| JaLCDOI | 10.18926/AMO/30567 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Kimura, Ikuro| Yamana, Masatoshi| NNishishita, Akira| Sugiyama, Motoharu| Miyata, Akira| |
| Abstract | A urinary iron excretion test was carried out in 22 patients with iron deficiency anemia. The iron excretion index was significantly higher in patients with intractable iron deficiency anemia compared with normal subjects and anemic patients who were responsive to iron therapy. The findings suggest that iron excretion may be a factor that modulates the response of patients to iron therapy. |
| Keywords | iron excretion iron deficiency anemia saccharated iron oxide. |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 41 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446838 |
| Web of Science KeyUT | A1980JS13800005 |
| JaLCDOI | 10.18926/AMO/30566 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Miyamoto, Kanji| Miyano, Keiko| Miyoshi, Isao| Hamasaki, Kazuhide| Nishihara, Ryuji| Terao, Seiya| Kimura, Ikuro| Maeda, Kenichiro| Matsumura, Kazuyoshi| Mishijima, Katsumi| Tanaka, Toshio| |
| Abstract | Cytogenetic studies were performed on a biopsy specimen of a jaw tumor and on a bone marrow aspirate from a Japanese patient with Epstein-Barr virus-negative Burkitt's lymphoma. A 14q + chromosome was found in cells from either source, although each contained a different clone. Other karyotypic abnormalities present in common included 2dir dup (1q) (q21 leads to q32), 3q+, 6p--, +12, +mar. |
| Keywords | non-African Burkitt's lymphoma chromosome 14q+. |
| Amo Type | Brief Note |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 61 |
| End Page | 65 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446841 |
| Web of Science KeyUT | A1980JS13800008 |
| JaLCDOI | 10.18926/AMO/30565 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Hidaka, Hideyuki| Omura, Sachiko| Oda, Takuzo| |
| Abstract | Several DNA-histone complexes were reconstituted in the presence and absence of urea. The fiber size of DNA-histone H1 complex was about 20 A in width with knobs 100 to 250 A in diameter interspersed at an average interval of about 1,100 A. H1-was associated with DNA segments corresponding to a DNA size of fewer than 100 base pairs. DNA-histones H2A, H2B, H3 and H4 complex consisted of globular subunits 100 to 150 A in diameter alternating with thin strands, like beads on a string. DNA-whole histones complex was 200 to 250 A in width and had a condensed configuration. The nuclease digestion pattern of the complexes containing histones H2A, H2B, H3 and H4 was regular, similar to that of chromatin, and was disrupted by urea. The complex containing H1 was inactive for in vitro RNA synthesis by escherichia coli RNA polymerase, whereas the other complexes were active. The complexes reconstituted in the absence of urea had template activities slightly less than in the presence of urea. |
| Keywords | finestructure template activity DNA-histone complex reconstitution reconstitution electron microscopy nuclease digestion. |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446834 |
| Web of Science KeyUT | A1980JS13800001 |
| JaLCDOI | 10.18926/AMO/30564 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Kimura, Ikuro| Sugiyama, Motoharu| Ishibashi, Ken| Miyata, Akira| Matsuzaka, Hiroto| |
| Abstract | The effect of desferrioxamine on several hematological parameters was studied in growing rats. Animals given desferrioxamine intramuscularly (150 mg/kg daily) had increased urinary iron after one week, and decreased hemoglobin after 2 weeks. The difference in hemoglobin concentration between the treated and control groups was significant after 4 weeks of treatment with desferrioxamine, but the difference in the numbers of erythrocytes was not significant. The anemia was of hypochromic type. Desferrioxamine at this dosage did not retard growth. These findings support our previously reported concept of "iron-losing anemia". |
| Keywords | desferrioxamine iron excretion iron deficiency anemia. |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 31 |
| End Page | 35 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446837 |
| Web of Science KeyUT | A1980JS13800004 |
| JaLCDOI | 10.18926/AMO/30563 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Yamada, Teruo| Talbot, Alan| Hirakawa, Misahisa| Kobayashi, Naohide| Shiwaku, Yoshitomo| Kosaka, Futami| Kimoto, Tetsuo| |
| Abstract | Renal cortex was studied during experimentally induced ischemia. A transient increase in anerobic glycolysis occurred with concomitant swelling of both the Golgi apparatus and mitochondria. These intracytoplasmic organelles underwent marked changes in their intracellular positions. Infolding of cytoplasmic membrane at the basal side of proximal tubule cells increased in complexity and proceeded to enclose various intracytoplasmic microorganelles such as mitochondria and the Golgi apparatus. Piling up in layers was particularly marked around mitochondria. This piling up appeared as myelin-like structures on the free surface of, and within, proximal tubule cells, and followed disruption of the brush border at the free surface. Histological examination of thin sections showed that the fused portions of this brush border were actually brush border cytoplasmic membrane piled up in layers giving the appearance of myelin-like structures. After two hours of ischemia, parts of the membrane of these myelin-like structures were disrupted. Large vacuoles developed and these were thought to be related to the large vacuoles seen during cell degeneration. |
| Keywords | Myelin-like structures ischemia kidney |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 19 |
| End Page | 30 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446836 |
| Web of Science KeyUT | A1980JS13800003 |
| JaLCDOI | 10.18926/AMO/30562 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Takaya, Yasumasa| Ota, Zensuke| Makino, Hirofumi| Kida, Keiko| Miyoshi, Akira| Hiramatsu, Makoto| Takahashi, Kayo| Ofuji, Tadashi| |
| Abstract | Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the short dimension 13.8+/-3.6 A in nephrosis whereas the long dimension was 12.3+/-2.5 A and the short dimension 8.4+/-1.0 A in normal rats. Changes in the pores in GBM were thought to result in increased permeability of serum protein and hence proteinuria. |
| Keywords | gromerular basement membranc aminonucleoside nephrosis negative staining. |
| Amo Type | Brief Note |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 67 |
| End Page | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446842 |
| Web of Science KeyUT | A1980JS13800009 |
| JaLCDOI | 10.18926/AMO/30561 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Miyoshi, Masanori| Nakashima, Yusaku| Hirakawa, Shuzo| Mitsunaga, Mikio| Nakagawa, Osamu| Miura, Hiroshi| Suzuki, Shinya| Ofuji, Tadashi| |
| Abstract | Function of pituitary-thyroid axis was studied in rats with experimentally induced thyroiditisWistar strain female rats were immunized with homologous thyroid extract in Freund's complete adjuvant and with simultaneous intradermal injection of pertussis vaccine concentrate. They received booster shots at the first and third week after the initial immunization. Serum thyroid hormones and TSH were measured just before, and at weekly intervals after, the initial immunization. Histological examination of the thyroid gland at the second week after immunization showed slight infiltration of macrophages in the thyroid follicles. From the third to the fourth week, massive lymphoid cell infiltration and destruction of follicular architecture developed in all immunized rats. Serum R3 levels slightly decreased during the second week, increased transiently during the third week, then decreased again thereafter. Serum T4 levels decreased slightly durinf the fourth week. Serum TSH levels were not elevated significantly during the third week, but the response to TRH was significantly increased at this time. Basal TSH levels were increased during the fourth week. The TRH test was a sensitive method capable of detecting minimal failure of thyroid function undetected by other routine measuremens of thyroid hormones and TSH. |
| Keywords | thyroid function thyrotropin (TSH) experimental thyroiditis thyroid hormones. |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 11 |
| End Page | 17 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446835 |
| Web of Science KeyUT | A1980JS13800002 |
| JaLCDOI | 10.18926/AMO/30560 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Tsuji, Takao| Inoue, Junichi| Shinohara, Toru| Tsuchiya, Masao| Onoue, Kimiaki| Araki, Kiyonori| Nagashima, Hideo| Nakashima, Akira| Naito, Kunihiko| |
| Abstract | Fragmented sheep red blood cell (SRBC) membrane was used for detection of T-cells in liver biopsy specimens from patients with chronic active hepatitis. SRBC was separated with Lymphoprep, sonicated, then filtered through a 3 mu Millipore-membrane as a fragmented SRBC reagent. Tissue T-cells were stained by an indirect immunofluorescent technique using SRBC reagent and fluorescein isothiocyanate (FITC)-labelled rabbit anti-SRBC. Positively staining lymphocytes were present in portal tracts and in areas of piecemeal necrosis. There also seemed to be a positive correlation between the number of positively staining lymphocytes and the activity of chronic hepatitis; numerous lymphocytes being stained in areas of severe piecemeal necrosis. Our findings suggest that the fragmented SRBC technique for detection of T-cells is reliable and reproducible, that it could be used as a clinical routine method, and that it is useful for further elucidating the nature of host immune reactions on tissue levels.< |
| Keywords | T-lymphocyte T-cell lymphocyte receptor chronic active hepatitis immune response. |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 51 |
| End Page | 59 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446840 |
| Web of Science KeyUT | A1980JS13800007 |
| JaLCDOI | 10.18926/AMO/30559 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Asahi, Toshihiko| Matsumura, Yosuke| Tanahashi, Toyoko| Yoshimoto, Jun| Kaneshige, Tetsuzo| Fujita, Yukitoshi| Ohmori, Hiroyuki| |
| Abstract | Seventy-eight patients were treated with intravesical instillation of Thio-Tepa in an attempt to prevent postoperative recurrences of bladder tumors. Fifty-six patients who were given no preventive treatment against recurrences were taken as the control group. The patients in this series presented at the Okayama University Hospital between 1961 and 1976 and only the first recurrence after the primary operation was taken into consideration. There was no significant difference in the recurrence rates of the control and instillation groups. |
| Keywords | bladder tumor intravesical instillation thiotepa recurrence rate. |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 1980-02 |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 43 |
| End Page | 49 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 6446839 |
| Web of Science KeyUT | A1980JS13800006 |
