
en-affil=Department of Radiation Research, Advanced Science Research CenterOkayama University
kn-affil=
en-keyword=Monoterpenes
kn-keyword=Monoterpenes
en-keyword= Linalool
kn-keyword= Linalool
en-keyword=X-ray irradiation
kn-keyword=X-ray irradiation
en-keyword= Reactive oxygen species
kn-keyword= Reactive oxygen species
en-keyword= SSB
kn-keyword= SSB
END
start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=3
article-no=
start-page=219
end-page=226
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201706
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Immunological Impact of Chemotherapy on the Tumor Microenvironment of Oral Squamous Cell Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
en-copyright=
kn-copyright=
en-aut-name=TakakuraHiroaki
en-aut-sei=Takakura
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=DomaeShohei
en-aut-sei=Domae
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
kn-affil=
affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=oral squamous cell carcinoma
kn-keyword=oral squamous cell carcinoma
en-keyword=programmed cell death 1 ligand-1
kn-keyword=programmed cell death 1 ligand-1
en-keyword=tumor microenvironment
kn-keyword=tumor microenvironment
en-keyword=neoadjuvant chemotherapy
kn-keyword=neoadjuvant chemotherapy
en-keyword=immunohistochemistry
kn-keyword=immunohistochemistry
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150620
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Adsorption and removal of strontium in aqueous solution by synthetic hydroxyapatite
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hydroxyapatite (HAP) is a main mineral constituent of bone and tooth and has an outstanding biocompatibility. HAP is a possible sorbent for heavy metals in wastewater due to its high adsorption capacity and low water solubility. We developed a removal system of 90Sr from aqueous solution by HAP column procedure. More than 90 % of 90Sr was adsorbed and removed from the 90Sr containing solution. Divalent cations, Ca2+, had little effect on the removal of 90Sr up to a concentration of 1 mmol L−1. This clearly indicates that the HAP column technique is advantageous with respect to the capacity to adsorb 90Sr from water present in the environment.
en-copyright=
kn-copyright=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YamashitaJun
en-aut-sei=Yamashita
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YamamotoYoko
en-aut-sei=Yamamoto
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
affil-num=2
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
affil-num=3
en-affil=
kn-affil=Institute of Plant Science and Resources, Okayama University
affil-num=4
en-affil=
kn-affil=Institute of Plant Science and Resources, Okayama University
affil-num=5
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
en-keyword=Strontium
kn-keyword=Strontium
en-keyword=Hydroxyapatite
kn-keyword=Hydroxyapatite
en-keyword=Adsorption
kn-keyword=Adsorption
en-keyword=Desorption
kn-keyword=Desorption
en-keyword=Divalent cation
kn-keyword=Divalent cation
END
start-ver=1.4
cd-journal=joma
no-vol=301
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Serological analysis of a recombinant cDNA expression library (SEREX) derived from two lung adenocarcinoma cancer cell lines using autologous sera led to the isolation of 41 positive cDNA clones comprising 28 different antigens. They coded for a variety of nuclear and cytoplasmic proteins. Among the antigens, nucleoporin 107 (NUP107) was isolated most frequently (5 of 41 clones). The second most frequently isolated antigen was coded for by C21orf58 (4 of 41 clones). During serological analysis of selected antigens based on their reactivity to sera from normal individuals and lung cancer patients, none of the antigens showed a cancer-restricted recognition pattern. However, five genes including NUP107 showed higher expression when we examined the changes in gene expression in five different adenocarcinoma cell lines, including those used in SEREX, compared with their levels in normal lung tissues by cDNA microarray analysis. On the other hand, the expression levels of five genes including C21orf58 were down regulated in all adenocarcinoma cell lines. This SEREX study combining comprehensive gene expression assays has added to the growing list of lung cancer antigens, which may aid the development of diagnostic and immunotherapeutic reagents for patients with lung cancer.
en-copyright=
kn-copyright=
en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MohamedAli Eldib Ali
en-aut-sei=Mohamed
en-aut-mei=Ali Eldib Ali
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KitaokaKenta
en-aut-sei=Kitaoka
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OhueYoshihiro
en-aut-sei=Ohue
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NakayamaEiichi
en-aut-sei=Nakayama
en-aut-mei=Eiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
affil-num=2
en-affil=
kn-affil=Faculty of Science, Alexandria University
affil-num=3
en-affil=
kn-affil=Hyogo Prefectural Awaji Hospital
affil-num=4
en-affil=
kn-affil=Department of Medicine, Kawasaki Medical University
affil-num=5
en-affil=
kn-affil=Faculty of Health and Welfare, Kawasaki University of Medical Welfare
affil-num=6
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
en-keyword=Lung adenocarcinoma
kn-keyword=Lung adenocarcinoma
en-keyword=SEREX
kn-keyword=SEREX
en-keyword=Tumor antigen
kn-keyword=Tumor antigen
en-keyword=NUP107
kn-keyword=NUP107
en-keyword=MYL6B
kn-keyword=MYL6B
END
start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=2
article-no=
start-page=91
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Assessment of Radioactivity Levels of 210Pb and 40K in Tobacco and Radiation Exposure from Smoking
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
en-copyright=
kn-copyright=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Department of Radiation Research Shikata Laboratory, Advanced Science Research Center, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=tobacco
kn-keyword=tobacco
en-keyword=radionuclides
kn-keyword=radionuclides
en-keyword=smoking
kn-keyword=smoking
en-keyword=intake
kn-keyword=intake
en-keyword=radiation exposure
kn-keyword=radiation exposure
END
start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=5
article-no=
start-page=279
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Allergens of the house dust mite, Dermatophagoides pteronyssinus, in patients with mite allergic rhinitis: a clinical investigation by intracutaneous skin tests and nasal provocation tests.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P < 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.
en-copyright=
kn-copyright=
en-aut-name=NishiokaKeiko
en-aut-sei=Nishioka
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SaitoChisato
en-aut-sei=Saito
en-aut-mei=Chisato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NaganoToshiaki
en-aut-sei=Nagano
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OkanoMitsuhiro
en-aut-sei=Okano
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NakagawaFumio
en-aut-sei=Nakagawa
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NishiokaSatoko
en-aut-sei=Nishioka
en-aut-mei=Satoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Hiroshima City Hospital
affil-num=2
en-affil=
kn-affil=Okayama City Hospital
affil-num=3
en-affil=
kn-affil=Okayama Univeristy
affil-num=4
en-affil=
kn-affil=Okayama Uniiversity
affil-num=5
en-affil=
kn-affil=Okayama University
affil-num=6
en-affil=
kn-affil=Okayama University
affil-num=7
en-affil=
kn-affil=Okayama University
affil-num=8
en-affil=
kn-affil=Okayama University
en-keyword=mite allergen
kn-keyword=mite allergen
en-keyword=skin test
kn-keyword=skin test
en-keyword=nasal provoration test
kn-keyword=nasal provoration test
en-keyword=allergen rhinitis
kn-keyword=allergen rhinitis
END
start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=5
article-no=
start-page=279
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Allergens of the house dust mite, Dermatophagoides pteronyssinus, in patients with mite allergic rhinitis: a clinical investigation by intracutaneous skin tests and nasal provocation tests.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P < 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.
en-copyright=
kn-copyright=
en-aut-name=NishiokaKeiko
en-aut-sei=Nishioka
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SaitoChisato
en-aut-sei=Saito
en-aut-mei=Chisato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NaganoToshiaki
en-aut-sei=Nagano
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OkanoMitsuhiro
en-aut-sei=Okano
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NakagawaFumio
en-aut-sei=Nakagawa
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NishiokaSatoko
en-aut-sei=Nishioka
en-aut-mei=Satoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Hiroshima City Hospital
affil-num=2
en-affil=
kn-affil=Okayama City Hospital
affil-num=3
en-affil=
kn-affil=Okayama Univeristy
affil-num=4
en-affil=
kn-affil=Okayama University
affil-num=5
en-affil=
kn-affil=Okayama University
affil-num=6
en-affil=
kn-affil=Okayama University
affil-num=7
en-affil=
kn-affil=Okayama University
affil-num=8
en-affil=
kn-affil=Okayama University
en-keyword=mite allergen
kn-keyword=mite allergen
en-keyword=skin test
kn-keyword=skin test
en-keyword=nasal provoration test
kn-keyword=nasal provoration test
en-keyword=allergen rhinitis
kn-keyword=allergen rhinitis
END
start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulinlike
growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported p53 regulatory regions in the IGFBP3 gene; one upstream of the promoter and one intronic. We previously reported a hot spot of promoter hypermethylation of IGFBP-3 in
human hepatocellular carcinomas and derivative cell lines. As the hot spot locates at the putative upstream p53 consensus sequences, these p53 consensus sequences are really functional is a question to be answered.
Methods: In this study, we examined the p53 consensus sequences upstream of the IGFBP-3 promoter for the p53 induced expression of IGFBP-3. Deletion, mutagenesis, and methylation
constructs of IGFBP-3 promoter were assessed in the human hepatoblastoma cell line HepG2 for promoter activity.
Results: Deletions and mutations of these sequences completely abolished the expression of IGFBP-3 in the presence of p53 overexpression. In vitro methylation of these p53 consensus
sequences also suppressed IGFBP-3 expression. In contrast, the expression of IGFBP-3 was not affected in the absence of p53 overexpression. Further, we observed by electrophoresis mobility
shift assay that p53 binding to the promoter region was diminished when methylated.
Conclusion: From these observations, we conclude that four out of eleven p53 consensus sequences upstream of the IGFBP-3 promoter are essential for the p53 induced expression of
IGFBP-3, and hypermethylation of these sequences selectively suppresses p53 induced IGFBP-3 expression in HepG2 cells.
en-copyright=
kn-copyright=
en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ShinjiToshiyuki
en-aut-sei=Shinji
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=IwasakiYoshiaki
en-aut-sei=Iwasaki
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=YumotoEichiro
en-aut-sei=Yumoto
en-aut-mei=Eichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KoideNorio
en-aut-sei=Koide
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=
kn-affil=Okayama University Advanced Science Research Center, Department of Radiation Research, Shikata Laboratory
affil-num=2
en-affil=
kn-affil=Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry
affil-num=3
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
affil-num=4
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
affil-num=5
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
affil-num=6
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
affil-num=7
en-affil=
kn-affil=Okayama University Advanced Science Research Center, Department of Radiation Research, Shikata Laboratory
affil-num=8
en-affil=
kn-affil=Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry
END
start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=
article-no=
start-page=11
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=200512
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic study on the effects of the archeological investigation and the construction work
on the environmental radiation
kn-title=埋蔵文化財発掘調査および建設工事が環境放射線に及ぼす影響に関する基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, we investigated how the excavation of ruins and the construction work affected the environmental radiation in the Shikata campus of Okayama University (S-campus). The environmental radiation was steady in the S-campus until 1997, but began to change since 1998, while the ruin's survey and the construction work started frequently after 1998 in the S-campus. In general, the soil and the concrete include the natural radioisotope (uranium series and thorium series, etc). When ruins are surveyed, it is necessary to move a large amount of the soil. In addition, a large amount of the concrete is used for the construction work. To measure the environmental radiation, the monitor posts were set up on the east and west sides of the building of the Radioisotope Center (RIC). We sampled the soil in the container in each place. We used the high-purity germanium detector to analyze them. The monitor posts showed the difference in the in-air dose rate in each place in the S-campus. The in-air dose rate at the east side of the RIC was higher than that at the west side. The result of analysis showed that the soil includes the (40)K at the east side. While the specific activity of the 40K was 0.849Bq/g at the east side, the (40)K was hardly detected in the soil at the west side. The each soil included the 214-lead and 214-bismus ((214)Pb, (214)Bi), however, there was no significant difference in the specific activity of the each soil. The concrete included (40)K, whose specific activity was 0.492Bq/g. It was suggested that the change of the environmental radiation was attributed to radon and its daughter nuclides in the soil rather than the radiation from the concrete in the buildings.
en-copyright=
kn-copyright=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=1
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=2
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=3
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=4
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター
affil-num=2
en-affil=
kn-affil=岡山大学医学部
affil-num=3
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター
affil-num=4
en-affil=
kn-affil=岡山大学医学部
en-keyword=archeological investigation
kn-keyword=archeological investigation
en-keyword=construction work
kn-keyword=construction work
en-keyword=environmental radiation
kn-keyword=environmental radiation
en-keyword=soil
kn-keyword=soil
en-keyword=concrete
kn-keyword=concrete
END
start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=
article-no=
start-page=33
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学における核燃料物質の安全管理のための劣化ウランと天然ウランの鑑別について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In Japan, the Law for the Regulation of Nuclear Source Materials, Nuclear Fuel Materials and Reactors (Regulation Law) controls the nuclear fuel materials such as thorium (Th), uranium (U) and plutonium (Pu). Under the Regulation Law, all related materials and reactors are needed to register to the Government. In Okayama University, many nuclear fuel materials, mainly uranium compounds, are registered and stored in 11 departments, separately. Discrimination between depleted uranium and natural uranium is important for the observance of the Regulation Law and the safety management of the nuclear fuel materials in the Okayama University. However, the discrimination of the two kind of uranium has poorly analyzed. In this study, we analyzed several uranium compounds by using γ-ray spectrometry to determine whether the depleted uranium or not.
en-copyright=
kn-copyright=
en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=1
ORCID=
en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=花房直志
kn-aut-sei=花房
kn-aut-mei=直志
aut-affil-num=2
ORCID=
en-aut-name=KinnoIkuo
en-aut-sei=Kinno
en-aut-mei=Ikuo
kn-aut-name=金野郁雄
kn-aut-sei=金野
kn-aut-mei=郁雄
aut-affil-num=3
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=迫田晃弘
kn-aut-sei=迫田
kn-aut-mei=晃弘
aut-affil-num=4
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=6
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=2
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設
affil-num=3
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設
affil-num=4
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=7
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設
en-keyword=Nuclear Fuel Materials
kn-keyword=Nuclear Fuel Materials
en-keyword=Depleted Uranium
kn-keyword=Depleted Uranium
en-keyword=Natural Uranium
kn-keyword=Natural Uranium
en-keyword=γ-ray Spectrometry
kn-keyword=γ-ray Spectrometry
END
start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Estimation of Completion of Dormancy in Grapevine Bud Based on Cumulative Temperature
kn-title=積算温度によるブドウの芽の休眠完了予測
en-subtitle=
kn-subtitle=
en-abstract=ブドウの芽の休眠完了と温度との関係を調査するため，温度条件の異なる７園（中信農試，山梨果試，岡山農試，岡山農試北部支場，岡山大学，福岡農試および宮崎）で栽培されている‘巨峰’と‘ピオーネ’から低温遭遇量の異なる３時期（12月，１月，２月）に結果母枝を採取した．直ちに岡山大学に送り，１芽を持つ挿し穂に調整した後，25または30℃のインキュベーター（14時間日長）に入れ，２日間隔で60日間発芽を調査した．処理開始時の7.2℃以下の遭遇量は中信農試で最も多く，次いで岡山農試北部支場，山梨果試，岡山農試，岡山大学，福岡農試，宮崎の順で，中信農試と宮崎では処理時期により2.5～4.8倍の差があった．発芽所要日数は，両品種とも処理時期が遅いほど，また温度が高いほど少なく，60％発芽所要日数もほぼ同様の傾向であった．‘巨峰’の発芽所用日数は中信農試，岡山大学および宮崎で少ない一方，岡山農試，山梨果試および福岡農試で多く，また‘ピオーネ’では福岡農試と岡山大学で少なく，山梨果試と岡山農試で多かった．７園のうち４園で低温遭遇量と発芽所要日数との間に負の相関がみられたが，相関係数は低かった．一方，11月以降処理開始までの０℃以上の温度の積算値と処理開始から発芽までの25または30℃での積算値を合計した積算温度と発芽所要日数との間には１園を除き極めて高い正の相関が認められた．これらの結果を基に，積算温度によるブドウの休眠完了予測の可能性を考察した．
kn-abstract= This study was conducted to investigate the relationship between completion of dormancy of grapevine
bud and temperature. Canes of ‘Kyoho’ and ‘Pione’ grapevines (Vitis labrusca×V. vinifera) grown in 7 vineyards with different temperature conditions, in Nagano, Northern Okayama, Yamanashi, Okayama, Okayama University, Fukuoka and Miyazaki, were collected at three different chilling exposures,
December, January and February. These were then sent to Okayama University all at the same time. Cuttings with one bud were put into growth chambers kept at 25 or 30°C with 14 hours daylength, and budbreak in each cutting was surveyed at two day intervals for 60 days. Cumulative chilling hours (CCH) of exposure to below 7.2°C in each treatment time was largest in Nagano, followed in order by Northern Okayama, Yamanashi, Okayama, Okayama University, Fukuoka and Miyazaki. The CCH in Nagano was 2.5 to 4.8 times larger than in Miyazaki depending on the treatment time. The later the treatment time and the higher the temperature, the fewer were the number of days to first budbreak (NDFB) after treatment, irrespective of cultivar. A similar trend was observed in the number of days to 60% budbreak. In ‘Kyoho’ the NDFB was short in Nagano, Okayama University and Miyazaki, and longer in Okayama, Yamanashi and Fukuoka. In ‘Pione’ the NDFB was short in Fukuoka and Okayama University, and longer in Yamanashi and Okayama. The result was a weak negative correlation observed between CCH and NDFB in 4 of 7 vineyards. However, there was a strong positive correlation between NDFB and cumulative temperature (CT), a summation of temperature and hours of exposure to above 0°C from November 1 to treatment time and hours of exposure to 25 or 30°C from start of treatment to budbreak in each plot, in 6 vineyards excluding Miyazaki. The importance of estimating the completion of dormancy in grapevine bud based on CT is discussed.
en-copyright=
kn-copyright=
en-aut-name=KubotaNaohiro
en-aut-sei=Kubota
en-aut-mei=Naohiro
kn-aut-name=久保田尚浩
kn-aut-sei=久保田
kn-aut-mei=尚浩
aut-affil-num=1
ORCID=
en-aut-name=PotjanapimonChaiwat
en-aut-sei=Potjanapimon
en-aut-mei=Chaiwat
kn-aut-name=ポジャナピモンチャイワット
kn-aut-sei=ポジャナピモン
kn-aut-mei=チャイワット
aut-affil-num=2
ORCID=
en-aut-name=FukudaFumio
en-aut-sei=Fukuda
en-aut-mei=Fumio
kn-aut-name=福田文夫
kn-aut-sei=福田
kn-aut-mei=文夫
aut-affil-num=3
ORCID=
en-aut-name=FujiiaYuichiro
en-aut-sei=Fujiia
en-aut-mei=Yuichiro
kn-aut-name=藤井雄一郎
kn-aut-sei=藤井
kn-aut-mei=雄一郎
aut-affil-num=4
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=5
ORCID=
en-aut-name=KurafujiYuki
en-aut-sei=Kurafuji
en-aut-mei=Yuki
kn-aut-name=倉藤祐輝
kn-aut-sei=倉藤
kn-aut-mei=祐輝
aut-affil-num=6
ORCID=
en-aut-name=OgoroAtsuo
en-aut-sei=Ogoro
en-aut-mei=Atsuo
kn-aut-name=尾頃敦郎
kn-aut-sei=尾頃
kn-aut-mei=敦郎
aut-affil-num=7
ORCID=
en-aut-name=KunugiYukihiro
en-aut-sei=Kunugi
en-aut-mei=Yukihiro
kn-aut-name=功刀幸博
kn-aut-sei=功刀
kn-aut-mei=幸博
aut-affil-num=8
ORCID=
en-aut-name=KobayashiKazushi
en-aut-sei=Kobayashi
en-aut-mei=Kazushi
kn-aut-name=小林和司
kn-aut-sei=小林
kn-aut-mei=和司
aut-affil-num=9
ORCID=
en-aut-name=ShigeharaIzumi
en-aut-sei=Shigehara
en-aut-mei=Izumi
kn-aut-name=茂原泉
kn-aut-sei=茂原
kn-aut-mei=泉
aut-affil-num=10
ORCID=
en-aut-name=YamashitaHiroyuki
en-aut-sei=Yamashita
en-aut-mei=Hiroyuki
kn-aut-name=山下裕之
kn-aut-sei=山下
kn-aut-mei=裕之
aut-affil-num=11
ORCID=
en-aut-name=FujishimaHiroyuki
en-aut-sei=Fujishima
en-aut-mei=Hiroyuki
kn-aut-name=藤島宏之
kn-aut-sei=藤島
kn-aut-mei=宏之
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=応用植物科学コース
affil-num=2
en-affil=
kn-affil=応用植物科学コース
affil-num=3
en-affil=
kn-affil=応用植物科学コース
affil-num=4
en-affil=
kn-affil=岡山県農業総合センター農業試験場
affil-num=5
en-affil=
kn-affil=岡山県農業総合センター農業試験場
affil-num=6
en-affil=
kn-affil=岡山県農業総合センター農業試験場
affil-num=7
en-affil=
kn-affil=岡山県農業総合センター農業試験場
affil-num=8
en-affil=
kn-affil=山梨県果樹試験場
affil-num=9
en-affil=
kn-affil=山梨県果樹試験場
affil-num=10
en-affil=
kn-affil=長野県中信農業試験場
affil-num=11
en-affil=
kn-affil=長野県中信農業試験場
affil-num=12
en-affil=
kn-affil=福岡県農業総合試験場
en-keyword=budbreak
kn-keyword=budbreak
en-keyword=chilling exposure
kn-keyword=chilling exposure
en-keyword=growing region
kn-keyword=growing region
en-keyword=temperature condition
kn-keyword=temperature condition
en-keyword=Vitis labrusca × V. vinifera
kn-keyword=Vitis labrusca × V. vinifera
END
start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=2
article-no=
start-page=125
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ＳＥＲＥＸ法によるマウス移植腫瘍の抗原解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究所 免疫学
en-keyword=SEREX
kn-keyword=SEREX
en-keyword=Meth A
kn-keyword=Meth A
en-keyword=Mouse
kn-keyword=Mouse
en-keyword=Antibody
kn-keyword=Antibody
en-keyword=Cancer/testis (CT) anigen
kn-keyword=Cancer/testis (CT) anigen
END
start-ver=1.4
cd-journal=joma
no-vol=115
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=プロアクロシン結合タンパク sp32 前駆体のヒトホモログ遺伝子の同定とがん・精巣 (CT) 抗原－岡山大学医学賞（林原賞）を受賞して－
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 免疫学
en-keyword=OY-TES-1
kn-keyword=OY-TES-1
en-keyword=sp32
kn-keyword=sp32
en-keyword=Cancer/testis（CT）antigen
kn-keyword=Cancer/testis（CT）antigen
en-keyword=Sperm protein
kn-keyword=Sperm protein
en-keyword=Cancer
kn-keyword=Cancer
END
start-ver=1.4
cd-journal=joma
no-vol=119
cd-vols=
no-issue=2
article-no=
start-page=127
end-page=129
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=XAGE-1expression in non-small cell Lung cancer and antibody response in patients
kn-title=非小細胞肺癌における癌・精巣抗原XAGE-1の発現と免疫応答の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NakagawaKazuhiko
en-aut-sei=Nakagawa
en-aut-mei=Kazuhiko
kn-aut-name=中川和彦
kn-aut-sei=中川
kn-aut-mei=和彦
aut-affil-num=1
ORCID=
en-aut-name=NoguchiYuji
en-aut-sei=Noguchi
en-aut-mei=Yuji
kn-aut-name=野口雄司
kn-aut-sei=野口
kn-aut-mei=雄司
aut-affil-num=2
ORCID=
en-aut-name=OkumuraHideo
en-aut-sei=Okumura
en-aut-mei=Hideo
kn-aut-name=奥村英雄
kn-aut-sei=奥村
kn-aut-mei=英雄
aut-affil-num=3
ORCID=
en-aut-name=SatoShuichiro
en-aut-sei=Sato
en-aut-mei=Shuichiro
kn-aut-name=佐藤修一郎
kn-aut-sei=佐藤
kn-aut-mei=修一郎
aut-affil-num=4
ORCID=
en-aut-name=TanakaMotoyuki
en-aut-sei=Tanaka
en-aut-mei=Motoyuki
kn-aut-name=田中志幸
kn-aut-sei=田中
kn-aut-mei=志幸
aut-affil-num=5
ORCID=
en-aut-name=ShimonoMichihide
en-aut-sei=Shimono
en-aut-mei=Michihide
kn-aut-name=下野玄英
kn-aut-sei=下野
kn-aut-mei=玄英
aut-affil-num=6
ORCID=
en-aut-name=Ali EldibAli Mohamed
en-aut-sei=Ali Eldib
en-aut-mei=Ali Mohamed
kn-aut-name=アリ・エルディブ アリモハメド
kn-aut-sei=アリ・エルディブ アリ
kn-aut-mei=モハメド
aut-affil-num=7
ORCID=
en-aut-name=AoeMotoi
en-aut-sei=Aoe
en-aut-mei=Motoi
kn-aut-name=青江基
kn-aut-sei=青江
kn-aut-mei=基
aut-affil-num=8
ORCID=
en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=9
ORCID=
en-aut-name=UenakaAkiko
en-aut-sei=Uenaka
en-aut-mei=Akiko
kn-aut-name=上中明子
kn-aut-sei=上中
kn-aut-mei=明子
aut-affil-num=10
ORCID=
en-aut-name=OharaNobuya
en-aut-sei=Ohara
en-aut-mei=Nobuya
kn-aut-name=大原信哉
kn-aut-sei=大原
kn-aut-mei=信哉
aut-affil-num=11
ORCID=
en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=吉野正
kn-aut-sei=吉野
kn-aut-mei=正
aut-affil-num=12
ORCID=
en-aut-name=YamashitaKazuki
en-aut-sei=Yamashita
en-aut-mei=Kazuki
kn-aut-name=山下和城
kn-aut-sei=山下
kn-aut-mei=和城
aut-affil-num=13
ORCID=
en-aut-name=TsunodaTsukasa
en-aut-sei=Tsunoda
en-aut-mei=Tsukasa
kn-aut-name=角田司
kn-aut-sei=角田
kn-aut-mei=司
aut-affil-num=14
ORCID=
en-aut-name=ShimizuNobuyoshi
en-aut-sei=Shimizu
en-aut-mei=Nobuyoshi
kn-aut-name=清水信義
kn-aut-sei=清水
kn-aut-mei=信義
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ORCID=
en-aut-name=NakayamaEiichi
en-aut-sei=Nakayama
en-aut-mei=Eiichi
kn-aut-name=中山睿一
kn-aut-sei=中山
kn-aut-mei=睿一
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ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学
affil-num=9
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター
affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学
affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学
affil-num=13
en-affil=
kn-affil=川崎医科大学附属病院 消化器外科学
affil-num=14
en-affil=
kn-affil=川崎医科大学附属病院 消化器外科学
affil-num=15
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学
affil-num=16
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学
en-keyword=XAGE-1b
kn-keyword=XAGE-1b
en-keyword=癌精巣抗原
kn-keyword=癌精巣抗原
en-keyword=非小細胞肺癌
kn-keyword=非小細胞肺癌
END