| JaLCDOI | 10.18926/15318 |
|---|---|
| Title Alternative | 老令者の気管支喘息,各臨床病型における換気機能の特徴 |
| FullText URL | 063_044_049.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro| |
| Abstract | Ventilatory function was examined in 20 elderly patients with bronchial asthma in relation to clinical asthma types, and the results were compared with those of younger asthmatics. 1. Ventilatory parameters such as FEV(1.0%), % PEFR, % MMF, % V(50) and % V(25), which repressent obstructive ventilatory dysfunction, were in general lower in older asthmatics than in the youger cases. 2. The values of % V(50) and % V(25), representing ventilatory dysfunction in small airways, were significantly lower in the older subjects with type Ib and II compared to the younger cases with same types. 3. Markedly decreased values in ventilatory parameters, particularly in % MMF, % V(50) and % V(25) were observed in both older and younger subjects with type II. The results suggest that ventilatory function decreases with aging and the decrease is related to the pathophysiological changes in the airways. |
| Keywords | Ventilatory function (換気機能) small airways (細気管支) clinical asthma types (臨床病型) elderly asthmatics (老年者気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 44 |
| End Page | 49 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307531 |
| JaLCDOI | 10.18926/15316 |
|---|---|
| Title Alternative | 老年者の気管支喘息. アレルギー反応と気道細胞反応 |
| FullText URL | 063_039_043.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia. |
| Keywords | elderly subjects (老年者) lgE-mediated allergic reaction (IgE系反応) ventilatory function (換気機能) BAL neutrophilia (BAL好中球) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 39 |
| End Page | 43 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307727 |
| JaLCDOI | 10.18926/15313 |
|---|---|
| FullText URL | 063_034_038.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro| |
| Abstract | The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4). |
| Keywords | Total IgE IgG IgG(4) aging bronchial asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 34 |
| End Page | 38 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307767 |
| JaLCDOI | 10.18926/15309 |
|---|---|
| Title Alternative | Correlations between bone mineral density measured by QCT and risk factors of Osteoporosis |
| FullText URL | 063_030_033.pdf |
| Author | Honke, Naoko| Kusaura, Yasuhiro| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| Takatori, Akimasa| Okuda, Hiroyuki| Nakai, Mutsuro| Akiyama, Tsuneo| |
| Abstract | 27～85才の女性143例における骨塩量を,定量的QCT法 (quantitative computed tomography)を用いて測定し,年令,身長,体重及び原疾患(慢性関節リウマチ),使用薬剤(ステロイド･骨強化剤)の因子の骨塩量に及ぼす影響について検討した｡その結果,1)加令とともに骨塩量は低下するが,特に40才代後半から60才代にかけての低下が顕著であり,また, 他因子の影響を受けやすい｡2)体型的因子としては.痩せ型で低身長の人に低値の傾向がある｡3)ステロイド使用の有無における検討において,特に50才代で使用群が著明に低値であることが明らかとなった｡また,薬剤の因子の考察に関しては,さらに経時的検討か必要であると思われた｡ |
| Keywords | 骨粗鬆症 (Osteoporosis) 定量的コンピューター断層法 (QCT (quantitative computed tomograpy)) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 30 |
| End Page | 33 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307603 |
| JaLCDOI | 10.18926/15306 |
|---|---|
| Title Alternative | 気管支喘息における気道内への好中球の出現とその意義 換気機能と関連して |
| FullText URL | 063_025_029.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Kimura, Ikuro| |
| Abstract | Ventilatory function was compared between two age-matched asthma groups : group A (study group) consists of 8 patients with bronchial asthma with marked neutrophilia (20% or more) in the BAL fluid and group B (control group) of 8 patients with neutrophils (less than 5% of total BAL cells). The values of six ventilatory parameters were lower in group A than in group B, and a significant difference was found in FEV(1.0%), % MMF, % V(50) and % V(25) between groups A and B. Of these parameters, the value of % V(25) was markedly decreased in group A compared with group B. The results show that ventilatory dysfunction in airways, especially in small airways, is closely correlated to increased number of neutrophils in BAL fluid. |
| Keywords | ventilatory function (換気機能) neutrophils in BAL fluid (好中球, BAL) small airways (細気管支) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 25 |
| End Page | 29 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307993 |
| JaLCDOI | 10.18926/15304 |
|---|---|
| Title Alternative | 気管支喘息における気道内への好酸球の出現とその意義. 過分泌と関連して. |
| FullText URL | 063_014_018.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | A correlation between the proportion of eosinophils in bronochoalveolar lavage (BAL) fluid and amount of expectoration was examined in patients with atopic asthma. The subjects were divided into two groups : cases with high proportion (20% of more) (group A) and low proportion (less than 5%) (group B) of eosinophils in the BAL fluid. Any significant difference was not paesent in the value of each ventilatory parameter between the two groups. The amount of expectoration/day was significantly higher in group A compared with group B (p<0.001). These results suggest that eosinophilia in BAL fluid correlates to mucus hypersecretion in the airways of patients with atopic asthma. |
| Keywords | Eosinophilia (好酸球) Hypersecretion (過分泌) BAL fluid (BAL) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 14 |
| End Page | 18 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307156 |
| JaLCDOI | 10.18926/15302 |
|---|---|
| Title Alternative | 気管支喘息における気道内リンパ球の出現とその意義.IgE系反応との関連について. |
| FullText URL | 063_019_024.pdf |
| Author | Tanizaki, Yosihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro| |
| Abstract | Relationship of the proportion of lymphocytes in bronchoalveolar lavage (BAL) fiutd to IgE-mediated reactions and to ventilatory function was studied in two age-matched asthma groups : group A of 11 subjects with BAL lymphocytes over 30% and group B of 11 subjects with BAL leyphocytes less than 10%. Of the eleven subjects in group A, 3 (27.3%) were atopic and 4 (36.4%) were non-atopic. The proportion of BAL lymphocytes in subjects with serum IgE level more than 300 IU/ml, who were all older than 50 years, was significantly higher than that in subjects with serum IgE less than 100 IU/ml in group A (p<0.05). While of the eleven subjects of group B, 5 (45.5%) were atopic and 4 (36.4%) were non-atopic. The value of % V(25) was significantly higher in the atopics compared with the non-atopics in group A (p<0.05), although no significant difference was found in the value of % V(25) between the two asthma types in group B. The results show that an increased number of lymphocytes in BAL fluid may be enhanced by IgE-mediated allergic reactions in the elderly, and that the decreased value of % V(25) may be associated withan increased number of lymphocytes in BAL fluid in non-atopics. |
| Keywords | Lymphocytes (リンパ球) BAL fluid (BAL液) IgE antibody (IgE抗体) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 19 |
| End Page | 24 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307202 |
| JaLCDOI | 10.18926/15300 |
|---|---|
| Title Alternative | Clinical effects of spa therapy on bronchial asthma. |
| FullText URL | 063_007_013.pdf |
| Author | Mifune, Takashi| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masahiro| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| |
| Abstract | ステロイド依存性重症難治性喘息を中心に,喘息に対する温泉療法の臨床効果を,症例の背景因子に基づいて検討した｡1.現年令あるいは発症年令が高い症例でより有効であった｡2.非アトピー性の症例において有効率が高率であった｡3.臨床病型別では,細気管支閉塞型において最も有効率が高く,17例中16例(94.1%)が有効であった｡4.ステロイド減量効果は.71症例中43例(60.6%)で認められた｡細気管支閉塞型の症例でステロイド減量不能の症例を多く認めた｡ |
| Keywords | 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 臨床病型 (clinical asthmaty) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 7 |
| End Page | 13 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307411 |
| JaLCDOI | 10.18926/15298 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性喘息に対する複合温泉療法の作用機序 |
| FullText URL | 063_001_006.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Effects of complex spa therapy, which comprises swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy, were analyzed in patients with steroid-dependent intractable asthma (SDIA) by comparison between the subjects with and without efficacy of the therapy. 1. The complex spa therapy was effective in the patients with lower levels of FEV(1.0%) and % PEFR. 2. The complex spa therapy was not always effective in the patients with a low value of % V(25), which represents depressed airflow in the small airways. 3. The efficacy of the complex spa therapy was found in the patients showing a low value of % V(25) accompanied by BAL neutrophilia, but not found in those without increased proportion (more than 10% ) of neutrophils in BAL fluid. The results reveal that the complex spa therapy is effective in patients with SDIA showing low values of FEV(1.0%) and % PEFR, and in those with a low value of % V(25) and BAL neutrophilia. |
| Keywords | complex spa therapy (複合温泉療法) ventilatory function (換気機能) BAL neutrophilia (BAL好中球増多) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307537 |
