JaLCDOI 10.18926/15326
Title Alternative Clinical evaluation of an endoscopic image filing system, Olympus SDF-3
FullText URL 063_074_078.pdf
Author Ochi, Koji| Miyake, Hirofumi| Matsumoto, Shuji| Seno, Toshinobu| Tanaka, Juntaro| Harada, Hideo| Mitsunobu, Fumihiro| Tanizaki, Yosiro|
Abstract 光ディスクとパーソナルコンピュータを組み合わせた内視鏡画像ファイリングシステムは電子内視鏡の画像の保存・管理,検索・再生などに威力を発揮する。今回,われわれはオリンパス社製内視鏡ファイリングシステムSDF-3を使用する機会を得たので,その有用性や問題点の検討を行った。有用性としては,①内視鏡画像を検査終了後直ちに再生し,再検討できる,②多数の項目についての検索や統計処理が可能である,③限られたスペース内で大量の画像データの一括保存・管理が可能であるなどが挙げられる。一方,問題点としては,①内視鏡再生画像は画質が劣化する,②検索機能を十分に活用するにはかなり煩雑な人力操作を必要とする,③光ディスクの清掃が必要であるなどがあげられる。本内視鏡ファイリングシステムに今後必要な改良点やその展望についても合わせて考案を加えた。
Abstract Alternative Olympus SDF-3, an endoscopic image filing system using an electronic endoscope in conjunction with a personal computer and an optical disk, has been recently developed. We evaluated the usefulness of this filing system with 449 cases of gastroduodenal endoscopy. As a result, we have found that this filing system has following advantages : (1) one can review endoscopic images immediately after endoscopic examinations ; (2) previously documented endoscopic image can be searched and reviewed in a short time ; (3) statistical analysis of documented cases is facilitated. However, it has some disadvantages as well to be improved : (1) quality of endoscopic images is deteriorated in the process of filing ; (2) putting patients' data into the filing system is time-consuming ; (3) frequent cleaning of an optic disk is required. This endoscopic image filing system needs to be further developed and refined.
Keywords 画像ファイリングシステム (image filing system) 電子内視鏡 (electronic endoscope)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 74
End Page 78
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307278
Author 三朝分院看護部|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Others
JaLCDOI 10.18926/15336
Title Alternative Significance of spa therapy in modern medicine and its social request
FullText URL 063_110_116.pdf
Author Tanizaki, Yoshiro|
Abstract ステロイド依存性重症難治性喘息を中心に,温泉療法の臨床効果,作用機序およびその社会的要請について総括的な検討を行った。1.重症型喘息に対する温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,鉱泥湿布療法などの有効性が高いため,これらの治療法を組合わせた複合温泉療法が現在行われている。そして,これらの温泉療法は,いずれも細気管支領域の病変(狭窄ないし閉塞)に対して有効であり,気管支肺胞洗浄法(BAL)により観察されるairway inflammationを有する症例が増えつつある現在,極めて有用な治療法の1つと考えられる。2.入院による温泉療法で軽快した後は,それぞれの地元で継続療法を行うことが症状の安定化のために必要である。3.重症型喘息は当院への入院例で見る限り,明らかに増加の傾向にあり,薬物療法の限界を越えたこれらの症例の治療には温泉療法が必要であり,周囲環境の変化や高齢化社会を迎えて,その社会的要請は年ごとに増加しつつあると考えられる。
Abstract Alternative Significance, clinical effects, action mechanisms and social request of spa therapy were discussed in relation to the treatment for patients with steroid-dependent intractable asthma (SDIA) and to modern medicine. 1. Complex spa therapy comprising swimming training in a hot spring pool, inhalation with iodine salt solution and fango therapy is highly effective in patients with SDIA. The action mechanism of complex spa therapy is clearly proved to improve the narrowing and obstruction of the small airways of those with SDIA. The complex spa therapy is more required for the treatment of asthma, because number of asthma patients with airway inflammation increases in recent years. 2. After spa therapy during admission, patients should continue their maintenance therapy to keep their asthma stable. 3. The number of patients with SDIA clearly increases, and antiasthmatic drugs except corticosteroid hormone are not effective for these patients. Thus, complex spa therapy is more necessary for the therapy of these asthma patients.
Keywords 重症型喘息 (Intractable asthma) 温泉プール水泳訓練 (Swimmlng trainlng in a hot spring pool) ヨードゾル吸入療法 (Inhalation therapy with iodine salt solution) 鉱泥湿布療法 (Fango therapy) 複合温泉療法 (Complex spa therapy)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 110
End Page 116
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307632
JaLCDOI 10.18926/15300
Title Alternative Clinical effects of spa therapy on bronchial asthma.
FullText URL 063_007_013.pdf
Author Mifune, Takashi| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masahiro| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract ステロイド依存性重症難治性喘息を中心に,喘息に対する温泉療法の臨床効果を,症例の背景因子に基づいて検討した。1.現年令あるいは発症年令が高い症例でより有効であった。2.非アトピー性の症例において有効率が高率であった。3.臨床病型別では,細気管支閉塞型において最も有効率が高く,17例中16例(94.1%)が有効であった。4.ステロイド減量効果は.71症例中43例(60.6%)で認められた。細気管支閉塞型の症例でステロイド減量不能の症例を多く認めた。
Abstract Alternative Clinical effects of spa therapy were studied in 93 patients in relation to allergological-characteristics. Forty-seven of the 93 patients were steroid-dependent intractable asthma. 1. Spa therapy was effective in the patients over the age of 41 and over 41 at onset. 2. Spa therapy was more effective in nonatopic patients than in atopic. 3. Regarding clinical classification of asthma type (simple bronchoconstriction type, bronchoconstriction + hypersecretion type and bronchiolar obstruction type), spa therapy was most effective in the patients with bronchioar obstruction type (94.1%). 4. In 43 of the 71 patients (60.6%), the dose of corticosteroid used was reduced by spa therapy. In the patient with bronchiolar obstruction type, reduction of corticosteroid by spa therapy was observed with a low propor-
Keywords 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 臨床病型 (clinical asthmaty)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 7
End Page 13
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307411
Author 岡山大学医学部附属病院三朝分院|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Others
JaLCDOI 10.18926/15328
Title Alternative Relationship between bone mineral densities of second metacarpal bone and lumber spine
FullText URL 063_099_105.pdf
Author Nakai, Mutsuo| Okuda, Hiroyuki| Akiyama, Tsuneo| Takatori, Akimasa| Tanizaki, Yoshiro|
Abstract QCTおよびDIP法による測定値の相関性について検討し,DIP法による腰椎骨塩量の推定および,スクリーニングへの適用について考察した。QCT値とΣGS/DやMClとの相関関係の検討では.対象のQCT値が低値か高値かによって相関関係がかなり異なることが明らかになった。すなわち,QCT値が低い領域は,QCT値と,ΣGS/DやMCIに明らかな正の相関関係が認められたが,一方, QCT値が高い領域では,相関関係は認められなかった。また,ΣGS/D=2.8mmAI以上,またはMCI=0.48以上の症例においては腰椎圧迫骨折の危険は小さく,ΣGS/D=1.8mmAI以下,またはMCI=0.24以下の症例においては腰椎圧迫骨折の危険が大きい可能性が示唆された。
Abstract Alternative To compare bone mineral density between second metacarpal bone and lumber spine, two measuring methods, digital image processing method (DIP) for second metacarpal bone and quantitative computed tomography (QCT) for lumber spine were employed in this study. The bone mineral density was evaluated in 89 females and the results were compared between the two methods. A correlation between the bone mineral densities by QCT and ΣGS/D was found in subjects showing low mineral density by QCT, but not in those with high mineral density. These results reveal that DIP is useful to observe bone mineral density and if ΣGS/D and MCI are enough high, almost he hasn't risk of fracture of lumber spine.
Keywords 骨粗鬆症 (osteoporosis) 骨塩量 (bone mineral density) QCT (quantitative computed tomography) DIP法 (digital image processing method)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 99
End Page 105
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307484
JaLCDOI 10.18926/15330
Title Alternative The efficacy of maternity swimming to reduce mother's weight
FullText URL 063_085_088.pdf
Author Okuda, Hiroyuki| Takatori, Akimasa| Sakata, Junko| Kamimoto, Manabu| Fujii, Junko| Dokai, Chiho| Tanizaki, Yoshiro|
Abstract 第1報において妊婦水泳に関する妊婦の認識について報告し (1) ,第2報において妊婦水泳の現状とその適応について報告した (2) 。その後,第3報において妊婦水泳が母児の循環系におぼす影響について報告し (3) ,第4報にて出産後1年間の児の予後調査を行った (4) 。今回は,妊婦水泳による体重減少効果について検討を行った。その結果,妊婦水泳前後で平均460gの体重減少がみられた。また水泳を10回以上行った妊婦において,水泳を行っている期間の体重増加が水泳を行っていない期間の体重増加に比べて有意に少なかった。これより,妊婦水泳には一定の減量効果があり,肥満妊婦の治療にも応用できると考えられた。
Abstract Alternative The efficacy of awimming to reduce mother's weight were studided retrospectively in 107 women. Each time they swum for a hour. They were given a chance of swimming at only one time in a week. Most of them reduced their weight after the swimming. The average of the weight loss was 460 gram after each time of swimming. In women who had a chance of swimming at ten times or more, the mother's weight gain in a week when they had a chance of swimming, was statistically (p<0.01) less than the weight in a week when they didn't swim. Thus, the maternity swimming was thought to have the efficacy to reduce mother's weight. If the maternlty swimming is clinically applied for the treatment of obese pregnant women, their weight will reduce efficiently.
Keywords 妊婦水泳 (Maternity Swimming) 体重減少 (Reduce mother's weight)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 85
End Page 88
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307789
JaLCDOI 10.18926/15335
Title Alternative Physical therapy of patients with total hysterectomy
FullText URL 063_106_109.pdf
Author Kamimoto, Manabu| Okuda, Hiroyuki| Tanizaki, Yoshiro|
Abstract 子宮全摘術を受け,回復期に理学療法を実施した患者に,自転車エルゴメーターによる同一負荷運動時の心拍数について施行前と退院時の変化を検討した。その結果,退院時に心拍数は有意に減少した。しかし,その減少の程度は理学療法実施回数と相関しなかった。患者は水中運動を積極的に実施し,速やかに家庭生活を含めた社会生活への復帰が可能となった。退院後の外来診察時に異常も認められず,理学療法の有効性並びに安全性が確認された。
Abstract Alternative Twenty-one patients with total hysterectomy had a physical therapy program, including swimming training in a hot spring pool, muscle stretching and muscle strengthening exercise. Effects of this program were evaluated by bicycle ergometric challenge test. Maximum increased heart rate of the patients on the ergometric challenge test was significantly lower after the end of the program compared with the initial value before program (p<0.02). However, the effects of such physical therapy program on heart rate did not correlate with the frequency of the program. All patients were able to return to social work without any difficulties. These results support the efficacy of the physical therapy program in our hospital.
Keywords 子宮全摘術 (Abdominal hysterectomy) 術後理学療法 (Postoperative Physical therapy) 自転車エルゴメーター (Bicycle ergometer) 心拍数 (Heart rate)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 106
End Page 109
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307203
JaLCDOI 10.18926/15329
Title Alternative Character, Habit and Taste of woman with coldeness in their bodies
FullText URL 063_079_084.pdf
Author Takatori, Akimasa| Okuda, Hiroyuki| Sakata, Junko| Fujii, Junko| Tanizaki, Yoshiro|
Abstract 冷え性の発現は寒冷刺激に対する血管運動性体温調節と密接に関係しているが,患者の性格・生活習慣・食事の嗜好等にも関わっていると考えられる。そこで今回は冷え性婦人100名を対象にCMl調査と35項目にのぼるアンケート調査を行った。その結果,冷え性の増悪因子として,日頃の運動不足・神経症的性格傾向・過労・食べ物の嗜好がクローズアップされ,この面での生活指導が冷え性の治療を行っていく上で,薬物的な治療と並んで重要であることか示唆された。
Abstract Alternative The character, habit and taste were studied about by means of a questionnaire survey and Cornell Medical Index in 100 women who felt cold in their part of bodies. More than 30% of the women showed the neurotic personality, They had a tendency to dislike the greasy foods, and frequently had sweet foods. More than 50% of them ordinally complained of shoulder stiffness and generalfatigue. The women who played sports weekly were less than 20%. The neurotic porsonality, the tendency to dislike the greasy foods and the lack of exercise were seemed to be the feature of their character, taste, and habit. Thus, improvement of their personality and life style may have a good effect on the coldness in women.
Keywords 冷え性 (Coldness in women) 性格 (Character) 生活習慣 (Habit) 嗜好 (Taste)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 79
End Page 84
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307750
Author Matsubara, Fumie| Endou, Hiroi| Kitani, Hikaru| Tanizaki, Yoshiro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Data or Dataset
JaLCDOI 10.18926/15338
Title Alternative Immunotherapy in house dust mite sensitive asthma
FullText URL 063_117_122.pdf
Author Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro|
Abstract ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である。この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する。また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する。
Abstract Alternative Immunotherapy with house dust extract is employed as a treatment of patients with house dust mite sensitive bronchial asthma. Although 70-80% efficacy of the treatment is reported, mechanisms of its efficacy are not clear yet. In this paper, reported studies of IgE antibody, IgG antibody, IgG4 antibody, antiidiotypic antibody, reactivity of mast cells and function of lymphocytes are reviewed. A new type of immunotherapy with allergen antibody immune complex and a potential use of influenza virus hemaglutinin peptide analogue are also referred.
Keywords ダニ喘息 (House dust mite sensitive bronchial asthma) 免疫療法 (lmmunotherapy)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 117
End Page 122
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307745
JaLCDOI 10.18926/15327
Title Alternative Inhibitory effect of furosemide on histamine release from human basophils
FullText URL 063_095_098.pdf
Author Kitani, Hikaru| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Abstract furosemideは利尿剤として知られているが,吸入することにより気道収縮に対して抑制的に作用することが近年報告されている。その抑制作用の機序を明らかにする目的で,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果を検討した。健常人4例,アトピー型気管支喘息患者8例を対象として全血法で抗ヒトIgE刺激によるヒスタミン遊離を観察した。なお,furosemideの最終濃度は0,1,10,100μg/mlに調整して添加実験を行った。健常人,気管支喘息いずれにおいても,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果はみられなかった。
Abstract Alternative Inhibitory effect of furosemide on histamine release from basophils induced by anti-IgE was examined in 4 healthy subjects and 8 patients with atopic asthma. The experiments of basophil histamine release were carried out by using whole blood method. The mean values of histamine release after 15 min preincubation with furosemide at various concentrations were not significantly decreased, in both healthy and asthmatic subjects compared to those of histamine release without furosemide. The results obtained here show that furosemide does not inhibit histamine release from basophils by the whole blood method.
Keywords 気管支喘息 (Bronchial asthma) フロセミド (Furosemide) ヒスタミン遊離 (Histamine release)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 95
End Page 98
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307119
JaLCDOI 10.18926/15313
FullText URL 063_034_038.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro|
Abstract The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4).
Keywords Total IgE IgG IgG(4) aging bronchial asthma
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 34
End Page 38
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307767
JaLCDOI 10.18926/15304
Title Alternative 気管支喘息における気道内への好酸球の出現とその意義. 過分泌と関連して.
FullText URL 063_014_018.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro|
Abstract A correlation between the proportion of eosinophils in bronochoalveolar lavage (BAL) fluid and amount of expectoration was examined in patients with atopic asthma. The subjects were divided into two groups : cases with high proportion (20% of more) (group A) and low proportion (less than 5%) (group B) of eosinophils in the BAL fluid. Any significant difference was not paesent in the value of each ventilatory parameter between the two groups. The amount of expectoration/day was significantly higher in group A compared with group B (p<0.001). These results suggest that eosinophilia in BAL fluid correlates to mucus hypersecretion in the airways of patients with atopic asthma.
Abstract Alternative アトピー型気管支喘息のなかから,気管支肺胞洗浄液(BALF)中の好酸球の出現頻度が20%以上の症例(グループA)と5%以下の症例(グループB)の2群を選び出し,それぞれの換気機能および喀痰量を比較検討した。その結果,換気機能には両群間に有意の差は見られなかったが,1日喀痰量は,BALF中好酸球の著明増多を示すグループAにおいて有意に多い傾向が見られた。これらの結果は,BALF中好酸球増多と過分泌との間にはある程度の関連があることを示しているものと考えられた。
Keywords Eosinophilia (好酸球) Hypersecretion (過分泌) BAL fluid (BAL) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 14
End Page 18
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307156
JaLCDOI 10.18926/15309
Title Alternative Correlations between bone mineral density measured by QCT and risk factors of Osteoporosis
FullText URL 063_030_033.pdf
Author Honke, Naoko| Kusaura, Yasuhiro| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| Takatori, Akimasa| Okuda, Hiroyuki| Nakai, Mutsuro| Akiyama, Tsuneo|
Abstract 27~85才の女性143例における骨塩量を,定量的QCT法 (quantitative computed tomography)を用いて測定し,年令,身長,体重及び原疾患(慢性関節リウマチ),使用薬剤(ステロイド・骨強化剤)の因子の骨塩量に及ぼす影響について検討した。その結果,1)加令とともに骨塩量は低下するが,特に40才代後半から60才代にかけての低下が顕著であり,また, 他因子の影響を受けやすい。2)体型的因子としては.痩せ型で低身長の人に低値の傾向がある。3)ステロイド使用の有無における検討において,特に50才代で使用群が著明に低値であることが明らかとなった。また,薬剤の因子の考察に関しては,さらに経時的検討か必要であると思われた。
Abstract Alternative Bone mineral density (BMD) was measured in 143 females aged 27 to 85 years old to investigate the correlations between BMD and several factors such as age, height, presence of rheumatoid arthritis and corticosteroid or bone intensifying drug therapy. 1) BMD values decreased with aglng and the most remarkable decrease was observed at the age of latter half of 40's to 60's. 2) Women with slim and low stature tended to have low BMD values. 3) BMD values of women with steroid therapy were significantry lower than those without corticosteroid at the age of 50's (p<0.01). However, further study is necessary to confirm the effect of drugs on BMD.
Keywords 骨粗鬆症 (Osteoporosis) 定量的コンピューター断層法 (QCT (quantitative computed tomograpy))
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 30
End Page 33
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307603
JaLCDOI 10.18926/15306
Title Alternative 気管支喘息における気道内への好中球の出現とその意義 換気機能と関連して
FullText URL 063_025_029.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Kimura, Ikuro|
Abstract Ventilatory function was compared between two age-matched asthma groups : group A (study group) consists of 8 patients with bronchial asthma with marked neutrophilia (20% or more) in the BAL fluid and group B (control group) of 8 patients with neutrophils (less than 5% of total BAL cells). The values of six ventilatory parameters were lower in group A than in group B, and a significant difference was found in FEV(1.0%), % MMF, % V(50) and % V(25) between groups A and B. Of these parameters, the value of % V(25) was markedly decreased in group A compared with group B. The results show that ventilatory dysfunction in airways, especially in small airways, is closely correlated to increased number of neutrophils in BAL fluid.
Abstract Alternative 気管支喘息を対象に,年令をmatchさせた2つのグループ,すなわち,気管支肺胞洗浄液(BALF)中の好中球の出現頻度が20%以上の8症例(グループA)と,BALF中の好中球の出現頻度が5%以下の8症例(グループB)における換気機能について比較検討を行った。6つの換気パラメーターは,全般的にグループAにおいてグループBに比べ低い傾向が見られ,FEV(1.0%),% MMF,% V(50)および% V(25)値は,いずれもグループAにおいて有意に低い値が示された。これらのパラメーターのうち,% V(25)値はグループBに比べグループAにおいて著明に低い値が示された。これらの結果は,気道における換気障害,特に小ないし細気管支領域の換気障害は,BALF中の好中球の出現頻度とある程度関連していることを示すものと考えられた。
Keywords ventilatory function (換気機能) neutrophils in BAL fluid (好中球, BAL) small airways (細気管支) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 25
End Page 29
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307993
JaLCDOI 10.18926/15321
Title Alternative IgE受容体を介する刺激に対する好塩基球の形態的変化の顕微鏡的観察. 抗原と抗IgE刺激の特徴とその相違点
FullText URL 063_050_057.pdf
Author Tanizaki, Yoshiro| Nakagawa, Saburo| Kimura, Ikuro|
Abstract Differences in morphological changes of basophils between antigen and anti-IgE stimulation were examined in atopic subjects in relation to histamine release. 1. Antigen- induced release of histamine was remarkably more rapid and larger at any incubation time than the release by anit-IgE, and a significant difference was found at 3 to 9 min. 2. Decrease in number of basophils induced by antigen was significantly higher for 12 to 15 min incubation time than that by anti-IgE. 3. Morphological changes of basophils representing increased motility such as an increased ratio of short to long axis diameter (L/S ratio) and an increased incidence of basophils with localized granules (LG) were more often observed in antigen stimulation compared with anti-IgE, and the L/S ratio of the cells was significantly more increased in antigen stimulation at 6 and 15 min. 4. There was no difference in morphological changes of basophils showimg swollen type (degranulation) such as an increased mean diameter (MD) of the cells between antigen and anti-IgE. These results suggest that antigen activates basophils and induces increased motility more strongly than anti-IgE, but the action on degranulation was not different between the two agents.
Abstract Alternative 抗原および抗IgE刺激時の好塩基球の形態変化の特徴について,ヒスタミン遊離との関連のもとに,顕微鏡下に経時的に観察した。1.抗原刺激時のヒスタミン遊離は,15分間のincubationのいずれの時期においても,抗IgE刺激に比べ有意に多く,incubation時間3分と9分では両者間に有意の差が見られた。2.抗原刺激時の好塩基球数の減少も抗IgE刺激に比べより高度であった。3.運動亢進により洋梨型を示す抗塩基球では,長径/短径比の増大が見られた。この長径/短径比の増大を示す好塩基球は,抗原刺激時に抗IgE刺激に比べより高頻度に見られ,特にincubation6分と15分では両者間に有意の差が見られた。4.膨化型を示す好塩基球ではその平均直径の増大が見られるが,この平均直径の増大については,抗原と抗lgE刺激との間に差は見られなかった。以上の結果より,抗原刺激では,好塩基球のactivate,運動亢進へ の過程が抗IgE刺激時と比べより高度であるが,膨化への過程には両者間に差が見られないことが示唆された。
Keywords Histamine release (ヒスタミン遊離) Morphological changes of basophils (好塩基球の形態的変化) Antigen (抗原) Anti-IgE (抗IgE) IgE receptors (IgE受容体)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 50
End Page 57
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307320
JaLCDOI 10.18926/15302
Title Alternative 気管支喘息における気道内リンパ球の出現とその意義.IgE系反応との関連について.
FullText URL 063_019_024.pdf
Author Tanizaki, Yosihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro|
Abstract Relationship of the proportion of lymphocytes in bronchoalveolar lavage (BAL) fiutd to IgE-mediated reactions and to ventilatory function was studied in two age-matched asthma groups : group A of 11 subjects with BAL lymphocytes over 30% and group B of 11 subjects with BAL leyphocytes less than 10%. Of the eleven subjects in group A, 3 (27.3%) were atopic and 4 (36.4%) were non-atopic. The proportion of BAL lymphocytes in subjects with serum IgE level more than 300 IU/ml, who were all older than 50 years, was significantly higher than that in subjects with serum IgE less than 100 IU/ml in group A (p<0.05). While of the eleven subjects of group B, 5 (45.5%) were atopic and 4 (36.4%) were non-atopic. The value of % V(25) was significantly higher in the atopics compared with the non-atopics in group A (p<0.05), although no significant difference was found in the value of % V(25) between the two asthma types in group B. The results show that an increased number of lymphocytes in BAL fluid may be enhanced by IgE-mediated allergic reactions in the elderly, and that the decreased value of % V(25) may be associated withan increased number of lymphocytes in BAL fluid in non-atopics.
Abstract Alternative 気管支喘息を対象に,気管支肺胞洗浄液(BALF)中のリンパ球の出現頻度と,IgE系反応および換気機能との関連について検討を加えた。対象は,同年齢の2つのグループ,すなわち,BALF中リンパ球出現頻度30%以上の症例(グループA)と10%以下の症例(グループB)に分けて,それぞれ11例ずっで比較検討を行った。グループAでは,11例中3例がアトピー型,4例が非アトピー型であった。血清IgEが300IU/ml以上の症例(いずれも50才以上)では,100IU/ml以下の症例に比べ,BALF中リンパ球の出現頻度は,有意に高い傾向を示した。一方,グループBの11例では,アトピー型5例,非アトピー型4例であった。% Ⅴ(25)値は,グループAではアトピー型で,非アトピー型に比べ有意に高い値を示した。これらの結果は,50才以上の症例では,IgE系の反応がリンパ球の出現頻度を増強させること,そして,非アトピー型では,リンパ球の出現頻度と% Ⅴ(25)笛値との間にある程度の関連が見られることを示唆しているものと考えられた。
Keywords Lymphocytes (リンパ球) BAL fluid (BAL液) IgE antibody (IgE抗体) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 19
End Page 24
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307202
JaLCDOI 10.18926/15345
Title Alternative 気管支喘息の発症における加齢の影響について
FullText URL 063_142_147.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Tanizaki, Yoshiro|
Abstract Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61.
Abstract Alternative 気管支喘息の発症機序の一つとして,IgE抗体にmediateされる即時型アレルギー反応や好塩基球の反応性の関与が明らかにされている。本論文では,即時型アレルギー反応や抗ヒトIgEや特異抗原に対する好塩基球の反応性が加齢によりどのような影響を受けるかについて検討を加えた。ハウスダスト,ブタクサ,アスペルギルス,アルテルナリア,クラドスポリウム,ブロンカスマ などによる皮内反応の陽性率は,加齢とともに低下する傾向を示した。一方カンジダによる皮内反応の陽性率は,41~50歳および61歳以上の年齢層で高度であった。血清IgE値は加齢とともに低下する傾向がみられた。ハウスダスト特異的IgE抗体,吸入誘発試験の陽性率は,加齢とともに低下する傾向を示した。一方カンジダでは特異的IgE抗体,吸入誘発試験いずれも41~50歳および61歳以上の年齢層で比較的高い陽性率が観察された。抗ヒトIgEに対する好塩基球の反応性は,血清IgEが高値(501IU/ml以上)の場合は年齢と関係なくIgE依存性であったが,血清IgE値の低い症例(301IU/ml以下)では年齢が高い群でその反応性が低い症例の比率が大きかった。ハウスダストに対する好塩基球の反応性は,抗ヒトIgE同様年齢が高い群ほど反応性が低い症例の比率が大きかった。カンジダに対する好塩基球の反応性は,41~50歳および61歳以上の年齢層の症例でより高度であった。
Keywords Skin test (皮内反応) IgE Provocation test (吸入誘発試験) Basophil reactivity (好塩基球の反応性) Aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 142
End Page 147
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307130
JaLCDOI 10.18926/15322
Title Alternative 高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について
FullText URL 063_058_062.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kotoh, Naoki| Tada, Shinya| Kimura, Ikuro|
Abstract Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects.
Abstract Alternative 高齢者(61才以上)の健常人48名および気管支喘息患者69例を対象に,カンジダ特異的IgGおよびIgG(4)抗体を測定し,その増加の機序について若干の検討を加えた。なお,対照としては,30才以下の健常者および気管支喘息患者を選んだ。1.カンジダ特異的IgGおよびIgG(4)抗体価は,30才以下では,健常人に比べ気管支喘息症例で高い傾向が見られ,特異的IgG抗体では両者間に有意の差が見られた(p<0.05)。2.カンジダ特異的IgGおよびIgG(4)抗体は,健常人および気管支喘息症例いずれも加齢とともに増加する傾向が見られ,71才では,30才以下の症例に比べ有意に高い抗体価を示した。3.61才以上の高齢者では,特異的IgG,IgG(4)抗体いずれにおいても,健常人と気管支喘息患者との間に有意の差は見られなかった。
Keywords Candida albicans (カンジダ特異的IgG) Specific IgG IgG(4) Bronchial asthma (気管支喘息) Aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 58
End Page 62
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307284