| Author | 岡山大学医学部附属病院三朝分院| |
|---|---|
| Published Date | 1992-06 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume63 |
| Content Type | Others |
| Author | Matsubara, Fumie| Endou, Hiroi| Kitani, Hikaru| Tanizaki, Yoshiro| |
|---|---|
| Published Date | 1992-06 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume63 |
| Content Type | Data or Dataset |
| Author | 三朝分院看護部| |
|---|---|
| Published Date | 1992-06 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume63 |
| Content Type | Others |
| JaLCDOI | 10.18926/15345 |
|---|---|
| Title Alternative | 気管支喘息の発症における加齢の影響について |
| FullText URL | 063_142_147.pdf |
| Author | Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Tanizaki, Yoshiro| |
| Abstract | Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61. |
| Keywords | Skin test (皮内反応) IgE Provocation test (吸入誘発試験) Basophil reactivity (好塩基球の反応性) Aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 142 |
| End Page | 147 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307130 |
| JaLCDOI | 10.18926/15343 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離 |
| FullText URL | 063_134_141.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE. |
| Keywords | Ca(2+) influx (Ca2+流入) histamine release (ヒスタミン遊離) house dust (ハウスダスト) Candida albicans (カンジダ) anti-lgE (抗ヒトIgE) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 134 |
| End Page | 141 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307872 |
| JaLCDOI | 10.18926/15341 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する好塩基球の反応性. 2.分泌機序における形態的変化 |
| FullText URL | 063_128_133.pdf |
| Author | Tanizaki, Yoshiro| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | Morphological changes of blood basophils activated by antigen and anti-IgE were discussed in relation to release mechanisms of the cells. 1. Basophils activated by antigen and anti-IgE show two different types : A form (pear-shaped) and B from (swollen type), on smear preparartions. 2. Pear-shaped basophils(reactive basophils), which appear after stimulation by antigen and anti-IgE, can be observed by the staining solution for the direct count of basophils and eosinophils. 3. The incidence of reactive basophils increases after addition of antigen. Thus, observation of reactive basophils can be clinically applied for detecting allergen (DCRB ; direct connt of reactive basophils). 4. Observation of morphological basophil response by phase- contrast microscopic motion pictures demonstrates that basophils activated by antigen show two different reponses, increase in motility (oriented movement) and degranulation. |
| Keywords | morphological changes of basophils (好塩基球の形態的変化) reactive basophils (反応好塩基球) degranulation (脱顆粒) histamine release (ヒスタミン遊離) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 128 |
| End Page | 133 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| JaLCDOI | 10.18926/15339 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化 |
| FullText URL | 063_123_127.pdf |
| Author | Tanizaki, Yoshiro| Kimura, Ikuro| |
| Abstract | Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood. The peripheral basophil count is at a normal level in non-attack stage of asthmatics as in healthy subjects. The basophil count increases in pre-attack stages, and decreases during attack stages. These findings suggest that number of basophils changes in close relation to asthma cycle, and that by observing number of basophils in the peripheral blood, it is possible to detect near future attacks. The decrease in number of basophils and histamine release by stimulation with antigen and anti-IgE can be observed in vitro in whole blood and basophils separated by density gradient centrifugation and by counterflow centrifugation elutriation. The decreased number of basophils in the peripheral blood represents migration of the cells into local allergic reaction sites. |
| Keywords | basophils (好塩基球) bronchial asthma (気管支喘息) asthma cycle (喘息発作) histamine release (ヒスタミン遊離) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 123 |
| End Page | 127 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307920 |
| JaLCDOI | 10.18926/15338 |
|---|---|
| Title Alternative | Immunotherapy in house dust mite sensitive asthma |
| FullText URL | 063_117_122.pdf |
| Author | Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro| |
| Abstract | ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である｡この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する｡また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する｡ |
| Keywords | ダニ喘息 (House dust mite sensitive bronchial asthma) 免疫療法 (lmmunotherapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 117 |
| End Page | 122 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307745 |
| JaLCDOI | 10.18926/15336 |
|---|---|
| Title Alternative | Significance of spa therapy in modern medicine and its social request |
| FullText URL | 063_110_116.pdf |
| Author | Tanizaki, Yoshiro| |
| Abstract | ステロイド依存性重症難治性喘息を中心に,温泉療法の臨床効果,作用機序およびその社会的要請について総括的な検討を行った｡1.重症型喘息に対する温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,鉱泥湿布療法などの有効性が高いため,これらの治療法を組合わせた複合温泉療法が現在行われている｡そして,これらの温泉療法は,いずれも細気管支領域の病変(狭窄ないし閉塞)に対して有効であり,気管支肺胞洗浄法(BAL)により観察されるairway inflammationを有する症例が増えつつある現在,極めて有用な治療法の1つと考えられる｡2.入院による温泉療法で軽快した後は,それぞれの地元で継続療法を行うことが症状の安定化のために必要である｡3.重症型喘息は当院への入院例で見る限り,明らかに増加の傾向にあり,薬物療法の限界を越えたこれらの症例の治療には温泉療法が必要であり,周囲環境の変化や高齢化社会を迎えて,その社会的要請は年ごとに増加しつつあると考えられる。 |
| Keywords | 重症型喘息 (Intractable asthma) 温泉プール水泳訓練 (Swimmlng trainlng in a hot spring pool) ヨードゾル吸入療法 (Inhalation therapy with iodine salt solution) 鉱泥湿布療法 (Fango therapy) 複合温泉療法 (Complex spa therapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 110 |
| End Page | 116 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307632 |
| JaLCDOI | 10.18926/15335 |
|---|---|
| Title Alternative | Physical therapy of patients with total hysterectomy |
| FullText URL | 063_106_109.pdf |
| Author | Kamimoto, Manabu| Okuda, Hiroyuki| Tanizaki, Yoshiro| |
| Abstract | 子宮全摘術を受け,回復期に理学療法を実施した患者に,自転車エルゴメーターによる同一負荷運動時の心拍数について施行前と退院時の変化を検討した｡その結果,退院時に心拍数は有意に減少した｡しかし,その減少の程度は理学療法実施回数と相関しなかった｡患者は水中運動を積極的に実施し,速やかに家庭生活を含めた社会生活への復帰が可能となった｡退院後の外来診察時に異常も認められず,理学療法の有効性並びに安全性が確認された。 |
| Keywords | 子宮全摘術 (Abdominal hysterectomy) 術後理学療法 (Postoperative Physical therapy) 自転車エルゴメーター (Bicycle ergometer) 心拍数 (Heart rate) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 106 |
| End Page | 109 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307203 |
| JaLCDOI | 10.18926/15331 |
|---|---|
| Title Alternative | ラット腹腔肥満細胞のCa(2+) influxおよびヒスタミン遊離に対する抗アレルギー薬アゼラスチンの抑制効果について |
| FullText URL | 063_089_094.pdf |
| Author | Tanizaki, Yoshiro| Ohtani, Jun| Kimura, Ikuro| |
| Abstract | The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited (45)Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 μg/ml showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The maximal inhibitory rate was 38.1%. The effect of azelastine on (45)Ca uptake and histamine release was dose-dependent, and compatible at employed cocentration of the agent. 3. Tachpylaxis to azelastine was not found in this experimental system. |
| Keywords | Azelastine (アゼラスチン) Rat mast cells (ラット肥満細胞) (45)Ca uptake (Ca(2+)uptake) Histamine release (ヒスタミン遊離) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 89 |
| End Page | 94 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307786 |
| JaLCDOI | 10.18926/15330 |
|---|---|
| Title Alternative | The efficacy of maternity swimming to reduce mother's weight |
| FullText URL | 063_085_088.pdf |
| Author | Okuda, Hiroyuki| Takatori, Akimasa| Sakata, Junko| Kamimoto, Manabu| Fujii, Junko| Dokai, Chiho| Tanizaki, Yoshiro| |
| Abstract | 第1報において妊婦水泳に関する妊婦の認識について報告し (1) ,第2報において妊婦水泳の現状とその適応について報告した (2) ｡その後,第3報において妊婦水泳が母児の循環系におぼす影響について報告し (3) ,第4報にて出産後1年間の児の予後調査を行った (4) 。今回は,妊婦水泳による体重減少効果について検討を行った。その結果,妊婦水泳前後で平均460gの体重減少がみられた｡また水泳を10回以上行った妊婦において,水泳を行っている期間の体重増加が水泳を行っていない期間の体重増加に比べて有意に少なかった｡これより,妊婦水泳には一定の減量効果があり,肥満妊婦の治療にも応用できると考えられた。 |
| Keywords | 妊婦水泳 (Maternity Swimming) 体重減少 (Reduce mother's weight) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 85 |
| End Page | 88 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307789 |
| JaLCDOI | 10.18926/15329 |
|---|---|
| Title Alternative | Character, Habit and Taste of woman with coldeness in their bodies |
| FullText URL | 063_079_084.pdf |
| Author | Takatori, Akimasa| Okuda, Hiroyuki| Sakata, Junko| Fujii, Junko| Tanizaki, Yoshiro| |
| Abstract | 冷え性の発現は寒冷刺激に対する血管運動性体温調節と密接に関係しているが,患者の性格･生活習慣･食事の嗜好等にも関わっていると考えられる｡そこで今回は冷え性婦人100名を対象にCMl調査と35項目にのぼるアンケート調査を行った｡その結果,冷え性の増悪因子として,日頃の運動不足･神経症的性格傾向･過労･食べ物の嗜好がクローズアップされ,この面での生活指導が冷え性の治療を行っていく上で,薬物的な治療と並んで重要であることか示唆された。 |
| Keywords | 冷え性 (Coldness in women) 性格 (Character) 生活習慣 (Habit) 嗜好 (Taste) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 79 |
| End Page | 84 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307750 |
| JaLCDOI | 10.18926/15328 |
|---|---|
| Title Alternative | Relationship between bone mineral densities of second metacarpal bone and lumber spine |
| FullText URL | 063_099_105.pdf |
| Author | Nakai, Mutsuo| Okuda, Hiroyuki| Akiyama, Tsuneo| Takatori, Akimasa| Tanizaki, Yoshiro| |
| Abstract | QCTおよびDIP法による測定値の相関性について検討し,DIP法による腰椎骨塩量の推定および,スクリーニングへの適用について考察した｡QCT値とΣGS/DやMClとの相関関係の検討では.対象のQCT値が低値か高値かによって相関関係がかなり異なることが明らかになった｡すなわち,QCT値が低い領域は,QCT値と,ΣGS/DやMCIに明らかな正の相関関係が認められたが,一方, QCT値が高い領域では,相関関係は認められなかった｡また,ΣGS/D=2.8mmAI以上,またはMCI=0.48以上の症例においては腰椎圧迫骨折の危険は小さく,ΣGS/D=1.8mmAI以下,またはMCI=0.24以下の症例においては腰椎圧迫骨折の危険が大きい可能性が示唆された。 |
| Keywords | 骨粗鬆症 (osteoporosis) 骨塩量 (bone mineral density) QCT (quantitative computed tomography) DIP法 (digital image processing method) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 99 |
| End Page | 105 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307484 |
| JaLCDOI | 10.18926/15327 |
|---|---|
| Title Alternative | Inhibitory effect of furosemide on histamine release from human basophils |
| FullText URL | 063_095_098.pdf |
| Author | Kitani, Hikaru| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro| |
| Abstract | furosemideは利尿剤として知られているが,吸入することにより気道収縮に対して抑制的に作用することが近年報告されている｡その抑制作用の機序を明らかにする目的で,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果を検討した｡健常人4例,アトピー型気管支喘息患者8例を対象として全血法で抗ヒトIgE刺激によるヒスタミン遊離を観察した｡なお,furosemideの最終濃度は0,1,10,100μg/mlに調整して添加実験を行った｡健常人,気管支喘息いずれにおいても,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果はみられなかった｡ |
| Keywords | 気管支喘息 (Bronchial asthma) フロセミド (Furosemide) ヒスタミン遊離 (Histamine release) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 95 |
| End Page | 98 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307119 |
| JaLCDOI | 10.18926/15326 |
|---|---|
| Title Alternative | Clinical evaluation of an endoscopic image filing system, Olympus SDF-3 |
| FullText URL | 063_074_078.pdf |
| Author | Ochi, Koji| Miyake, Hirofumi| Matsumoto, Shuji| Seno, Toshinobu| Tanaka, Juntaro| Harada, Hideo| Mitsunobu, Fumihiro| Tanizaki, Yosiro| |
| Abstract | 光ディスクとパーソナルコンピュータを組み合わせた内視鏡画像ファイリングシステムは電子内視鏡の画像の保存･管理,検索･再生などに威力を発揮する｡今回,われわれはオリンパス社製内視鏡ファイリングシステムSDF-3を使用する機会を得たので,その有用性や問題点の検討を行った｡有用性としては,①内視鏡画像を検査終了後直ちに再生し,再検討できる,②多数の項目についての検索や統計処理が可能である,③限られたスペース内で大量の画像データの一括保存･管理が可能であるなどが挙げられる｡一方,問題点としては,①内視鏡再生画像は画質が劣化する,②検索機能を十分に活用するにはかなり煩雑な人力操作を必要とする,③光ディスクの清掃が必要であるなどがあげられる｡本内視鏡ファイリングシステムに今後必要な改良点やその展望についても合わせて考案を加えた。 |
| Keywords | 画像ファイリングシステム (image filing system) 電子内視鏡 (electronic endoscope) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 74 |
| End Page | 78 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307278 |
| JaLCDOI | 10.18926/15325 |
|---|---|
| Title Alternative | 気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 |
| FullText URL | 063_069_073.pdf |
| Author | Tanizaki, Yosiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Harada, Hideo| Ochi, Koji| Kimura, Ikuro| |
| Abstract | Delayed cutaneous hypersensitivity towards Candida albicans was examined in 200 patients with bronchial asthma in relation to patient age and the level of total IgE. 1. Delayed skin reactivity towards C.albicans was depressed in the patients between the ages of 10 and 20 and in those over the age of 61. A significant difference was present in delayed skin reactivity between the groups of 10-20 and 41-50 years old. 2. The frequency of the patients with positive delayed skin reactivity towards C.albicans was the highest in those with low levels of total IgE (0 -100 IU/ml) and the low est in those with high levels of total IgE (over than 1001 IU/ml). The results suggest that cell-mediated immunity towards C.albicans is depressed re lating to atopics in the patients between 10 and 20 and to aging in the patients over 61. |
| Keywords | cell-mediated immunity (細胞性免疫) bronchial asthma (気管支喘息) atopics (アトピー) aging (加齢) カンジダ |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 69 |
| End Page | 73 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307949 |
| JaLCDOI | 10.18926/15324 |
|---|---|
| Title Alternative | 臨床所見および検査成績からのスコアーによる喘息分類の特徴 |
| FullText URL | 063_063_068.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro| |
| Abstract | Twenty six patients with bronchial asthma was classified by clinical symptoms and singns (clinical diagnosis), and the classification by clinical diagnosis was compared with the classification by a score calculated from clinical findings and examinations (score diagnosis). 1. Of 12 subjects with type Ia classified by clinical diagnosis, 8 cases with 0 to 49 ml/day of expectoration were evaluated as type Ia by score diagnosis. While four type Ia cases with 50 to 99ml/day of expectoration were calssified as type Ib by score diagnosis. The increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF) of these four cases was similar to the incidence in type Ib cases with hypersecretion. 2. All of 6 subjects with type Ib by clinical diagnosis were estimated as type Ib by score diagnosis. 3. Of 8 cases with type II by clinical diagnosis, 7 cases were assessed as type II by score diagnosis. One case with type II by clinical diagnosis and with the score of 10 points was evaluated as questionable type II by score diagnosis. |
| Keywords | asthma classification (喘息分類) bronchoconstriction (気管支攣縮) hypersecretion (過分泌) bronchiolar obstruction (細気管支閉塞) score diagnosis (スコアー診断) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 63 |
| End Page | 68 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307348 |
| JaLCDOI | 10.18926/15322 |
|---|---|
| Title Alternative | 高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について |
| FullText URL | 063_058_062.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kotoh, Naoki| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects. |
| Keywords | Candida albicans (カンジダ特異的IgG) Specific IgG IgG(4) Bronchial asthma (気管支喘息) Aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 58 |
| End Page | 62 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307284 |
| JaLCDOI | 10.18926/15321 |
|---|---|
| Title Alternative | IgE受容体を介する刺激に対する好塩基球の形態的変化の顕微鏡的観察. 抗原と抗IgE刺激の特徴とその相違点 |
| FullText URL | 063_050_057.pdf |
| Author | Tanizaki, Yoshiro| Nakagawa, Saburo| Kimura, Ikuro| |
| Abstract | Differences in morphological changes of basophils between antigen and anti-IgE stimulation were examined in atopic subjects in relation to histamine release. 1. Antigen- induced release of histamine was remarkably more rapid and larger at any incubation time than the release by anit-IgE, and a significant difference was found at 3 to 9 min. 2. Decrease in number of basophils induced by antigen was significantly higher for 12 to 15 min incubation time than that by anti-IgE. 3. Morphological changes of basophils representing increased motility such as an increased ratio of short to long axis diameter (L/S ratio) and an increased incidence of basophils with localized granules (LG) were more often observed in antigen stimulation compared with anti-IgE, and the L/S ratio of the cells was significantly more increased in antigen stimulation at 6 and 15 min. 4. There was no difference in morphological changes of basophils showimg swollen type (degranulation) such as an increased mean diameter (MD) of the cells between antigen and anti-IgE. These results suggest that antigen activates basophils and induces increased motility more strongly than anti-IgE, but the action on degranulation was not different between the two agents. |
| Keywords | Histamine release (ヒスタミン遊離) Morphological changes of basophils (好塩基球の形態的変化) Antigen (抗原) Anti-IgE (抗IgE) IgE receptors (IgE受容体) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 50 |
| End Page | 57 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307320 |
