| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Takahashi, Takahide| Tanaka, Takehiro| Toji, Tomohiro| Hiraoka, Sakiko| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-10-07 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 8893604 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 33083067 |
| DOI | 10.1155/2020/8893604 |
| Web of Science KeyUT | 000583201400001 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/8893604 |
| FullText URL | fulltext.pdf Figure.tif |
|---|---|
| Author | Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Keywords | diclofenac low dose post‐ERCP pancreatitis |
| Note | This is the peer reviewed version of the following article: Takeshi Tomoda et. al. Efficacy of low dose rectal diclofenac for preventing post‐endoscopic retrograde cholangiopancreatography pancreatitis: Propensity score‐matched analysis. Digestive Endoscopy, which has been published in final form at https://doi.org/10.1111/den.13828. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2020-09-02 |
| Publication Title | Digestive Endoscopy |
| Volume | volume33 |
| Publisher | Wiley |
| Start Page | 656 |
| End Page | 662 |
| ISSN | 0915-5635 |
| NCID | AA10907137 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32881078 |
| DOI | 10.1111/den.13828 |
| Web of Science KeyUT | 000577757600001 |
| Related Url | isVersionOf https://doi.org/10.1111/den.13828 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Inoue, Hirohumi| Tanaka, Takehiro| Matsumi, Akihiro| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tomoda, Takeshi| Horiguchi, Shigeru| Yagi, Takahito| Okada, Hiroyuki| |
| Keywords | IPMN PJC LBC BD SurePath |
| Published Date | 2020-09-29 |
| Publication Title | BMC Gastroenterology |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 319 |
| ISSN | 1471-230X |
| NCID | AA12034934 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 32993498 |
| DOI | 10.1186/s12876-020-01465-y |
| Web of Science KeyUT | 000576989100004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-020-01465-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Tomoda, Takeshi| Matsumi, Akihiro| Ishihara, Yuki| Saragai, Yosuke| Takada, Saimon| Muro, Shinichiro| Uchida, Daisuke| Okada, Hiroyuki| |
| Keywords | Endoscopic ultrasound-guided fine needle aspiration Pancreaticobiliary cancer Neoplasm recurrence |
| Published Date | 2020 |
| Publication Title | Gut and Liver |
| Volume | volume14 |
| Issue | issue5 |
| Publisher | Gut and Liver |
| Start Page | 652 |
| End Page | 658 |
| ISSN | 1976-2283 |
| NCID | AA12329814 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31818050 |
| NAID | 120006891207 |
| DOI | 10.5009/gnl19200 |
| Web of Science KeyUT | 000569359000016 |
| Related Url | isVersionOf https://doi.org/10.5009/gnl19200 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirai, Mami| Kinugasa, Hideaki| Nouso, Kazuhiro| Yamamoto, Shumpei| Terasawa, Hiroyuki| Onishi, Yuma| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Onishi, Hideki| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki| |
| Keywords | ctDNA hepatocellular carcinoma liquid biopsy prediction prognosis TERT promoter mutation |
| Published Date | 2020-08-24 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume36 |
| Publisher | Wiley |
| Start Page | 1118 |
| End Page | 1125 |
| ISSN | 0815-9319 |
| NCID | AA10727383 |
| Content Type | Journal Article |
| File Version | author |
| PubMed ID | 32830343 |
| DOI | 10.1111/jgh.15227 |
| Web of Science KeyUT | 000568136400001 |
| Related Url | isVersionOf https://doi.org/10.1111/jgh.15227 |
| FullText URL | fulltext.pdf Figure_A.tif Figure_B.tif Figure_C.tif Figure_D.tif |
|---|---|
| Author | Ako, Soichiro| Kawano, Seiji| Okada, Hiroyuki| |
| Published Date | 2020-07-23 |
| Publication Title | Clinical Gastroenterology and Hepatology |
| Volume | volume20 |
| Issue | issue2 |
| Publisher | AGA Institute |
| Start Page | e12 |
| End Page | e13 |
| ISSN | 15423565 |
| NCID | AA11845942 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the AGA Institute |
| File Version | author |
| PubMed ID | 32712389 |
| DOI | 10.1016/j.cgh.2020.07.044 |
| Related Url | isVersionOf https://doi.org/10.1016/j.cgh.2020.07.044 |
| JaLCDOI | 10.18926/AMO/60364 |
|---|---|
| FullText URL | 74_4_275.pdf |
| Author | Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment. |
| Keywords | oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 275 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843758 |
| Web of Science KeyUT | 000562508700002 |
| NAID | 120006880203 |
| JaLCDOI | 10.18926/AMO/60363 |
|---|---|
| FullText URL | 74_4_265.pdf |
| Author | Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun| |
| Abstract | Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy. |
| Keywords | Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 265 |
| End Page | 274 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843757 |
| Web of Science KeyUT | 000562508700001 |
| NAID | 120006880202 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uchida, Daisuke| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Okada, Hiroyuki| |
| Keywords | oxidative stress chronic hepatitis hepatocellular carcinoma |
| Published Date | 2020-05-28 |
| Publication Title | Nutrients |
| Volume | volume12 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 1576 |
| ISSN | 2072-6643 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32481552 |
| DOI | 10.3390/nu12061576 |
| Web of Science KeyUT | 000554005200001 |
| Related Url | isVersionOf https://doi.org/10.3390/nu12061576 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanabe, Katsuyuki| Kanzaki, Hiromitsu| Wada, Takahira| Nakashima, Yuri| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun| |
| Keywords | case report gastric cancer IgA nephropathy nivolumab steroid |
| Published Date | 2020-05-22 |
| Publication Title | Medicine |
| Volume | volume99 |
| Issue | issue21 |
| Publisher | Lippincott, Williams & Wilkins |
| Start Page | e20464 |
| ISSN | 0025-7974 |
| NCID | AA00728867 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 the Author(s). |
| File Version | publisher |
| PubMed ID | 32481351 |
| DOI | 10.1097/MD.0000000000020464 |
| Web of Science KeyUT | 000551508200106 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000020464 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Shumpei| Onishi, Hideki| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| Keywords | Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Low-dose cisplatin plus 5-fluorouracil alpha-Fetoprotein Des-gamma-carboxy prothrombin |
| Published Date | 2020-04-21 |
| Publication Title | Gastrointestinal Tumors |
| Volume | volume7 |
| Issue | issue3 |
| Publisher | Karger |
| Start Page | 83 |
| End Page | 92 |
| ISSN | 2296-3774 |
| NCID | AA12665877 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s) |
| File Version | publisher |
| DOI | 10.1159/000506941 |
| Web of Science KeyUT | 000551254300003 |
| Related Url | isVersionOf https://doi.org/10.1159/000506941 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Murakami, Toshi| Tanaka, Takehiro| Oka, Shohei| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-06-04 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 6381670 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 32566328 |
| DOI | 10.1155/2020/6381670 |
| Web of Science KeyUT | 000542326600001 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/6381670 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Miyahara, Koji| Sakaguchi, Chihiro| Takenaka, Ryuta| Kobayashi, Sayo| Mouri, Hirokazu| Tanaka, Shigetomi| Toyokawa, Tatsuya| Tanaka, Shouichi| Nishimura, Mamoru| Yamauchi, Kenji| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | 18F-fluorodeoxyglucose-positron emission tomography mesenchymal tumor gastric neoplasms gastrointestinal stromal tumor schwannoma |
| Published Date | 2020-05-01 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1301 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32370028 |
| DOI | 10.3390/jcm9051301 |
| Web of Science KeyUT | 000540223800058 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm9051301 |
| JaLCDOI | 10.18926/AMO/59958 |
|---|---|
| FullText URL | 74_3_245.pdf |
| Author | Yamamoto, Shumpei| Takayama, Hiroshi| Shimodate, Yuichi| Takezawa, Rio| Nishimura, Naoyuki| Doi, Akira| Mouri, Hirokazu| Matsueda, Kazuhiro| Mizuno, Motowo| Okada, Hiroyuki| |
| Abstract | Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy. |
| Keywords | vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 245 |
| End Page | 250 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577023 |
| Web of Science KeyUT | 000543363400008 |
| NAID | 120006862799 |
| JaLCDOI | 10.18926/AMO/59957 |
|---|---|
| FullText URL | 74_3_237.pdf |
| Author | Oyama, Atsushi| Uchida, Daisuke| Shiraha, Hidenori| Sawahara, Hiroaki| Kato, Ryo| Iwamuro, Masaya| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Abstract | The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC. |
| Keywords | enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 237 |
| End Page | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577022 |
| Web of Science KeyUT | 000543363400007 |
| NAID | 120006862798 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Takahashi, Takahide| Ota, Yoko| Tanaka, Takehiro| Asada, Noboru| Yano, Shuya| Uka, Mayu| Nakamura, Rei| Baba, Yuki| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-04-09 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 7947540 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 32328319 |
| DOI | 10.1155/2020/7947540 |
| Web of Science KeyUT | 000528921300002 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/7947540 |
| FullText URL | text_correction.pdf table3_correction.pdf |
|---|---|
| Author | Tomoda, Takeshi | Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Note | Correction to: Surgical Endoscopy https://doi.org/10.1007/s00464-020-07385-y| |
| Published Date | 2020-02-06 |
| Publication Title | Surgical Endoscopy |
| Volume | volume35 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 239 |
| End Page | 240 |
| ISSN | 09302794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32030547 |
| DOI | 10.1007/s00464-020-07399-6 |
| Web of Science KeyUT | 000515963500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-07399-6 |
| FullText URL | fulltext.pdf table.pdf |
|---|---|
| Author | Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| chida, Daisuke| atsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Keywords | Malignant biliary obstruction Double-balloon enteroscope Endoscopic retrograde cholangiopancreatography Surgically altered anatomy |
| Note | This fulltext is aailable in Jan. 2021.| |
| Published Date | 2020-01-16 |
| Publication Title | Surgical Endoscopy |
| ISSN | 09302794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31950273 |
| DOI | 10.1007/s00464-020-07385-y |
| Web of Science KeyUT | 000507705600001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-07385-y |
| Title Alternative | Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia |
|---|---|
| FullText URL | 131_139.pdf |
| Author | 三浦 公| Iwamuro, Masaya| Toyokawa, Tatsuya| Takenaka, Ryuta| Inoue, Masafumi| Ito, Mamoru| Okada, Hiroyuki| |
| Abstract | To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety. |
| Keywords | 機能性ディスペプシア (functional dyspepsia) ヘリコバクター・ピロリ (Helicobacter pylori) プロトンポンプ阻害剤 (proton pomp inhibitor) 消化管運動機能改善剤 (acotiamide) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2019-12-02 |
| Volume | volume131 |
| Issue | issue3 |
| Start Page | 139 |
| End Page | 143 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.131.139 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2019 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.131.139 |
| NAID | 130007782646 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uchida, Daisuke| Kato, Hironari| Matsumoto, Kazuyuki| Ishihara, Yuki| Matsumi, Akihiro| Saragai, Yosuke| Takada, Saimon| Yabe, Shuntaro| Muro, Shinichiro| Tomoda, Takeshi| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Keywords | Endoscopic ultrasound Diagnostic screening program Pancreatic diseases Biliary tract diseases |
| Published Date | 2019-12-18 |
| Publication Title | BMC Gastroenterology |
| Volume | volume19 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 220 |
| ISSN | 1471-230X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2019 |
| File Version | publisher |
| PubMed ID | 31852458 |
| DOI | 10.1186/s12876-019-1141-7 |
| Web of Science KeyUT | 000510482800002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-019-1141-7 |
